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1. 发明公开

EP1412533A2 VERFAHREN ZUR ANALYSE VON MAKROMOLEKÜLEN, ANALYSEVORRICHTUNG UND VERFAHREN ZUR HERSTELLUNG EINER ANALYSEVORRICHTUNG 审中-公开
标题翻译：法分析大分子，分析装置及其制造方法的分析装置
公开(公告)号：EP1412533A2
公开(公告)日：2004-04-28
申请号：EP02764659.5
申请日：2002-07-09
申请人： Advalytix AG
发明人： SCRIBA, Jürgen , GAUER, Christoph
IPC分类号： C12Q1/68
CPC分类号： G01N33/54366 , B01J2219/00533 , B01J2219/00659 , B01J2219/00702 , B01L3/502792 , B01L2300/0636 , B01L2300/089 , B01L2400/0436 , B01L2400/0439 , B01L2400/0496 , C12Q1/6837 , G01N33/54386
摘要： The invention relates to a method for analysing macromolecules using a microarray, which consists of several spots in a known arrangement. Said spots comprise a plurality of first macromolecules that differ at least partially. The microarray is located on the surface of a solid body, preferably a chip. According to the method, at least one drop of liquid containing macromolecules is applied to the surface of the solid body, the quantity of liquid being so small that only one spot or a small group of spots of the microarray comes or come into contact with the drop of liquid. After a predetermined time has elapsed, the drop of liquid is displaced onto a subsequent spot or an additional small group of spots with the help of the transmission pulse of a surface sound wave. The spots that come into contact with the drop of liquid are then analysed to identify whether a reaction with the material of said drop has occurred. The invention also relates to a method for producing an analysis device for macromolecules. According to said method, at least one drop of liquid containing at least one type of macromolecule is applied to the surface of a solid body, preferably a chip, whereby the macromolecules have an active group that is activated during a modification of a corresponding external parameter, in order to allow bonding to the surface or to molecules that have already been bonded. The drop is displaced to a desired location on the surface with the help of the transmission pulse of one or more surface sound waves. The external parameter is modified in a homogeneous, non-local manner, permitting the bonding of the macromolecules to form the spot of a microarray, in which macromolecules from the drop of liquid are bonded to the surface. The invention also relates to an analysis device for carrying out the inventive analysis method.

2. 发明公开

EP1212832A1 VORRICHTUNG UND VERFAHREN ZUR ORTSAUFGELÖSTEN DETEKTION 有权
标题翻译： VORRICHTUNG UND VERFAHREN ZURORTSAUFGELÖSTENDETEKTION
公开(公告)号：EP1212832A1
公开(公告)日：2002-06-12
申请号：EP00960661.7
申请日：2000-09-14
申请人： Advalytix AG
发明人： BEIL, Florian , STREIBL, Martin , WIXFORTH, Achim
IPC分类号： H03H9/64 , G01B17/00 , G06K11/14 , H03H9/145
CPC分类号： G06F3/0436 , G01B17/00
摘要： The invention relates to a device for the high-sensitivity resolution detection of an external variable, comprising a substrate, at least one device for generating acoustic surface waves by applying an input frequency, provided on said substrate, at least one active surface, which can be charged with the acoustic surface waves by the generating device, said surface waves interacting with an external variable, and at least one device for receiving the surface waves after they have passed through the interaction field, this device also being provided on the substrate. The surface wave generating device is configured in such a way that the range of propagation of the surface waves in the active surface changes with the input frequency. The invention also relates to a method for the high-sensitivity resolution detection of an external variable. According to said method, acoustic surface waves are sent out over an active area of a substrate and detected. Surface waves of different frequencies pass through other areas of the active surface. The active area is caused to interact locally with the external variable and a change in the parameters of the surface waves is shown by this interaction.
摘要翻译：用于外部变量的高灵敏度分辨率检测的设备技术领域本发明涉及一种用于外部变量的高灵敏度分辨率检测的设备，该设备包括：衬底;至少一个设备，用于通过施加输入频率来产生声表面波，所述设备设置在所述衬底上; 由发生装置对声表面波进行充电，所述表面波与外部变量相互作用，以及至少一个用于在表面波穿过交互场后接收表面波的装置，该装置也设置在基板上。表面波发生装置被配置为使得有源表面中的表面波的传播范围随输入频率而变化。本发明还涉及用于外部变量的高灵敏度分辨率检测的方法。根据所述方法，将声表面波发送到衬底的有效区域上并进行检测。不同频率的表面波通过有效表面的其他区域。通过这种相互作用来显示活动区域与外部变量局部相互作用，并且表面波参数的变化。

