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51. 发明公开

EP2603563A1 FUNCTIONALIZED COPOLYMERS OF ISOOLEFINS AND DIOLEFINS AND THEIR USE AS COMPATIBILIZERS 失效转让
标题翻译：异烯烃和二烯烃的共聚物功能化及其作为代理兼容性
公开(公告)号：EP2603563A1
公开(公告)日：2013-06-19
申请号：EP11815968.0
申请日：2011-08-11
申请人： Lanxess Inc. , The University of Western Ontario
发明人： STOJCEVIC, Goran , ARSENAULT, Gilles , GILLIES, Elizabeth, R. , BONDUELLE, Collin, V.
IPC分类号： C09D5/00 , A61L29/08 , B05D5/04 , C08F236/04 , C08F8/00 , C08F8/08 , C08F8/14 , C09D147/00 , A61M25/00
CPC分类号： A61L31/10 , A61L29/085 , A61L29/14 , A61L2420/08 , B05D5/04 , B05D7/54 , B05D2201/02 , B05D2530/00 , C08C19/06 , C08F210/12 , C09D123/18 , C09D123/22 , C09D123/30 , C08F236/08
摘要： Functionalized copolymers of isoolefins and conjugated diolefins, methods of preparing said copolymers, and their use as compatibilizers are disclosed. The diolefin monomer units of the co-polymer are modified at the C-C double bond along the backbone of the copolymer to include an oxygen containing functional group such as epoxide, ester or alcohol. The functionalized copolymers improve the wettabilty of a non-hydrophilic surface towards hydrophilic polymer and allows for the formation of homogenous layers of the hydrophilic polymers. In particular, the spreading of a hydrophilic polymer on a non-hydrophilic substrate is facilitated by applying the co-polymers as an interfacial layer between the two incompatible materials. The resulting coated substrates exhibit resistance to protein adsorption and cell growth after grafting. The co-polymers are especially suited in the coating of biomedical devices where a high degree of uniformity of the coated surface is required.

52. 发明公开

EP2603547A1 METHODS FOR PREPARATION OF NOVEL GRAFT COPOLYMERS 失效转让
标题翻译：工艺用于制造新的移植
公开(公告)号：EP2603547A1
公开(公告)日：2013-06-19
申请号：EP11815967.2
申请日：2011-08-11
申请人： Lanxess Inc. , The University of Western Ontario
发明人： STOJCEVIC, Goran , FERRARI, Lorenzo, P. , ADKINSON, Dana, K. , GILLIES, Elizabeth, R. , BONDUELLE, Collin, V.
IPC分类号： C08G81/02 , C08F8/00 , C08F8/08 , C08F8/14
CPC分类号： C08F279/02 , C08C19/30 , C08F8/00 , C08F8/08 , C08F8/14 , C08F210/12 , C08F236/08 , C08G81/025 , C08J3/03 , C08J2323/22 , C08J2323/26
摘要： The present invention relates to novel graft copolymers of functionalized poly(isoolefin-co-conjugated diolefin, and a process of preparing such graft copolymers. The present invention also relates to a method of preparing functionalized copolymers of isoolefins and conjugated diolefins.

