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41. 发明公开

EP1889048A4 DYNAMIC BACKGROUND SIGNAL EXCLUSION IN CHROMATOGRAPHY/MASS SPECTROMETRY DATA-DEPENDENT DATA ACQUISITION 审中-公开
标题翻译：背景信号IN色谱动态排除/ MASS数据相关数据采集
公开(公告)号：EP1889048A4
公开(公告)日：2010-12-22
申请号：EP06752779
申请日：2006-06-08
申请人： MDS INC DOING BUSINESS THROUGH , APPLIED BIOSYSTEMS CANADA LTD
发明人： LE BLANC YVES , BLOOMFIELD NICHOLAS
IPC分类号： G01N30/88 , G01N30/72 , G01N37/00 , H01J49/26
CPC分类号： G01N30/8675 , G01N30/72 , G01N30/861 , G01N30/8641 , H01J49/0031
摘要： Methods and systems for obtaining mass spectrographic data of a substance. Methods include subjecting a substance to a chromatographic process or other separating process, ionizing the output thereof, and subjecting the ionized output to recursive mass spectrometry analyses; and provide improved processing and analysis of data acquired during the repeated analyses. Systems according to one aspect of the invention comprise ion sources, mass spectrometers capable of analyzing ions of selected mass, and controllers adapted to receive from the mass spectrometers and retain signals representing data representing pluralities of mass spectrograms. The controllers can be adapted to generate information useful for describing extracted ion chromatograms, using data associated with the pluralities of mass spectrograms and non-linear curve approximation algorithms; and to use the generated information to generate further information useful in further analysis of the ionized substance.

42. 发明授权

EP2045332B1 Proteome-wide quantification of small molecule binding to cellular target proteins 有权
标题翻译：蛋白质组量化较少结合至细胞的靶蛋白分子
公开(公告)号：EP2045332B1
公开(公告)日：2010-07-07
申请号：EP07117996.4
申请日：2007-10-05
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Daub, Henrik , Bairlein, Michaela , Sharma, Kirti , Godl, Klaus , Tebbe, Andreas , weber, Christoph
IPC分类号： C12Q1/48 , G01N33/543 , G01N33/68
CPC分类号： G01N33/54306 , C12Q1/485 , G01N30/6043 , G01N30/7233 , G01N30/8675 , G01N33/6851

43. 发明公开

EP2153219A2 METHOD AND SYSTEM FOR DETECTING PEPTIDE PEAKS IN HPLC-MS SIGNALS 审中-公开
标题翻译：用于检测HPLC-MS信号中的肽峰的方法和系统
公开(公告)号：EP2153219A2
公开(公告)日：2010-02-17
申请号：EP08776692.9
申请日：2008-05-30
申请人： Politecnico di Milano
发明人： LEVANDER, Fredrik , CAPPADONA, Salvatore , PATTINI, Linda , CERUTTI, Sergio , JAMES, Peter
IPC分类号： G01N30/86 , G06F17/00 , G06F17/14
CPC分类号： G01N30/8675 , G01N30/8603 , G01N30/8617 , G01N30/8641
摘要： The present invention relates to a method, a computer tool and a system for detecting peptide peaks in measurement signals (11) generated by HPLC-MS instruments. The method comprises the steps of: providing an intensity column vector (SIC) representative of the elution values at a specific mass value (m/z) of the measurement signal (11); performing a wavelet decomposition (15) of such values of said intensity column vector (SIC) to generate a first processed vector (16) representative of the smoothed intensity values of the intensity column vector (SIC); providing a threshold value (S) and performing a wavelet decomposition (17) as a function of the value of said threshold (S) to generate the second processed vector (18) representative of said intensity column vector (SIC) cleaned of any oscillations generated by stochastic noise (e(t)); processing said first processed vector (16) and said second processed vector (18) to generate a third processed vector (19) identifying the baseline values of said intensity column vector (SIC); processing said intensity column vector (SIC) and said second (18) and third (19) vectors to generate e filtered vector (20) identifying any peak value (ZJ) below the background noise (12).
摘要翻译：本发明涉及用于检测由HPLC-MS仪器产生的测量信号（11）中的肽峰的方法，计算机工具和系统。该方法包括以下步骤：提供表示在测量信号（11）的特定质量值（m / z）处的洗脱值的强度列矢量（SIC）; 对所述强度列向量（SIC）的这些值执行小波分解（15）以产生表示强度列向量（SIC）的平滑强度值的第一经处理向量（16）; 提供阈值（S）并根据所述阈值（S）的值执行小波分解（17）以产生表示所述强度列矢量（SIC）的第二经处理矢量（18），所述强度列矢量（SIC）通过随机噪声（e（t））; 处理所述第一处理矢量（16）和所述第二处理矢量（18）以产生识别所述强度列矢量（SIC）的基线值的第三处理矢量（19）; 处理所述强度列向量（SIC）和所述第二（18）和第三（19）向量以产生识别低于背景噪声（12）的任何峰值（ZJ）的e滤波向量（20）。