3. 发明授权

EP1843833B1 VERFAHREN UND VORRICHTUNG ZUR DOSIERUNG UND DURCHMISCHUNG KLEINER FLÜSSIGKEITSMENGEN, APPARAT UND VERWENDUNG 有权
标题翻译：方法和设备用量和混合液体，设备和使用少量
公开(公告)号：EP1843833B1
公开(公告)日：2009-04-15
申请号：EP05820542.8
申请日：2005-12-16
申请人： Advalytix AG
发明人： GAUER, Christoph
IPC分类号： B01F13/00 , B01F11/02 , B01L3/00
CPC分类号： B01L3/50273 , B01F11/0266 , B01F11/0283 , B01F13/0059 , B01L3/502776 , B01L2300/089 , B01L2400/0436 , B01L2400/0496 , B01L2400/0688
摘要： The invention relates to a method for the integrated dosing and intermixing of small amounts of liquid. According to said method, a first liquid is conveyed into or onto a first reservoir (3), and a second reservoir (1) is entirely filled with a second liquid. The first and the second liquid are brought in contact with each other via at least one joining duct structure (5) which comprises at least one area that is provided with a smaller cross section than the reservoirs in the viewing direction of the connecting line between the two reservoirs. A laminar flow is created along at least one portion of the joining duct structure, and the liquids are thoroughly mixed in the second reservoir. The invention further relates to a device and an apparatus for carrying out the disclosed method as well as one use thereof.

4. 发明公开

EP1934575A1 AKUSTISCHE KONZENTRATIONSVERFAHREN, KONZENTRATIONSVORRICHTUNG UND REAKTIONSVERFAHREN 有权
标题翻译： ACOUSTIC浓缩法，浓缩装置和方法反应
公开(公告)号：EP1934575A1
公开(公告)日：2008-06-25
申请号：EP06805912.0
申请日：2006-09-27
申请人： Advalytix AG
发明人： GAUER, Christoph , MANN, Wolfgang
IPC分类号： G01N1/40 , B01D49/00 , G01N29/00
CPC分类号： G01N1/40 , G01N2001/4094 , G01N2035/00554
摘要： The invention relates to a concentration method for concentrating materials in a liquid consisting in pouring the liquid in a material-containing receptacle and in irradiating it by acoustic waves in such a way that a stationary flow pattern with different flow rate areas is formed in the receptacle. A concentration device for carrying out the inventive method and a reaction method applying said concentration method are also disclosed.

