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81. 发明公开

EP1026149A1 AMIDOCARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译： AMOCOCARBOXYLIC酸衍生物
公开(公告)号：EP1026149A1
公开(公告)日：2000-08-09
申请号：EP98945527.4
申请日：1998-09-30
申请人： Sankyo Company Limited
发明人： YANAGISAWA, Hiroaki, Sankyo Company, Limited , SAKURAI, Mitsuya, Sankyo Company, Limited , TAKAMURA, Makoto, Sankyo Company, Limited , FUJIWARA, Toshihiko, Sankyo Company, Limited
IPC分类号： C07C233/69
CPC分类号： C07D213/20 , C07C233/69 , C07C235/42 , C07C235/48 , C07C235/84 , C07C237/32 , C07D209/30 , C07D213/64 , C07D213/82 , C07D215/54 , C07D295/155 , C07D413/12
摘要： Amidocarboxylic acid derivatives of the formula:
[wherein R 1 represents a hydrogen atom, etc.; R 2 represents an alkylene group; R 3 represents a hydrogen atom, etc; R 4 represents a hydrogen atom, etc., X represents a substituted or unsubstituted aryl group, etc.; Y represents an oxygen atom, etc.; Z represents an alkylene group, etc.; and W represents an alkyl group, etc.], pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof are useful as a therapeutic agent and/or preventive agent for diabetes mellitus, hyperlipemia, arteriosclerosis, hypertension, etc.
摘要翻译：下式的酰胺羧酸衍生物：[其中R1代表氢原子等; R2代表亚烷基; R3代表氢原子等; R4表示氢原子等，X表示取代或未取代的芳基等。 Y代表氧原子等; Z表示亚烷基等。 W表示烷基等]，其药理学上可接受的盐及其药理学上可接受的酯可用作糖尿病，高脂血症，动脉硬化症，高血压等的治疗剂和/或预防剂

82. 发明公开

EP1021396A1 POLYALKANOLAMIDE TACKIFYING RESINS FOR CREPING ADHESIVES 失效
标题翻译： Polyalkanolamides粘结性树脂胶粘剂绉布
公开(公告)号：EP1021396A1
公开(公告)日：2000-07-26
申请号：EP98934214.2
申请日：1998-07-10
申请人： HERCULES INCORPORATED
发明人： ALLEN, Anthony, J.
IPC分类号： C07C233/18 , C07C233/60 , C07C233/69 , C07C235/08 , C07C231/02 , D21H21/14 , D21H17/14
CPC分类号： C07C233/60 , C07C233/18 , C07C233/69 , C07C235/08 , C07C2601/14 , D21H21/146
摘要： Water soluble polyalkanolamides and a process to prepare same by reacting polycarboxylic acid or its anhydride, ester of halide derivative with at least one alkanolamine and optionally with a polyamine and removing the condensation by product water, alcohol or hydrogen halide. These compounds are useful as tackifying resins for creping adhesives.

83. 发明公开

EP0752421A1 Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists 失效
标题翻译：邻位取代的含有3（杂）芳基环，它们的制备以及它们作为前列腺素E2（PGE2）拮抗剂的用途的芳族化合物
公开(公告)号：EP0752421A1
公开(公告)日：1997-01-08
申请号：EP96304888.9
申请日：1996-07-02
申请人： ZENECA LIMITED
发明人： Breault, Gloria Anne , Oldfield, John , Tucker, Howard , Warner, Peter
IPC分类号： C07D213/40 , C07D213/55 , C07D213/74 , C07D213/75 , A61K31/44 , C07D233/54 , A61K31/415 , C07D237/24 , A61K31/50 , C07C63/04 , C07C63/64 , A61K31/19 , C07C65/05 , C07C65/21 , C07C229/38 , C07C229/52 , C07C229/60 , C07C233/65 , C07C233/69 , C07C237/30 , C07C237/32 , C07C323/32 , C07C323/62
CPC分类号： C07D213/75 , C07C63/331 , C07C65/105 , C07C65/24 , C07C229/38 , C07C229/52 , C07C229/60 , C07C233/65 , C07C233/69 , C07C237/30 , C07C237/32 , C07C323/62 , C07D213/55 , C07D213/80 , C07D233/64 , C07D237/24
摘要： The invention relates to compounds of the formula
wherein:

