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1. 发明授权

EP1810665B1 Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same 有权
标题翻译：聚合物组合物具有治疗剂成结晶相，及其生产方法
公开(公告)号：EP1810665B1
公开(公告)日：2015-03-04
申请号：EP06256581.7
申请日：2006-12-27
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Dave, Vipul
IPC分类号： A61K9/00 , A61K47/48 , A61K31/196 , A61K31/337 , A61K31/427 , A61K31/454 , A61K31/4745 , A61K31/485 , A61K31/565 , A61K31/65 , A61L27/54 , A61L31/16 , A61L33/00 , A61K9/50
CPC分类号： A61K31/65 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/427 , A61K31/436 , A61K31/454 , A61K31/4745 , A61K31/485 , A61K31/565 , A61K47/6957 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61L2300/63 , Y10S977/904 , Y10S977/906 , C08L67/04

2. 发明授权

EP1941848B1 Intraluminal medical device having varialble axial flexibility about the circumference of the device 有权转让
标题翻译：具有围绕装置的外周的可变轴向运动管腔内医疗装置
公开(公告)号：EP1941848B1
公开(公告)日：2010-07-28
申请号：EP08250014.1
申请日：2008-01-03
申请人： Cordis Corporation
发明人： Marrey, Ramesh V , Krever, Matthew , Olsen, Daniel , Burgermeister, Robert
IPC分类号： A61F2/90
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91558 , A61F2250/0018 , A61F2250/0029

3. 发明公开

EP1895288A3 Systems and methods for fatigue testing stents 有权
标题翻译：测试支架疲劳的系统和方法
公开(公告)号：EP1895288A3
公开(公告)日：2009-07-08
申请号：EP07253062.9
申请日：2007-08-03
申请人： Cordis Corporation
发明人： Black, Erin , Burgermeister, Robert , Grishaber, Randy-David Bruce , Overaker, David W.
IPC分类号： G01N3/32 , A61F2/24 , G01N3/12
CPC分类号： G01N3/32 , A61F2/82 , G01N2203/0005 , G01N2203/0073 , G01N2203/0266
摘要： Systems and methods for fatigue testing one or more stents based on measured electrical resistance levels of each stent. Pairs of lead lines from an ohmmeter are connected to a respective stent. The respective stent is mounted onto an expander having an interior tapered portion into which a correspondingly tapered expansion pin is received. Cyclic loading strains are applied to the respective stent as an expansion pin is inserted into a corresponding one of the expanders. Stent fracture or failure occurs when cyclic loading exceeds the stents architectural and material capacity. Such fracture fatigue or failure is identified by increased electrical resistance levels. Resistance may be continuously monitored to more readily identify the onset of fatigue or failure. The expansion pins extend from a movable plate, and the expanders comprise a part of corresponding stations that extend from a fixed plate.

4. 发明公开

EP1797914A3 Polymeric stent having modified molecular structures in the flexible connectors and in the radial struts and the radial arcs of the hoops 审中-公开
标题翻译：聚合物支架与所述柔性连接件改变的分子结构和所述轮胎的径向支撑和径向弧
公开(公告)号：EP1797914A3
公开(公告)日：2007-11-07
申请号：EP06256291.3
申请日：2006-12-09
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Narayanan, Pallassana V , Dave, Vipul , Overaker, David W.
IPC分类号： A61L31/04 , A61L31/14 , A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2210/0004 , A61F2230/0013 , A61F2250/0018 , A61F2250/0028 , A61L31/04 , A61L31/14
摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics.
In one embodiment a substantially tubular intraluminal medical device has a longitudinal axis and a radial axis. The device comprises: a plurality of hoops formed from a polymeric material, the plurality of hoops comprising a plurality of radial struts and a plurality of radial arcs, the plurality of radial struts having a first amount of alignment of the polymer chains comprising the polymeric material in a direction substantially parallel to the longitudinal axis and the plurality of radial arcs having a second amount of alignment of the polymer chains comprising the polymeric material in a direction substantially parallel to the radial axis, the first amount of alignment being substantially equal to the second amount of alignment; and a plurality of bridges formed from a polymeric material interconnecting the plurality of hoops, each of the plurality of bridges comprising a plurality of flexible struts and a plurality of flexible arcs, the plurality of flexible struts having a first amount of alignment of the polymer chains comprising the polymeric material in a direction substantially parallel to the longitudinal axis and the plurality of flexible arcs having a second amount of alignment of the polymer chains comprising the polymeric material in a direction substantially parallel to the radial axis, the first amount of alignment being greater than the second amount of alignment.

