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81. 发明公开

EP3177590A1 LOW TEMPERATURE FREE RADICAL INITIATED PROCESS FOR THE PREPARATION OF 3-((3,3,3-TRIFLUOROPROPYL)THIO)PROPIONIC ACID AND ESTERS THEREOF 审中-公开
标题翻译：低温自由基引发工艺用于生产3 - （（3,3,3-三氟丙基）硫基）丙酸及其酯类
公开(公告)号：EP3177590A1
公开(公告)日：2017-06-14
申请号：EP14899236.5
申请日：2014-10-17
申请人： Dow AgroSciences LLC
发明人： GRAY, Kaitlyn
IPC分类号： C07C319/14
CPC分类号： C07C319/18 , C07C323/52
摘要： 3-((3,3,3-Trifluoropropyl)thio)propionic acid and esters thereof are prepared by a low temperature free radical process involving the free radical coupling of 3-mercaptopropionic acid and esters thereof with 3,3,3-trifluoropropene. The ratio of linear to branched isomer is enhanced.
摘要翻译： 3 - （（3,3,3-三氟丙基）硫代）丙酸及其酯通过低温自由基方法涉及的3-巯基丙酸和酯中的游离自由基偶合与3,3,3-三氟丙烯它们的制备。线性与支链异构体的比率提高。

82. 发明公开

EP3024818A1 PROCESS FOR THE PREPARATION OF A POLYUNSATURATED KETONE COMPOUND 有权
标题翻译： PROCESS FOR产生多个不饱和酮化合物
公开(公告)号：EP3024818A1
公开(公告)日：2016-06-01
申请号：EP14742219.0
申请日：2014-07-23
申请人： Avexxin AS
发明人： SANDBERG, Marcel , AUKRUST, Inger Reidun
IPC分类号： C07C319/02 , C07C319/14 , C07C321/08 , C07C323/22 , C07C327/22
CPC分类号： C07C319/14 , C07C319/02 , C07C319/26 , C07C327/22 , C07C321/08 , C07C323/22
摘要： The invention relates to the manufacture of certain polyunsaturated compounds employing a particular application of the Mitsonobu reaction in the presence of at least one anti-oxidant. We have found a method of making a pharmaceutically-acceptable polyunsaturated ester or thioester compound directly, which can ultimately be converted to the advantageous ketone compounds, in which unwanted oxidation and cis/trans isomerization are substantially reduced or eliminated using particular Mitsonobu chemistry.

83. 发明授权

EP2046735B1 SUBSTITUTED PHENYLSULFUR TRIFLUORIDES AS FLUORINATING AGENTS 有权转让
标题翻译：替代物LS EL EL EL EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP2046735B1
公开(公告)日：2015-05-06
申请号：EP07840515.6
申请日：2007-07-25
申请人： UBE Industries, Ltd.
发明人： UMEMOTO, Teruo , SINGH, Rajendra P.
IPC分类号： C07C381/00 , C07B39/00 , C07C319/14 , C07C319/20 , C07C323/03 , C07C323/19 , C07C17/093 , C07C17/16 , C07C17/18 , C07C17/361 , C07C19/08 , C07C22/08 , C07C23/10
CPC分类号： C07C17/18 , C07B39/00 , C07C17/093 , C07C17/16 , C07C17/361 , C07C45/65 , C07C51/60 , C07C319/14 , C07C319/20 , C07C323/19 , C07C381/00 , C07C2601/14 , C07C19/08 , C07C22/08 , C07C23/10 , C07C323/03 , C07C63/10 , C07C63/04

84. 发明授权

EP2298749B1 Verfahren zur Herstellung von Thioethern 有权
标题翻译：一种制备硫醚过程
公开(公告)号：EP2298749B1
公开(公告)日：2014-12-24
申请号：EP10177806.6
申请日：1999-05-04
申请人： BASF SE
发明人： Rheinheimer, Joachim , von Deyn, Wolfgang , Gebhardt, Joachim , Rack, Michael , Lochtman, Rene , Götz, Norbert , Keil, Michael , Witschel, Matthias , Hagen, Helmut , Mißlitz, Ulf , Baumann, Ernst
IPC分类号： C07D261/04 , C07D413/10 , C07C251/40 , C07C319/14
CPC分类号： C07C249/06 , C07C201/10 , C07C201/12 , C07C205/44 , C07C209/62 , C07C251/48 , C07C253/00 , C07C255/50 , C07C315/04 , C07C319/14 , C07D261/04 , C07D413/10 , C07C323/09 , C07C317/24 , C07C317/32 , C07C205/06 , C07C211/52

