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71. 发明授权

EP0171037B1 3-Carbonyl-1-aminoalkyl-1H-indoles useful as analgesics and preparation thereof 有权转让
标题翻译：有用的3-羰基-1-氨基甲基-1H-吲哚作为其制剂及其制备方法
公开(公告)号：EP0171037B1
公开(公告)日：1992-06-17
申请号：EP85109689.1
申请日：1985-08-01
申请人： STERLING WINTHROP INC.
发明人： Bell, Malcolm Rice
IPC分类号： C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D409/06 , C07D413/06
CPC分类号： C07D231/12 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/30 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D409/06 , C07D413/06

72. 发明公开

EP0444451A3 3-Arylcarbonyl-1H-indoles useful as therapeutic agents 失效
标题翻译： 3-ARYLCARBONYL-1H-INDOLES有用的治疗药物
公开(公告)号：EP0444451A3
公开(公告)日：1992-04-08
申请号：EP91101689.7
申请日：1991-02-07
申请人： STERLING WINTHROP INC.
发明人： d'Ambra, Thomas Edward , Bacon, Edward Richard , Bell, Malcolm Rice , Carabateas, Philip Michael , Eissenstat, Michael Allen , Kumar, Virendra , Mallamo, John Peter , Ward, Susan Jean
IPC分类号： C07D209/12 , A61K31/40 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/06 , C07D417/04 , C07D417/06
CPC分类号： C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06
摘要： 2-R₂-R₄-substituted-3-R₃-CO-1-[(C-attached-N-heteryl)-(Alk) n ]-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.

73. 发明公开

EP0471756A1 SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF 有权转让
标题翻译： FOR USE蛋白水解酶抑制剂和一种用于生产糖精。
公开(公告)号：EP0471756A1
公开(公告)日：1992-02-26
申请号：EP90907695.0
申请日：1990-05-01
申请人： STERLING WINTHROP INC.
发明人： DUNLAP, Richard, Paul , BOAZ, Neil, Warren , MURA, Albert, Joseph , HLASTA, Dennis, John
IPC分类号： A61K31 , A61P1 , A61P29 , A61P43 , C07D275 , C07D417 , C07D471
CPC分类号： C07D275/06 , C07D417/12 , C07D417/14 , C07D471/04
摘要： De nouveaux dérivés de saccharine substitués en position 2 utiles comme inhibiteurs d'enzymes protéolytiques, des compositions contenant ces dérivés pour le traîtement de maladies dégénératives et des méthodes d'utilisation de ces dérivés sont décrits dans la présente invention.

74. 发明公开

EP0351541A1 Safety syringe and combination needle cannula and lock therefor 失效转让
标题翻译： Sicherheitsspritze und Kombination vonNadelkanüleund ihrer Festhaltevorrichtung。
公开(公告)号：EP0351541A1
公开(公告)日：1990-01-24
申请号：EP89110483.8
申请日：1989-06-09
申请人： STERLING WINTHROP INC.
发明人： Haber, Terry McGovern , Foster, Clark Berg
IPC分类号： A61M5/32 , A61M5/24
CPC分类号： A61M5/24 , A61M5/2466 , A61M5/322 , A61M5/344 , A61M5/346 , A61M2005/2414 , A61M2005/247 , A61M2005/31516 , A61M2005/3223 , A61M2005/3231
摘要： A combination retractable needle cannula (32;68) and cannula lock (22;70) which is to be interfaced with a prefilled medication carpule (2;62) at the cylinder of a conventional hypodermic syringe (50). The cannula lock includes a clamp having a pair of oppositely disposed jaws (26;76) which are normally separated from one another so that the needle cannula can be releasably retained therebetween. In the pre-injection state, the jaws of the clamp are surrounded by and rotated towards one another by an expandable outer sleeve (60) so as to retain the cannula in an axially extended position between the jaws for administering an injection. In the post-injection state, and after the contents of the carpule have been expulsed via the cannula, the clamp is displaced by the carpule outwardly of the sleeve, whereby the jaws of the clamp are free to rotate away from one another to release the cannula. The cannula may then be retracted within and completely surrounded by the empty carpule so that the cannula can be safely discarded after use while avoiding an accidental needle stick and the spread of a contagious, and possibly life threatening, disease.
摘要翻译：组合的可缩回的针插管（32; 68）和插管锁（22; 70），其将与常规皮下注射器（50）的圆柱体处的预充式药物针头（2; 62）接合。插管锁包括具有一对相对设置的夹爪（26; 76）的夹具，其通常彼此分离，使得针插管可释放地保持在其间。在预注射状态下，夹具的夹爪被可膨胀外套筒（60）包围并相互转动，以便将套管保持在夹爪之间的轴向延伸位置，用于施加注射。在后喷射状态下，并且在通过套管已经将小胡椒的内容物排出之后，夹具被套管向外的卡彼尔位移，由此夹具的夹爪可以彼此自由旋转以释放插管。然后套管可以缩回到空的小胡子内并完全被空的小胡子包围，使得插管可以在使用后被安全地丢弃，同时避免意外的针刺和蔓延的传染性和可能危及生命的疾病。