5. 发明公开

EP1832251A2 Apparatus for treating a bifurcated region of a conduit and method for placing a medical device at a bifurcated conduit 有权转让
标题翻译： Vorrichtung zur Behandlung eines verzweigten Bereichs einesGefäßes
公开(公告)号：EP1832251A2
公开(公告)日：2007-09-12
申请号：EP07251017.5
申请日：2007-03-12
申请人： Cordis Corporation
发明人： Krever, Matthew , Burgermeister, Robert , Schulting, Edwin , Van Erp, Wilhelms , Dirks, Richard
IPC分类号： A61F2/84
CPC分类号： A61F2/954 , A61F2/856 , A61F2/91 , A61F2/958 , A61F2250/0039 , A61F2250/006
摘要： An apparatus and method for treating a diseased body conduit at a bifurcation point is provided. A system having devices mounted thereon is advanced into the bifurcated region of the conduit. The system includes a delivery means, such as a catheter having a shaft with varying torsional properties along its length and a delivery apparatus mounted at its distal end. A distal end of the delivery means can be inserted into the main branch and at least one side branch of a vessel bifurcation. The distal end includes at least two expansion members having expandable devices or prostheses mounted thereon. One device is configured such that one expansion member extends through the length of the scaffold while the other expansion member extends through the side-structure of the scaffold. A second scaffold is mounted on the expansion member extending through the side-structure of the first scaffold. The devices are positioned within the main and side branches of the bifurcation and are expanded.
摘要翻译：提供了一种在分叉点处理患病体导管的装置和方法。具有安装在其上的装置的系统进入导管的分叉区域。该系统包括输送装置，例如具有沿其长度具有变化的扭转特性的轴的导管和安装在其远端的输送装置。输送装置的远端可以插入主分支和血管分叉的至少一个侧支。远端包括至少两个膨胀构件，其具有安装在其上的可扩张装置或假体。一个装置构造成使得一个膨胀构件延伸穿过支架的长度，而另一个膨胀构件延伸穿过支架的侧面结构。第二支架安装在延伸穿过第一支架的侧面结构的膨胀构件上。设备位于分叉的主分支和侧分支中，并扩展。

6. 发明公开

EP1825870A2 Implantable device formed from polymer and plasticizer blends having modified molecular structures 审中-公开
标题翻译：由具有改性分子结构的聚合物和增塑剂共混物形成的可植入装置
公开(公告)号：EP1825870A2
公开(公告)日：2007-08-29
申请号：EP07250639.7
申请日：2007-02-15
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Dave, Vipul , Narayanan, Pallassana V. , Overaker, David W
IPC分类号： A61L27/50 , A61L27/14 , A61L31/04 , A61L31/14
CPC分类号： A61L31/04 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91575 , A61F2220/0008 , A61F2220/0075 , A61F2230/0013 , A61L31/141 , A61L31/18 , B23K2203/42 , B23K2203/50
摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. The polymeric materials may include additives such as drugs or other bioactive agents as well as radiopaque agents. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics.
In one embodiment, an implantable medical device comprises a frame structure, the frame structure including at least one element having one or more sections being formed from at least one polymer and at least one plasticizer blended to create a deformable frame structure having increased toughness, and wherein at least one of the one or more sections having an amount of alignment of the polymer chains of the blend in a direction of the at least one or more sections greater than an amount of alignment of the polymer chains of the blend in a direction of another of the at least one or more sections.
摘要翻译：生物相容性材料可以被配置成任何数量的可植入医疗装置，包括腔内支架。可以使用聚合物材料来制造这些装置中的任何装置，包括支架。支架可以是气囊可扩张的或自扩张的。聚合物材料可以包括添加剂如药物或其他生物活性剂以及不透射线的试剂。通过聚合物的优先机械变形，聚合物链可以被定向以实现某些期望的性能特征。在一个实施方案中，可植入医疗装置包括框架结构，所述框架结构包括至少一个元件，所述至少一个元件具有由至少一种聚合物和至少一种增塑剂共混形成的具有增加的韧性的可变形框架结构的一个或多个部分，以及其中所述一个或多个部分中的至少一个在所述至少一个或多个部分的方向上具有所述共混物的聚合物链的排列量大于所述共混物的聚合物链在排列方向上的排列量至少一个或多个部分中的另一个。

7. 发明公开

EP1800708A1 Guidewire with distal expansion feature 有权转让
标题翻译：导丝远端扩张特征
公开(公告)号：EP1800708A1
公开(公告)日：2007-06-27
申请号：EP06256411.7
申请日：2006-12-16
申请人： Cordis Corporation
发明人： Inderbitzen, Mark N. , Burgermeister, Robert , Johnson, Kirk L.
IPC分类号： A61M25/09
CPC分类号： A61M25/09 , A61M25/0141 , A61M2025/09008 , A61M2025/09125
摘要： A guidewire navigable through body vessels of a human subject for delivery of a catheter or the like is provided. The guidewire includes an expandable segment movable between a collapsed state and an expanded state. If the catheter encounters resistance in a vessel and cannot be advanced further, the medical professional can move the expandable segment to the expanded state in which the expandable segment engages an inner surface of the catheter. The expandable segment locks onto the catheter, which allows the guidewire and catheter to be advanced through the vessel together as a single unit. An inflatable balloon catheter movable along the guidewire requires only a single tube and is sealed by the expandable segment of the guidewire for subsequent inflation.