85. 发明公开

EP2749565A1 GLYCOSIDE COMPOUND, METHOD FOR PRODUCING THIOETHER, ETHER, METHOD FOR PRODUCING ETHER, METHOD FOR PRODUCING GLYCOSIDE COMPOUND, METHOD FOR PRODUCING NUCLEIC ACID 有权转让
标题翻译：糖苷化合物，生产硫醚的方法，醚，生产醚的方法，生产糖苷化合物的方法，生产核酸的方法
公开(公告)号：EP2749565A1
公开(公告)日：2014-07-02
申请号：EP12825586.6
申请日：2012-08-24
申请人： Bonac Corporation
发明人： AOKI, Eriko , SUZUKI, Hiroshi , ITOH, Akihiro
IPC分类号： C07H19/067 , B01J31/02 , C07C319/14 , C07C319/20 , C07C323/12 , C07H19/167 , C07B61/00 , C12N15/09
CPC分类号： C07H19/06 , C07C319/14 , C07C319/16 , C07C319/20 , C07C323/12 , C07C323/25 , C07H1/00 , C07H19/067 , C07H19/16 , C07H19/167 , C07H21/00 , C07H23/00 , Y02P20/55
摘要： Provided is a glucoside compound, which is capable of providing a phosphoramidite, which can be produced at a low cost and can produce a nucleic acid in a high yield and with high purity.
A glycoside compound represented by the following chemical formula (1).

In the chemical formula (1),
B is an atomic group having a nucleic acid base skeleton, and optionally having a protecting group,
R 1 and R 2 are each a hydrogen atom or a protecting group,
or R 1 and R 2 in conjunction optionally form an atomic group represented by the following chemical formula (R 1 R 2 A) or (R 1 R 2 B):

each R 1a is a hydrogen atom, a straight chain or branched alkyl group and the like,
L 1 is an unsubstituted or alkyl-substituted ethylene group,
R 3 is a group represented by the following chemical formula (R 3 ):

in the chemical formula (R 3 ),
n is a positive integer, and
[D 1 ] is an electron-withdrawing group.
摘要翻译：本发明提供一种能够提供可以以低成本制造且能够以高收率且高纯度制造核酸的亚磷酰胺化合物的葡糖苷化合物。由以下化学式（1）表示的糖苷化合物。在化学式（1）中，B是具有核酸碱基骨架并且任选地具有保护基的原子团，R 1和R 2各自是氢原子或保护基，或者R 1和R 2任选地形成原子（R 1 R 2 A）或（R 1 R 2 B）表示的基团：各R 1a为氢原子，直链或支链烷基等，L 1为未取代或烷基取代的亚乙基，R 3为化学式（R3）：在化学式（R3）中，n是正整数，[D1]是吸电子基团。

86. 发明公开

EP2394979A4 INTERMEDIATE OF CILASTATIN AND PREPARATION METHOD THEREOF 有权转让
标题翻译：为它的西司他丁和方法的中间
公开(公告)号：EP2394979A4
公开(公告)日：2013-07-24
申请号：EP10738218
申请日：2010-02-08
申请人： ZHEJIANG HISOAR PHARMACEUTICAL CO LTD
发明人： TANG HE , YUAN WENQIU , FU JIA
IPC分类号： C07C69/716 , C07C59/115 , C07C67/08 , C07C67/313 , C07C69/675 , C07C319/14 , C07C323/59
CPC分类号： C07C69/675 , C07C51/08 , C07C59/115 , C07C67/08 , C07C67/313 , C07C253/00 , C07C319/14 , C07C2601/02 , C07C69/716 , C07C323/59 , C07C255/16

87. 发明公开

EP2402348A4 FIELD EFFECT TRANSISTOR 有权转让
标题翻译： FELDEFFEKTTRANSISTOR
公开(公告)号：EP2402348A4
公开(公告)日：2012-06-20
申请号：EP10746251
申请日：2010-02-25
申请人： UNIV HIROSHIMA , NIPPON KAYAKU KK
发明人： KUWABARA HIROKAZU , IKEDA MASAAKI , TAKIMIYA KAZUO
IPC分类号： C07D495/04 , C07C319/14 , C07C323/22 , C07D517/00 , H01L21/336 , H01L29/786 , H01L51/05 , H01L51/30
CPC分类号： C07D495/04 , C07C319/14 , H01L51/0005 , H01L51/0074 , H01L51/0541 , H01L51/0545 , C07C323/22

