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31. 发明授权

EP2072070B1 SUBSTRATE AND METHOD FOR PRODUCTION THEREOF 有权
标题翻译：衬底及其制造方法
公开(公告)号：EP2072070B1
公开(公告)日：2016-11-09
申请号：EP07807191.7
申请日：2007-09-13
申请人： Toray Industries, Inc.
发明人： SAKAGUCHI, Hirokazu , TAKAHASHI, Hiroshi , UENO, Yoshiyuki , SUGAYA, Hiroyuki
IPC分类号： A61L33/10 , A61L31/00 , A61L33/00 , A61M1/18
CPC分类号： A61K47/34 , A61K31/40 , A61L31/16 , A61L33/0011 , A61L2300/42 , A61M1/3672 , A61M1/3673

32. 发明公开

EP2957306A1 BLOOD PURIFICATION COLUMN 有权
标题翻译： BLUTREINIGUNGSKOLONNE
公开(公告)号：EP2957306A1
公开(公告)日：2015-12-23
申请号：EP14751732.0
申请日：2014-02-07
申请人： Toray Industries, Inc.
发明人： FUJIEDA, Hiroaki , UENO, Yoshiyuki , TANAKA, Kazumi
IPC分类号： A61M1/36
CPC分类号： A61M1/3679 , A61M1/1006 , A61M1/14 , A61M1/36 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3652 , A61M1/3672 , A61M2205/75 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/28 , B01J20/28019 , B01J20/28023 , B01J20/2805
摘要： The present invention relates to a filter built into a blood purification column, and aims to dramatically improve the removal of air that gets into the column and to prevent blood activation due to air remaining inside of the column and decreased adsorption performance due to decreased contact surface between blood and an adsorbent. This blood purification column has an adsorbent and a casing, both ends of which are open ends, and the adsorbent is housed inside of the casing. Of the two ends of the casing, one is the blood inflow end and the other is the blood outflow end. A filter is arranged on the blood inflow end and/or the blood outflow end of the casing, and this filter fulfils the following conditions. (1) The opening ratio of the filter is 5-80% (2) The equivalent diameter of the openings in the filter is 1-5000µm (3) The ratio of the equivalent diameter of the openings to the average circle equivalent diameter of the gaps in the absorbent is 45% or greater.
摘要翻译：本发明涉及内置于血液净化塔中的过滤器，其目的在于显着改善进入柱内的空气的去除并防止由于残留在塔内部的空气引起的血液活化，并且由于接触表面减小而降低了吸附性能血液和吸附剂之间。该血液净化柱具有吸附剂和壳体，其两端为开口端，吸附剂容纳在壳体的内部。在套管的两端，一个是血液流入端，另一个是血液流出端。过滤器布置在壳体的血液流入端和/或血液流出端上，并且该过滤器满足以下条件。（1）过滤器的开口率为5-80％（2）过滤器开口的当量直径为1-5000μm（3）开口当量直径与平均圆当量直径的比值吸收剂中的间隙为45％以上。

33. 发明公开

EP2832386A1 POLYSULFONE-BASED HOLLOW FIBER MEMBRANE AND HOLLOW FIBER MEMBRANE MODULE FOR PURIFYING BLOOD PREPARATION 审中-公开
标题翻译：中空纤维膜聚砜中空纤维膜组件用于清洁血液制剂
公开(公告)号：EP2832386A1
公开(公告)日：2015-02-04
申请号：EP13768390.0
申请日：2013-03-28
申请人： Toray Industries, Inc.
发明人： OSABE, Masahiro , KISHIKAWA, Tatsuya , UENO, Yoshiyuki , SHIMAGAKI, Masaaki
IPC分类号： A61M1/18 , B01D63/02 , B01D69/08 , B01D71/68
CPC分类号： B01D71/68 , B01D69/02 , B01D69/08 , B01D69/087 , B01D2325/02 , B01D2325/36 , B01D2325/38
摘要： The present invention is intended to provide a polysulfone-based hollow fiber membrane and a hollow fiber membrane module for purifying a blood preparation, which allow for deproteinization of the blood preparation so that a highly safe blood preparation can be efficiently obtained. The present invention provides a polysulfone-based hollow fiber membrane for purifying a blood preparation, the membrane having a hydrophilic polymer on a surface thereof which contacts the blood preparation, in which the abundance ratio of the hydrophilic polymer is from 40 to 60% by mass, and porosity at the surface is from 8 to 30%.