53. 发明公开

EP2462649A1 BIO-FUEL CELL SYSTEM 审中-公开
标题翻译：生物燃料电池系统
公开(公告)号：EP2462649A1
公开(公告)日：2012-06-13
申请号：EP10805912.2
申请日：2010-08-09
申请人： The University of Western Ontario
发明人： KARAMANEV, Dimitre Gueorguiev , PUPKEVICH , Victor R . , HOJJATI , Hossein
IPC分类号： H01M8/16 , C12M1/00 , C12M1/04 , C12P3/00 , H01M2/16
CPC分类号： H01M4/90 , H01M4/92 , H01M8/0293 , H01M8/04186 , H01M8/06 , H01M8/08 , H01M8/1004 , H01M8/1023 , H01M8/1025 , H01M8/1027 , H01M8/1032 , H01M8/1039 , H01M8/16 , H01M8/188 , Y02E60/527 , Y02E60/528
摘要： The present invention discloses a new type of bio-fuel cell, based on the microbial regeneration of the oxidant, ferric ions. The bio-fuel cell is based on the cathodic reduction of ferric to ferrous ions, coupled with the microbial regeneration of ferric ions by the oxidation of ferrous ions, at a pH less than about 1.2, with fuel (such as hydrogen) oxidation on the anode electrode. The microbial regeneration of ferric ions is achieved by microorganisms such as
Leptospirillurn ferriphilum . Electrical generation is coupled with the consumption of carbon dioxide from atmosphere and its transformation into microbial cells, which can be used as a single-cell protein.
摘要翻译：本发明公开了一种基于氧化剂三价铁离子的微生物再生的新型生物燃料电池。该生物燃料电池基于三价铁离子的阴极还原，再加上在低于约1.2的pH下通过亚铁离子的氧化对三价铁离子的微生物再生，其中燃料（例如氢）在阳极电极。铁离子的微生物再生通过微生物例如钩端螺旋体（Leptospirillurn ferriphilum）来实现。发电与大气中二氧化碳的消耗及其向微生物细胞的转化相结合，微生物细胞可用作单细胞蛋白质。

54. 发明公开

EP2403979A1 METHOD FOR PRODUCING HYPERTHERMAL HYDROGEN MOLECULES AND USING SAME FOR SELECTIVELY BREAKING C-H AND/OR Si-H BONDS OF MOLECULES AT OR ON SUBSTRATE SURFACES 审中-公开
标题翻译：用于生产HYPER泰尔氢分子和它们用于选择性BREAK CON C-H和/或分子AT或SUSBSTRATFLÄCHEN的Si-H键
公开(公告)号：EP2403979A1
公开(公告)日：2012-01-11
申请号：EP10748260.6
申请日：2010-03-03
申请人： The University of Western Ontario
发明人： LAU, Leo W. M. , YANG, De-Quan , TREBICKY, Tomas , NIE, Heng Yong
IPC分类号： C25B1/02 , H05H1/24 , H05H3/02
CPC分类号： H05H3/02 , B05D3/007 , B05D3/068 , B05D3/145 , C01B3/00 , C01B3/02 , Y02E60/324
摘要： A method for producing hyperthermal molecular hydrogen is disclosed and use of same for selectively breaking C-H or Si-H bonds without breaking other bonds are disclosed. A hydrogen plasma is maintained and protons are extracted with an electric field to accelerate them to an appropriate kinetic energy. The protons enter into a drift zone to collide with molecular hydrogen in gas phase. The cascades of collisions produce a high flux of hyperthermal molecular hydrogen with a flux many times larger than the flux of protons extracted from the hydrogen plasma. The nominal flux ratio of hyperthermal molecular hydrogen to proton is controlled by the hydrogen pressure in the drift zone, and by the length of the drift zone. The extraction energy of the protons is shared by these hyperthermal molecules so that average energy of the hyperthermal molecular hydrogen is controlled by extraction energy of the protons and the nominal flux ratio. Since the hyperthermal molecular hydrogen projectiles do not carry any electrical charge, the flux of hyperthermal hydrogen can be used to engineer surface modification of both electrical insulating products and conductive products. When this method of generating a high flux of hyperthermal molecular hydrogen is applied to bombard organic precursor molecules (or silicone, or silane molecules) with desirable chemical functionality/functionalities on a substrate, the C-H or Si-H bonds are thus cleaved preferentially due to the kinematic selectivity of energy deposition from the hyperthermal hydrogen projectiles to the hydrogen atoms in the precursor molecules. The induced cross-linking reactions produce a stable molecular layer having a controllable degree of cross-linking and retaining the desirable chemical functionality/functionalities of the precursor molecules.

