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41. 发明公开

EP1645299A1 Improved geometry and metallic material for controlled recoil stent 审中-公开
标题翻译： Verbesserte几何和金属材料材料fen einen支架KontrolliertemRückschlag
公开(公告)号：EP1645299A1
公开(公告)日：2006-04-12
申请号：EP05256005.9
申请日：2005-09-27
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Dave, Vipul , Grishaber, Randy-David Burce
IPC分类号： A61L31/14 , A61L31/02 , A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2230/0013 , A61L31/022 , A61L31/04 , A61L31/042 , A61L31/043 , A61L31/14
摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. The biocompatible material may comprise metallic and non-metallic materials. These materials maybe designed with a microstructure that facilitates or enables the design of devices with a wide range of geometries adaptable to various loading conditions.
An embodiment is described in which an intraluminal scaffold comprises at least one load bearing element which has a luminal surface and an abluminal surface. The load bearing element has a predetermined wall thickness. The wall thickness is defined by the radial distance between the luminal surface and the abluminal surface, and a predetermined feature width. An area bounded by the wall thickness and the feature width comprises three zones, a first zone undergoing a change in compressive and/or tensile stress due to an external load, a second zone undergoing a change in tensile and/or compressive stress due to the external load and a neutral zone between the first and second zones. The feature width is the linear distance across the first, neutral and second zones in a direction substantially orthogonal to the wall thickness. The load bearing element is fabricated from a metallic material processed to have a microstructure with a granularity of about 32 microns or less and at least one internal grain boundary within the bounded area.
摘要翻译：生物相容性材料可以被配置成任何数量的可植入医疗装置，包括腔内支架。生物相容性材料可以包括金属和非金属材料。这些材料可以设计成具有微结构，其有助于或使得能够适应各种负载条件的宽范围几何形状的器件的设计。描述了一种实施方案，其中管腔内支架包括至少一个承载元件，其具有腔表面和腔内表面。承载元件具有预定的壁厚。壁厚由腔表面和外侧表面之间的径向距离和预定特征宽度限定。由壁厚和特征宽度界定的区域包括三个区域，由于外部负载而经历压缩和/或拉伸应力变化的第一区域，由于第二区域受到拉伸和/或压缩应力的改变，第二区域由于外部负载和第一和第二区域之间的中性区域。特征宽度是在与壁厚基本正交的方向上跨越第一，中性和第二区域的线性距离。承载元件由加工成具有约32微米或更小的颗粒度的微结构和在有界区域内的至少一个内部晶界的金属材料制成。

42. 发明公开

EP1604691A3 Biocompatible alloy for implantable medical devices 无效
标题翻译：植入式医疗用品生物相容性合金
公开(公告)号：EP1604691A3
公开(公告)日：2006-01-11
申请号：EP05253049.0
申请日：2005-05-18
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Grishaber, Randy-David Burce
IPC分类号： A61L27/04 , A61L31/02
CPC分类号： A61L27/047 , A61L31/022
摘要： A biocompatible solid-solution alloy may be formed into any number of implantable medical devices. The solid-solution alloy comprises a combination of elements in specific ratios that make it magnetic resonance imaging compatible while retaining the characteristics required for implantable medical devices. The biocompatible solid-solution alloy is a Cobalt-Chromium alloy having substantially reduced Iron, Silicon, Phosphorous and Sulfur content.
There is described an implantable medical device being formed from a solid-solution alloy comprising Chromium in the range from about 10 weight percent to about 30 weight percent, Tungsten in the range from about 5 weight percent to about 20 weight percent, Nickel in the range from about 5 weight percent to about 20 weight percent, Manganese in the range from about 0 weight percent to about 5 weight percent, Carbon in the range from about 0 weight percent to about 1 weight percent, Iron in an amount not to exceed 0.12 weight percent, Silicon in an amount not to exceed 0.12 weight percent, Phosphorus in an amount not to exceed 0.04 weight percent, Sulfur in an amount not to exceed 0.03 weight percent and the remainder Cobalt.

