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1. 发明公开

EP2661505A4 SYSTEM FOR AND METHOD OF DETERMINING CANCER PROGNOSIS AND PREDICTING RESPONSE TO THERAPY 审中-公开
标题翻译：系统和方法用于确定预后和预测响应后治疗
公开(公告)号：EP2661505A4
公开(公告)日：2015-01-14
申请号：EP12731958
申请日：2012-01-09
申请人： UNIV JEFFERSON
发明人： WALDMAN SCOTT A , HYSLOP THERESA
IPC分类号： C12Q1/68 , G06F19/00 , G06F19/20
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , G06F19/20 , G06F19/3431 , G16H50/30 , G16H50/70
摘要： A database for predicting clinical outcomes based upon quantitative tumor burden in lymph node samples from an individual is provided. The database comprises data sets from a plurality of individuals. The data sets include clinical outcome data and data regarding number of lymph nodes evaluated, maximum number of biomarker detected in any single node, median normalized expression levels detected across all evaluated lymph nodes and the maximum normalized expression levels detected in any evaluated lymph nodes and the database also includes stratified risk categories based upon recursive partitioning of data. A system for predicting clinical outcomes based upon quantitative tumor burden in lymph node samples from an individual is provided which includes the database linked to a data processor, an input interface and an output interface. Method of preparing a database and method for predicting clinical outcome for a test patient based upon quantitative tumor burden in lymph node samples from an individual using a system that includes the database linked to a data processor, an input interface and an output interface. The method comprises measuring quantitative tumor burden in a plurality of lymph node samples from an individual, inputting the results into the system and processing with data in the database. The results of the processing of the data is the assignment of data test patient to a stratified risk category. Output is produced that displays test patient's identity and assigned stratified risk category.

2. 发明公开

EP2613776A4 COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION 有权
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR MUSKELREPARATUR UND -REGENERATION
公开(公告)号：EP2613776A4
公开(公告)日：2014-03-12
申请号：EP11822537
申请日：2011-08-31
申请人： UNIV JEFFERSON
发明人： IWAMOTO MASAHIRO , PACIFICI MAURIZIO
IPC分类号： A61K31/19 , A61K31/185 , A61K31/192 , A61P21/00
CPC分类号： A61K31/192 , A61K31/185 , A61K31/19 , A61K31/415 , A61K35/12 , A61K45/06
摘要： The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RARΥ agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.
摘要翻译：本发明提供了用于肌肉修复或再生的方法，其包括在肌肉损伤部位向受试者施用治疗有效量的与RAR激动剂接触预处理的RAR激动剂或干细胞。另外，本发明提供包含RAR激动剂治疗的干细胞的组合物以及所述细胞用于肌肉修复或再生的方法。在一个实施方案中，干细胞是间充质干细胞。在一个实施方案中，RAR激动剂是RARγ激动剂。在一个实施方案中，RAR激动剂的施用在受损的肌肉组织发生的受试者的增加的内源性类视色素信号传导期间开始。

3. 发明公开

EP2400975A4 Use of guanylyl cyclase c agonists to suppress appetite 审中-公开
标题翻译：的鸟苷酸环化酶C激动剂抑制食欲使用
公开(公告)号：EP2400975A4
公开(公告)日：2012-11-28
申请号：EP10746791
申请日：2010-02-24
申请人： UNIV JEFFERSON
发明人： VALENTINO MICHAEL , LIN JEIRU EGERIA , WALDMAN SCOTT A
IPC分类号： A61K38/17 , A61K35/74
CPC分类号： A61K38/1709 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0362 , A61K35/74 , A61K48/00 , C07K14/705 , C12N15/8509
摘要： Compositions comprising a guanylyl cyclase C agonist formulated for sustained specific release of an amount effective to suppress appetite when administered orally to an individual are disclosed. Compositions comprising a guanylyl cyclase C agonist formulated for intravenous delivery in an amount effective to suppress appetite when administered intravenously to an individual are also disclosed. Methods of suppressing appetite in an individual are disclosed.

4. 发明公开

EP2097090A4 PEPTIDE AND TREATMENT FOR HIV-1 INFECTION 有权
标题翻译：肽和治疗HIV-1感染
公开(公告)号：EP2097090A4
公开(公告)日：2012-07-11
申请号：EP07862468
申请日：2007-12-04
申请人： UNIV JEFFERSON , OYAGEN INC
发明人： ZHANG HUI , SMITH HAROLD C
IPC分类号： A61K38/55 , A61K38/10 , A61K39/395 , C07K5/00 , C07K7/00 , C07K14/00
CPC分类号： C07K14/00 , A61K38/162 , A61K45/06 , A61K2300/00

5. 发明公开

EP1599165A4 THE USE OF GCC LIGANDS 审中-公开
标题翻译：使用GCC配体
公开(公告)号：EP1599165A4
公开(公告)日：2010-09-08
申请号：EP04709828
申请日：2004-02-10
申请人： UNIV JEFFERSON
发明人： WALDMAN SCOTT A , PITARI GIOVANNI MARIO , PARK JASON , SCHULZ STEPHANIE , WOLFE HENRY R
IPC分类号： A61K38/00 , A61K20060101 , A61K6/00 , A61K38/10 , A61K38/12 , A61K38/17 , A61K39/02 , A61K39/395 , A61K47/48 , A61P35/00 , A61P35/04 , C07K14/245 , G01N33/574
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/177 , A61K47/6415 , A61K51/088 , G01N33/57446

