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71. 发明公开

EP3274733A1 MAGNETIC RESONANCE IMAGING THERMOMETRY USING PROTON RESONANCE FREQUENCY AND T1 MEASUREMENTS 审中-公开
标题翻译：利用质子共振频率和T1测量的磁共振成像温度测量
公开(公告)号：EP3274733A1
公开(公告)日：2018-01-31
申请号：EP16714823.8
申请日：2016-03-28
申请人： Koninklijke Philips N.V.
发明人： WEISS, Steffen
IPC分类号： G01R33/48 , A61B5/055 , G01R33/50
CPC分类号： G01R33/4804 , A61B5/015 , A61B5/055 , A61B18/02 , A61B18/12 , A61B18/1815 , A61B18/20 , A61B34/25 , A61B90/37 , A61B2018/00714 , A61B2018/00791 , G01R33/50 , G01R33/5608
摘要： The invention provides for a method of operating a medical instrument (100, 400, 500, 600), with magnetic resonance imaging system (102). The method comprises acquiring (202) equilibrium magnetization magnetic resonance imaging data (148) by controlling the magnetic resonance imaging system according to a T1 measuring magnetic resonance imaging protocol and calculating an equilibrium magnetization baseline image (156). The method further comprises repeatedly acquiring (206) the dynamic PRFS magnetic resonance data according to a proton resonance frequency shift magnetic resonance imaging protocol. The method further comprises repeatedly acquiring (208) magnetic resonance data portions (152) according to the T1 measuring magnetic resonance imaging protocol with a saturation preparation (804) at the start of the acquisition. The acquisition of the dynamic PRFS magnetic resonance data and the magnetic resonance data portions are interleaved. The method further comprises repeatedly reassembling (212) the resonance data portions into dynamic T1 magnetic resonance data. The method further comprises repeatedly calculating (214) a T1 map (158) using the reassembled dynamic T1 magnetic resonance data and the equilibrium magnetization image. The method further comprises repeatedly calculating (216) a PRFS phase calibration (160) using the dynamic PRFS magnetic resonance data and the T1 map. The method further comprises repeatedly calculating (218) a PRFS temperature map (162) using the dynamic PRFS magnetic resonance data and the PRFS phase calibration if the PRFS phase calibration has been calculated.

72. 发明公开

EP2627246A4 METHODS AND APPARATUSES FOR RELATING MULTIPLE MAGNETIC RESONANCE PHYSICAL PARAMETERS TO MYELIN CONTENT IN THE BRAIN 有权
公开(公告)号：EP2627246A4
公开(公告)日：2018-01-17
申请号：EP10858465
申请日：2010-10-14
申请人： SYNTHETICMR AB
发明人： WARNTJES MARCEL
IPC分类号： G01R33/50 , A61B5/00 , A61B5/055 , G01R33/56
CPC分类号： A61B5/0042 , A61B5/055 , G01R33/50 , G01R33/5608
摘要： A computerized method of generating a map of myelin tissue of a brain is described. In addition sub-maps of different myelin contents can be imaged. The method uses a simulation model comprising at least two interacting tissue compartments.

73. 发明公开

EP3218734A4 METHOD AND APPARATUS FOR MULTI-SLICE IMAGING OF T-2 RELAXATION TIME 审中-公开
公开(公告)号：EP3218734A4
公开(公告)日：2017-12-20
申请号：EP15859828
申请日：2015-10-29
申请人： BETH ISRAEL DEACONESS MEDICAL CT INC
发明人： BASHA TAMER , NEZAFAT REZA
IPC分类号： G01R33/50 , G01R33/483 , G01R33/56 , G01R33/561 , G01R33/567
CPC分类号： G01R33/5602 , G01R33/36 , G01R33/385 , G01R33/4835 , G01R33/4838 , G01R33/50 , G01R33/5613 , G01R33/5673
摘要： An MRI method includes performing a first image acquisition module of a pulse sequence to acquire a first MR data from slices disposed at different locations in a region of interest (ROI) of an object; performing a second image acquisition module of the pulse sequence, to acquire a second MR data from the slices disposed at the different locations of the ROI, with a T2 preparation time different than that of the first image acquisition module; and generating a T2 map based on the acquired first MR data and the acquired second MR data.