43. 发明公开

EP1525897A2 Steerable balloon catheter 有权转让
标题翻译： Steuerbarer Ballonkatheter
公开(公告)号：EP1525897A2
公开(公告)日：2005-04-27
申请号：EP04256537.4
申请日：2004-10-22
申请人： Cordis Corporation
发明人： Burgermeister, Robert
IPC分类号： A61M25/10
CPC分类号： A61M25/0152 , A61M25/0138 , A61M25/0147 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M2025/0042 , A61M2025/09008 , A61M2025/09083 , A61M2025/09133 , A61M2025/1075 , A61M2025/1093
摘要： A steerable balloon catheter including a balloon catheter supported by a steerable guidewire having a deflectable distal tip. The guidewire comprises a longitudinal hypotube and a spring coil attached to the distal end of the hypotube and includes a longitudinally movable deflection member which is attached to the distal end of the spring coil and a tip retaining member which extends from the distal end of the hypotube to the distal end of the spring coil for providing very precise deflection of the distal tip of the balloon catheter.
摘要翻译：一种可导向的球囊导管，其包括由可转向的导丝支撑的球囊导管，其具有可偏转的远端。导丝包括纵向海波管和附接到海波管的远端的弹簧线圈，并且包括连接到弹簧线圈的远端的纵向运动的偏转构件和从海波管的远端延伸的尖端保持构件到达弹簧线圈的远端，用于提供球囊导管的远端尖端的非常精确的偏转。

44. 发明公开

EP1512381A2 Side branch stent with split proximal end 审中-公开
标题翻译：支架近端紧固件Enenfüreinen Seitenast
公开(公告)号：EP1512381A2
公开(公告)日：2005-03-09
申请号：EP04255234.9
申请日：2004-08-28
申请人： Cordis Corporation
发明人： Fischell, Tim A. , Fischell, David R. , Burgermeister, Robert , Grishaber, Randy-David Burce
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/848 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2002/821 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2250/006
摘要： Two stents for implantation into a vessel of a human body are described. The first stent is in the form of a longitudinal axis, a proximal end and a distal end. The stent has a distal section comprising a plurality of circumferential sets (12) of strut members. Each set of strut members is longitudinally separated each from the other and each set of strut members forms a cylindrical portion of the stent. The stent also has a proximal section comprising at least three spokes (15). Each spoke is connected to the proximal-most circumferential set (18) of strut members of the distal section of the stent.
The second stent also has a longitudinal axis, a proximal end and a distal end. The stent has a cylindrical distal section and a split proximal section designed to be flared outward with respect to the cylindrical distal section.
摘要翻译：描述了用于植入人体血管的两个支架。第一个支架是纵轴，近端和远端的形式。该支架具有包括支柱构件的多个周向组（12）的远端部分。每组支柱构件彼此纵向分离，并且每组支柱构件形成支架的圆柱形部分。支架还具有包括至少三个辐条（15）的近端部分。每个辐条连接到支架的远端部分的支柱构件的最近端圆周组件（18）。第二支架还具有纵轴，近端和远端。支架具有圆柱形远端部分和设计成相对于圆柱形远端部分向外扩张的分离近侧部分。

