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1. 发明公开

EP1439212A4 HYDROPHILIC MATERIAL AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：用于生产亲水性材料和工艺
公开(公告)号：EP1439212A4
公开(公告)日：2006-01-25
申请号：EP02772971
申请日：2002-10-03
申请人： TORAY INDUSTRIES
发明人： SUGAYA HIROYUKI , EIKA YOSHIHIRO , UENO YOSHIYUKI
IPC分类号： A61L33/00 , A61M1/36 , B01D67/00 , B01D69/02 , B01D71/68 , B01D71/82 , D06M10/10 , C09K3/00 , A61M1/18 , B01D69/08
CPC分类号： B01D67/0088 , A61L33/0035 , A61M1/3673 , B01D67/0011 , B01D67/009 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/30 , B01D2323/34 , B01D2325/28 , B01D2325/36 , C08L81/06 , C08L39/06
摘要： The present invention relates to a hydrophilic substance production method characterized in that polyvinylpyrrolidone-containing material wetted with an aqueous solution of a cationic polymer is treated with radiation. The invention makes it possible to produce material for blood treatment that prevents adsorption of blood platelets.

2. 发明授权

EP3088014B1 MEDICAL DEVICE 有权
公开(公告)号：EP3088014B1
公开(公告)日：2018-06-20
申请号：EP14875327.0
申请日：2014-12-19
申请人： Terumo Kabushiki Kaisha
发明人： ANZAI, Takao , NISHIDA, Kaori
IPC分类号： A61L33/00 , A61L29/00 , A61L31/00 , A61L33/06
CPC分类号： A61L33/0035 , A61L31/048 , A61L31/16 , A61L33/0023 , A61L33/064 , A61L33/068 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2420/02 , C08L33/12
摘要： The invention relates to a medical device including a base member and a coating layer containing an antithrombogenic material and covering a surface of the base member. The antithrombogenic material contains a copolymer having a repeating unit (A) represented by the following formula (1) : wherein R 11 is a hydrogen atom or a methyl group, Z is an oxygen atom or -NH-, R 12 is a C 1-6 alkylene group, R 13 and R 14 are each independently a C 1-4 alkyl group, and R 15 is a C 1-2 alkylene group, and a repeating unit (B) represented by the following formula (2): wherein R 21 is a hydrogen atom or a methyl group, R 22 is a C 1-6 alkylene group, and R 23 is a C 1-4 alkyl group. The repeating unit (A) is contained in a proportion of 1 to 7 mol% based on all the structural units of the copolymer. The invention makes it possible to provide a medical device having excellent antithrombogenicity even under severe use conditions prone to thrombus formation.

3. 发明公开

EP2683420A1 IMPROVEMENTS TO IMMOBILISED BIOLOGICAL ENTITIES 有权转让
标题翻译： VERBESSERUNGEN AN IMMOBILISITENTEN BIOLOGISCHEN EINHEITEN
公开(公告)号：EP2683420A1
公开(公告)日：2014-01-15
申请号：EP12708138.8
申请日：2012-03-09
申请人： Gore Enterprise Holdings, Inc. , W.L. Gore & Associates, Inc.
发明人： LEONTEIN, Karin , ANTONI, Per , NYSTRÖM, Daniel , BEGOVAC, Paul , PIETRZAK, Krzysztof
IPC分类号： A61L27/34 , A61L31/10 , A61L33/00 , A61K47/48
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
摘要翻译：特别地描述了具有包括层状涂层的表面的装置，其中外涂层包含多个阳离子超支化聚合物分子，其特征在于具有（i）分子量为14-1,000Da的核心部分（ii）总分子量（iii）总分子量与核心部分分子量的比例为至少80:1，和（iv）官能端基，其中一个或多个所述官能端基具有共价连接的抗凝剂实体于此。