A is an optionally substituted ring system provided that the -Z-B-R 1 and -X-D linking groups are positioned in a 1,2 relationship to one another on ring carbon atoms and the ring atom positioned ortho to the -X- linking group (and therefore in the 3-position relative to the -Z- linking group) is not substituted;
B is an optionally substituted ring system
D is optionally substituted: pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, thienyl, furyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl or phenyl;
R 1 is positioned on ring B in a 1,3 or 1,4 relationship with the -Z- linking group in 6-membered rings and in a 1,3-relationship with the -Z- linking group in 5-membered rings and is as defined in the description;
X is -OCH 2- , -SCH 2- , -CH 2 CH 2- , CH 2- , -O-, -S- or -N(R 4 )CH 2- wherein the left hand atom is attached to A and the right hand atom is attached to D;
Z is of the formula -CH(R 3 )CH(R 3 )N(R 2 )-, -N(R 2 )CH(R 3 )-, -CH(R 3 )P 1 -, -(CH(R 3 ))m- or -CH(R 3 )N(R 2 )-
wherein
R 2 is hydrogen, C 1-6 alkyl (optionally substituted by hydroxy, cyano, nitro, amino, halo, C 1-4 alkanoyl, C 1-4 alkoxy or trifluoromethyl) C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-3 alkyl, C 3-6 cycloalkylC 2-3 alkenyl, C 5-6 cycloalkenyl, C 5-6 cycloalkenylC 1-3 alkyl, C 5-6 cycloalkenylC 2-3 alkenyl, phenyl, phenylC 1-3 alkyl or 5- or 6-membered heteroarylC 1-3 alkyl;
R 3 is hydrogen or C 1-4 alkyl;
P 1 is oxygen or sulphur, m is 2 or 3 and R 4 is hydrogen or C 1-4 alkyl and wherein the left hand atom is attached to A and the right hand atom is attached to B; provided that when Z is -CH(R 3 )N(R 2 )- or -(CH(R 3 ))m-, X is not -OCH 2 -; and N-oxides of -NR 2 where chemically possible;
and S-oxides of sulphur containing rings where chemically possible;
and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof.

Processes for their preparation, intermediates in their preparation, their use as pharmaceutical agents and pharmaceutical compositions containing them.
The compounds of the invention are useful in the treatment of pain such as the pain associated with joint conditions (such as rheumatoid arthritis and osteoarthritis), postoperative pain, post-partum pain, the pain associated with dental conditions (such as dental caries and gingivitis), the pain associated with burns (including sunburn), the treatment of bone disorders (such as osteoporosis, hypercalcaemia of malignancy and Paget's disease), the pain associated with sports injuries and sprains and all other painful conditions in which E-type prostaglandins wholly or in part play a pathophysiological role.
摘要翻译：本发明涉及下式的化合物 worin：A是任选substituiertem环系统提供DASS死-ZBR <1>和-Xd连接基团在1,2关系彼此在环碳原子和被定位环原子邻位的-X-的连接基团（并且相对于-Z-连接基团的3位在THEREFORE）不substituiertem; B是任选substituiertem环系统D是任选substituiertem：吡啶基，吡嗪基，嘧啶基，哒嗪基，吡咯基，噻吩基，呋喃基，咪唑基，吡唑基，噻唑基，异噻唑基，恶唑基，异恶唑基或苯基; [R <1>与-Z-连接基团1,3-或1,4-关系在5元被定位在环B在6元环，而在与所述-Z-连接基团1,3-关系环和是如说明书中所定义; X是-OCH 2，-SCH 2，-CH 2 CH 2，CH 2，-O - ， - S-或-N（R <4>）CH2 worin左手原子连接于A和右手原子是附着到D; Z为式CH（R <3>）CH（R <3>）N（R <2>） - ， - N（R <2>）CH（R <3>） - ， - CH（R <3>）P <1> - ， - （CH（R <3>））m-或-CH（R <3>）N（R <2>） - 氢worinř<2>是，C 1-6烷基（任选地被羟基，氰基，硝基，氨基，卤素，C1-4alkanoyl，C 1-4烷氧基或三氟甲基substituiertem）C 2-6烯基，C 2-6炔基，C 3-6环烷基，C3-6cycloalkylC1-3alkyl，C3-6cycloalkylC2-3alkenyl，C5- 6cycloalkenyl，C5-6cycloalkenylC1-3alkyl，C5-6cycloalkenylC2-3alkenyl，苯基，phenylC1-3alkyl或5-或6-元heteroarylC1-3alkyl; [R <3>是氢或C 1-4烷基; P <1>为氧或硫，m是2或3，R <4>是氢或C 1-4烷基和worin左手原子连接于A和右手原子连接到B; 提供确实当Z是-CH（R <3>）N（R <2>） - 或 - （CH（R <3>））间 - 时，X不是-OCH 2; 和-NR <2>的N-氧化物在化学上可能; 和含硫环的S-氧化物在化学上可能; 和药学上可接受的盐和体内可水解的酯和酰胺。它们的制备方法，其制备中间体，其作为药物和含有它们的药物组合物。本发明的化合物可用于治疗疼痛的有用：如与关节条件（颜色：如类风湿性关节炎和骨关节炎）相关的疼痛，手术后疼痛，产后疼痛，与牙齿条件（颜色相关的疼痛：如龋齿和牙龈炎），烧伤（包括晒伤相关的疼痛），骨疾病（治疗：如骨质疏松症，恶性高血钙和Paget氏病），与运动损伤和扭伤和其中E型前列腺素全所有其它疼痛病症相关的疼痛或部分发挥病理生理作用。