5. 发明公开

EP1933124A1 STIRRING VESSEL, STIRRING METHOD, STIRRER, ANALYZER PROVIDED WITH STIRRER 审中-公开
标题翻译： RÜHRGEFÄSS，RÜHRVERFAHREN，RÜHRER，ANALYSEGERÄTMITRÜHRER
公开(公告)号：EP1933124A1
公开(公告)日：2008-06-18
申请号：EP05790357.7
申请日：2005-10-05
申请人： Olympus Corporation , Advalytix AG
发明人： MURAKAMI, Miyuki
IPC分类号： G01N1/36 , G01N35/02 , B01F11/02
CPC分类号： B01F11/0266 , G01N1/38 , G01N35/025 , G01N2001/386 , G01N2035/00524 , G01N2035/00554
摘要： The present invention aims to provide a stirring vessel, a stirring method, a stirrer and an analyzer provided with the stirrer, in which an acoustic flow can reach a gas/liquid interface, whereby a liquid can be stirred over a wide range from the bottom part of the vessel to the gas/liquid interface. The present invention provides a stirring vessel, a stirring method, a stirrer and an analyzer provided with the stirrer, which stir a retained liquid with an acoustic wave. A stirring vessel (5) has at least one surface acoustic wave device (23), which emits an acoustic wave into a liquid (Ls), provided to the stirring vessel (5) as deviated. The stirring method for stirring a liquid with an acoustic wave includes a step of asymmetrically emitting an acoustic wave into a liquid, and a step of generating an asymmetric flow into the liquid by the asymmetric acoustic wave, wherein the liquid is stirred with the asymmetric flow.
摘要翻译：本发明的目的在于提供一种搅拌容器，搅拌方法，搅拌器和具有搅拌器的分析器，其中声流可以到达气/液界面，从而可以在底部的宽范围内搅拌液体一部分容器到气/液界面。本发明提供一种搅拌容器，搅拌方法，搅拌器和具有搅拌器的分析器，其用声波搅拌保留的液体。搅拌容器（5）具有至少一个表面声波装置（23），该弹性表面波装置（23）将声波发射到设置在搅拌容器（5）上的液体（Ls）中。用声波搅拌液体的搅拌方法包括将声波不对称地发射到液体中的步骤，以及通过不对称声波产生不对称流入液体的步骤，其中液体与不对称流动一起搅拌。

6. 发明公开

EP1781410A1 VERFAHREN ZUR BEWEGUNG VON KLEINEN FLÜSSIGKEITSMENGEN IN MIKROKANÄLEN DURCH AKUSTISCHE WELLEN 有权
标题翻译：用于液体少量在微渠道BY声波中的运动
公开(公告)号：EP1781410A1
公开(公告)日：2007-05-09
申请号：EP05802009.0
申请日：2005-10-20
申请人： Advalytix AG
发明人： GAUER, Christoph , VON GUTTENBERG, Zeno
IPC分类号： B01L3/00 , F04B19/00 , B01F13/00
CPC分类号： F04B19/006 , B01F11/0258 , B01F13/0059 , B01L3/50273 , B01L2300/0816 , B01L2300/0861 , B01L2400/0436 , B01L2400/088 , F04F7/00 , Y10T137/0391
摘要： The invention relates to a method for displacing small amounts of fluids in micro channels, wherein an amount of fluid is introduced into a channel system which comprises at least one area which corresponds, in a topological manner, to a ring, such that a path which is closed to the fluid is formed. Acoustic waves which comprise at least one asymmetrical component on the plane of the channel system are radiated into the fluid, said component defining the direction of displacement of the fluid. The invention also relates to a micro channel system for carrying out said inventive method.

7. 发明授权

EP1409722B1 VERFAHREN ZUR ANALYSE VON MAKROMOLEKÜLEN 有权
标题翻译：法分析大分子
公开(公告)号：EP1409722B1
公开(公告)日：2009-03-25
申请号：EP01994813.2
申请日：2001-12-19
申请人： Advalytix AG
发明人： GAUER, Christoph
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B01F11/02 , B01J19/0046 , B01J2219/00533 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C40B40/06 , C40B40/10 , G01N2291/102 , C12Q2565/513
摘要： The invention relates to a method for analysing macromolecules with the aid of a microarray on which a plurality of first, initially partially different macromolecules are disposed in a known arrangement. The microarray is arranged on the surface of a solid body on which an area is defined, said area having wetting properties which are different from those of the surrounding solid body surface in such a way that a liquid with a plurality of second macromolecules can preferably reside thereon; the liquid with the second macromolecules is disposed on the solid body surface and at least partially removed once more therefrom and the second macromolecules remaining from the removal process are detected in local resolution mode in order to determine on the basis of the situation thereof which of the first macromolecules have bonded with the second macromolecules. The invention also relates to a method wherein a surface wave is sent to the liquid in order to distribute and/or mix said liquid on a microarray. The invention further relates to a device for carrying out the inventive methods and to advantageous uses thereof.

