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41. 发明公开

EP3277328A1 FERROMAGNETIC PARTICLES BOUND TO POLYMERIC IMPLANTS 有权
标题翻译：铁磁颗粒与聚合物植入物结合
公开(公告)号：EP3277328A1
公开(公告)日：2018-02-07
申请号：EP16718751.7
申请日：2016-03-31
申请人： Yale University
发明人： FAHMY, Tarek , SINUSAS, Albert , LEE, Jung, Seok , KIM, Dongin
IPC分类号： A61L27/04 , A61L27/06 , A61L27/52 , A61L27/54 , A61L31/02 , A61L31/16 , A61L24/02 , A61L27/44 , A61L31/12 , A61L24/00 , C08L67/04
CPC分类号： A61L31/022 , A61K49/126 , A61L24/0073 , A61L24/02 , A61L27/04 , A61L27/042 , A61L27/06 , A61L27/18 , A61L27/20 , A61L27/306 , A61L27/34 , A61L27/44 , A61L27/446 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/028 , A61L31/042 , A61L31/06 , A61L31/088 , A61L31/10 , A61L31/125 , A61L31/128 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2400/12 , A61L2420/02
摘要： It has been discovered that iron-platinum magnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to, polymeric materials, especially hydrogels, and magnetized. The magnetized materials are used to attract, capture, and/or retain magnetically labeled cells in the material in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe:Pt is very important for introducing a crystal structure LIO interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a “Super Conducting Quantum Interference Scaffold”, which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.

42. 发明公开

EP3244937A1 VERFAHREN ZUR HERSTELLUNG EINES AUFSATZES EINER ABDECKVORRICHTUNG FÜR EINE KNOCHENDEFEKTSTELLE; VORRICHTUNG ZUR ABDECKUNG UND/ODER REKONSTRUKTION EINER KNOCHENDEFEKTSTELLE 审中-公开
标题翻译：制造用于骨骼缺陷的覆盖装置的尖端的方法; 用于覆盖和/或重建骨头电话的装置
公开(公告)号：EP3244937A1
公开(公告)日：2017-11-22
申请号：EP16708072.0
申请日：2016-01-11
申请人： Reoss GmbH
发明人： SEILER, Marcus
IPC分类号： A61L27/06 , A61C8/02 , A61L27/18 , A61L31/02 , A61L31/06 , A61F2/28 , G06F19/00
CPC分类号： A61F2/2846 , A61C8/0006 , A61C8/008 , A61F2002/2835 , A61F2002/285 , A61F2002/30034 , A61F2002/30062 , A61F2002/30561 , A61F2002/30576 , A61F2002/30784 , A61F2002/30838 , A61F2002/3092 , A61F2002/3093 , A61L27/06 , A61L27/18 , A61L31/022 , A61L31/06 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/412 , A61L2400/18 , A61L2430/02 , A61L2430/12 , G06F19/00 , G06F19/325 , G16H50/50 , C08L67/04
摘要： A method for producing an attachment piece (4), which has at least one predetermined break point (16), a cover device for a bone defect site (2), and a device (1) for covering and/or reconstructing a bone defect site (2) are proposed, wherein by comparing a first data set, which represents the affected bone defect site (2) in the actual state, against a second data set, which represents the desired state of a bone regenerated at the bone defect site (2), wherein the second data set was calculated or was recorded at a time when the bone at the site now to be regenerated was still a healthy bone (18), it is possible that the regenerated bone, which arises through the regeneration of the bone defect site (2), has a form corresponding to the form that the bone at the site to be regenerated had when it was still healthy.

43. 发明公开

EP3175018A1 METALLISCHES WERKSTÜCK AUS TITAN UND/ODER TITAN-LEGIERUNG UND/ODER NICKEL-TITAN-LEGIERUNGEN SOWIE NITINOL MIT PORIGER OBERFLÄCHE UND HERSTELLUNGSVERFAHREN 审中-公开
标题翻译： METAL WORK钛和/或钛合金及/或镍钛合金和镍钛合金与表面钻研和方法
公开(公告)号：EP3175018A1
公开(公告)日：2017-06-07
申请号：EP15759628.9
申请日：2015-07-31
申请人： Christian-Albrechts-Universität zu Kiel
发明人： BAYTEKIN-GERNGROSS, Melike , GERNGROSS, Mark-Daniel , ADELUNG, Rainer , CARSTENSEN, Jürgen
IPC分类号： C23F1/26 , A61L27/06 , A61F2/30 , B08B7/00 , C25F3/08 , H01L21/311 , H01L21/3213
CPC分类号： C23F1/26 , A61F2002/30925 , A61L27/06 , A61L27/56 , A61L2400/18 , A61L2430/02 , C22C14/00 , C23F1/30 , H01L2924/01022
摘要： The invention relates to a surface-treated metallic workpiece of titanium and/or titanium alloys with titanium as the main constituent and/or nickel-titanium alloys and also nitinol, wherein on the treated surface the metal is free from inclusions, precipitates of other metals, accumulations of alkali metals, alkaline earth metals and/or aluminium, intermetallic phases, and/or mechanically highly defect-rich regions, and the surface has a first roughness and a second roughness, wherein the first roughness is provided by depressions in the form of pores, the pores having a diameter in the range between 0.5 and 50 µm - being open in the direction of the surface and closed in the direction of the workpiece, and at least some of the pores having an undercut, and the second roughness is provided by randomly distributed elevations and depressions in the range of 100 nm and less. The invention also relates to a production process for a surface-treated workpiece.
摘要翻译：本发明涉及一种用钛作为主要成分和/或镍 - 钛合金，因此镍钛诺，worin经处理的表面的金属是不含夹杂物上的表面处理的金属工件钛和/或钛合金的，其它金属的沉淀物，碱金属，碱土金属和/或铝，金属间相，和/或富缺陷机械高度的区域，并且该表面的堆积具有第一粗糙度和第二粗糙度，worin第一粗糙度是通过凹陷的形式提供的孔，其直径在0.5和50微米之间的范围内的孔隙 - 是在所述表面的方向上开口，并在工件的方向关闭，并且至少一些孔具有底切，并且所述第二粗糙度通过随机分布的突起和凹陷在100nm和更低的范围内提供的。因此本发明涉及一种用于表面处理工件的制造方法。