85. 发明公开

EP0689435A1 VERWENDUNG VON SUBSTITUIERTEN ALKYLNITRATEN ZUR BEHANDLUNG DES KRANKHAFT ERHÖHTEN AUGENINNENDRUCKES 失效
标题翻译：代替医疗责任硝酸烷基酯的治疗使用升高的眼内压
公开(公告)号：EP0689435A1
公开(公告)日：1996-01-03
申请号：EP94911162.0
申请日：1994-03-12
申请人： BYK NEDERLAND BV
发明人： BRON, Jan , STERK, Geert Jan , TIMMERMAN, Hendrik , VAN DER WERF, Jan Fetze
IPC分类号： C07D333 , A61K31 , A61P27 , C07C203 , C07C205 , C07C219 , C07C233 , C07C323 , C07D213 , C07D335
CPC分类号： C07C205/59 , A61K31/21 , A61K31/22 , A61K31/34 , A61K31/38 , A61K31/44 , C07C203/04 , C07C205/37 , C07C205/41 , C07C205/42 , C07C205/60 , C07C219/16 , C07C233/69
摘要： The invention pertains to the use of compounds of formula (I) wherein R1 and R2 stand for the constituents indicated in the description, and of their pharmacologically tolerable salts in the preparation of medicines for the treatment of pathologically increased intra-ocular pressure.

86. 发明公开

EP0688601A1 Cyclic amidocarboxy surfactants, synthesis and use thereof 失效
标题翻译： ZyklischeAmidokarboxyoberflächenaktiveVerbindungen，ihre Herstellung und deren Verwendung
公开(公告)号：EP0688601A1
公开(公告)日：1995-12-27
申请号：EP95201082.5
申请日：1990-06-29
申请人： STEPAN COMPANY
发明人： Goze, Jean M. , Bernhardt, Randal J. , Hartlage, James A. , Smith, Norman R. , Lietz, Dennis E. , Kay, James W. , Breitbeil, Fred W. , Sajic, Branco , Rockwell, Ned Miles , McConnell, Nina , Mohring, William Richard
IPC分类号： B01F17/00
CPC分类号： D06M15/693 , A01N25/30 , A23L29/10 , A61K8/06 , A61K8/445 , A61Q5/006 , A61Q5/02 , A61Q5/12 , A61Q19/00 , B01F17/0042 , C07C211/63 , C07C215/40 , C07C233/65 , C07C233/69 , C08F2/26 , C10L1/328 , C11D1/10 , C11D1/88 , C11D3/001 , D06M7/00 , D06M13/415 , D06M2200/40
摘要： A composition comprising an emulsion of an oil phase and a water phase, wherein the emulsion comprises an emulsifier of the formula:

wherein:
R represents C₁-C₄₀ alkyl, C₁-C₄₀ alkenyl, alkylaryl where the alkyl portion is C₁-C₄₀ alkyl, aryl, C₃-C₇ cycloalkyl, or R₁-O-R₂ where R₁ and R₂ independently represent C₁-C₂₂ alkyl, C₁-C₂₂ alkenyl, alkylaryl where the alkyl portion is C₁-C₂₂ alkyl, aryl, or C₃-C₇ cycloalkyl;
x represents a cation;
m is an integer satisfying the valency of X; and
the composition is at a pH of 5.0 to 10.
摘要翻译：一种组合物，其包含油相和水相的乳液，其中所述乳液包含下式的乳化剂：其中：R表示C 1 -C 40烷基，C 1 -C 40烯基，烷基部分为C 1 -C 40的烷基芳基烷基，芳基，C 3 -C 7环烷基或R 1 -O-R 2，其中R 1和R 2独立地表示C 1 -C 22烷基，C 1 -C 22链烯基，烷基部分为C 1 -C 22烷基，芳基或C 3 -C 7环烷基的烷基芳基; x表示阳离子; m是满足X的化合价的整数; 组合物的pH为5.0〜10。

