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71. 发明公开

EP2496604A1 CANINE ANTI-CD20 ANTIBODIES 有权
标题翻译： ANTIKÖRPERGEGEN HUNDE-CD20
公开(公告)号：EP2496604A1
公开(公告)日：2012-09-12
申请号：EP10776068.8
申请日：2010-11-08
申请人： IDEXX Laboratories, Inc.
发明人： BEALL, Melissa
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2887 , A61K39/39541 , A61K39/39558 , C07K14/70596 , C07K16/3061 , C07K2317/33 , C12N5/163 , G01N33/5052 , G01N33/564
摘要： The invention provides canine CD20 specific antibodies, methods of making the antibodies and methods of use of the antibodies.
摘要翻译：本发明提供犬CD20特异性抗体，制备抗体的方法和抗体的使用方法。

72. 发明公开

EP2440653A1 METHODS OF GENERATING HYBRID/CHIMERIC CELLS, AND USES THEREOF 有权转让
标题翻译：用于生产混合/嵌合细胞和方法及其用途
公开(公告)号：EP2440653A1
公开(公告)日：2012-04-18
申请号：EP10785597.5
申请日：2010-06-10
申请人： BTS Research International Pty Ltd
发明人： KASEKO, Galina , MAHAWORASILPA, Tohsak L.
IPC分类号： C12N5/16 , C12N5/20 , C12N5/24
CPC分类号： C12N5/166 , C12N5/163 , C12N2510/02
摘要： The present invention relates to hybrid cells and methods for producing hybrid cells. In particular, the invention relates to hybrid cells generated from the hybridization of at least three cells where at least two cells are derived from different lineages. The invention further relates to the use of hybrid cells for the expression of proteins useful in a range of diagnostic, prophylactic, therapeutic and/or research applications.

73. 发明公开

EP2365062A1 Rapid production of monoclonal antibodies 有权
标题翻译： Schnelle Herstellung单克隆抗体Antikörper
公开(公告)号：EP2365062A1
公开(公告)日：2011-09-14
申请号：EP10185463.6
申请日：2002-02-20
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , Abeome Corporation
发明人： Meagher, Richard B. , Laterza, Vince
IPC分类号： C12N5/16 , G01N33/50 , C07K16/40
CPC分类号： C12N5/163 , C07K16/40 , C12N2510/02 , C12N2517/02 , G01N33/5052 , G01N2800/52
摘要： The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides populations of hybridomas and B cells that can be utilized to make a monoclonal antibody of interest.
摘要翻译：本发明涉及遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还涉及在制备单克隆抗体的方法中利用遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还提供可用于制备感兴趣的单克隆抗体的杂交瘤和B细胞群体。

74. 发明公开

EP2242836A4 METHOD OF MAKING HYBRID CELLS THAT EXPRESS USEFUL ANTIBODIES 有权转让
标题翻译：用于生产杂交细胞用于表达抗体的
公开(公告)号：EP2242836A4
公开(公告)日：2011-05-25
申请号：EP09713631
申请日：2009-01-28
申请人： UNIV JEFFERSON
发明人： DESSAIN SCOTT K , ADEKAR SHARAD P
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C07K16/1282 , C07K2317/21 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C12N5/163 , C12N2501/23 , C12N2501/52 , C12N2510/02