44. 发明公开

EP1825251A4 METHOD FOR ANALYZING LIPOPROTEINS 失效转让
标题翻译：法分析脂蛋白
公开(公告)号：EP1825251A4
公开(公告)日：2009-09-23
申请号：EP05811455
申请日：2005-11-24
申请人： OKAZAKI MITSUYO
发明人： OKAZAKI MITSUYO
IPC分类号： G01N30/86 , G01N30/88 , G01N33/92
CPC分类号： G01N30/8675 , G01N30/8679 , G01N33/92 , G01N2030/8813 , G01N2030/8831
摘要： A method of analysis of lipoproteins according to the present invention comprises the steps of: separating a plurality of classes of lipoproteins contained in a subject sample by liquid chromatography and then detecting signals derived from components included in the separated lipoproteins; and assuming that the lipoproteins are constituted of subclasses estimated from component peaks comprising anchor peaks and extra essential peaks and then calculating an approximated curve corresponding to summation of the component peaks using the above described detected signals.

45. 发明公开

EP1760464A4 MULTI-COMPONENT MEDICINE EVALUATION METHOD 有权转让
标题翻译：评估程序FOR ONE几个组件对现有的医疗
公开(公告)号：EP1760464A4
公开(公告)日：2009-07-29
申请号：EP05751196
申请日：2005-06-06
申请人： TSUMURA & CO
发明人： YANO KOUYA , HATTORI NAOKO
IPC分类号： G01N30/86 , G01N30/74 , G01N30/88
CPC分类号： G01N30/8675 , G01N30/8686 , G01N2030/8809 , G01N2030/8813

46. 发明公开

EP2053401A1 A method for measuring the biological diversity of a sample 审中-公开
标题翻译： Verfahren zur Messung der biologischenDiversitäteiner Probe
公开(公告)号：EP2053401A1
公开(公告)日：2009-04-29
申请号：EP07301485.4
申请日：2007-10-23
申请人： I.N.R.A. Institut National de la Recherche Agronomique
发明人： Loisel, Patrice , Hamelin, Jérôme , Godon, Jean-Jacques , Haegeman, Bart , Harmand, Jérôme
IPC分类号： G01N33/569 , G01N30/86
CPC分类号： G01N33/569 , G01N30/8675
摘要： This invention concerns a computer-implemented method for estimating diversity in a sample, which can apply to any sample, and in particular to a sample whom species distribution is unknown.
The method of the invention comprises steps essentially involving two components, (a) a migration of a sample comprising molecules on a surface area, whereby molecules migrate on a surface area according to their nucleotide or aminoacid sequence and (b) method steps for the diversity measurement, which are preferably performed through the working of one or several computer program(s).
摘要翻译：本发明涉及用于估计样本中的多样性的计算机实现的方法，该方法可应用于任何样本，特别是涉及物种分布未知的样本。本发明的方法包括基本上包括两个组分的步骤：（a）在表面积上包含分子的样品的迁移，其中分子根据其核苷酸或氨基酸序列在表面积上迁移，和（b）多样性的方法步骤测量，其优选地通过一个或多个计算机程序的操作来执行。

47. 发明公开

EP2045332A1 Proteome-wide quantification of small molecule binding to cellular target proteins 有权
标题翻译：蛋白质组学定量分析仪（Zelelproteine gebundener）Moleküle
公开(公告)号：EP2045332A1
公开(公告)日：2009-04-08
申请号：EP07117996.4
申请日：2007-10-05
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Daub, Henrik , Bairlein, Michaela , Sharma, Kirti , Godl, Klaus , Tebbe, Andreas , weber, Christoph
IPC分类号： C12Q1/48 , G01N33/543 , G01N33/68
CPC分类号： G01N33/54306 , C12Q1/485 , G01N30/6043 , G01N30/7233 , G01N30/8675 , G01N33/6851
摘要： This invention relates to methods for the evaluation and/or quantification of the binding affinity of small molecules or other compounds to target components contained within an analyte, such as target proteins contained within the proteome of a cell or tissue.
摘要翻译：本发明涉及用于评估和/或定量小分子或其它化合物对分析物中包含的靶组分（例如包含在细胞或组织的蛋白质组中的靶蛋白）的结合亲和力的方法。

