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1. 发明公开

EP3495004A1 BIOLOGICAL COMPONENT ADHESION-SUPPRESSING MATERIAL 审中-实审
公开(公告)号：EP3495004A1
公开(公告)日：2019-06-12
申请号：EP17836877.5
申请日：2017-07-28
申请人： Toray Industries, Inc.
发明人： USHIRO, Suguru , HAYASHI, Akihiro , UENO, Yoshiyuki
IPC分类号： A61M1/16 , A61L33/00 , B01D69/12
摘要： The purpose of the present invention is to provide a biological component adhesion-suppressing material that is able to suppress adhesion of platelets and proteins even when coming into contact with blood, etc. The present invention comprises a substrate which is provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.

2. 发明授权

EP1535657B1 PROCESS FOR PRODUCING MODIFIED SUBSTRATE 有权
公开(公告)号：EP1535657B1
公开(公告)日：2018-09-26
申请号：EP03792729.0
申请日：2003-08-20
申请人： TORAY INDUSTRIES, INC.
发明人： UENO, Yoshiyuki , TAKAHASHI, Hiroshi , SUGAYA, Hiroyuki
IPC分类号： B01D67/00 , B01D63/02 , B01D65/02 , B01D69/08 , B01D71/40 , C08J7/18 , C08J7/00 , A61L33/00 , B01D71/68
CPC分类号： B01D67/0093 , A61L33/0082 , B01D69/10 , B01D71/68 , B01D2323/02 , B01D2323/12 , B01D2323/14 , B01D2323/16 , B01D2323/30 , B01D2323/34 , B01D2323/36
摘要： The present invention provides a modified substrate including a hydrophilic polymer wherein the soluble hydrophilic polymer ratio is 15 weight percent or less and the number of adhered human blood platelets is 10/4.3x10 mu m or less. In addition, the present invention provides a method for producing a modified substrate including a step of irradiating the substrate with radiation while the substrate is brought into contact with an aqueous solution containing a hydrophilic polymer and an antioxidant. The present invention provides a modified substrate having high hematologic compatibility wherein the hydrophilic polymer is immobilized on the surface of the substrate, and a method for producing the same.

3. 发明公开

EP3195930A1 FIBER FOR PROTEIN ADSORPTION AND COLUMN FOR PROTEIN ADSORPTION 有权
标题翻译：蛋白质吸附用纤维和柱吸附蛋白质
公开(公告)号：EP3195930A1
公开(公告)日：2017-07-26
申请号：EP15841455.7
申请日：2015-09-16
申请人： Toray Industries, Inc.
发明人： KASUYA, Junichi , TOMITA, Naotoshi , UENO, Yoshiyuki
IPC分类号： B01J20/26 , A61M1/36 , B01J20/28
CPC分类号： D01F8/06 , A61L31/041 , A61M1/36 , A61M1/3679 , B01D15/08 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/267 , B01J20/28 , B01J20/28023 , B01J20/281 , B01J20/3085 , B01J2220/52 , C08J7/14 , C08L23/12 , C08L25/06 , C08L2203/02 , C08L2203/12 , C08L2205/025 , C08L2205/03 , D06M11/55 , D06M13/13 , D06M13/392 , D06M2101/20 , D06M2400/01 , D10B2509/00
摘要： The present invention aims to provide a fiber for protein adsorption and a column for protein adsorption which show less elution and hence are safe, and have high protein adsorption capacity. The present invention provides a fiber for protein adsorption, wherein the fiber has a water absorption percentage of 1 to 50%, and the fiber comprises a polymer containing as repeat units an aromatic hydrocarbon or a derivative thereof, wherein part of aromatic rings contained in the repeat units are cross-linked through a structure represented by the following General Formula (I). The present invention also provides a column for protein adsorption using it. Here, A in the General Formula is selected from an alkyl aliphatic group, phenyl aromatic group, and amino group.
摘要翻译：本发明的目的在于提供一种蛋白质吸附用纤维和蛋白质吸附用柱子，洗脱少，安全性高，蛋白质吸附容量高。本发明提供一种蛋白质吸附用纤维，其特征在于，纤维的吸水率为1〜50％，该纤维包含含有芳香族烃或其衍生物作为重复单元的聚合物，该芳香族烃的一部分重复单元通过由以下通式（I）表示的结构交联。本发明还提供了使用它的蛋白质吸附柱。这里，通式中的A选自烷基脂族基团，苯基芳族基团和氨基。

