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1. 发明公开

EP4425145A2 AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD 审中-公开
公开(公告)号：EP4425145A2
公开(公告)日：2024-09-04
申请号：EP24188187.9
申请日：2016-02-12
申请人： HITACHI HIGH-TECH CORPORATION
发明人： YABUTANI, Chie , SUZUKI, Naoto , MAKINO, Akihisa
IPC分类号： G01N1/38
CPC分类号： G01N33/96 , G01N21/272 , G01N33/4905 , G01N21/82 , G01N1/38 , G01N2035/0053420130101 , G01N2035/0054420130101 , G01N2035/0055420130101 , G01N2035/044420130101 , G01N33/86 , G01N35/025
摘要： Provided are an analysis device and a method that enable automated preparation of mixed blood plasma obtained by mixing subject blood plasma and normal blood plasma at a prescribed ratio. The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light. The specimen dispensing mechanism 101 dispenses the subject blood plasma alone, the normal blood plasma alone, and the subject blood plasma and the normal blood plasma at least at one mixing ratio, into the plurality of specimen containers 103, thereby preparing mixed blood plasma.

2. 发明公开

EP4385401A1 SYSTEM FOR DELIVERING A SENSING DEVICE INTO A BODY 审中-公开
公开(公告)号：EP4385401A1
公开(公告)日：2024-06-19
申请号：EP22212996.7
申请日：2022-12-13
申请人： Koninklijke Philips N.V.
发明人： GLEICH, Bernhard , RAHMER, Juergen Erwin
IPC分类号： A61B5/0215 , A61B5/1495 , A61B5/157 , G01N33/96 , A61B5/145
CPC分类号： A61B5/0215 , A61B5/1495 , G01N33/96 , A61B5/14542 , A61B5/14503
摘要： The invention relates to a system (100) for delivering a sensing device (10; 20) into a body that allows to measure at least one property of a body fluid. The system comprises a storage portion (101) for storing the sensing device before delivery, the system allowing to withdraw body fluid from the body into the storage portion, and a reference sensor (102) configured to carry out a reference measurement of the property to be measured, the reference measurement being carried out on body fluid withdrawn from the body into the storage portion. After the reference measurement has been carried out, the sensing device can be delivered from the storage portion into the body. The presented system allows to simplify accurate measurements of body fluids.

3. 发明公开

EP4380952A1 REPORTER LABELED ANNULAR CLOT SYSTEM FOR DIAGNOSIS AND RESEARCH 审中-实审
公开(公告)号：EP4380952A1
公开(公告)日：2024-06-12
申请号：EP22853898.9
申请日：2022-08-04
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人： ALVES, Nathan J. , ZENG, Ziqian
IPC分类号： C07K14/08 , A61K39/12
CPC分类号： C07K14/75 , G01N33/86 , G01N2333/7520130101 , G01N33/96 , G01N2800/5220130101 , G01N2500/0420130101 , C12Q1/37

4. 发明公开

EP4356144A2 ANTIGEN ANALOGUE FOR IMMUNOMETRIC DIAGNOSTIC ASSAYS AND METHOD OF USE THEREOF 审中-实审
公开(公告)号：EP4356144A2
公开(公告)日：2024-04-24
申请号：EP22825707.7
申请日：2022-06-14
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： HIRSCH, Brett , ZHENG, Jian , DAGGETT, Stephen
IPC分类号： G01N33/78 , G01N33/574 , G01N33/577
CPC分类号： C07K14/005 , C12N2770/2003120130101 , C07K14/58 , C07K14/635 , G01N2333/63520130101 , G01N2333/16520130101 , G01N2333/5820130101 , G01N33/96

5. 发明公开

EP3315966A1 STANDARD THYROID GLAND HORMONE SOLUTION 审中-公开
标题翻译：标准的甲状腺激素解决方案
公开(公告)号：EP3315966A1
公开(公告)日：2018-05-02
申请号：EP16817859.8
申请日：2016-06-27
申请人： Fujirebio Inc.
发明人： IBANEZ, Yukina , UMEDA, Kazuyuki , KITAMURA, Yoshiyuki
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , G01N33/96
摘要： Disclosed are a standard solution of a thyroid hormone which is easily adjusted from lot to lot for consistent performance and a method of preparing a standard curve in an immunoassay using the same. The standard solution of a thyroid hormone contains the thyroid hormones and a cyclodextrin or a derivative thereof in a buffer solution. The method of generating a standard curve includes: preparing a plurality of standard solutions of a thyroid hormone containing the thyroid hormone at different known concentrations and a cyclodextrin or a derivative thereof in a buffer solution; and subjecting each standard solution of the thyroid hormone to the immunoassay to prepare a standard curve based on the relationship between the concentration of the thyroid hormone contained in each standard solution of the thyroid hormone and the signal in the immunoassay.
摘要翻译：公开了一种标准的甲状腺激素溶液，其可以容易地根据批次的不同进行调整以获得一致的性能，并且提供了使用该标准溶液在免疫测定中制备标准曲线的方法。甲状腺激素的标准溶液在缓冲溶液中含有甲状腺激素和环糊精或其衍生物。产生标准曲线的方法包括：制备多种含有不同已知浓度的甲状腺激素和环糊精或其衍生物的甲状腺激素在缓冲溶液中的标准溶液; 并根据甲状腺激素各标准溶液中所含的甲状腺激素浓度与免疫测定中的信号之间的关系制备标准曲线以制备甲状腺激素的每种标准溶液进行免疫测定。