87. 发明公开

EP0655444A1 Oxazoline derivative, process for preparing the same and agricultural and horticultural chemical for controlling noxious organisms containing the same 失效
标题翻译：唑啉衍生物，它们的制备方法和农业及园艺用含有准备Schädlungen的控制。
公开(公告)号：EP0655444A1
公开(公告)日：1995-05-31
申请号：EP94402677.2
申请日：1994-11-23
申请人： UBE INDUSTRIES, LTD.
发明人： Obata, Tokio, c/o Ube Res.Lab. Ube Ind. Ltd. , Fujii, Katsutoshi, c/o Ube Res.Lab. Ube Ind. Ltd. , Shikita, Shoji c/o Ube Res.Lab. Ube Ind. Ltd. , Goka, Kouichi, c/o Ube Res.Lab. Ube Ind. Ltd.
IPC分类号： C07D263/14 , A01N43/80 , C07D413/12 , C07C233/69
CPC分类号： C07D413/12 , A01N43/80 , A01N47/02 , C07C233/69 , C07D263/14
摘要： Disclosed are an oxazoline compound represented by the formula (I):

wherein R¹ represents halogen, hydrogen, alkyl, alkoxy, haloalkyl, haloalkoxy, phenyl, phenoxy, benzyl, benzyloxy, pyridyloxy, pyridylmethyloxy, alkoxy-substituted alkyl, nitro, cyanomethyloxy, haloalkylsulfonyloxy, alkylsulfonyloxy, or alkylthio; R² represents hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkylthio, or haloalkoxy; R¹ and R² may be combined to form a saturated or unsaturated 6-membered ring with oxygen; R³ represents hydrogen, halogen or alkoxy; R⁴ represents hydrogen, alkyl, or halogen; R⁵ represents hydrogen, halogen, or alkyl; X¹ represents halogen, alkyl, haloalkyl, or alkoxy; X² represents halogen, hydrogen , or alkoxy; X³ represents hydrogen or halogen; and n represents an integer of 2 to 5;
an amidoethyl halide derivative used for synthesis of the same, a process for preparing the same, and an agricultural and horticultural chemical for controlling noxious organisms comprising the same as an active ingredient.
摘要翻译：公开的是在由式（I）表示的恶唑啉化合物： worin - [R <1> darstellt卤素，氢，烷基，烷氧基，卤代烷基，卤代烷氧基，苯基，苯氧基，苄基，苄氧基，吡啶氧基，吡啶基甲氧基，烷氧基烷基substituiertem ，硝基，氰基甲基，卤代烷基，烷基磺酰氧基，或烷硫基; [R <2> darstellt氢，卤素，烷基，卤代烷基，烷氧基，烷硫基，或卤代烷氧基; [R <1>和R <2>可以被组合以形成具有氧的饱和或不饱和6元环; [R <3> darstellt氢，卤素或烷氧基; [R <4> darstellt氢，烷基，卤素或; [R <5> darstellt氢，卤素或烷基; X <1> darstellt卤素，烷基，卤代烷基，或烷氧基; X <2> darstellt卤素，氢或烷氧基; X <3> darstellt氢或卤素; 和n darstellt到2至5的整数; 到酰氨基乙基用于相同的，一个用于制备相同的过程合成卤衍生物，以及农业和园艺化学防治有害生物包含其作为上的活性成分。

