专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3029149A1 Method of the identification of gene regulation targets 审中-公开
标题翻译： Verfahren zur Identifizierung von Genregulationszielen
公开(公告)号：EP3029149A1
公开(公告)日：2016-06-08
申请号：EP14196170.6
申请日：2014-12-03
申请人： Fundacio Centre de Regulacio Genomica , ICREA, Institució Catalana de Recerca I Estudis Avançats
发明人： Papasaikas, Panagiotis , Tejedor Vaquero, Juan Ramón , Valcarcel Juarea, Juan Ramón
IPC分类号： C12Q1/68
摘要： A method arising from knocking down the components of the splicing machinery on alternative splicing events relevant for cell proliferation and apoptosis and using this information to reconstruct a network of functional interactions. The network accurately captures known physical and functional associations and identifies new ones, revealing remarkable regulatory potential of core spliceosomal components. It can be used to infer targets for alternative splicing regulation and drugs directed to disease assocaited to altered splicing events.
摘要翻译：一种方法是将剪接机构的组分敲入与细胞增殖和凋亡相关的可变剪接事件，并使用该信息重建功能性相互作用的网络。网络准确捕获已知的物理和功能关联并识别新的物质和功能关联，揭示核心剪接体组分的显着调控潜力。它可用于推断用于选择性剪接调节的靶标和针对改变剪接事件的疾病的药物。

2. 发明公开

EP1750119A1 Novel chiral derivatizing reagent for the determination of enantiomeric excesses 审中-公开
标题翻译： Neue chirale Derivatisierungsreagenzien zur Bestimmung对应的Überschusses
公开(公告)号：EP1750119A1
公开(公告)日：2007-02-07
申请号：EP05107264.3
申请日：2005-08-05
申请人： Institut Catala D'Investigacio Quimica , ICREA, Institució Catalana de Recerca I Estudis Avançats
发明人： Pericàs Brondo, Miquel A. , Jimeno Mollet, Cirili , Vidal i Ferran, Anton , Rodríguez Escrich, Sergi , Popa Madeleine, Dana
IPC分类号： G01N24/08 , C07B57/00
CPC分类号： G01R33/44 , C07B57/00 , G01N24/08 , G01N24/088
摘要： A method for the determination of the enantiomeric composition of a chiral compound comprising (a) derivatising said chiral compound with a enantiomerically and diastereomerically pure compound of general formula I and (b) analysing the resulting mixture by an analytic technique.

wherein Ar is an optionally substituted aromatic or heteroaromatic group.
摘要翻译：一种用于测定手性化合物的对映异构体组合物的方法，包括（a）用对映异构体和非对映异构体纯的通式I化合物衍生所述手性化合物，和（b）通过分析技术分析所得混合物。其中Ar是任选取代的芳族或杂芳族基团。

3. 发明公开

EP1770095A1 Efficient catalysts for the asymmetric epoxidation of electron deficient as well as non electron deficient alkenes 审中-公开
标题翻译： Effiziente Katalysatoren zur不对称的Epoxidierung von mit Elektronenmangel sowie ohne Elektronenmangel Alkenen
公开(公告)号：EP1770095A1
公开(公告)日：2007-04-04
申请号：EP05108856.5
申请日：2005-09-26
申请人： Institut Catala D'Investigacio Quimica , ICREA, Institució Catalana de Recerca I Estudis Avançats
发明人： Vidal i Ferran, Anton , Nieto Alonso, Natàlia , Molas Porqueras, Pineda Dr. , Benet-Buchholz, Jordi Dr.
IPC分类号： C07D493/10
CPC分类号： C07D493/10
摘要： A compound of formula I and its enantiomeric counterpart V; a process for the preparation of diol I, and alternatively diol V, comprising a) the acetylation of diol II, or respectively diol VI, with an acetylating agent, wherein said acetylation is performed in the presence of a Lewis acid and b) an aqueous work-up of the reaction mixture; and a method for producing an enantiomerically enriched epoxide from an alkene, said method comprising admixing said alkene, a substantially enantiomerically pure chiral diol selected from the group comprising diol I and diol V and an oxidizing agent. The method can further comprise the addition of a phase-transfer catalyst.
摘要翻译：式I化合物及其对映异构体对应物V; 二醇I的制备方法，或二醇V，其包括a）二醇II或二醇VI与乙酰化剂的乙酰化，其中所述乙酰化在路易斯酸存在下进行，和b）水性反应混合物的后处理; 以及从烯烃制备对映异构体富集的环氧化物的方法，所述方法包括混合所述烯烃，一种选自二醇I和二醇V的基本上对映体纯的手性二醇和氧化剂。该方法还可以包括加入相转移催化剂。