88. 发明授权

EP1448517B1 METHOD OF PREPARING 4-CHLORO-3-METHYL-2-BUTENYLPHENYL SULFIDE, DI(4-CHLORO-3-METHYL-2-BUTENYL)SULFIDE AND DI(4-CHLORO-3-METHYL-2-BUTENYL)SULFONE FOR SYNTHESIS OF NATURAL CAROTENOID PRODUCTS 有权
标题翻译： PROCESS FOR 4-氯-3-甲基-2-丁烯基苯基硫醚的制备中，二（4-氯-3-甲基-2-丁烯基）硫化物和二（4-氯-3-甲基-2-丁烯基）砜TO 合成自然科学CAROTINOIDPRODUKTEN的
公开(公告)号：EP1448517B1
公开(公告)日：2012-04-18
申请号：EP02788903.9
申请日：2002-10-30
申请人： SK Innovation Co., Ltd. , Koo, Sangho
发明人： KOO, Sangho , YANG, Jae-Deuk , KIM, Jeong-Soo , LEE, Sijoon , PARK, Minsoo
IPC分类号： C07C319/14
CPC分类号： C07C403/24 , C07C315/04 , C07C317/08 , C07C319/14 , C07C2601/16 , C07C317/14 , C07C323/05
摘要： Disclosed is a method of preparing intermediates required for synthesis of natural carotenoid products using sulfone compounds, which is advantageous in terms of high preparation efficiency due to a relatively simple process. Specifically, there is provided the preparation method of 4-chloro-3-methyl-2-butenylphenylsulfide as a C5-unit compound for lengthening a carbon chain, and di(4-chloro-3-methyl-2-butenyl)sulfide as a C10-unit compound for forming a central polyene moiety. In addition, di(4-chloro-3-methyl-2-butenyl)sulfone as a selective oxide of the di(4-chloro-3-methyl-2-butenyl)sulfide and a preparation method thereof are provided.

89. 发明授权

EP2072499B1 Verfahren zur Herstellung von Thiodiglycolsäuredialkylester 有权
标题翻译：制备硫代二乙醇酸二烷基酯的方法
公开(公告)号：EP2072499B1
公开(公告)日：2012-02-22
申请号：EP08169741.9
申请日：2008-11-24
申请人： Saltigo GmbH
发明人： Rodefeld, Lars , Broda, Witold , Sommer, Joachim , Westen, Joachim , Richter, Hartmut
IPC分类号： C07C319/14 , C07C323/52
CPC分类号： C07C319/14 , C07C323/52

90. 发明公开

EP2295405A1 Low sulfur metal detergent-dispersants 无效
标题翻译： Schwefelarme金属Detergenz-Dispergiermittel
公开(公告)号：EP2295405A1
公开(公告)日：2011-03-16
申请号：EP10181769.0
申请日：2006-07-10
申请人： Chevron Oronite S.A. , Chevron Oronite Company LLC
发明人： Le Coent, Jean-Louis , Campbell, Curtis, Bay , Toman, Jeffrey, J.
IPC分类号： C07C321/24 , C07C319/02 , C07C319/14 , C10M159/22 , C10M169/04
CPC分类号： C10M159/22 , C10M2207/262 , C10M2219/089 , C10N2210/01 , C10N2210/02 , C10N2230/12 , C10N2230/52 , C10N2270/00
摘要： A process for preparing an alkaline earth metal alkylhydroxybenzoate reaction product, said process comprising:
a) neutralizing at least one alkylphenol with an alkali metal base to form an alkali metal alkylphenate;
b) carboxylating the alkali metal alkylphenate with carbon dioxide to obtain an alkali metal alkylhydroxybenzoate; and
c) acidifying the alkali metal alkylhydroxybenzoate to form the alkylhydroxybenzoic acid, and further reacting the alkylhydroxybenzoic acid with a molar excess of an alkaline earth metal base to form an alkaline earth metal alkylhydroxybenzoate reaction product;

wherein at least one of the alkylphenol, alkylphenate, alkylhydroxbenzoic acid, alkali metal alkylhydroxybenzoate and alkaline earth metal alkylhydroxybenzoate is reacted with a sulfur source to achieve a sulfur content in the range of about 0.1 to 1.2 wt % in the alkaline earth metal alkylhydroxybenzoate reaction product, and wherein at least 50 mole % of the starting alkylphenol is converted to the alkaline earth metal alkylthydroxybenzoate reaction product.
摘要翻译：一种制备碱土金属烷基羟基苯甲酸酯反应产物的方法，所述方法包括：a）用碱金属碱中和至少一种烷基酚以形成碱金属烷基酚盐; b）用二氧化碳使碱金属烷基酚盐羧化，得到碱金属烷基羟基苯甲酸酯; 和c）酸化碱金属烷基羟基苯甲酸酯以形成烷基羟基苯甲酸，并进一步使烷基羟基苯甲酸与摩尔过量的碱土金属碱反应形成碱土金属烷基羟基苯甲酸酯反应产物; 其中烷基苯酚，烷基苯酚，烷基羟基苯甲酸，碱金属烷基羟基苯甲酸酯和碱土金属烷基羟基苯甲酸酯中的至少一种与硫源反应，以在碱土金属烷基羟基苯甲酸酯反应产物中达到约0.1至1.2重量％的硫含量，并且其中至少50摩尔％的起始烷基酚转化为碱土金属烷基羟基苯甲酸烷基酯反应产物。

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