45. 发明公开

EP1236445A3 Flexible stent 无效
标题翻译：灵活的支架
公开(公告)号：EP1236445A3
公开(公告)日：2002-11-27
申请号：EP02251396.4
申请日：2002-02-28
申请人： Cordis Corporation
发明人： Burgermeister, Robert
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/3008 , A61F2002/30112 , A61F2002/30324 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/91583 , A61F2230/0004 , A61F2230/0054 , A61F2250/0036 , A61F2250/0098
摘要： A preferred embodiment of a stent provides a folded strut section that provides both structural rigidity and reduction in foreshortening of the stent mechanism. A flexible section provides flexibility for delivery of the stent mechanism. In a second embodiment, flexible section columns are angled with respect to each other, and to the longitudinal axis of the stent. These relatively flexible sections are oppositely phased in order to negate any torsion along their length. In yet another embodiment, the flexible connector can take on an undulating shape (like an "N"), but such that the longitudinal axis of the connector is not parallel with the longitudinal axis of the stent. Finally, a new method is disclosed for making stents. The method consists of performing a standard photochemical machining process of cutting, cleaning and coating the tube with a photoresist. However, unlike former methods, the photoresist image is developed on the surface of the cylindrical metallic tube, which results in a controlled variable etching rate at selected sites on the cylindrical metallic tube during the etching process. Further embodiments provide living hinge connectors and connections along the length of the radial strut member.

46. 发明公开

EP2269572A1 Polymeric compositions comprising crystalline therapeutic agents and their preparations 审中-公开
标题翻译：聚合物组合物具有治疗剂成结晶相，及其生产方法
公开(公告)号：EP2269572A1
公开(公告)日：2011-01-05
申请号：EP10174437.3
申请日：2006-12-27
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Dave, Vipul
IPC分类号： A61K9/00 , A61K47/48 , A61K31/196 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/454 , A61K31/4745 , A61K31/485 , A61K31/565 , A61K31/65 , A61L27/54 , A61L31/16 , A61L33/00 , A61F2/84 , A61K9/50
CPC分类号： A61K31/65 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/427 , A61K31/436 , A61K31/454 , A61K31/4745 , A61K31/485 , A61K31/565 , A61K47/6957 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61L2300/63 , Y10S977/904 , Y10S977/906 , C08L67/04
摘要： A method for forming a drug-containing polymeric composition comprises forming crystalline particles of at least one therapeutic agent. The crystalline particles are encapsulated into at least one biocompatible polymer to form a drug-containing polymeric composition. At least a portion of the crystalline particles remain crystalline in the drug-containing polymeric composition.
摘要翻译：一种用于形成含有药物的组合物的聚合方法包括形成至少一种治疗剂的结晶颗粒。的结晶颗粒被包封在至少一种生物相容的聚合物，以形成含有药物的聚合物组合物。至少所述结晶颗粒的一部分保持在含有药物的组合物的聚合物的结晶。

47. 发明授权

EP1374802B1 Stent with diagonal flexible connecting links 有权转让
标题翻译：支架与灵活，斜连接件
公开(公告)号：EP1374802B1
公开(公告)日：2010-10-06
申请号：EP03254113.8
申请日：2003-06-27
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Majercak, David C. , Fischell, David R. , Hojeibane, Hikmat , Fischell, Robert E.
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013

48. 发明公开

EP1803475A3 Method to develop an organised microstructure within an implantable medical device 审中-公开
标题翻译：一种用于可植入医疗装置内的显影有组织显微方法
公开(公告)号：EP1803475A3
公开(公告)日：2009-07-08
申请号：EP06256583.3
申请日：2006-12-27
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Grishaber, Randy-David Bruce , Park, Jin S.
IPC分类号： A61L27/50
CPC分类号： A61L27/50 , A61L2400/18
摘要： A method to facilitate the ability to engineer an organized microstructure within a monolithically homogeneous implantable biomaterial, particularly metallic alloys, is provided. By starting with an ultra-fine grained, equiaxed microstructure having an averaged linear grain size of less than 5 µm (5 microns), a functionally graded microstructure is developed by establishing a temperature gradient across the cross sectional dimension. In the case of a tubular product form, this dimension would be framed by the outer and inner surfaces. By ensuring one surface is held at a substantially lower temperature than the other surface a temperature gradient is developed. The present invention also provides an implantable medical device which includes an organized microstructure. In accordance with the present invention, the organized microstructure includes a first surface region having said ultra-fine grained, equiaxed microstructure and a second surface region comprising a recrystallized, coarser grained microstructure having an average linear grain size of greater than 25 µm (25 microns), wherein the first and second surface regions are separated by a transition region.