48. 发明授权

EP1943511B1 PROCEDE DE DETERMINATION DE LA TENEUR EN GAZOLE DANS UNE HUILE LUBRIFIANTE DE MOTEUR A COMBUSTION 有权
标题翻译： PROCEDURE用于确定柴油油的含量用于内燃机
公开(公告)号：EP1943511B1
公开(公告)日：2009-03-18
申请号：EP06831303.0
申请日：2006-10-26
申请人： RENAULT S.A.S.
发明人： FITAMEN, Eric , TIQUET, Laurent
IPC分类号： G01N33/28 , G01N30/02 , G01N30/86 , C10M175/02 , C10M101/02
CPC分类号： G01N30/8675 , C10M177/00 , G01N30/02 , G01N30/8631 , G01N33/2835 , G01N2030/025 , Y10T436/21 , Y10T436/214

49. 发明公开

EP1995593A1 CHROMATOGRAPH MASS SPECTROSCOPE 失效
标题翻译：色谱 - MASSENSPEKTROMETER
公开(公告)号：EP1995593A1
公开(公告)日：2008-11-26
申请号：EP06715341.1
申请日：2006-03-07
申请人： Shimadzu Corporation
发明人： SUMIYOSHI, Takashi
IPC分类号： G01N30/72 , G01N27/62
CPC分类号： G01N27/62 , G01N30/7233 , G01N30/8651 , G01N30/8658 , G01N30/8675 , G01N30/8696
摘要： In a chromatograph mass spectrometer capable of defining an appropriate measurement time range and selectively performing a scan measurement, selected ion monitoring (SIM) measurement or simultaneous scan/SIM measurement in that time range, a total ion chromatogram 51 obtained by a scan measurement of a standard sample and a previously-created compound table 52 are displayed on the screen of a display unit in the process of setting parameters in a measurement condition table. An operator selects a compound that should undergo the simultaneous scan/SIM measurement, then places a checkmark in an appropriate check box in the compound table 52, and finally clicks the "Auto-Create" button 54. Then, a measurement time range for the selected compound is defined by adding a time span before and after the retention time of that compound, respectively, and a measurement condition table 53 is automatically created and displayed on the screen. This table includes instructions for performing a simultaneous scan/SIM measurement at specific mass-to-charge ratios characteristic of the selected compound during the aforementioned measurement time range.
摘要翻译：在能够定义适当的测量时间范围并选择性地进行扫描测量，在该时间范围内选择离子监测（SIM）测量或同时扫描/ SIM测量）的色谱质谱仪中，通过扫描测量获得的总离子色谱图51 在测量条件表中设置参数的过程中，在显示单元的屏幕上显示标准样品和先前创建的复合表52。操作员选择应进行同步扫描/ SIM测量的化合物，然后在复合表52中的相应复选框中设置复选标记，最后点击“自动创建”按钮54.然后，测量时间范围为通过分别在该化合物的保留时间之前和之后添加时间跨度来定义所选择的化合物，并且自动创建测量条件表53并显示在屏幕上。该表包括在上述测量时间范围内执行所选化合物的特定质荷比特性的同时扫描/ SIM测量的说明。

50. 发明公开

EP1946087A2 METHOD AND SYSTEM FOR CHEMICAL AND PHYSICAL CHARACTERIZATION OF COMPLEX SAMPLES 审中-实审
标题翻译：方法和系统的化学和复杂样品的物理特性
公开(公告)号：EP1946087A2
公开(公告)日：2008-07-23
申请号：EP06817122.2
申请日：2006-10-18
申请人： Separation Systems Inc.
发明人： LUBKOWITZ, Joaquin A. , MENDEZ, Aaron , MENEGHINI, Robert I.
IPC分类号： G01N23/00
CPC分类号： G01N30/8675 , G01N30/68 , G01N30/7206 , G01N30/8682 , G01N30/8686 , G01N33/28 , G01N2030/8854
摘要： A method and system for rapid determination of a composition, such as crude oils and fractions thereof, and s obtaining the information necessary to assess the yield of commercially valuable fuel and lube oil fractions in a single process, variations of the method and system use Gas Chromatography - FID/Mass Spectrometry and other features, including an auto sampler, a wall coated capillary column, a temperature programmable injector, and a data processing system for compiling and processing the experimental data. The system and method further include a computer system with application software or other processing mechanism and optionally a communication network. One variation provides a graphical user interface for the entry of data and for displaying information, such as in a graphical manner, to show the relationship of various determined outputs and results.

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