88. 发明公开

EP0538231A1 Fungicides for the control of take-all disease of plants 失效
标题翻译： Fungizidefürdie Kontrolle der Wurzelerkrankung von Pflanzen。
公开(公告)号：EP0538231A1
公开(公告)日：1993-04-21
申请号：EP92870168.9
申请日：1992-10-16
申请人： MONSANTO COMPANY
发明人： Phillion, Dennis Paul , Braccolino, Diane Susan , Graneto, Matthew James , Phillips, Wendell Gary , Van Sant, Karey Alan , Walker, Daniel Mark , Wong, Sai Chi
IPC分类号： A01N55/00 , A01N37/18 , A01N55/02 , A01N37/40 , C07F7/08 , C07F7/22 , C07F7/30 , C07C233/65 , C07C317/44 , A01N55/04 , A01N37/44 , C07C235/60 , C07C323/62 , C07C233/69 , C07C237/30 , C07C233/66
CPC分类号： C07C317/44 , A01N37/18 , A01N37/26 , A01N37/40 , A01N37/44 , A01N41/10 , A01N55/00 , A01N55/02 , A01N55/04 , C07C233/65 , C07C233/66 , C07C233/69 , C07C235/60 , C07C237/30 , C07C323/60 , C07C2601/04 , C07C2601/08 , C07F7/0812 , C07F7/0814 , C07F7/0818 , C07F7/2212 , C07F7/30 , C07F15/025
摘要： A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula

wherein Z₁ and Z₂ are C or N and are part of an aromatic ring selected from benzene, pyridine, thiophene, furan, pyrrole, pyrazole, thiazole, and isothiazole;
A is selected from -C(X)-amine, -C(O)-SR₃, -NH-C(X)R₄, and -C(=NR₃)-XR₇;
B is -W m -Q(R₂)₃ or selected from o-tolyl, 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R₄;
Q is C, Si, Ge, or Sn;
W is -C(R₃) p H (2-p) -; or when Q is C, W is selected from -C(R₃) p H (2-p) -, -N(R₃) m H (1-m) -, -S(O) p -, and -O-;
X is O or S;
n is 0, 1, 2, or 3;
m is 0 or 1;
p is 0, 1, or 2;
each R is independently selected from

a) halo, formyl, cyano, amino, nitro, thiocyanato, isothiocyanato, trimethylsilyl, and hydroxy;
b) C1-C4 alkyl, alkenyl, alkynyl, C3-C6 cycloalkyl, and cycloalkenyl, each optionally substituted with halo, hydroxy, thio, amino, nitro, cyano, formyl, phenyl, C1-C4 alkoxy, alkylcarbonyl, alkylthio, alkylamino, dialkylamino, alkoxycarbonyl, (alkylthio)carbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfinyl, or alkylsulfonyl;
c) phenyl, furyl, thienyl, pyrrolyl, each optionally substituted with halo, formyl, cyano, amino, nitro, C1-C4 alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylamino, dialkylamino, haloalkyl, and haloalkenyl;
d) C1-C4 alkoxy, alkenoxy, alkynoxy, C3-C6 cycloalkyloxy, cycloalkenyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, alkylcarbonylamino, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, (alkylthio)carbonyl, phenylcarbonylamino, phenylamino, each optionally substituted with halo;
wherein two R groups may be combined to form a fused ring;
each R₂ is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl and phenyl, each optionally substituted with R₄ or halogen; and wherein, when Q is C, R₂ may also be selected from halo, alkoxy, alkylthio, alkylamino, and dialkylamino;
wherein two R₂ groups may be combined to form a cyclo group with Q;
R₃ is C1-C4 alkyl;
R₄ is C1-C4 alkyl, haloalkyl, alkoxy, alkylthio, alkylamino, or dialkylamino; and
R₇ is C1-C4 alkyl, haloalkyl, or phenyl, optionally substituted with halo, nitro, or R₄;
or an agronomic salt thereof.
摘要翻译：一种通过在种植之前优选施用式（CHEM）的杀真菌剂，其中Z 5和Z 6为C或N并且是芳环的一部分的方法来控制植物的所有疾病的方法选自苯，吡啶，噻吩，呋喃，吡咯，吡唑，噻唑和异噻唑; A选自-C（X） - 胺，-C（O）-SR 7，-NH-C（X）R 8和-C（= NR 7）-XR1 / 2; B是-Wm-Q（R 6）7或选自邻甲苯基，1-萘基，2-萘基和9-菲基，各自任选被卤素或R 8取代; Q是C，Si，Ge或Sn; W是-C（R 7）pH（2-p） - ; 或当Q为C时，W选自-C（R 7）pH（2-p） - ， - N（R 7）m H（1-m） - ， - S（O）和-O-; X为O或S; n为0,1,2或3; m为0或1; p为0,1或2; 每个R独立地选自a）卤素，甲酰基，氰基，氨基，硝基，氰硫基，异硫氰酸根，三甲基甲硅烷基和羟基; 羟基，硫代，氨基，硝基，氰基，甲酰基，苯基，C 1 -C 4烷氧基，烷基羰基，烷硫基，烷氨基，C 1 -C 4烷基，二烷基氨基，烷氧基羰基，（烷硫基）羰基，烷基氨基羰基，二烷基氨基羰基，烷基亚磺酰基或烷基磺酰基; C）苯基，呋喃基，噻吩基，吡咯基，各自任选被卤素，甲酰基，氰基，氨基，硝基，C 1 -C 4烷基，烯基，炔基，烷氧基，烷硫基，烷基氨基，二烷基氨基，卤代烷基和卤代烯基取代。 d）C 1 -C 4烷氧基，烯氧基，炔氧基，C 3 -C 6环烷氧基，环烯氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，烷基氨基，二烷基氨基，烷基羰基氨基，氨基羰基，烷基氨基羰基，二烷基氨基羰基，烷基羰基，烷基羰基氧基，烷氧基羰基，（烷硫基）羰基，苯基羰基氨基，苯基氨基，各自任选被卤素取代; 其中两个R基团可以组合形成稠环; 每个R 6独立地选自烷基，烯基，炔基，环烷基，环烯基和苯基，各自任选被R 8或卤素取代; 并且其中当Q为C时，R 6也可以选自卤素，烷氧基，烷硫基，烷基氨基和二烷基氨基; 其中两个R 6基团可以与Q结合形成环基团; R 7是C 1 -C 4烷基; R 8是C 1 -C 4烷基，卤代烷基，烷氧基，烷硫基，烷基氨基或二烷基氨基; R 1/2是任选被卤素，硝基或R 8取代的C 1 -C 4烷基，卤代烷基或苯基; 或其农艺盐。升