55. 发明公开

EP2332122A1 SYSTEM AND METHOD FOR PROCESSING IMAGES 审中-公开
标题翻译：系统和方法进行图像处理
公开(公告)号：EP2332122A1
公开(公告)日：2011-06-15
申请号：EP09817153.1
申请日：2009-10-02
申请人： The University of Western Ontario
发明人： LEE, Ting, Yim
IPC分类号： G06T7/00 , A61B5/055 , A61B6/03 , G06T5/50
CPC分类号： G06T7/0016 , A61B5/0033 , A61B5/055 , A61B6/032 , A61B6/037 , A61B6/481 , A61B6/486 , A61B6/504 , A61B6/507 , A61B6/5258 , G06K9/52 , G06K9/6215 , G06T2200/24 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104
摘要： A method of processing a plurality of time separated images comprises selecting a plurality of imaging units in each image; measuring a temporal difference in each imaging unit; and selecting temporal differences above a threshold limit.

56. 发明公开

EP2262906A1 METHOD OF ASSESSING MAMMALIAN EMBRYO QUALITY 审中-公开
标题翻译：评估方法哺乳动物胚胎的质量
公开(公告)号：EP2262906A1
公开(公告)日：2010-12-22
申请号：EP09716229.1
申请日：2009-03-05
申请人： The University Of Western Ontario
发明人： KIDDER, Gerald M. , WANG, Hong-Xing , TONG, Dan , TEKPETEY, Francis R.
IPC分类号： C12Q1/02 , A61B5/053 , C12Q1/00 , G01N33/52 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： G01N33/56966 , G01N33/5091 , G01N2333/705
摘要： A method of assessing the health of each oocyte or embryo of a mammal from a plurality of oocytes/embryos of the mammal is provided. The method comprises the steps of: measuring gap junctional coupling strength or connexin43 expression of follicular cells associated with each oocyte; and identifying the gap junctional coupling strength/connexin43 expression of follicular cells associated with each oocyte, wherein the greater the coupling strength/connexin43 expression of follicular cells associated with an oocyte relative to the coupling strength/connexin43 expression of follicular cells associated with each other oocyte, the healthier the oocyte and the embryo resulting from that oocyte. Kits for conducting these methods are also provided.

57. 发明公开

EP2240502A1 PHOSPHONIUM IONIC LIQUIDS AND COATINGS MADE THEREFROM 有权
标题翻译： PHOSPHONIUMIONISCHE液体和由其制造的涂料
公开(公告)号：EP2240502A1
公开(公告)日：2010-10-20
申请号：EP09706792.0
申请日：2009-01-28
申请人： The University of Western Ontario
发明人： RAGOGNA, Paul J. , TINDALE, Jocelyn J.
IPC分类号： C07F9/54 , C09D5/00 , C09K3/16 , C09K3/18
CPC分类号： H01B1/122 , C07F9/5407 , C08K5/50 , C09D5/00 , C23C22/03 , Y02P20/542 , Y10T428/24802 , Y10T428/31678 , Y10T428/31935 , Y10T428/31938
摘要： ABSTRACT The present invention provides phosphonium ionic liquids (11) and coatings made therefrom. Highly fluorinated phosphonium ionic liquids based on (11) having been produced exhibiting high thermal stabilities, low melting points and temperature dependent solvent miscibilities. These salts and derivatives of (11) have also been employed in the preparation of superhydrophobic surfaces, indicating that ionic liquids are not only new alternative solvents, but also viable functional materials. All derivatives of (11) form biphasic systems with common laboratory solvents of ranging polarity at room temperature. Based on the solvent miscibility experiments with water and the high fluorine loading, the PILs showed obvious evidence of being hydrophobic. Coatings made with these phosphonium ionic liquids (11), salts and derivatives thereof were superhydrophobic with water contact angles were measured and all of the surfaces were determined to be superhydrophobic with contact angles > 150°.