34. 发明公开

EP2742997A1 CARRIER FOR ADSORPTION AND METHOD FOR PRODUCING SAME 有权
标题翻译： ADSORPTIONSTRÄGERUND HORTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2742997A1
公开(公告)日：2014-06-18
申请号：EP12821487.1
申请日：2012-08-08
申请人： Toray Industries, Inc.
发明人： TOMITA, Naotoshi , UENO, Yoshiyuki
IPC分类号： B01J20/26 , A61K35/14 , A61M1/36 , A61P7/00 , B01J20/30 , C08L101/00
CPC分类号： B01J20/267 , A61K38/00 , A61K47/00 , B01J20/26 , B01J20/30
摘要： The present invention aims to provide an adsorptive carrier having remarkable blood component-adsorbing capacity, especially inflammatory cytokine-adsorbing capacity irrespective of whether the carrier has an amide group and/or the like, which carrier also has high solvent resistance and heat resistance, and to provide a method for producing an adsorptive carrier, wherein introduction of a desired functional group on the surface of the carrier and cross-linking between aromatic rings can be achieved by a single step. The present invention provides an adsorptive carrier composed of one or more high-molecular-weight compounds each of which comprises two or more aromatic ring-containing repeating units, which aromatic rings are covalently bound to each other via the structure represented by the General Formula (I) below:

[wherein R 1 represents hydrogen or an organic group, and R 2 represents an organic group].
摘要翻译：本发明的目的在于提供具有显着的血液成分吸附能力，特别是炎性细胞因子吸附能力的吸附载体，而不管载体是否具有酰胺基等，该载体也具有高耐溶剂性和耐热性，以及提供一种生产吸附载体的方法，其中在载体的表面上引入所需的官能团和芳环之间的交联可以通过一个步骤实现。本发明提供一种吸附载体，其由一种或多种高分子量化合物组成，每种化合物包含两个或更多个含芳环的重复单元，所述芳族环通过通式（D）表示的结构彼此共价结合 I）：[其中R 1表示氢或有机基团，R 2表示有机基团]。

35. 发明公开

EP2286902A1 SEPARATION MEMBRANE, METHOD OF PRODUCING THE SAME AND SEPARATION MEMBRANE MODULE USING THE SEPARATION MEMBRANE 有权
标题翻译：分离膜，工艺用于生产和分离膜组件，使用分离膜
公开(公告)号：EP2286902A1
公开(公告)日：2011-02-23
申请号：EP09727576.2
申请日：2009-03-30
申请人： Toray Industries, Inc.
发明人： UENO, Yoshiyuki , FUJITA, Masaki , SUGAYA, Hiroyuki
IPC分类号： B01D69/02 , A61M1/16 , B01D69/08 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/68
摘要： Provided is a separation membrane module suffering from little sticking of organic matters, proteins, platelets and so on. A separation membrane which is a membrane comprising a polymer, characterized in that a functional layer is formed on the surface in one side of the membrane, the peak area percentage of carbon derived from ester group measured by the electron spectroscopy for chemical analysis (ESCA) on the surface of the preceding functional layer is 0.1% (by atomic number) or more but not more than 10 (% by atomic number), and the peak area percentage of carbon derived from ester group measured by the electron spectroscopy for chemical analysis (ESCA) on the surface opposite to the functional layer is not more than 10 (% by atomic number); and a separation membrane module provided with the same as a built-in membrane.
摘要翻译：本发明提供一种分离膜组件从有机物，蛋白质，血小板等小粘着痛苦。一种分离膜所有这是一种膜，其包含聚合物，其特征在于在没有的功能层设置在膜的一侧表面上形成的，碳的峰面积百分率从通过用于化学分析的电子能谱法测得的酯基团衍生的（ESCA）所述preceding-功能层的表面上为0.1％（按原子数）或更大但不超过10（原子数％），以及从酯基的碳的峰面积百分率通过用于化学分析的电子能谱法（测量 ESCA）上的表面相反的功能层是不大于10（原子数％）以上; 和一个分离膜组件设置有相同的作为内置在膜。