89. 发明公开

EP0512352A2 Substituted carboxylic acid derivatives 失效
标题翻译：替代品Carbonsäurederivate。
公开(公告)号：EP0512352A2
公开(公告)日：1992-11-11
申请号：EP92107135.3
申请日：1992-04-27
申请人： F. HOFFMANN-LA ROCHE AG
发明人： Guthrie, Robert William , Heathers, Guy Phillip , Higgins, Alan John , Kachensky, David Francis , Kierstead, Richard Wightmann , LeMahieu, Ronald Andrew , Mullin, John Guilfoyle, Jr. , Tilley, Jefferson Wright
IPC分类号： C07C59/90 , A61K31/19 , C07C65/40
CPC分类号： C07D215/233 , C07C45/004 , C07C45/46 , C07C45/56 , C07C45/71 , C07C47/55 , C07C49/825 , C07C49/84 , C07C59/68 , C07C59/90 , C07C65/40 , C07C69/00 , C07C69/007 , C07C69/734 , C07C69/738 , C07C205/37 , C07C205/56 , C07C219/14 , C07C229/36 , C07C229/42 , C07C233/54 , C07C233/69 , C07C233/87 , C07C235/22 , C07C235/24 , C07C235/78 , C07C235/84 , C07C251/48 , C07C271/22 , C07C281/14 , C07C309/65 , C07C311/29 , C07C317/44 , C07C323/12 , C07C323/18 , C07C323/62 , C07C2601/08 , C07C2601/18 , C07C2603/00 , C07D215/14 , C07D215/20 , C07D215/22 , C07D217/02 , C07D217/04 , C07D221/12 , C07D233/64 , C07D263/12 , C07D295/185 , C07D307/80 , C07D309/12 , C07D317/24 , C07D333/24 , C07D333/32 , C07D493/14 , C07F7/1856
摘要： The compounds of the formula
wherein A, B, Q, Ri, R 2 , R 2 ', X, Y, Z and n are as described in claim 1, when appropriate, in the form of enantiomers, racemates, diastereomeres or mixtures thereof or geometric isomers or mixtures thereof and, when a basic or acidic group is present, pharmaceutically acceptable salts thereof inhibit enzyme carnitine acyltransferase 1 (CAT-1) and are therefore useful in the prevention of injury to ischemic tissue, and can limit infarct size, improve cardiac function and prevent arrhythmias during and following a myocardial infarction. They can be prepared according to various methods which are known per se.
摘要翻译：式（CHEM）的化合物，其中A，B，Q，R 1，R 2，R 2'，X，Y，Z和n如权利要求1所述，当适当时，以对映体的形式，外消旋体，非对映体或混合物或其几何异构体或其混合物，并且当存在碱性或酸性基团时，其药学上可接受的盐抑制肉碱肉碱酰基转移酶1（CAT-1），因此可用于预防缺血组织的损伤，并且可以限制梗死面积改善心脏功能并预防心肌梗死期间和之后的心律失常。它们可以根据本身已知的各种方法来制备。