49. 发明公开

EP1859825A3 Polymeric stent having modified molecular structures in selected regions of the flexible connectors 审中-公开
标题翻译：聚合物支架具有改变的分子结构中的柔性连接件选定区域
公开(公告)号：EP1859825A3
公开(公告)日：2008-07-23
申请号：EP07252158.6
申请日：2007-05-25
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Contiliano, Joseph H. , Dave, Vipul , Li, Yufu , Narayanan, Pallanssana V. , Overaker, David W. , Zhang, Qiang
IPC分类号： A61L31/14 , A61F2/90
CPC分类号： A61L31/148 , A61B2017/00871 , A61F2/91 , A61F2/915 , A61F2/94 , A61F2002/91533 , A61F2002/91541 , A61F2210/0004 , A61F2210/0014 , A61F2230/0013 , A61F2250/0018 , A61F2250/0028 , A61L29/085 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/222 , A61L2300/236 , A61L2300/41 , A61L2300/416 , A61L2300/42
摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics.

50. 发明公开

EP1892008A2 A medical delivery system for delivery of a medically useful payload 有权转让
标题翻译： Medizinisches Verabreichungssystem zur Verabreichung einer medizinischen Nutzlast
公开(公告)号：EP1892008A2
公开(公告)日：2008-02-27
申请号：EP07252634.6
申请日：2007-06-28
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Krever, Matthew , Marrey, Ramesh V. , Olsen, Daniel
IPC分类号： A61M25/00 , A61M25/01
CPC分类号： A61M25/0043 , A61B1/0051 , A61B1/0056 , A61B17/22 , A61B2017/003 , A61F2/95 , A61M25/005 , A61M25/0051 , A61M25/0053 , A61M25/0054 , A61M25/0068 , A61M25/008 , A61M25/0102 , A61M25/0105 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0158 , A61M2025/0059
摘要： A device for carrying a medically useful payload positioned upon the device to a location of interest in a conduit of a patient. The device comprises an intralumenal element sized and dimensioned to travel to a location of interest in a conduit of a patient and a flexible element positioned at a distal end of the intralumenal element wherein the flexible element exhibits the capability to bend substantially unidirectionally. The flexible element, when encountering a non-linear path bends in the permitted direction in conformance to the non-linear path. In particular, embodiments concern a delivery system for delivering a medically useful payload through the vasculature to a site of interest in the patient's body. The medically useful payload may be a therapeutic device, such as a stent, and it may be a diagnostic tool, such as an imaging device. Owing to its structural attributes, the presently-inventive delivery system is well suited for carrying medical payload to and through vessel curvature and to branched regions (i.e., bifurcations) in same. Also, the device is well-suited to traveling through a vessel over a guiding element, such as a guidewire, which itself exhibits curvature.
摘要翻译：一种用于将位于所述装置上的医疗有用的有效载体携带到患者的导管中的感兴趣位置的装置。该装置包括体腔内元件，其尺寸和尺寸适于行进到患者的导管中的感兴趣位置，以及定位在腔内元件的远端的柔性元件，其中柔性元件具有基本上单向弯曲的能力。当遇到非线性路径时，柔性元件在允许的方向上弯曲，以符合非线性路径。特别地，实施例涉及用于将通过脉管系统递送医学上有用的有效载荷递送到患者体内感兴趣的部位的递送系统。医学上有用的有效载荷可以是诸如支架的治疗装置，并且其可以是诸如成像装置的诊断工具。由于其结构属性，本发明的递送系统非常适合于将医疗有效负载运送到血管曲率并通过血管曲率和分支区域（即分叉）。此外，该装置非常适合于穿过诸如导丝之类的引导元件（其本身呈曲率的）的容器。

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