4. 发明公开

EP3141296A1 HOLLOW FIBER MEMBRANE MODULE AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译： HOHLFASERMEMBRANMODUL UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP3141296A1
公开(公告)日：2017-03-15
申请号：EP15789788.5
申请日：2015-05-07
申请人： Toray Industries, Inc.
发明人： HAYASHI, Akihiro , UENO, Yoshiyuki
IPC分类号： B01D71/68 , A61M1/18 , B01D63/02 , B01D65/02 , B01D69/02 , B01D69/08 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/52
CPC分类号： B01D71/68 , B01D63/02 , B01D63/021 , B01D65/02 , B01D69/02 , B01D69/08 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/52 , B01D2325/36
摘要： Disclosed is a hollow fiber membrane module including a case and a hollow fiber membrane built in the case, wherein the hollow fiber membrane contains a polysulfone-based polymer and a hydrophilic polymer, and satisfies the following (A) and (B), and an amount of an eluted substance contained in a liquid obtained by circulating ultrapure water heated at 37°C through a passage of an inner surface side of the hollow fiber membrane for 4 hours at 200 mL/min is 1.0 mg/m 2 or less:
(A) an insoluble component accounts for less than 3% by mass of the total mass of the hollow fiber membrane when the hollow fiber membrane is dissolved in N,N-dimethylacetamide; and
(B) a flexible layer exists on a surface of a functional layer in a wet state and the flexible layer has a thickness of 7 nm or more. The present invention provides a hollow fiber membrane module including a hollow fiber membrane containing a polysulfone-based polymer and a hydrophilic polymer built therein, which elutes little eluted substance and exhibits high biocompatibility, while change in performance due to crosslinking of the hydrophilic polymer is suppressed.
摘要翻译：公开了一种中空纤维膜组件，其包括壳体和内置于其中的中空纤维膜，其中中空纤维膜含有聚砜系聚合物和亲水性高分子，满足下述（A）和（B），将通过使中空纤维膜的内表面侧通过中空纤维膜的内表面侧以200mL / min通过4小时而使在37℃下加热的超纯水循环而得到的液体中所含的洗脱物的量为1.0mg / m 2以下：（ A）中空纤维膜溶解在N，N-二甲基乙酰胺中时，不溶成分占中空纤维膜总质量的3质量％以下; 和（B）在湿态的功能层的表面上存在柔性层，柔性层的厚度为7nm以上。本发明提供一种中空纤维膜组件，其包括含有聚砜系聚合物和内置亲水性聚合物的中空纤维膜，其中洗脱少量洗脱物质并表现出高生物相容性，同时由于亲水性聚合物的交联而导致的性能变化被抑制。

5. 发明公开

EP3006060A1 ADSORPTION CARRIER-PACKED COLUMN 有权
标题翻译：吸附柱
公开(公告)号：EP3006060A1
公开(公告)日：2016-04-13
申请号：EP14804488.6
申请日：2014-05-30
申请人： Toray Industries, Inc.
发明人： TOMITA, Naotoshi , SHIMADA, Kaoru , UENO, Yoshiyuki
IPC分类号： A61M1/36
CPC分类号： B01D15/22 , A61M1/3633 , A61M1/365 , A61M1/3679 , A61M2202/0439 , B01D29/0022 , B01D2201/342 , B01J20/28023 , B01J20/3208 , B01J20/3251 , B01J2220/58
摘要： The present invention aims to provide an adsorption carrier-packed column which enables reduction of bypassing, and improvement of the performance of the adsorption carrier. The present invention provides an adsorption carrier-packed column comprising a central pipe, adsorption carrier, plate A, and plate B, wherein an insertion material C is inserted between the adsorption carrier and the plate A; an insertion material D is inserted between the adsorption carrier and the plate B; the ratio of the deformation rate of the insertion material C (C 1 ) to the deformation rate of the adsorption carrier (E 0 ) is 1≤C 1 /E 0 ≤10, and the ratio of the deformation rate of the insertion material D (D 1 ) to the deformation rate of the adsorption carrier (E 0 ) is 1≤D 1 /E 0 ≤10; and the ratio of the thickness of the insertion material C (T C ) to the distance of a gap between the adsorption carrier and the plate A (L A ) is 1.1≤T C /L A ≤4, and the ratio of the thickness of the insertion material D (T D ) to the distance of a gap between the adsorption carrier and the plate B (L B ) is 1.1≤T D /L B ≤4.