6. 发明公开

EP3273250A1 AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD 有权转让
标题翻译：自动分析装置和自动分析方法
公开(公告)号：EP3273250A1
公开(公告)日：2018-01-24
申请号：EP16768208.7
申请日：2016-02-12
申请人： Hitachi High-Technologies Corporation
发明人： YABUTANI Chie , SUZUKI Naoto , MAKINO Akihisa
IPC分类号： G01N35/00 , G01N33/86 , G01N33/96 , G01N35/02 , G01N35/04
CPC分类号： G01N33/86 , G01N1/38 , G01N21/272 , G01N21/82 , G01N33/4905 , G01N33/96 , G01N35/00 , G01N35/00722 , G01N35/00732 , G01N35/0092 , G01N35/0095 , G01N35/02 , G01N35/025 , G01N35/04 , G01N35/1002 , G01N2035/00356 , G01N2035/00534 , G01N2035/00544 , G01N2035/00554 , G01N2035/00831 , G01N2035/00891 , G01N2035/0094 , G01N2035/0441 , G01N2035/0444
摘要： Provided are an analysis device and a method that enable automated preparation of mixed blood plasma obtained by mixing subject blood plasma and normal blood plasma at a prescribed ratio. The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light. The specimen dispensing mechanism 101 dispenses the subject blood plasma alone, the normal blood plasma alone, and the subject blood plasma and the normal blood plasma at least at one mixing ratio, into the plurality of specimen containers 103, thereby preparing mixed blood plasma.
摘要翻译：本发明提供一种分析装置和方法，其能够自动制备通过将受试者血浆和正常血浆以预定比例混合而获得的混合血浆。自动分析装置100具备：检体分注机构101，其将被加入对象的血浆和/或通常的血浆，以将被检体血浆的凝固时间修正为多个检体容器103; 包含目标血浆和/或正常血浆的反应容器104; 向反应容器104内分注试剂的试剂分注机构106，以及检测部113，其将来自光源115的光照射到在反应容器104内添加有试剂的被检测对象血浆和/或正常血浆中，根据所获得的散射来测定凝固时间光和/或透射光。检体分注机构101将被检者血浆本身，正常血浆本身以及被检者血浆和正常血浆至少以一种混合比例分配到多个检体容器103中，从而制备混合血浆。

7. 发明公开

EP3258242A1 BLOOD ANALYZING METHOD, BLOOD ANALYZER, COMPUTER PROGRAM, CALIBRATOR SET, AND CALIBRATOR SET MANUFACTURING METHOD 无效
标题翻译：血液分析方法，血液分析仪，计算机程序，校准器组和校准器组的制造方法
公开(公告)号：EP3258242A1
公开(公告)日：2017-12-20
申请号：EP17175990.5
申请日：2017-06-14
申请人： SYSMEX CORPORATION
发明人： Hayasaki, Junki
IPC分类号： G01N21/27 , G01N33/86
CPC分类号： G01N33/86 , G01N21/272 , G01N21/49 , G01N21/59 , G01N21/82 , G01N33/49 , G01N33/96 , G01N35/00693 , G01N2021/5969 , G01N2021/825 , G01N2201/127 , G01N2333/75 , G01N2800/224
摘要： A method to make it possible to obtain a value related to the amount of DD by FDP measurement.
The method includes optically measuring a first calibration sample prepared from an FDP measurement reagent and a first calibrator containing D-dimer (DD) and having a first value relating to the ratio of the content of fibrin/fibrinogen degradation product FDP to the content of DD, acquiring first calculation data based on temporal change of optical information obtained by optical measurement of the first calibration measurement sample, performing optical measurement of a second calibration measurement sample prepared from FDP measurement reagent and a second calibrator containing DD and having a second value that is different from the first value related to the ratio of the content of FDP to the content of DD, acquiring second calculated data based on a temporal change in optical information obtained by optical measurement of the second calibration measurement sample, and acquiring calibration curve information indicating the relationship between the calculation data and the value relating to the amount of DD based on the first calculation data, the second calculation data, the first value, and the second value.
摘要翻译：通过FDP测量可以获得与DD量相关的值的方法。该方法包括光学测量由FDP测量试剂和含有D-二聚体（DD）并且具有与纤维蛋白/纤维蛋白原降解产物FDP的含量与DD的含量的比率有关的第一值的第一校准物制备的第一校准样品基于通过第一校准测量样本的光学测量获得的光学信息的时间变化获取第一计算数据，对由FDP测量试剂制备的第二校准测量样本和包含DD的第二校准器进行光学测量，并且具有第二值不同于与FDP的含量与DD的含量的比率相关的第一值，基于通过第二校准测量样本的光学测量获得的光学信息的时间变化来获取第二计算数据，并且获取指示计算数据与值re之间的关系基于第一计算数据，第二计算数据，第一值和第二值确定DD的量。