45. 发明授权

EP2913022B1 METHOD FOR MANUFACTURING ONE-PIECE DENTAL IMPLANT 失效
标题翻译：用于生产ONE PIECE牙科植入物
公开(公告)号：EP2913022B1
公开(公告)日：2017-03-01
申请号：EP13858014.7
申请日：2013-09-11
申请人： GC Corporation
发明人： NAMETA Yoshinori , TAKAYAMA Masayuki , IKEYA Ryosuke , HIROTA Kazuo
IPC分类号： A61L27/06 , A61L27/10 , A61C8/00 , A61C13/00
CPC分类号： A61C13/0006 , A61C8/0012 , A61C8/005 , A61C8/0075 , A61C13/0003 , A61L27/06 , A61L27/10 , F04C2270/0421

46. 发明公开

EP2992908A4 METHOD FOR TREATING SURFACE OF IMPLANT 审中-公开
标题翻译：方法用于将植入物表面处理
公开(公告)号：EP2992908A4
公开(公告)日：2016-12-28
申请号：EP13883807
申请日：2013-09-24
申请人： OSSTEM IMPLANT CO LTD
发明人： HA KYUNG WON , CHOI KYOO OK
IPC分类号： A61L27/28 , A61C8/00 , A61L27/06 , A61L27/20 , A61L27/34
CPC分类号： A61L31/14 , A61C8/0013 , A61L27/06 , A61L27/20 , A61L27/28 , A61L27/34 , A61L31/022 , A61L31/08 , A61L2400/18 , A61L2420/02 , B05D3/007
摘要： Disclosed is a method for treating a surface of an implant. The disclosed method for treating the surface of the implant comprises the steps of: coating a surface treatment composition containing an organic material having a hydrophilic group on the surface of the implant (coating step); and drying the coated surface treatment composition (drying step).

47. 发明公开

EP2991582A4 REINFORCED PROSTHETIC TISSUE VALVES 审中-公开
标题翻译：增强移植组织FOLD
公开(公告)号：EP2991582A4
公开(公告)日：2016-10-05
申请号：EP14791562
申请日：2014-04-29
申请人： CORMATRIX CARDIOVASCULAR INC
发明人： MATHENY ROBERT G , FALLON ANNA
IPC分类号： A61F2/00 , A61F2/24 , A61F6/24 , A61L27/06 , A61L27/36
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2210/0004 , A61L27/06 , A61L27/3633 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/204 , A61L2300/414 , A61L2300/434 , A61L2430/20

48. 发明公开

EP3041521A1 METHOD OF MANUFACTURING AN IMPLANT FOR USE IN A SURGICAL PROCEDURE 有权转让
标题翻译：方法用于生产植入物用在外科手术
公开(公告)号：EP3041521A1
公开(公告)日：2016-07-13
申请号：EP13756887.9
申请日：2013-09-02
申请人： Stryker European Holdings I, LLC
发明人： PROCTER, Philip , SÖRENSEN, Jan Henrik , STECKEL, Hartwig , SÖRENSEN, Torben Christian , WELCH, Ken
IPC分类号： A61L27/06 , A61L27/32 , A61L27/54 , A61L27/58
CPC分类号： A61L27/32 , A61L27/06 , A61L27/54 , A61L27/58 , A61L2300/406 , A61L2300/606 , A61L2420/02 , B05D1/18 , C23C26/00 , C23C28/042 , C25D11/26
摘要： A method of manufacturing an implant for use in a surgical procedure, a corresponding implant and the use thereof during the incorporation of a substance is presented. Specifically anodized and blasted titanium implant substrates are provided with a hydroxyapatite (HA) coating for incorporating for example a therapeutic agent. In particular, an anodizing procedure by an electrolytic process in an alkaline liquid is carried out. Moreover, blasting of the anodized titanium implant substrate is carried out by the presented method. The HA coating can be in the range of 1 to 5 µm, particularly in the range of 1 to 3 µm. A local delivery of the active pharmaceutical ingredient is achieved by the implant of the present invention. Moreover, the implant allows for the removal of the implant without damaging surrounding tissue or a bone. Moreover, the HA coating is provided to the substrate such that enhanced fixation as measured by pull-out force is achieved whilst having a relatively low removal torque. The HA coating and drug incorporation may be carried out sequentially but also co-precipitation approach can be used.
摘要翻译：制造植入物在外科手术中使用的的方法，相应的植入物和物质的掺入过程中其使用被呈现。具体而言阳极和喷砂的钛植入物基底设置有羟基磷灰石（HA）涂层结合了用于实施例的治疗剂。特别地，为了在碱性液体通过在电解工艺的阳极氧化过程被执行。更上方，阳极氧化的钛植入物基材的喷砂是由所提出的方法进行。 HA涂层可以是在1至5微米的范围内，特别是在1至3微米的范围内。活性药物成分的局部递送是通过本发明的植入物来实现的。更上方，植入物允许在不损伤周围组织或骨移除植入物。更完了，通过拉出力测量实现，同时具有相对低的移除扭矩HA涂层被提供给检查并增强固定基材。 HA涂层和药物结合可以顺序地进行，但可用于这样的共沉淀方法。