4. 发明公开

EP3269699A1 CATALYTIC CARBOXYLATION OF ACTIVATED ALKANES AND/OR OLEFINS 审中-公开
标题翻译：活化烷烃和/或烯烃的催化羧化
公开(公告)号：EP3269699A1
公开(公告)日：2018-01-17
申请号：EP16382336.2
申请日：2016-07-15
申请人： Fundació Institut Català d'investigació Quimica , ICREA, Institució Catalana de Recerca I Estudis Avançats
发明人： MARTÍN ROMO, Rubén , JULIÁ HERNÁNDEZ, Francisco , CORNELLA, Josep
IPC分类号： C07C51/15 , C07C53/126 , C07C53/128 , C07C53/134 , C07C57/30 , C07C61/08 , C07C67/29 , C07C67/313 , C07C69/24 , C07C69/34 , C07C69/46 , C07C69/92
CPC分类号： C07C67/313 , C07C51/15 , C07C67/29 , C07C2601/14 , C07C53/128 , C07C53/126 , C07C69/46 , C07C69/34 , C07C69/92 , C07C69/24 , C07C53/134 , C07C61/08 , C07C57/30
摘要： The present invention relates to a method of reacting starting materials with an activating group, namely alkanes carrying a leaving group and/or olefins, with carbon dioxide under transition metal catalysis to give carboxyl group-containing products. It is a special feature of the method of the present invention that the carboxylation predominantly takes place at a preferred position of the molecule irrespective of the position of the activating group. The carboxylation position is either an aliphatic terminus of the molecule or it is a carbon atom adjacent to a carbon carrying an electron withdrawing group. The course of the reaction can be controlled by appropriately choosing the reaction conditions to yield the desired regioisomer.
摘要翻译：本发明涉及在过渡金属催化作用下使起始原料与活化基团（即带有离去基团和/或烯烃的烷烃）与二氧化碳反应以产生含羧基产物的方法。本发明方法的一个特殊特征是羧化主要发生在分子的优选位置，而与活化基团的位置无关。羧化位置是分子的脂族末端或是与携带吸电子基团的碳相邻的碳原子。反应的过程可以通过适当选择反应条件来控制以产生期望的区域异构体。

5. 发明公开

EP2327711A1 METHODS FOR REMOVING PROLAMINS FROM WHEAT THAT ARE TOXIC TO THOSE SUFFERING FROM COELIAC DISEASE 审中-公开
标题翻译：程序对消除对腹腔疾病的人醇溶蛋白有毒谷物
公开(公告)号：EP2327711A1
公开(公告)日：2011-06-01
申请号：EP09806479.3
申请日：2009-07-31
申请人： Universitat Rovira I Virgili , ICREA, Institució Catalana de Recerca I Estudis Avançats
发明人： O'SULLIVAN, Ciara, Kathleen , BERMUDO REDONDO, Mª, Carmen , KATAKIS, Ioannis
IPC分类号： C07K1/14
CPC分类号： C07K1/1133 , A23L5/23 , A23L5/27 , A23L7/10 , A23L33/20 , A23V2002/00 , A23V2200/304 , A23V2250/5486
摘要： The present invention relates to a composition for removing gliadins and glutanins, which are prolamins that are toxic to patients suffering from coeliac disease, contained in heat-processed and non-heat-processed foods. The composition of the invention comprises a reducing agent for irreversible reduction of disulphide bridges and a solvent with a high boiling point and/or high dielectric constant in a buffer with a pH between 4 and 9. The invention also relates to the method for removing gluten (gliadins and glutenins) from food products, which is compatible with an enzyme-linked immunosorbant assay (ELISA), that allows detection of hydrolized and non-hydrolized gluten (gliadins and glutenins). Lastly, the invention relates to a kit for implementing said method.
摘要翻译：本发明涉及一种组合物，用于去除麦醇溶蛋白和glutanins，哪些是谷醇溶蛋白确实是有毒的，从乳糜泻中，包含在热加工和非热加工过的食品的患者。本发明的组合物包含为二硫桥的不可逆还原，并用在缓冲液中的高沸点和/或高介电常数的溶剂中与图4和9，本发明因此涉及到方法用于去除麸质之间的pH还原剂从食品（麦醇溶蛋白和麦谷蛋白），所有这些是与酶联免疫吸附测定（ELISA）兼容，确实允许水解和非水解谷蛋白（麦醇溶蛋白和麦谷蛋白）的检测。最后，本发明涉及一种用于实施所述方法的试剂盒。