90. 发明公开

EP0486510A1 CYCLIC AMIDOCARBOXY SURFACTANTS, SYNTHESIS AND USE THEREOF 失效
标题翻译：骑行AMIDOKARBOXYOBERFLÄCHENAKTIVE化合物，生产和使用。
公开(公告)号：EP0486510A1
公开(公告)日：1992-05-27
申请号：EP90910659.0
申请日：1990-06-29
申请人： STEPAN COMPANY
发明人： GOZE, Jean, M. , BERNHARDT, Randal, J. , HARTLAGE, James, A. , SMITH, Norman, R. , LIETZ, Dennis, E. , KAY, James, W. , BREITBEIL, Fred, W. , SAJIC, Branco , ROCKWELL, Ned, Miles , McCONNELL, Nina, Montserrat , MOHRING, William, Richard
IPC分类号： A01N37 , A01N25 , A23L1 , A61K8 , A61Q5 , A61Q19 , B01F17 , B01J13 , C07C211 , C07C215 , C07C233 , C07C235 , C07D233 , C08F2 , C09D125 , C09D133 , C10L1 , C10L10 , C10M133 , C11D1 , C11D3 , D06M13 , D06M15 , C10N10 , C10N30 , C10N40
CPC分类号： D06M15/693 , A01N25/30 , A23L29/10 , A61K8/06 , A61K8/445 , A61Q5/006 , A61Q5/02 , A61Q5/12 , A61Q19/00 , B01F17/0042 , C07C211/63 , C07C215/40 , C07C233/65 , C07C233/69 , C08F2/26 , C10L1/328 , C11D1/10 , C11D1/88 , C11D3/001 , D06M7/00 , D06M13/415 , D06M2200/40
摘要： Tensio-actifs amidocarboxy cycliques de la formule générale (I), dans laquelle R1 et R2 sont indépendamment utilisés dans le groupe composé essentiellement de H ou de groupes alkyle, cycloalkyle, alkylène, alcaryle, aryle ou R3-O-R4 linéaires ou ramifiés, substitués ou non substitués, contenant de 1 à 40 atomes de carbone, R3 et R4 étant indépendamment choisis dans le groupe composé de groupes alkyle, cycloalkyle, alkylène, alcaryle et aryle linéaires ou ramifiés, substitués ou non subsitutés, contenant de 1 à 22 atomes de carbone, y représente un nombre entier dont la valeur satisfait la valence de M; et M représente un cation et est de préférence choisi dans les groupes composés de H, Na, NH4 [comprenant (CH3CH2)3NH, (CH3CH2)2NH2, (HOCH2CH2)3NH, (HOCH2CH2)2NH2 ainsi que des dérivés d'ammonium similaires], Ba, Ca, Mg, Al, Ti, Zr ainsi que leurs mélanges. Ces tensio-actifs sont utiles dans une variété d'applications techniques telles que les émulsifiants à rupture rapide se trouvant dans des produits de soins personnels; les tensio-actifs de polymérisation de latex destructibles dans la fabrication et la composition de divers systèmes de revêtement ou adhésif; les agents d'adoucissement de tissus domestiques; les émulsifiants de produits alimentaires; les tensio-actifs stables aux agents caustiques; les tensio-actifs stables aux agents de blanchiment, divers détergents domestiques et agents de nettoyage de surfaces dures, les émulsifiants destinés au ciment de portland et au béton; les agents de flottation/enrichissement destinés à l'extraction/traitement de divers minerais, les additifs d'électrodéposition et/ou de finition de surfaces pour des marchandises métalliques; les additifs du plâtre, du gypse et de divers matériaux de construction les additifs de récupération d'huile améliorée; les agents d'humidification et de lubrification de traitement textile industriel; les agents de compatibilité/tensio-actifs destinés aux systèmes de mousses en polyuréthane/isocyanurate, les additifs de réduction en pâte de

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