49. 发明公开

EP3025196A1 VERFAHREN ZUR HERSTELLUNG EINER MEDIZINISCHEN VORRICHTUNG ODER EINER VORRICHTUNG MIT STRUKTURELEMENTEN, VERFAHREN ZUM MODIFIZIEREN DER OBERFLÄCHE EINER MEDIZINISCHEN VORRICHTUNG ODER EINER VORRICHTUNG MIT STRUKTURELEMENTEN, MEDIZINISCHE VORRICHTUNG UND SCHICHTVERBUND MIT EINEM SUBSTRAT 审中-公开
标题翻译：方法用于生产医用设备或结构部件，方法用于修改医疗设备的表面或与结构元件，医疗设备和复合层基板的设备的设备
公开(公告)号：EP3025196A1
公开(公告)日：2016-06-01
申请号：EP14745108.2
申请日：2014-07-25
申请人： Acquandas GmbH
发明人： LIMA DE MIRANDA, Rodrigo
IPC分类号： G03F7/00 , G03F7/20 , G03F7/40 , A61F2/82 , A61L27/06
CPC分类号： G03F7/40 , A61B17/32 , A61B2017/00526 , A61F2/82 , A61L31/022 , A61L31/088 , A61L2400/16 , A61L2420/02 , G03F7/00 , G03F7/0035 , G03F7/0037 , G03F7/201 , H01L21/00
摘要： The invention relates to a method for producing a medical device (1) with structure elements (2), said method comprising the following method steps: provision of a substrate (3); optional deposition of a layer of a sacrificial material (4) on the substrate (3); application of a photoresist layer (5) to the substrate (3), in particular to the layer of sacrificial material (4), and structuring of the photoresist layer (5) according to the shape of the structure elements (2) that are to be produced, such that first free spaces (6) are formed which are open on the side facing away from the substrate (3) and are delimited by side faces (7) of the photoresist layer (5), wherein an angle (8) is set between the side faces (7) and the substrate (3); deposition of sacrificial material (9), such that, in the first free spaces (6), first mask elements (10) from sacrificial material (9) are formed which are adapted to the inner contour (13) of the first free spaces (6); removal of the photoresist layer (5), such that second free spaces (11) are formed between the first mask elements (10); deposition, in particular physical vapour deposition, of a first material (12) of the device (1) to be produced in the second free spaces (11) and on the upper face (33) of the first mask elements (10), and removal of the sacrificial material (4, 9) and/or carrying out of further process steps.
摘要翻译：与结构元件的医疗设备是通过提供一种基板制成; OPTIONALLY沉积在基底上的牺牲材料层; 以及将光致抗蚀剂层的基板。牺牲材料和光致抗蚀剂层雅丁到结构元件的形状的结构化的层中产生搜索做第一自由空间形成了是在背离基片的一侧开放，并通过光致抗蚀剂层的侧面被分隔。的角度被设定的侧面和基板之间。牺牲材料在第一自由空间从牺牲材料，以便第一掩模元件angepasst到第一自由空间的内轮廓被沉积。光致抗蚀剂层被除去所以没有第二自由空间的第一掩模元件之间形成。

50. 发明授权

EP2398517B1 ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION 有权
标题翻译：抗菌表面及其制备方法
公开(公告)号：EP2398517B1
公开(公告)日：2016-04-20
申请号：EP10743393.0
申请日：2010-02-18
申请人： Versitech Limited , City University of Hong Kong
发明人： YEUNG, Waikwok, Kelvin , CHEUNG, Manchee , LUK, Dipkei, Keith , YEUNG, Cheyan , KAO, Yitsun, Richard , CHU, Kimho, Paul
IPC分类号： A61L27/06 , A61L27/22 , A61L27/34 , A61L27/54
CPC分类号： A61L27/06 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2300/404 , A61L2300/602 , A61L2300/606 , C08L89/00

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