75. 发明公开

EP2287607A1 METHOD FOR QUANTIFICATION OF ANTIGEN-SPECIFIC CANINE OR HUMAN IGE 有权
标题翻译：量化抗原特异性犬或人IGE的方法
公开(公告)号：EP2287607A1
公开(公告)日：2011-02-23
申请号：EP09746584.3
申请日：2009-05-12
申请人： Riken , Animal Allergy Clinical Laboratories
发明人： MASUDA, Kenichi , ISHII, Yasuyuki , YASUDA, Nobutaka
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , C07K16/06 , C07K16/42 , C07K16/4291 , C07K2317/33 , C12N5/163 , G01N33/536 , G01N33/537 , G01N33/543 , G01N33/96 , G01N2333/435 , G01N2469/20 , G01N2496/05 , G01N2800/24 , Y10S435/975 , Y10T436/10 , Y10T436/106664
摘要： Provided are convenient and effective means of quantifying antigen-specific canine and human IgEs, specifically a method of quantifying antigen-specific canine IgE and a method of quantifying antigen-specific human IgE, each comprising the following steps (A) to (D): (A) a step for contacting a biological sample from a subject with an antigen to bind the IgE in the sample and the antigen, (B) a step for measuring the IgE in a standard sample from a laboratory animal other than the subject, sensitized with the antigen of the step (A), using a substance that recognizes subject IgE and also recognizes the IgE of the laboratory animal, and generating a standard curve, (C) a step for detecting the conjugate formed in the step (A), using a substance that recognizes subject IgE and also recognizes the IgE of the laboratory animal, used in the step (B), and (D) a step for quantifying the amount of IgE in the biological sample from the subject using the amount of conjugate detected in the step (C) and the standard curve generated in the step (B).
摘要翻译：提供定量抗原特异性犬和人IgE的方便和有效的方法，具体而言，定量抗原特异性犬IgE的方法和定量抗原特异性人IgE的方法，每个方法包括以下步骤（A）至（D）：（A）将来自受试者的生物样品与抗原接触以结合样品中的IgE和抗原的步骤，（B）测量来自除受试者以外的实验动物的标准样品中的IgE的步骤，敏化与步骤（A）的抗原接触，使用识别受试者IgE并识别实验动物的IgE并产生标准曲线的物质，（C）检测步骤（A）中形成的缀合物的步骤，（B）中使用识别受试者IgE并且也识别实验动物的IgE的物质的步骤，以及（D）使用检测到的缀合物的量定量来自受试者的生物样品中IgE的量的步骤在步骤中（C）和步骤（B）中产生的标准曲线。

77. 发明公开

EP1916303A1 Nucleic acids encoding rearranged human immunoglobulin sequences from transgenic transchromosomal mice 有权
标题翻译： Fürrearrangierte人类免疫球蛋白顺式转录酶Nukleinsäurenaus transchromosomalen transgenischenMäusen
公开(公告)号：EP1916303A1
公开(公告)日：2008-04-30
申请号：EP07021977.9
申请日：2001-11-30
申请人： MEDAREX, INC. , KIRIN BEER KABUSHIKI KAISHA
发明人： Tomizuka, Kazuma , Ishida, Isao , Lonberg, Nils , Halk, Ed
IPC分类号： C12N15/12 , C12N15/85 , C12N5/06 , C12N5/20 , C07K16/00 , A01K67/027
CPC分类号： A01K67/0278 , A01K67/02 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K39/00 , A61K2039/505 , C07K14/70535 , C07K16/00 , C07K16/18 , C07K16/243 , C07K16/2812 , C07K16/2818 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/92 , C12N5/0635 , C12N5/163 , C12N15/8509 , C12N2015/8518 , C12P21/005 , C12Q1/6881 , C12Q2600/158
摘要： The present invention provides novel transgenic nonhuman mammals capable of producing human sequence anti-bodies, as well as methods for producing and using these antibodies.
摘要翻译：本发明提供了能够产生人序列抗体的新型转基因非人类哺乳动物，以及生产和使用这些抗体的方法。

78. 发明授权

EP1354034B1 TRANSGENIC TRANSCHROMOSOMAL RODENTS FOR MAKING HUMAN ANTIBODIES 有权
标题翻译： TRANSCHROMOSOMALE TRANSGEN-鼠类为制造抗体HUMÄNEN
公开(公告)号：EP1354034B1
公开(公告)日：2007-11-14
申请号：EP01987182.1
申请日：2001-11-30
申请人： MEDAREX, INC. , KIRIN BEER KABUSHIKI KAISHA
发明人： TOMIZUKA, Kazuma , ISHIDA, Isao , LONBERG, Nils , HALK, Ed
IPC分类号： C12N15/00 , A01K67/027 , C12N5/06 , C07K16/00 , C12N5/20
CPC分类号： A01K67/0278 , A01K67/02 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K39/00 , A61K2039/505 , C07K14/70535 , C07K16/00 , C07K16/18 , C07K16/243 , C07K16/2812 , C07K16/2818 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/92 , C12N5/0635 , C12N5/163 , C12N15/8509 , C12N2015/8518 , C12P21/005 , C12Q1/6881 , C12Q2600/158
摘要： The present invention provides a transgenic nonhuman mammal, preferably a rodent, comprising two human immunoglobulin loci, wherein one of two said human immunoglobulin loci is a human heavy chain locus and the other locus is a human light chain locus; and wherein only one of said loci is of a transchromosome. In some transgenic nonhuman mammals, the endogenous mammalian heavy chain locus and at least one mammalian light chain locus are inactivated. In some such transgenic nonhuman mammals, the endogenous mammalian heavy chain locus and kappa light chain locus are inactivated. The present invention further provides methods of generating a plurality of B cells from a transgenic nonhuman mammal expressing human antibody sequences. Additional methods of the invention comprise fusing the plurality of B cells with immortalized cells to form hybridomas. The present invention also provides methods of generating a human sequence antibody from a transgenic nonhuman mammal.