6. 发明公开

EP1439856A4 RECOMBINANT RABIES VACCINE AND METHODS OF PREPARATION AND USE 有权
标题翻译：重组狂犬病疫苗及其制备方法和用途
公开(公告)号：EP1439856A4
公开(公告)日：2005-01-19
申请号：EP02801021
申请日：2002-10-10
申请人： UNIV JEFFERSON
发明人： DIETZSCHOLD BERNHARD , HOOPER DOUGLAS CRAIG , SCHNELL MATTHIAS J
IPC分类号： A61K39/205 , C12N7/01
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5254 , C12N2760/20134

7. 发明公开

EP1414445A4 PARTIAL AGONISTS AT THE GLYCINE MODULATORY SITE OF THE NMDA RECEPTOR FOR TREATING COGNITIVE DYSFUNCTION 审中-公开
标题翻译：认知障碍的治疗NMDA受体的局部ARGONISTEN的GLIZINMODULIERENDEN点
公开(公告)号：EP1414445A4
公开(公告)日：2004-05-06
申请号：EP00957483
申请日：2000-08-16
申请人： UNIV JEFFERSON
发明人： SCHNEIDER JAY S
IPC分类号： A61K31/00 , A61K31/195 , A61K31/198 , A61K31/42 , A61K38/52 , A61K45/06
CPC分类号： A61K45/06 , A61K31/00 , A61K31/195 , A61K31/198 , A61K31/42 , A61K38/52 , A61K2300/00

8. 发明公开

EP0906328A4 METHODS AND COMPOUNDS FOR CURING DISEASES CAUSED BY MUTATIONS 失效
标题翻译：方法和化合物用于治疗由基因突变引起的疾病
公开(公告)号：EP0906328A4
公开(公告)日：2003-06-18
申请号：EP97922597
申请日：1997-05-01
申请人： UNIV JEFFERSON
发明人： KMIEC ERIC B , COLE-STRAUSS ALLYSON , YOON KYONGGEUN
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P7/00 , A61P7/06 , C07H21/00 , C07K14/805 , C12N15/113 , C12N15/00 , C12N15/10 , C12N15/11
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C07K14/805 , C12N2310/13 , C12N2310/321 , C12N2310/53 , C12N2310/3521
摘要： The invention concerns the use of duplex oligonucleotides having both 2'-deoxyribonucleotides and ribonucleotides, wherein there is base pairing between the two types of nucleotides. The sequence of the oligonucleotide is selected so that the 3' and 5' most regions of the oligonucleotides are homologous with (identical to) the sequence of a preselected target gene of a cell. The two regions of homology embrace a region that is heterologous with the target sequence. The introduction of the oligonucleotide into the nucleus of the cell causes the alteration of the target gene such that the sequence of the altered target gene is the sequence of the heterologous region. Consequently, the oligonucleotides of the invention are termed chimeric mutation vectors (CMV). In one embodiment of the invention the target gene is a globin gene and the target cell is a hematopoietic stem cell. This embodiment can be used to correct certain hemoglobinopathies such as Sickle Cell Disease, β-thalassemia and Gaucher Disease. The rate of correction of the globin gene is high enough so that no selection of the treated hematopoietic stem cells is required to obtain a therapeutically significant effect. In one embodiment the ribonucleotides of the CMV contain methylated 2'-O.

9. 发明公开

EP1100496A4 SMALL MOLECULE INHIBITORS OF BCL-2 PROTEINS 审中-公开
标题翻译：小分子BCL-2蛋白来抑制
公开(公告)号：EP1100496A4
公开(公告)日：2002-10-23
申请号：EP99937146
申请日：1999-07-20
申请人： UNIV JEFFERSON
发明人： HUANG ZIWEI , LUI DONGXIANG , HAN XIAOBING , ZHANG ZHIJIA , WANG JIALUN
IPC分类号： A61K31/35 , A61K31/352 , A61K31/404 , A61K31/428 , A61K31/437 , A61K31/496 , A61K31/517 , A61K31/5377
CPC分类号： A61K31/5377 , A61K31/35 , A61K31/352 , A61K31/404 , A61K31/428 , A61K31/437 , A61K31/496 , A61K31/517

10. 发明公开

EP1003769A4 COMPOSITIONS THAT SPECIFICALLY BIND TO COLORECTAL CANCER CELLS AND METHODS OF USING THE SAME 审中-公开
标题翻译：组合物与特定结肠癌细胞的结合和申请流程。
公开(公告)号：EP1003769A4
公开(公告)日：2002-08-21
申请号：EP98939279
申请日：1998-08-07
申请人： UNIV JEFFERSON
发明人： WALDMAN SCOTT A , PEARLMAN JOSHUA M , BARBER MICHAEL T , SCHULZ STEPHANIE , PARKINSON SCOTT J
IPC分类号： A61K31/7088 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P35/04 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/574 , C12N15/63
CPC分类号： G01N33/57419 , A61K39/00 , A61K2039/51 , C07K14/705 , C07K2319/00 , Y10S435/81

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