8. 发明公开

EP1772121A1 Catheter for treating an intimal dissection after stent implantation 有权转让
标题翻译： Katheter zur Behandlung von intimaler Dissektion nach der Anordnung eines Stents
公开(公告)号：EP1772121A1
公开(公告)日：2007-04-11
申请号：EP06255131.2
申请日：2006-10-04
申请人： Cordis Corporation
发明人： Fischell, David R. , Burgermeister, Robert
IPC分类号： A61F2/84 , A61M25/01
CPC分类号： A61F2/958 , A61F2/95 , A61F2002/9528 , A61M2025/0183
摘要： A rescue catheter (60) is designed for placement over a fixed guide wire stent delivery catheter after an intimal dissection has been detected following the placement of a stent into an artery of a human body. The rescue catheter (60) comprises a guidewire tube (64) having proximal and distal (63) ends, and a slit snap-on section (62) fixedly attached near the distal end (63) of the guidewire tube (64). The guidewire tube must be sufficiently long so that the distal end of the catheter (60) can reach the desired point in the human vascular system. The slit snap-on section (62) is designed to be snapped onto the shaft of the fixed guide wire stent delivery catheter.
摘要翻译：救生导管（60）设计用于在将支架置于人体的动脉中后检测到内膜解剖之后放置在固定的导丝支架输送导管上。所述救援导管（60）包括具有近端（63）端部的导丝管（64）和固定地附接在所述导丝管（64）的远端（63）附近的切口卡扣部分（62）。导丝管必须足够长，使得导管（60）的远端可以达到人血管系统中的所需点。裂缝卡扣部分62被设计成卡扣在固定导丝支架输送导管的轴上。

9. 发明公开

EP1525897A3 Steerable balloon catheter 有权转让
标题翻译：可控球囊导管
公开(公告)号：EP1525897A3
公开(公告)日：2006-03-01
申请号：EP04256537.4
申请日：2004-10-22
申请人： Cordis Corporation
发明人： Burgermeister, Robert
IPC分类号： A61M25/10 , A61M25/01
CPC分类号： A61M25/0152 , A61M25/0138 , A61M25/0147 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M2025/0042 , A61M2025/09008 , A61M2025/09083 , A61M2025/09133 , A61M2025/1075 , A61M2025/1093
摘要： A steerable balloon catheter including a balloon catheter supported by a steerable guidewire having a deflectable distal tip. The guidewire comprises a longitudinal hypotube and a spring coil attached to the distal end of the hypotube and includes a longitudinally movable deflection member which is attached to the distal end of the spring coil and a tip retaining member which extends from the distal end of the hypotube to the distal end of the spring coil for providing very precise deflection of the distal tip of the balloon catheter.

10. 发明公开

EP1623683A2 Intraluminal stent made of metal with well-defined granularity 审中-公开
标题翻译：腔内支架由具有明确粒度的金属制成
公开(公告)号：EP1623683A2
公开(公告)日：2006-02-08
申请号：EP05254515.9
申请日：2005-07-20
申请人： Cordis Corporation
发明人： Burgermeister, Robert , Grishaber, Randy-David Burce
IPC分类号： A61F2/06
CPC分类号： A61L31/14 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2210/0014 , A61F2230/0013
摘要： An intraluminal stent (100) comprises a plurality of hoop components (102) being formed as a continuous series of substantially circumferentially oriented radial strut members (106) and alternating radial arc members (108). One or more flexible connectors (104) connect adjacent hoop components to form a substantially tubular structure having a luminal surface and an abluminal surface. The single loop components are fabricated from a metallic material processed to have a microstructure, in at least the radial arc members, with a granularity of not more than about 32 µm and comprise from about 2 to about 10 substantially equiaxed grains as measured across the wall thickness.
摘要翻译：管腔内支架（100）包括多个环形部件（102），所述多个环形部件（102）形成为连续的一系列基本上周向定向的径向支柱部件（106）和交替的径向弧形部件（108）。一个或多个柔性连接器（104）连接相邻的箍部件以形成具有腔表面和腔外表面的基本管状结构。所述单回路部件由金属材料制成，所述金属材料在至少径向弧形构件中经过处理以具有微结构，所述金属材料具有不超过约32μm的粒度并且包括从壁上测量的约2至约10个基本上等轴晶粒厚度。

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