75. 发明公开

EP0137242A2 (Substituted) Phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof 有权转让
标题翻译：（取代phenylaliphatische）-isoxazoles它们作为抗病毒剂和它们的制备方法是有用的。
公开(公告)号：EP0137242A2
公开(公告)日：1985-04-17
申请号：EP84109911.2
申请日：1984-08-20
申请人： STERLING WINTHROP INC.
发明人： Guy, Dominic Diana
IPC分类号： C07D413/12 , A61K31/42 , C07D263/14
CPC分类号： C07D413/12 , C07C255/00 , C07D261/08 , C07D263/14 , C07D413/10
摘要： Compounds of the formulas
and
wherein R is lower-alkyl or substituted-lower-alkyl; R 1 , R 2 , R 3 and R 4 are each hydrogen, lower-alkyl or substituted lower-alkyl; R 5 is hydrogen, lower-alkyl, halogen, nitro, lower-alkoxy, lower-alkylthio or trifluoromethyl; R 6 is lower-alkyl; X is 0 or a single bond; and n is an integer from 3 to 9, are useful as antiviral agents, especially against picomaviruses.
摘要翻译：式 worin R是低级烷基或substituiertem - 低级烷基的化合物; R1，R2，R3和R4各自为氢，低级烷基或取代的低级烷基; R5是氢，低级 - 烷基，卤素，硝基，低级烷氧基，低级烷硫基或三氟甲基; R 6是低级烷基; X是O或单键; 并且n是从3到9的整数，是作为抗病毒剂是有用的，爱尤其是对小核糖核酸病毒。

76. 发明授权

EP0573102B1 Double-seal elastomeric stopper 有权转让
标题翻译：弹性体塞子具有双密封
公开(公告)号：EP0573102B1
公开(公告)日：1996-09-18
申请号：EP93201495.4
申请日：1993-05-25
申请人： STERLING WINTHROP INC.
发明人： Tirrell, Joseph V., c/o STERLING WINTHROP INC. , Brown, Neil H., c/o STERLING WINTHROP INC.
IPC分类号： B65D51/00
CPC分类号： B01L3/50825 , B65D51/002 , Y10S215/03

77. 发明公开

EP0695195A1 POLYMERIC X-RAY CONTRAST COMPOSITIONS CONTAINING IODINATED POLYMERIC BEADS 失效
标题翻译：含剂聚合编码的聚合物珠粒的X射线造影
公开(公告)号：EP0695195A1
公开(公告)日：1996-02-07
申请号：EP94914103.0
申请日：1994-04-12
申请人： STERLING WINTHROP INC.
发明人： ILLIG, Carl, R.
IPC分类号： A61K47 , A61K9 , A61K49
CPC分类号： A61K49/0461 , A61K49/0442 , B82Y5/00 , Y10S514/941 , Y10S514/942
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material in combination with a divalent cation capable of forming a coating on the gastrointestinal tract and iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000ν wherein said iodinated polymeric beads comprise a polymer containing repeating units of formula (I) wherein A is a repeating organic unit in the backbone chain of the polymer; and X is an organic moiety containing or iodinated aromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based on the molecular weight of X, in a pharmaceutically acceptable carrier.

