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    • 4. 发明公开
    • VERFAHREN ZUR KATALYTISCHEN HERSTELLUNG VON SUBSTITUIERTEN BIPYRIDYLDERIVATEN
    • 过程就取代BIPYRIDYLDERIVATEN的催化生产
    • EP1076648A1
    • 2001-02-21
    • EP99920777.2
    • 1999-04-24
    • Axiva GmbH
    • GEISSLER, HolgerGROSS, Peter
    • C07D213/22C07D213/80C07D213/79C07D213/30C07D215/04C07B37/02
    • C07B37/04C07D213/22C07D213/64C07D213/803
    • The invention relates to a method for producing dipyridyls by reacting at least one pyridine of general formula (III), where S', S'', S''', S'''' and S''''' are identical or different and independently of each other represent hydrogen, (C1-C18)-alkyl, alkoxy-(C1-C18), acyloxy-(C1-C18), aryloxy-(C1-C18), perfluoroacyloxy-(C1-C8), NO2, (C1-C18)-aryl, (C1-C18)-heteroaryl, halogen, hydroxy, nitro, nitroso, CN, COOH, CHO, PO3H2, SO3H, SO2R, SOR, NH2, NH-alkyl-(C1-C18), NH-alkyl2-(C1-C18), a protected amine, CF3, NHCO-alkyl-(C1-C4), N-alkyl-(C1-C4)-CO-alkyl-(C1-C4), COO-alkyl-(C1-C18), CONH2, CO-alkyl-(C1-C18), NHCOH, NHCOO-alkyl-(C1-C4), CO-(C1-C18)-aryl, COO-(C1-C18)-aryl, CHCH-CO2-alkyl-(C1-C18), CHCHCO2H, PO-phenyl2, PO-alkyl2-(C1-C4), (COO-)n (cation)n+, (PO32-)n(cation)2n+, (SO3-)n(cation)n+ and/or (O-)n(cation)n+, and where at least one of the substituents of S', S'', S''', S'''' and S''''' is chloride, bromide or iodine, where S', S'', S''', S'''' and/or S''''' together possibly form one or more aliphatic and/or aromatic rings and/or where S', S'', S''', S'''' and/or S''''' possibly form a bridge to at least one further pyridine of general formula (III) and/or where the rests S', S'', S''', S'''' and/or S''''' possibly have the meaning given above and are substituted with at least one rest having the meaning given above for S', S'', S''', S'''' and/or S''''', in water in the presence of an alcohol, a base, a palladium catalyst and possibly one or more additional solvents, at a temperature of between 0 and 200 °C.