6. 发明授权

EP1439212B1 HYDROPHILIC MATERIAL AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：用于生产亲水性材料和工艺
公开(公告)号：EP1439212B1
公开(公告)日：2008-01-02
申请号：EP02772971.4
申请日：2002-10-03
申请人： TORAY INDUSTRIES, INC.
发明人： SUGAYA, Hiroyuki , EIKA, Yoshihiro , UENO, Yoshiyuki
IPC分类号： C09K3/00 , B01D71/68 , B01D69/08 , A61M1/18
CPC分类号： B01D67/0088 , A61L33/0035 , A61M1/3673 , B01D67/0011 , B01D67/009 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/30 , B01D2323/34 , B01D2325/28 , B01D2325/36 , C08L81/06 , C08L39/06
摘要： A process for producing a hydrophilic material, characterized by treating a material comprising a polyvinyl pyrrolidone with a radiation while keeping the material wet with an aqueous solution containing a cationic polymer. By the process, a material for blood treatment can be produced with which the deposition of blood platelets is inhibited.

7. 发明授权

EP2659914B1 HOLLOW FIBER MEMBRANE MODULE 有权
公开(公告)号：EP2659914B1
公开(公告)日：2020-06-24
申请号：EP11854069.9
申请日：2011-12-27
申请人： Toray Industries, Inc.
发明人： UENO, Yoshiyuki , FUJITA, Masaki , SUGAYA, Hiroyuki , HASHIMOTO, Kazuyuki , TERASAKA, Hiroyuki , KOGANEMARU, Ryo
IPC分类号： A61L33/00 , A61M1/18 , B01D63/02 , B01D65/08 , B01D67/00

8. 发明公开

EP3608455A1 POROUS FIBER AND ADSORPTION COLUMN 有权
公开(公告)号：EP3608455A1
公开(公告)日：2020-02-12
申请号：EP18781532.9
申请日：2018-03-23
申请人： Toray Industries, Inc.
发明人： HAN, Aishan , FUJIEDA, Hiroaki , UENO, Yoshiyuki
IPC分类号： D01F6/00 , A61M1/36 , B01D15/00 , B01J20/20 , B01J20/28 , C01G23/047 , D01F6/52 , D01F8/10
摘要： The purpose of the present invention is to provide: a porous fiber that exhibits both improved adsorption capacity, and suppressed exposure and detachment of particulates; an adsorption column filled with said porous fiber; and a blood purification system in which an adsorption column is connected to a water removal column. In order to achieve this purpose, the porous fiber according to the present invention has the following constitution. Specifically, the porous fiber according to the present invention has a three-dimensional pore structure formed by a solid fiber, and satisfies all of the following conditions. (1) The porous fiber has particulates having a diameter of not more than 200 µm, and the perpcentage of area occupied by said particulates having a diameter of not more than 200 µm in a horizontal cross section of the three-dimensional pore structure is at least 3.0%. (2) The porous fiber does not contain said particulates having a diameter of not more than 200 µm in the region within 1.0 µm in the depth direction from the outermost surface.

9. 发明公开

EP3508232A1 MEDICAL MATERIAL, MEDICAL SEPARATION MEMBRANE, AND BLOOD PURIFIER 审中-公开
公开(公告)号：EP3508232A1
公开(公告)日：2019-07-10
申请号：EP17846214.9
申请日：2017-08-22
申请人： Toray Industries, Inc.
发明人： USHIRO, Suguru , HAYASHI, Akihiro , UENO, Yoshiyuki
IPC分类号： A61M1/18 , A61L33/06
摘要： The purpose of the present invention is to provide a medical material capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The present invention provides a medical material that is a copolymer comprising hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30° and less than 70°, and the glass transition temperature of the copolymer exists at only one point in the range from 45°C to less than 90°C.

10. 发明授权

EP2742997B1 CARRIER FOR ADSORPTION AND METHOD FOR PRODUCING SAME 有权
公开(公告)号：EP2742997B1
公开(公告)日：2018-09-19
申请号：EP12821487.1
申请日：2012-08-08
申请人： Toray Industries, Inc.
发明人： TOMITA, Naotoshi , UENO, Yoshiyuki
IPC分类号： B01J20/26 , B01J20/28 , B01J20/30 , A61K35/14 , A61M1/36 , A61P7/00 , C08L101/00 , A61K38/00 , C08F8/28
CPC分类号： B01J20/267 , A61K38/00 , A61K47/00 , B01J20/26 , B01J20/30
摘要： The present invention aims to provide an adsorptive carrier having remarkable blood component-adsorbing capacity, especially inflammatory cytokine-adsorbing capacity irrespective of whether the carrier has an amide group and/or the like, which carrier also has high solvent resistance and heat resistance, and to provide a method for producing an adsorptive carrier, wherein introduction of a desired functional group on the surface of the carrier and cross-linking between aromatic rings can be achieved by a single step. The present invention provides an adsorptive carrier composed of one or more high-molecular-weight compounds each of which comprises two or more aromatic ring-containing repeating units, which aromatic rings are covalently bound to each other via the structure represented by the General Formula (I) below: [wherein R 1 represents hydrogen or an organic group, and R 2 represents an organic group].

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