74. 发明公开

EP2936129A4 MAGNETIC RESONANCE FINGERPRINTING (MRF) USING ECHO SPLITTING 有权
标题翻译： MAGNETRESONANZ-FINGERABDRUCK（MRF）ANHAND VON ECHOSPALTUNG
公开(公告)号：EP2936129A4
公开(公告)日：2017-09-06
申请号：EP13865688
申请日：2013-09-19
申请人： UNIV CASE WESTERN RESERVE
发明人： JERECIC RENATE , GRISWOLD MARK , JIANG YUN , MA DAN
IPC分类号： G01R33/561 , G01R33/50 , G01R33/56
CPC分类号： G01R33/56 , G01R33/50 , G01R33/5602 , G01R33/561
摘要： Apparatus, methods, and other embodiments associated with nuclear magnetic resonance (NMR) fingerprinting using echo splitting are described. One example apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include the number of echo splitting pulses, spacings between echo splitting pulses, flip angle of echo splitting pulses, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, and a characterization logic configured to characterize a resonant species in the object as a result of comparing acquired signals to reference signals.
摘要翻译：描述了与使用回波分裂的核磁共振（NMR）指纹识别相关联的装置，方法和其他实施方式。一个示例装置包括NMR逻辑，其被配置为重复地并可变地采样与对象相关联的（k，t，E）空间以获取一组NMR信号。 NMR信号组的成员与（k，t，E）空间中的不同点相关联。采样以t和/或E以非恒定方式变化来执行。变化的参数可以包括回波分裂脉冲的数量，回波分裂脉冲之间的间隔，回波分裂脉冲的翻转角，回波时间，RF幅度和其他参数。 NMR装置还可以包括被配置为从NMR信号产生NMR信号演化的信号逻辑以及被配置为表征作为将采集的信号与参考信号进行比较的结果的对象中的共振物种的特征的表征逻辑。

75. 发明授权

EP2748651B1 NMR METHODS FOR ENDOTOXIN ANALYSIS 有权转让
公开(公告)号：EP2748651B1
公开(公告)日：2017-08-30
申请号：EP12833431.5
申请日：2012-09-20
申请人： T2 Biosystems, Inc. , Dhanda, Rahul, K. , Papkov, Vyacheslav , Lowery, Thomas
发明人： DHANDA, Rahul, K. , PAPKOV, Vyacheslav , LOWERY, Thomas
IPC分类号： G01N24/08 , G01R33/50
CPC分类号： G01N33/573 , G01N24/084 , G01R33/50

76. 发明公开

EP2554114A4 MAGNETIC RESONANCE IMAGING APPARATUS, MAGNETIC RESONANCE IMAGING METHOD AND IMAGE DISPLAY DEVICE 审中-公开
标题翻译： MAGNETRESONANZABBILDUNGSVORRICHTUNG，MAGNETRESONANZABBILDUNGSVERFAHREN UND BILDANZEIGEVORRICHTUNG
公开(公告)号：EP2554114A4
公开(公告)日：2017-04-26
申请号：EP11832601
申请日：2011-10-13
申请人： TOSHIBA MEDICAL SYS CORP
发明人： MIYAZAKI MITSUE
IPC分类号： G01R33/56 , G01R33/50
CPC分类号： G01R33/5608 , G01R33/50

77. 发明授权

EP2627412B1 THERAPEUTIC APPARATUS FOR HEATING A SUBJECT 有权转让
标题翻译：治疗装置用于加热PERSON
公开(公告)号：EP2627412B1
公开(公告)日：2015-08-05
申请号：EP11776898.6
申请日：2011-10-11
申请人： Koninklijke Philips N.V. , National Institutes Of Health (NIH)
发明人： PARTANEN, Ari Ilkka Mikael , DREHER, Matthew Robert , YARMOLENKO, Pavel Sergeyevich , VIITALA, Antti Johannes , ENHOLM, Julia Kristina , KÖHLER, Max Oskar
IPC分类号： A61N7/02 , G06F19/00 , G01R33/48 , G01R33/50 , A61N5/10 , A61B19/00 , A61B18/00
CPC分类号： A61N7/00 , A61B2017/00084 , A61B2018/00642 , A61B2018/00666 , A61B2018/00678 , A61B2018/00791 , A61B2090/374 , A61N5/10 , A61N7/02 , A61N2005/1085 , A61N2005/1087 , G01R33/4804 , G01R33/4814 , G01R33/50
摘要： A therapeutic apparatus (900, 1000) comprising a high intensity focused ultrasound system (904) for heating a target zone (940, 1022). The therapeutic apparatus further comprises a magnetic resonance imaging system (902). The therapeutic apparatus further comprises a memory (952) containing machine executable instructions (980, 982, 984, 986, 988, 990) for execution by a processor (944). Execution of the instructions cause the processor to: generate (702, 802) heating commands (964) which cause the high intensity focused ultrasound system to sonicate the subject; repeatedly acquire (704, 804) magnetic resonance data (954) during execution of the heating commands; repeatedly calculate (706, 806) a spatially dependent parameter (970); and repeatedly modify (708, 808) the heating commands in accordance with the spatially dependent parameter such that within the target zone the spatially dependent parameter remains below a first predetermined threshold and above a second predetermined threshold.