36. 发明公开

EP1439212A1 HYDROPHILIC MATERIAL AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：水蛭素材ZER SEINER HERSTELLUNG
公开(公告)号：EP1439212A1
公开(公告)日：2004-07-21
申请号：EP02772971.4
申请日：2002-10-03
申请人： TORAY INDUSTRIES, INC.
发明人： SUGAYA, Hiroyuki , EIKA, Yoshihiro , UENO, Yoshiyuki
IPC分类号： C09K3/00 , B01D71/68 , B01D69/08 , A61M1/18
CPC分类号： B01D67/0088 , A61L33/0035 , A61M1/3673 , B01D67/0011 , B01D67/009 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/30 , B01D2323/34 , B01D2325/28 , B01D2325/36 , C08L81/06 , C08L39/06
摘要： The present invention relates to a hydrophilic substance production method characterized in that polyvinylpyrrolidone-containing material wetted with an aqueous solution of a cationic polymer is treated with radiation. The invention makes it possible to produce material for blood treatment that prevents adsorption of blood platelets.
摘要翻译：亲水性物质的制造方法技术领域本发明涉及亲水性物质的制造方法，其特征在于，用阳离子性聚合物的水溶液润湿的含有聚乙烯吡咯烷酮的物质用辐射处理本发明使得可以生产防止血小板吸附的血液处理材料。

37. 发明公开

EP3845573A1 COPOLYMER AND MEDICAL MATERIAL CONTAINING THE SAME 有权
公开(公告)号：EP3845573A1
公开(公告)日：2021-07-07
申请号：EP21155811.9
申请日：2017-09-20
申请人： Toray Industries, Inc.
发明人： USHIRO, Suguru , HAYASHI, Akihiro , UENO, Yoshiyuki
IPC分类号： C08F226/02 , A61L33/06 , C08F226/10
摘要： The purpose of the present invention is to provide: a copolymer that is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof; and a medical material using same. Provided is a copolymer that comprises monomer unit A, monomer unit B, and monomer unit C represented in in chemical formula 1, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.

38. 发明公开

EP3777920A1 PHOSPHORUS ADSORBENT, POROUS FIBER AND PHOSPHORUS ADSORPTION COLUMN 审中-公开
公开(公告)号：EP3777920A1
公开(公告)日：2021-02-17
申请号：EP20197505.9
申请日：2016-11-11
申请人： Toray Industries, Inc.
发明人： HAN, Aishan , IWAKAWA, Sari , UENO, Yoshiyuki
IPC分类号： A61M1/36 , B01D15/08 , B01J20/02 , B01J20/06 , B01J20/28 , B01J20/32 , C01F17/00 , C01G23/047 , B01D15/12 , C01F17/247
摘要： The purpose of the present invention is to provide: a phosphorus adsorbent which is to be used for adsorbing phosphorous in extracorporeal circulation with little fear of disturbing the environment in vivo; a phosphorus adsorption column which comprises the phosphorus adsorbent disposed therein; a porous fiber which comprises the phosphorus adsorbent carried therein with little fear of disturbing the environment in vivo; and a phosphorus adsorption column which comprises the porous fiber disposed therein. To achieve the purpose as described above, the present invention has the following constitution. Namely, the phosphorus adsorbent, which is to be used for adsorbing phosphorus in extracorporeal circulation, is a powder comprising a carbonate of neodymium and having a solubility in 100 g of water at 20 °C of 10 mg or less. The porous fiber, which comprises the phosphorus adsorbent carried therein, shows a change in pH value of from -1.0 to +1.0 inclusive before and after stirring in physiological saline for 4 hours. The phosphorus adsorption columns respectively comprise the phosphorus adsorbent and the porous fiber each disposed therein.

39. 发明授权

EP3214210B1 POROUS POLYMER FIBERS FOR ADSORBENT MATERIAL 有权
公开(公告)号：EP3214210B1
公开(公告)日：2020-08-12
申请号：EP15856041.7
申请日：2015-10-20
申请人： Toray Industries, Inc.
发明人： FUJIEDA, Hiroaki , UENO, Yoshiyuki , TANAKA, Kazumi
IPC分类号： B01J20/28 , B01J20/26 , B01J20/30 , B01D15/20 , A61M1/36 , D01F6/00

40. 发明授权

EP2286902B1 SEPARATION MEMBRANE AND MODULE USING THE SEPARATION MEMBRANE 有权
公开(公告)号：EP2286902B1
公开(公告)日：2020-02-19
申请号：EP09727576.2
申请日：2009-03-30
申请人： Toray Industries, Inc.
发明人： UENO, Yoshiyuki , FUJITA, Masaki , SUGAYA, Hiroyuki
IPC分类号： B01D69/02 , A61M1/16 , B01D69/08 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/68 , B01D67/00

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