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31. 发明公开

EP0888371A1 4,7-DIALKOXY-N-ACETYLNEURAMINIC ACID DERIVATIVES AND METHODS FOR DETECTION OF INFLUENZA TYPE A AND B VIRUSES IN CLINICAL SPECIMENS 失效
标题翻译： 4,7-二烷氧基-N-ACETYLNEURAMINSAUREDERIVATE和用于A型流感临床样品中检测和乙方法
公开(公告)号：EP0888371A1
公开(公告)日：1999-01-07
申请号：EP97940823.0
申请日：1997-09-05
申请人： Oklahoma Medical Research Foundation
发明人： LIAV, Avraham , HANSJERGEN, Joyce Anne , SHIMASAKI, Craig, David
IPC分类号： C12Q1 , C07H7 , C07H15 , C07H17 , G01N33 , C12R1
CPC分类号： C07H7/027 , C12Q1/34 , C12Q2334/50 , G01N33/56983 , G01N2333/924
摘要： Chromogenic and fluorogenic 4,7-dialkoxy-N-acetylneuraminic acid substrates of general formula (I) are provided wherein R1 and R2 are alkyl groups containing 1 to 4 carbon atoms and R3 is a chromogenic or fluorogenic group. These substrates can be used to detect influenza types A and B in clinical samples or specimens. More particularly, these 4,7-dialkoxy-N-acetylneuraminic acid substrates can be used to distinguish between various viruses having neuraminidase reactivity. Thus, influenza type A and B viruses can be distinguished from parainfluenza type 1, 2, 3 and 4, and mumps using the 4,7-dialkoxy-N-acetylneuraminic acid derivatives of this invention. Diagnostic methods employing these substrates are provided to identify influenza type A and B viruses in clinical specimens and to distinguish from other viruses having neuraminidase reactivity.

32. 发明公开

EP0474410A3 Method for production of sialic acid 失效
标题翻译：生产唾液酸的方法
公开(公告)号：EP0474410A3
公开(公告)日：1994-04-20
申请号：EP91307753.3
申请日：1991-08-22
申请人： TAIYO KAGAKU Co., LTD.
发明人： Koketsu, Mamoru , Kawanami, Hiroshi , Juneja, Lekh Raj , Fujiki, Masaru , Hatta, Hajime , Nishimoto, Katsuya , Kim, Mujo , Yamazaki, Nagataka
IPC分类号： C07H13/04 , C07H1/08
CPC分类号： C07H13/04 , C07H7/027
摘要： The present invention is directed to a mehtod for producing crude sialic acid, comprising hydrolysis of a delipidated egg yolk and a method for producing high purity sialic acid, which comprises desalting a solution containing sialic acid obtainable by hydrolyzing a delipidated egg yolk,, adsorbing sialic acid to an anion exchange resin and then eluting said sialic acid. The present invention makes it possible to produce and purify sialic acid from delipidated egg yolk on an industrial scale.
摘要翻译：本发明涉及一种生产粗唾液酸的方法，其包括脱脂蛋黄的水解和生产高纯度唾液酸的方法，该方法包括使含脱水蛋黄水解得到的含唾液酸的溶液脱盐，所述脱脂蛋黄吸附唾液酸酸转化为阴离子交换树脂，然后洗脱所述唾液酸。本发明使得能够以工业规模从脱脂蛋黄中生产和纯化唾液酸。

33. 发明公开

EP0138436A3 Process for producing ketals of 2-Ketogulonic acid or its esters 失效
标题翻译： 2-乙酸或其酯的制造方法
公开(公告)号：EP0138436A3
公开(公告)日：1987-01-28
申请号：EP84306498
申请日：1984-09-24
申请人： Takeda Chemical Industries, Ltd.
发明人： Matsumura, Koichi
IPC分类号： C07H07/027
CPC分类号： C07H9/04 , C07H7/027
摘要： A novel process is disclosed for production of ketals of 2- ketogulonic acid or of its esters, which comprises reacting 2- ketogulonic acid or its esters with a ketone in the presence of a ketal formation catalyst. The process is advantageous from the industrial point of view to give ketals of 2-ketogulonic acid or of its esters.

34. 发明公开

EP0007751A1 Destruction by fermentation of 2-ketogluconate in the presence of 2-ketogulonate 有权
标题翻译：通过在2-酮古洛糖酸的存在下发酵2-酮基葡糖酸的破坏。
公开(公告)号：EP0007751A1
公开(公告)日：1980-02-06
申请号：EP79301384.8
申请日：1979-07-13
申请人： PFIZER INC.
发明人： Kita, Donald Albert , Gagne, John William , Fenton, Dennis Michael
IPC分类号： C07H7/02 , C12P7/60
CPC分类号： C12R1/39 , C07H7/027
摘要： 2-Ketogluconate present in a mixture with 2-ketogulonate is destroyed by fermentation with a strain of Pseudomonas fluorescens leaving desired 2-ketogulonate intact. Subsequent hydrolysis of the 2-ketogulonate yields ascorbic acid. The preferred Pseudomonas strains are NRRL B10 and ATCC 13430.