78. 发明公开

EP2689239A4 IMPROVED TECHNIQUES, SYSTEMS AND MACHINE READABLE PROGRAMS FOR MAGNETIC RESONANCE 审中-公开
标题翻译：方法的改进，磁系统和机器易读的程序
公开(公告)号：EP2689239A4
公开(公告)日：2014-12-24
申请号：EP12761093
申请日：2012-03-23
申请人： MILLIKELVIN TECHNOLOGIES LLC
发明人： KALECHOFSKY NEAL
IPC分类号： G01N24/08 , G01R33/28 , G01R33/32 , G01R33/483 , G01R33/50 , G01R33/56
CPC分类号： G01R33/543 , G01N24/08 , G01R33/282 , G01R33/32 , G01R33/4833 , G01R33/50 , G01R33/5601 , G01R33/5602

79. 发明公开

EP2615448A3 Magnetic resonance imaging methods 审中-公开
标题翻译：磁共振成像方法
公开(公告)号：EP2615448A3
公开(公告)日：2013-09-25
申请号：EP13151055.4
申请日：2013-01-11
申请人： Prad Research Development Limited
发明人： Song, Yi-Qiao , Han, Fei , Paulsen, Jeffrey
IPC分类号： G01N24/08 , G01R33/46 , G01R33/48 , G01R33/50 , G01R33/54 , G01R33/561
CPC分类号： G01R33/543 , G01N24/081 , G01R33/4824 , G01R33/50 , G01R33/5617
摘要： A method of investigating an object using nuclear magnetic resonance (NMR) equipment includes generating a one-dimensional projection of the object for each of a plurality of echoes utilizing echo train signal indications resulting from pulse sequences, and utilizing the plurality of one-dimensional projections, for each of the plurality of echoes, generating NMR image data for at least one location in the object. The NMR image data may be displayed. The displayed data may include a T2 decay curve, a T2 value display, a T2 distribution graph, or petrophysical data for at least one object location.
摘要翻译：使用核磁共振（NMR）设备来研究物体的方法包括利用由脉冲序列产生的回波串信号指示来针对多个回波中的每一个产生物体的一维投影，并利用多个一维投影针对所述多个回波中的每一个，生成用于所述物体中的至少一个位置的NMR图像数据。可以显示NMR图像数据。显示的数据可以包括T2衰减曲线，T2值显示，T2分布图或至少一个物体位置的岩石物理数据。

80. 发明公开

EP2499509A1 LOOK-LOCKER IR-SSFP FOR CARDIAC MR IMAGING WITH SIMULTANEOUS GENERATION OF CARDIAC T1 MAPS, CINE IMAGES AND IR -PREPARED IMAGES 审中-公开
标题翻译： LOOK-储物柜IR-SSFP用于心脏MR成像与心脏T1 MAPS，CINE IMAGES AND IR制备的图像同时生产
公开(公告)号：EP2499509A1
公开(公告)日：2012-09-19
申请号：EP10784273.4
申请日：2010-11-10
申请人： Deutsches Herzzentrum Berlin
发明人： MESSROGHLI, Daniel
IPC分类号： G01R33/50 , G01R33/563 , G01R33/56 , G01R33/561
CPC分类号： G01R33/50 , A61B5/055 , G01R33/4818 , G01R33/4824 , G01R33/5602 , G01R33/5614 , G01R33/5619 , G01R33/56308 , G01R33/56325 , G01R33/5673
摘要： The present invention is directed to a method for use in conducting cardiac MR imaging which allows for reconstruction of T1 maps, cine images and IR-prepared images from one raw data set, wherein the method comprises the following steps: a) acquisition of raw data by use of an ECG-triggered, segmented, inversion recovery (IR)-prepared Look-Locker type pulse sequence for data acquisition, wherein the pulse sequence encompasses more than one shot, wherein each shot comprises: i) an ECG-triggered inversion pulse; ii) SSFP cine data acquisition of radial segmented profiles over more than one RR-interval for a predefined acquisition duration AD; and iii) a relaxation duration RD, during which no data is acquired; b) retrospective gating of raw data by sorting acquired raw data for each RR-interval into a pre-determined number of heart phases by definition of specific time windows within the RR-intervals and sampling of raw data acquired during the time windows respectively; c) image reconstruction, wherein the retrospectively gated raw data is used for reconstruction of T1 maps, cine images and/or IR-prepared images.
摘要翻译：本发明涉及一种方法，以便进行心脏MR成像这对于T1地图，电影图像和从一个原始数据组IR制备的图像的重建允许，worin该方法包括以下步骤：a）采集的原始数据的通过使用ECG触发的，分段的，反转恢复（IR）进行数据采集-prepared查找储物柜型脉冲序列，的worin脉冲序列包括多于一个的拍摄，worin每个镜头包括：i）ECG触发反转脉冲 ; 超过了预定义的持续时间采集AD多于一个的RR间隔的径向分段简档ⅱ）SSFP电影数据采集; 和iii）持续时间松弛RD，其在没有数据被获取; b）由该RR间隔，并在分别的时间窗采集的原始数据的采样内的特定的时间窗口的定义分选获取的原始数据为每个RR间隔成心脏阶段的预先确定的数目的原始数据的回顾性门控; c）中的图像重构，worin回顾性门控的原始数据被用于T1的地图，电影图像和/或IR制备的图像的重建。

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