8. 发明公开

EP3254106A1 METHODS AND COMPOSITIONS FOR DIAGNOSING BRAIN INJURY OR NEURODEGENERATION 审中-公开
标题翻译：诊断脑损伤或神经退化的方法和组合物
公开(公告)号：EP3254106A1
公开(公告)日：2017-12-13
申请号：EP16746229.0
申请日：2016-02-01
申请人： Immunarray USA, Inc.
发明人： SOREK, Rachel , JAKOBI, Keren , EDMONDS, Donna
IPC分类号： G01N33/50 , G01N33/53 , C07K14/46
CPC分类号： G01N33/6896 , C07K14/47 , G01N33/54366 , G01N33/96 , G01N2800/28 , G01N2800/52 , G01N2800/56
摘要： Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject.

9. 发明公开

EP3233896A1 COMPOSÉ SYNTHÉTIQUE BIÉPITOPIQUE 审中-公开
标题翻译： COMPOSÉSYNTHÉTIQUEBIÉPITOPIQUE
公开(公告)号：EP3233896A1
公开(公告)日：2017-10-25
申请号：EP15821151.6
申请日：2015-12-17
申请人： Biomérieux
发明人： BETTSWORTH, Florence , BUSSERET, Sandrine , POTHION, Catherine
IPC分类号： C07K14/47 , G01N33/68
CPC分类号： G01N33/5308 , C07K14/47 , C07K14/4716 , C07K14/4723 , G01N33/53 , G01N33/531 , G01N33/6887 , G01N33/96 , G01N2333/4712 , G01N2800/32
摘要： The present invention concerns a bi-epitope compound of formula I: in which: -E1 and E2, identical or different, each separately represents a peptide sequence comprising at least one epitope of an analyte; X and Y, identical or different, each separately represents a linking arm, -the carrier molecule is soluble and -Z represents an amino acid derivative bearing a thiol function prior to the bonding of same with the carrier molecule. It also concerns the compositions containing this compound, and the use of such a compound or of the composition containing this compound as a control or standard in an immunoassay, the methods using the compound or the composition containing this compound as a control or standard, and finally the kits for implementing an immunoassay comprising the compound or the composition containing this compound.
摘要翻译：本发明涉及式I的双表位化合物：其中：-E1和E2相同或不同，各自分别表示包含分析物的至少一个表位的肽序列; X和Y相同或不同，各自独立地表示连接臂， - 载体分子可溶且-Z表示在与载体分子键合之前具有巯基官能团的氨基酸衍生物。还涉及含有该化合物的组合物，以及这种化合物或含有该化合物的组合物作为免疫测定的对照或标准的用途，使用该化合物或含有该化合物的组合物作为对照或标准的方法，以及最后是用于实施包含该化合物或含有该化合物的组合物的免疫测定的试剂盒。

10. 发明公开

EP3177639A1 ALZHEIMER'S DISEASE 审中-公开
标题翻译：阿尔茨海默氏病
公开(公告)号：EP3177639A1
公开(公告)日：2017-06-14
申请号：EP15747216.8
申请日：2015-08-03
申请人： The University of Sussex
发明人： SERPELL, Louise Charlotte , DAHAL, Liza
IPC分类号： C07K14/47
CPC分类号： G01N33/6896 , C07K14/4711 , G01N33/96 , G01N2333/4709 , G01N2500/00 , G01N2800/2821
摘要： Variant forms of Amyloid-beta (Aβ) and kits comprising a variant Aβ are disclosed. The invention also provides uses of these kits and the Aβ variants in Aβ studies, for example in assays and methods for screening novel compounds for use in treating Alzheimer's Disease.
摘要翻译：公开了变体形式的淀粉状蛋白-β（Aβ）和包含变体Aβ的试剂盒。本发明还提供了这些试剂盒和Aβ变体在Aβ研究中的用途，例如用于筛选用于治疗阿尔茨海默氏病的新化合物的试验和方法。

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