35. 发明公开

EP2706871A1 NUTRITIONAL PRODUCTS COMPRISING HUMAN MILK OLIGOSACCHARIDES AND METHODS FOR MANUFACTURE THEREOF 有权转让
标题翻译：与寡糖来自人乳的及其制造方法FOOD PRODUCTS
公开(公告)号：EP2706871A1
公开(公告)日：2014-03-19
申请号：EP12719746.5
申请日：2012-05-10
申请人： Nestec S.A.
发明人： BRASSART, Dominique , DEKANY, Gyula , ERDMANN, Peter , SCHWARZ, Andrea , SPRENGER, Norbert
IPC分类号： A23L1/29 , C07H3/06 , C07H15/04
CPC分类号： A23L5/00 , A23L7/00 , A23L29/30 , A23L33/00 , A23L33/125 , A23L33/40 , A23V2002/00 , C07H5/06 , C07H7/027 , C07H15/18 , A23V2250/28
摘要： A method for the manufacture of a mixture of human milk oligosaccharides is disclosed. The method involves the catalytic hydrogenolysis of compounds of the general formula 1 and 2. Nutritional substances including the manufactured HMOs are also disclosed.

36. 发明公开

EP2173759A4 OLIGOSIALIC ACID DERIVATIVES, METHODS OF MANUFACTURE, AND IMMUNOLOGICAL USES 审中-公开
标题翻译： OLIGOSIALINSÄÚREDERIVATE，工艺及其使用和它们的免疫学
公开(公告)号：EP2173759A4
公开(公告)日：2014-01-29
申请号：EP08796099
申请日：2008-07-03
申请人： CHILDRENS HOSP & RES CT OAK
发明人： MOE GREGORY R , HAGEN BRENT T
IPC分类号： C07H5/06 , A61K31/7008 , C07H19/00 , C07K2/00 , C07K9/00 , C07K14/00 , C07K16/00 , C07K16/30 , G01N33/574
CPC分类号： A61K39/0258 , A61K39/0011 , A61K39/095 , A61K2039/55505 , A61K2039/55544 , A61K2039/585 , A61K2039/6037 , C07H1/00 , C07H7/027 , C07H13/04 , C07K16/1217 , C07K16/1282 , C08B37/0006 , G01N33/57484 , G01N2333/22 , G01N2333/245 , G01N2400/02
摘要： The invention relates to methods of producing, and compositions comprising, an isolated alpha (2→8) or (2→9) oligosialic acid derivative bearing a non-reducing end enriched for one or more de-N-acetyl residues and resistant to degradation by exoneuraminidase. A representative production method involves: (i) treating an alpha (2→8) or (2→9) oligosialic acid precursor having a reducing end and a non-reducing end with sodium borohydride under conditions for de-N-acetylating the non-reducing end; and (ii) isolating alpha (2→8) or (2→9) oligosialic acid derivative having one or more de-N-acetylated residues and a non-reducing end that is resistant to degradation by exoneuraminidase. Isolated alpha (2→8) or (2→9) oligosialic acid derivatives that comprise a non-reducing end de-N-acetyl residue are provided, as well as antibodies specific for the derivatives, compositions comprising the derivatives, kits, and methods of use including protection against and detection of E. coli K1 and N. meningitidis bacterial infection, and in diagnosing and treating cancer.

37. 发明公开

EP2481746A1 Process for producing sugar chain asparagine derivative 审中-公开
标题翻译： Verfahren zur Herstellung von eines Zuckerketten-Asparaginderivats
公开(公告)号：EP2481746A1
公开(公告)日：2012-08-01
申请号：EP12162076.9
申请日：2002-06-19
申请人： Otsuka Chemical Co., Ltd. , Kajihara, Yasuhiro
发明人： Kajihara, Yasuhiro , Sasaki, Ken
IPC分类号： C07H13/10 , C07H15/12 , C07H5/06 , C07H7/027 , C12P13/04 , C12P19/04
CPC分类号： C07H13/10 , C07H5/06 , C07H7/027 , C07H15/12 , C12P13/04 , C12P19/04 , C12P19/28 , Y02P20/55
摘要： The present invention provides a process for preparing a sugar chain asparagine derivative. According to the process, various isolated sugar chain asparagine derivatives useful in the field of the development of pharmaceutical and the like can be conveniently obtained in a large amount as compared to that of the prior art. The present invention also provides a process for preparing a sugar chain asparagine and a process for preparing a sugar chain via a step for preparing a sugar chain asparagine derivative. The present invention further provides a novel sugar chain asparagine derivative, a sugar chain asparagine and a sugar chain.
摘要翻译：本发明提供了制备糖链天冬酰胺衍生物的方法。根据该方法，与现有技术相比，可以容易地获得用于药物开发领域的各种分离的糖链天冬酰胺衍生物。本发明还提供了制备糖链天冬酰胺的方法和通过制备糖链天冬酰胺衍生物的步骤制备糖链的方法。本发明还提供了一种新型糖链天冬酰胺衍生物，糖链天冬酰胺和糖链。