8. 发明公开

EP2004848A1 VERFAHREN ZUR CHARAKTERISIERUNG VON NUKLEINSÄUREN IN EINER MISCHPROBE 审中-公开
标题翻译：出于表征NUCLEIC方法在混合样品
公开(公告)号：EP2004848A1
公开(公告)日：2008-12-24
申请号：EP07711550.9
申请日：2007-02-15
申请人： Advalytix AG
发明人： GAUER, Christoph , WOLFGANG, Mann
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/507 , C12Q2545/114 , C12Q2565/518 , C12Q2565/513
摘要： The present invention relates to a method of characterizing a mixed sample comprising at least two particles with nucleic acids from different individuals, where each particle comprises nucleic acid from one or more individuals, in particular for the quantitative determination of the absolute and/or relative copy number of a predetermined sequence of an individual, of which nucleic acid is present in the mixed sample, comprising the steps: a) isolating the particles and applying at least two individual particles to a substrate, where each of the at least two particles is deposited in each case individually to a hydrophilic reaction site, surrounded by a hydrophobic zone, of the substrate in a volume of less than 10 µl so that precisely one particle is present per reaction site, b) analysis of at least two of the particles deposited to the substrate at the reaction site of the substrate in order to assign each of the particles to individuals from the mixed sample by means of genotyping, where at least 80% of the particles analysed are to be assigned to an individual, and c) further characterization of the analysed particles. Moreover, the present invention relates to a kit which is suitable in particular for carrying out the abovementioned method.

9. 发明授权

EP1420875B1 BEWEGUNGSELEMENT FÜR KLEINE FLÜSSIGKEITSMENGEN 有权
标题翻译：运动元件用于液体少量
公开(公告)号：EP1420875B1
公开(公告)日：2008-07-16
申请号：EP02703618.5
申请日：2002-03-04
申请人： Advalytix AG
发明人： SCRIBA, Jürgen , GAUER, Christoph
IPC分类号： B01F13/00 , B01J19/00 , B01F11/02 , H03H3/08 , H03H9/145 , H03H9/25 , B01L3/00
CPC分类号： B01F11/0266 , B01F13/0059 , B01F2215/0037 , B01J2219/00286 , B01J2219/00315 , B01J2219/00484 , B01J2219/00495 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B01L3/502715 , B01L3/50273 , B01L9/52 , B01L2300/0819 , B01L2300/18 , B01L2400/0436
摘要： The invention relates to a motion element for generating motion in small quantities of liquid. Said element comprises a plate-type body with two principal surfaces, at least one electrically-driven motion device being located on a first active surface in order to set in motion a liquid that is in contact with said active surface and also comprises electric contact elements for the motion device. The invention also relates to a motion device, which can be used with the inventive motion element, to a cartridge for accommodating an inventive motion element, to a reaction device for receiving an inventive cartridge and to a method for generating motion in small quantities of liquid.

10. 发明公开

EP1771577A2 VERFAHREN ZUM BESTIMMEN DER H[UFIGKEIT VON SEQUENZEN IN EINER PROBE 审中-公开
标题翻译： METHOD FOR SEQUENCE中确定所述H [UFIGKEIT在样品
公开(公告)号：EP1771577A2
公开(公告)日：2007-04-11
申请号：EP05776036.5
申请日：2005-07-27
申请人： Alopex GmbH , Advalytix AG
发明人： MANN, Wolfgang , GAUER, Christoph
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6851 , C12Q2545/114 , C12Q2537/143
摘要： The invention relates to a method or determination of the abundance of a given sequence or several sequences identical or nearly identical to the given sequence in a sample. The method comprises the following steps: carrying out one or more amplification reactions by means of which several different sections of the sequence or sequences of the sample are amplified to give an amplified product, detection of whether given different sections of the sequence of the sample have been amplified and determination of the number of the sequence(s) in the sample by means of the abundance of the presence or otherwise of the given different sections in the amplified product.

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