78. 发明授权

EP0485028B1 Snap together hypodermic syringe holder 失效转让
标题翻译：用于皮下注射的注射器的支架Zusammenschnappbarer
公开(公告)号：EP0485028B1
公开(公告)日：1996-01-03
申请号：EP91202830.5
申请日：1991-10-31
申请人： STERLING WINTHROP INC.
发明人： Stiehl, Mark , Sisto, Eugene , Bergstresser, William , Vacek, Ronald
IPC分类号： A61M5/24 , A61M5/315
CPC分类号： A61M5/24 , A61M5/315 , A61M5/31505 , A61M2005/2414 , A61M2005/2488 , A61M2005/3139

79. 发明公开

EP0645156A3 Collar for cartridge-needle unit 失效
标题翻译：衣领的盒针单元。
公开(公告)号：EP0645156A3
公开(公告)日：1995-09-13
申请号：EP94202786.3
申请日：1994-09-27
申请人： STERLING WINTHROP INC.
发明人： Stiehl, Mark A. , Bergstresser, William A. , Chapman, Raymond P. , Niedospial, John J.
IPC分类号： A61M5/32 , A61M5/24
CPC分类号： A61M5/3243 , A61M5/288 , A61M5/31511 , A61M5/3202
摘要： This invention relates to a collar (9) adapted for use in combination with activatable prefilled cartridge-need units and disposable holders. The collar (9) is adapted to fit over the hub (26) of the cartridge-needle unit and comprises a solid circumferential neck (11); a circumferential foot (13) interrupted in at least one point having inside (15) and outside (17) arcuate surfaces, the outside surface (17) having thereon a circumferentially outwardly extending ring (19) and the inside surface (15) having thereon at least one radially inwardly extending shelf (21); and at least one leg (25) connecting the neck (11) to the foot (13). The collar (9) provides improved safety reliability and thus reduces the susceptibility of health care workers to accidents, e.g. accidental needle strikes. In addition, the collar (9) can be easily and economically manufactured, e.g. by conventional precision injection molding techniques.

80. 发明公开

EP0645155A3 Holder for cartridge-needle unit 失效
标题翻译：保持器的盒针单元。
公开(公告)号：EP0645155A3
公开(公告)日：1995-09-13
申请号：EP94202781.4
申请日：1994-09-27
申请人： STERLING WINTHROP INC.
发明人： Stiehl, Mark A. , Bergstresser, William A. , Niedospial, John J.
IPC分类号： A61M5/32 , A61M5/24
CPC分类号： A61M5/24 , A61M5/31511 , A61M5/31515 , A61M5/3243 , A61M5/50 , A61M2005/2407 , A61M2005/247 , A61M2005/31518 , A61M2005/3246
摘要： This invention relates to a holder for use in combination with a pre-filled cartridge-needle unit, the holder comprising a hollow body (36) sized for housing the cartridge-needle unit therein having proximal and distal ends; means (32,34) for permitting the body (36) to move axially relative to the cartridge-needle unit and for retaining the cartridge-needle unit within the holder; wherein the distal end of the body (36) is elliptical in cross-section and the proximal end of the body (36) is circular in cross-section. In another preferred embodiment, the body comprises a pair of cam slots (39) at the distal end and a pair or retaining slots (37) at the proximal end, the slots (39,37) being sized to accept a circumferential ring (32) on the cartridge-needle unit and positioned to hold the cartridge-needle units in use and safe positions. The holder is easier to use and manufacture and reduces the susceptibility of health care workers to accidental needle strikes.

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