38. 发明授权

EP2013624B1 METHOD FOR THE IDENTIFICATION OF NEW LEADS FOR DRUG CANDIDATES 有权
标题翻译：方法确定新的候选药物先导化合物
公开(公告)号：EP2013624B1
公开(公告)日：2011-08-03
申请号：EP07733988.5
申请日：2007-03-14
申请人： Universität Basel
发明人： ERNST, Beat , CUTTING, Brian , SHELKE, Sachin V.
IPC分类号： G01N33/68 , C07H7/027 , C07H15/04 , G01R33/465
CPC分类号： G01N33/6845 , C07H7/027 , C07H15/04 , G01N24/088 , G01N2500/00 , G01R33/465
摘要： Disclosed is a method for producing new leads for drug candidates. The method employs a combinatorial approach for identifying high affinity ligands. The target may be unknown and/or may include one or more unknown binding sites. A method involving a combined screening and synthesis method for bi-site inhibitors is disclosed comprising: 1) determining if there is sufficient proximity between ligands binding to different sites of a target: e.g. by using spin-labelled ligands quenching can be measured with NMR if a first ligand and second allosteric ligand are in proximity 2) connecting both ligands having linkers, via in situ synthesis in the presence of the protein scaffold (e.g. target guided synthesis combined with fragment based self assembly). Click chemistry is a preferred embodiment here. Also disclosed are kits used in context of this method, leads discovered by the method and their use in drug development. Leads for drugs acting on myelin associated glycoprotein (MAG) have been identified and synthesised.

39. 发明授权

EP2084172B1 NEUE MIT BENZYLRESTEN SUBSTITUIERTE 1,4-BENZOTHIEPIN-1,1-DIOXIDDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG 有权
标题翻译： NEW用苄基取代的1,4-苯并硫-1,1-二氧化物的衍生物，用于生产药物含有它们及其用途
公开(公告)号：EP2084172B1
公开(公告)日：2010-12-22
申请号：EP07819434.7
申请日：2007-10-30
申请人： Sanofi-Aventis Deutschland GmbH
发明人： FRICK, Wendelin , GLOMBIK, Heiner , THEIS, Stefan , HEUER, Hubert , SCHAEFER, Hans-Ludwig , KRAMER, Werner
IPC分类号： C07H5/06 , A61K31/7028
CPC分类号： C07H5/06 , A61K31/38 , A61K31/7028 , A61K45/06 , C07D409/12 , C07H5/04 , C07H7/02 , C07H7/027 , C07H13/12 , C07H15/26 , A61K2300/00
摘要： The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. These compounds are suitable, for example, as hypolipidemics.

40. 发明公开

EP2119444A1 THERAPEUTIC AGENT FOR PAIN DISEASE 有权
标题翻译：治疗MITTEL GEGEN SCHMERZEN
公开(公告)号：EP2119444A1
公开(公告)日：2009-11-18
申请号：EP08704491.3
申请日：2008-02-06
申请人： Nippon Zoki Pharmaceutical Co., Ltd.
发明人： NAKAZAWA, Yoshitaka
IPC分类号： A61K31/7012 , A61P25/04 , C07H7/027
CPC分类号： A61K31/7012 , C07H7/027
摘要： Disclosed is an analgesic agent for a non-inflammatory pain disease, which comprises a sialic acid or a pharmaceutically acceptable salt thereof as an active ingredient. The sialic acid which is an active ingredient for the agent has an analgesic effect on a disease model animal of neurogenic pain which is an non-inflammatory pain. Therefore, the analgesic agent is useful as a pharmaceutical agent for the treatment of an non-inflammatory pain disease such as an neurogenic pain disease, e.g., trigeminal neuralgia, postherpetic neuralgia, entrapment neuropathy, complex regional pain syndrome, diabetic neuropathy, traumatic neuropathy, phantom limb pain, central pain after spinal cord injury or stroke, and neuropathy caused by pharmacotherapy or radiation therapy, or the like.
摘要翻译：公开了一种非炎症性疼痛疾病的止痛剂，其包含唾液酸或其药学上可接受的盐作为活性成分。作为药剂的活性成分的唾液酸对作为非炎症性疼痛的神经性疼痛的疾病模型动物具有镇痛作用。因此，止痛剂可用作治疗非炎症性疼痛疾病如神经性疼痛疾病，例如三叉神经痛，带状疱疹后神经痛，包埋神经病，复杂区域性疼痛综合征，糖尿病性神经病，外伤性神经病变，幻肢疼痛，脊髓损伤或中风后的中枢疼痛，以及由药物治疗或放射治疗引起的神经病变等。

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