58. 发明公开

EP2089061A1 INHIBITION OF SOX9 FUNCTION FN THE TREATMENT OF PROTEOGL YCAN-ASSOCIATED PATHOPHYSIOLOGICAL CONDITIONS 有权
标题翻译： SOX9功能的抑制病理生理有关的条件蛋白多糖的治疗
公开(公告)号：EP2089061A1
公开(公告)日：2009-08-19
申请号：EP07816052.0
申请日：2007-10-25
申请人： The University Of Western Ontario
发明人： BROWN, Arthur , GRIS, Paul
IPC分类号： A61K48/00 , A61K31/711 , A61K39/395 , A61P25/00 , C12Q1/00 , C12Q1/68 , C07H21/00 , C12N15/12
CPC分类号： C07K16/2845 , A61K31/711 , A61K2039/505 , C12N15/113 , C12N2310/11 , C12N2310/14 , G01N33/6887 , G01N2500/10
摘要： A method of treating a pathophysiological condition caused by the production of growth-inhibiting proteoglycans is provided. It is based on the finding that down-regulation of SOX9 results in decreased production of growth-inhibiting factors such as proteoglycans, and increased production of growth-promoting factors such as a laminin and fibronectin. The method of the present invention comprises the inhibition of SOX9 expression and function with an inhibitor such as an antisense oligonucleotide or a siRNA.

59. 发明公开

EP1893359A1 APPARATUS AND PROCESS FOR THE PYROLYSIS OF AGRICULTURAL BIOMASS 审中-公开
标题翻译： DEVICE AND METHOD FOR农业生物质热解
公开(公告)号：EP1893359A1
公开(公告)日：2008-03-05
申请号：EP06752770.5
申请日：2006-06-07
申请人： THE UNIVERSITY OF WESTERN ONTARIO , Agri-Therm Limited
发明人： BERRUTI, Franco, The University of Western Ontario , BRIENS, Cedric, The University of Western Ontario , GOLDEN, Ronald, Caprex Limited
IPC分类号： B09B3/00 , B01J8/18 , C02F11/10 , F23G5/027
CPC分类号： F23G5/0276 , C02F11/10 , C10B47/24 , C10B49/22 , C10B53/02 , F23C10/26 , F23G5/30 , F23G7/10 , F23G2203/503 , Y02E50/14
摘要： An integrated combustion chamber and fluidized bed pyrolysis reactor. In one embodiment, the combustion chamber is cylindrical and the pyrolysis reactor is provided annularly about the combustion chamber with an annular wall that provides a common surface for heat transfer. A lift tube in fluid communication with the pyrolysis reactor is provided within the combustion chamber for circulating biomass and an inert fluidizable media upwardly through the lift tube; this advantageously increases heat transfer and leads to more rapid pyrolysis. The media and biomass exit the lift tube into either a freeboard area of the pyrolysis reactor or into a low density region of the fluidized bed. A condensable gaseous product is produced during pyrolysis that has economic value. The apparatus and process are especially well suited to the pyrolysis of low density agricultural biomass. The apparatus is compact and particularly well suited to mobile operation.

60. 发明公开

EP1877549A2 HIV VACCINE 有权
标题翻译： HIV - 疫苗接种
公开(公告)号：EP1877549A2
公开(公告)日：2008-01-16
申请号：EP06727538.8
申请日：2006-02-24
申请人： THE UNIVERSITY OF WESTERN ONTARIO
发明人： KANG, Chil-Yong , LI, Yan
IPC分类号： C12N7/01
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5252 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/555 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N2710/14143 , C12N2710/16061 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16322
摘要： The present application is directed to a lentivirus consisting of a modified glyoprotem 120 (gp120) signal sequence or a functional fragment or variant thereof containing no more than one positively charged ammo acid, a vaccine comprising said virus and a method of preventing or treating a lentviral infection comprising administering said vaccine The modified signal sequence is from HIV-1 defined by SEQ ID Nos 3-6, a modification of the natural signal sequence of a HIV-1 sequence defined by SEQ ID No. 1.

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