6. 发明公开

EP2163305A1 Device and process for rapid isolation of a compound in a sample 审中-公开
标题翻译： Vorrichtung und Verfahren zur schnellen Isolierung einer Verbindung in einer Probe
公开(公告)号：EP2163305A1
公开(公告)日：2010-03-17
申请号：EP08015717.5
申请日：2008-09-05
申请人： INSTITUT FÜR MIKROTECHNIK MAINZ GmbH , Universitat Rovira I Virgili , ICREA, Institució Catalana de Recerca I Estudis Avançats
发明人： O'Sullivan, Ciara , Hahn, Thomas , Drese, Klaus-Stefan
IPC分类号： B01L3/00 , G01N1/00
CPC分类号： G01N27/44791 , B01L3/502753
摘要： A microfluidic device for rapid isolation of a compound or component contained in a sample together with other components consists of a matrix material containing an inlet for introducing said sample (5), a first (1) and a second (2) electrolyte reservoir having first and second electrodes, said electrodes embracing a membrane (4) between them, which membrane has an upper and a lower side, a sample trapping reservoir located adjacent the upper side of said membrane and said sample inlet (5). Said device further comprises a third electrolyte reservoir (6) having a third electrode (10), embracing with said first electrode a separation means capable of separating said component from the other components of said sample, said separating means (10) having an inlet and an exit, whereby said inlet is connected to said sample trapping reservoir (4) by a duct comprising a valve and said exit is connected to a recovery reservoir (7) and via a duct to said third electrode (6).
With said device a component contained in a sample can be isolated from other components by introducing said sample into said device and applying a first electrical potential between the first and second electrode, whereby said membrane retains the component to be isolated and concentrates it over said membrane in a sample trapping reservoir. After turning off the first electrical potential a duct connecting the sample trapping reservoir with separation means is opened and an electric potential in a second electric circuit between the first electrode and the third electrode is applied. Thereby a flux transporting the components from the sample trapping reservoir through said separation means is generated and the isolated components after their passage through the separation means are recovered.
摘要翻译：用于将样品中包含的化合物或组分与其它组分一起快速分离的微流体装置由含有用于引入所述样品（5）的入口的基质材料组成，第一（1）和第二（2）电解质储存器具有第一和第二电极，所述电极包围它们之间的膜（4），所述膜具有上侧和下侧，邻近所述膜的上侧和所述样品入口（5）定位的样品捕获储存器。所述装置还包括具有第三电极（10）的第三电解质储存器（6），所述第三电极（10）包围所述第一电极，所述分离装置能够将所述组分与所述样品的其它组分分离，所述分离装置（10）具有入口和出口，其中所述入口通过包括阀的管道连接到所述样品捕集容器（4），并且所述出口连接到回收容器（7）并且经由管道连接到所述第三电极（6）。利用所述装置，通过将所述样品引入所述装置并在所述第一和第二电极之间施加第一电位，所述样品中包含的组分可以与其它组分隔离，由此所述膜保留待分离的组分并将其浓缩在所述膜上在样品捕集池中。在关闭第一电位之后，打开将样品捕集容器与分离装置连接的管道，并施加第一电极和第三电极之间的第二电路中的电位。从而产生从样品捕获储器通过所述分离装置输送组分的通量，并且分离的组分在通过分离装置之后被回收。

7. 发明公开

EP1770094A1 Efficient synthesis of asymmetric epoxidation catalyst I 审中-公开
标题翻译： Effiziente Synthese von asymmetricrischem Epoxidierungs-Katalysator I
公开(公告)号：EP1770094A1
公开(公告)日：2007-04-04
申请号：EP05108855.7
申请日：2005-09-26
申请人： Institut Catala D'Investigacio Quimica , ICREA, Institució Catalana de Recerca I Estudis Avançats
发明人： Vidal i Ferran, Anton Dr. , Nieto Alonso, Natàlia , Molas Porqueras, Pineda Dr.
IPC分类号： C07D493/10
CPC分类号： C07D493/10 , C07D301/14
摘要： A process for the preparation of chiral ketone I from diol II comprising the acetylation of diol II with an acetylating agent, preferably an acetic acid derivative, wherein said acetylation is performed in the presence of a Lewis acid. The process can further comprise additional previous steps, so that chiral ketone I can be prepared in four steps starting from D-fructose. Alternatively, a process for the preparation of chiral ketone V from diol VI comprising the acetylation of diol VI with an acetylating agent, preferably an acetic acid derivative, wherein said acetylation is performed in the presence of a Lewis acid. The process can further comprise additional previous steps, so that chiral ketone V can be prepared starting from L-fructose, L-sorbose or D-arabinose.
摘要翻译：一种从二醇II制备手性酮I的方法，包括二醇II与乙酰化剂，优选乙酸衍生物的乙酰化反应，其中所述乙酰化在路易斯酸存在下进行。该方法可以进一步包括额外的先前步骤，使得手性酮I可以从D-果糖开始四步制备。或者，从二醇VI制备手性酮V的方法，其包括二醇VI与乙酰化剂，优选乙酸衍生物的乙酰化，其中所述乙酰化在路易斯酸存在下进行。该方法可以进一步包括额外的先前步骤，从而可以从L-果糖，L-山梨糖或D-阿拉伯糖开始制备手性酮V.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式