79. 发明公开

EP1798243A3 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumors 有权
标题翻译：神经节苷脂相关的重组抗体及其用于诊断的用途和肿瘤的治疗
公开(公告)号：EP1798243A3
公开(公告)日：2007-10-17
申请号：EP06076643.3
申请日：2002-04-08
申请人： Centro de Inmunologia Molecular
发明人： Mateo De Acosta Del Rio, Cristina Maria , Lombardero Valladares, J. , Roque Navarro, Lourdes Tatiana , Lopez Requena, Alejandro, Avenida de Acosta n° 210(bajos)
IPC分类号： C07K16/42 , A61K39/395 , A61P35/00 , A61P35/04
CPC分类号： C07K16/4208 , A61K31/7032 , A61K31/739 , A61K39/0011 , A61K39/395 , A61K39/39558 , A61K39/39566 , A61K2039/505 , A61K2039/55505 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/3076 , C07K16/3084 , C07K16/4241 , C07K16/4266 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C12N5/0694 , C12N5/163 , G01N33/57415 , G01N33/577 , G01N33/686 , G01N2033/57403 , G01N2800/7028 , A61K2300/00
摘要： The present invention is related with the obtaining of modified antibodies by means of the DNA recombinant technology from the murine monoclonal antibody P3 (MAb P3) produced by the hybridoma cell line deposited under Budapest Treaty with accession number ECACC 94113026 and from its anti-idiotype murine monoclonal antibody 1E10 (MAbai 1E10) produced by the hybridoma cell line with deposit number ECACC 97112901, with the objective of achieving monoclonal antibodies which preserve the biological function of specific binding to the antigen of the original antibodies, but being at the same time less immunogenic.
The chimeric antibodies of the invention contain the variable domains of the murine immunoglobulin and the constant regions of the human immunoglobulin; and those humanized, besides containing the constant regions of the human immunoglobulins, they are modified in the region of the murine frameworks (FRs) and in particular in those zones that could be in an antigenic site for the T cells, so several positions of the FRs are human as well. These antibodies can be used in the diagnosis and therapy of different types of tumors.
The present invention is also related with use of the antibodies for therapeutical and diagnostic purposes.

80. 发明公开

EP1614749A4 METHOD OF CONSTRUCTING HYBRIDOMA PRODUCING ANTIGEN-SPECIFIC ANTIBODY USING SINGLE ANTIGEN-SPECIFIC B LYMPHOCYTE AND METHOD OF PRODUCING MONOCLONAL ANTIBODY 审中-公开
标题翻译： PROCESS FOR抗原特异性抗体的杂交瘤制造的构建使用用于生产单克隆抗体的一个抗原特异性B淋巴细胞和方法
公开(公告)号：EP1614749A4
公开(公告)日：2006-10-25
申请号：EP04723704
申请日：2004-03-26
申请人： TOYAMA NEW INDUSTRY ORGANIZAIO , MURAGUCHI ATSUSHI , KISHI HIROYUKI , TAMIYA EIICHI , SUZUKI MASAYASU
发明人： MURAGUCHI ATSUSHI , KISHI HIROYUKI , TAMIYA EIICHI , SUZUKI MASAYASU , TOHBO KIHACHIRO , UENO MINORU , NAKAZATO HIROYOSHI
IPC分类号： C12N15/08 , C07K16/00 , C12N5/16 , C12P21/08
CPC分类号： C07K16/00 , C12N5/163
摘要： It is intended to provide a method of constructing a hybridoma producing an antigen-specific antibody with the use of an antigen-specific B lymphocyte and a method of producing a monoclonal antibody. The method of constructing a hybridoma producing an antigen-specific antibody comprises selecting a B lymphocyte reacting specifically with a certain antigen (an antigen-specific B lymphocyte), culturing the thus selected antigen-specific B lymphocyte, and fusing the antigen-specific B lymphocytes having proliferated by the culture with myeloma cells to give hybridomas. Using a hybridoma constructed by this method, a monoclonal antibody is produced.

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