4. 发明公开

EP1020495A4 ION COMPLEX, COATING MATERIAL, AND COATING METHOD 有权
标题翻译： ION-KOMPLEX，BESCHICHTUNGSMATERIAL，UND BESCHICHTUNGSVERFAHREN
公开(公告)号：EP1020495A4
公开(公告)日：2001-10-24
申请号：EP99933116
申请日：1999-07-27
申请人： M & M LAB CO LTD , TERUMO CORP
发明人： YOSHIOKA HIROSHI , MORI YUICHI , KUBOTA SUNAO
IPC分类号： A61L33/00 , A61L33/06 , C09D201/02 , C08L101/00 , C09D105/10 , C09D201/00
CPC分类号： A61L33/00 , A61L33/0011 , A61L33/0035 , A61L33/062 , C09D201/02 , Y10T428/31 , Y10T428/31504 , Y10T428/31855
摘要： An ion complex which comprises a water-insoluble polyion (P) and a water-soluble polyion (A); and is insoluble in water and soluble in an aqueous organic solvent. Such an ion complex becomes a coating material which can preferably be used for coating of various ionic substances (e.g., substance having biological activity such as an anticoagulant property or an antibacterial property).
摘要翻译：一种离子络合物，其包含水不溶性聚阳离子（P）和水溶性聚阳离子（A）; 并且不溶于水并可溶于含水有机溶剂。这样的离子络合物成为可以优选用于涂布各种离子性物质（例如具有抗凝血性，抗菌性等生物活性的物质）的涂料。

5. 发明公开

EP3375462A1 IMPROVEMENTS TO IMMOBILISED BIOLOGICAL ENTITIES 有权转让
公开(公告)号：EP3375462A1
公开(公告)日：2018-09-19
申请号：EP18170238.2
申请日：2012-03-09
申请人： W.L. Gore & Associates Inc.
发明人： LEONTEIN, Karin , ANTONI, Per , NYSTRÖM, Daniel , BEGOVAC, Paul , PIETRZAK, Krzysztof
IPC分类号： A61L27/34 , A61L31/10 , A61L33/00
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 500:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto, wherein the hyperbranched polymer is a dendrimer.

6. 发明公开

EP3141191A1 ENDOVASCULAR TREATMENT ASSISTANCE TOOL 审中-公开
标题翻译： ENDOVASKULÄRESBEHANDLUNGSHILFSWERKZEUG
公开(公告)号：EP3141191A1
公开(公告)日：2017-03-15
申请号：EP15788802.5
申请日：2015-05-08
申请人： Toray Industries, Inc. , Inoue, Kanji
发明人： INOUE, Kanji , YAGI, Takahiro , FUJITA, Masaki , KADOWAKI, Koji , TANAHASHI, Kazuhiro
IPC分类号： A61B17/00 , A61F2/01
CPC分类号： A61F2/013 , A61B17/00 , A61F2002/011 , A61F2002/015 , A61F2002/016 , A61F2230/0067 , A61F2230/0069 , A61F2230/0093 , A61L33/0035
摘要： An endovascular treatment aiding device whose filter is not caught by a treatment device during retrieval of the endovascular treatment aiding device is disclosed. The treatment aiding device comprises: a flexible shaft; a filter fixed to the shaft, which can be opened and closed in an umbrella-like manner; linear supporting members each of which connects the end portion in the opening-section side of the filter to a part of the shaft such that the filter can be closed by applying an external force to the proximal side; an elastomer member composed of an elastomer in which a penetrating hole (A) is formed, which elastomer member is arranged in the proximal side relative to the opening section of the filter such that the shaft penetrates the penetrating hole (A), wherein the outer diameter of the end face in which the penetrating hole (A) is formed is larger than the outer diameter of the opening-section side of the filter when the filter is closed; and an outer tube in which a penetrating hole (B) is formed, which outer tube is arranged in the proximal side relative to the opening section of the filter such that the shaft penetrates the penetrating hole (B) in a state which allows movement of the shaft in the longitudinal direction; wherein the elastomer member is fixed in the distal side of the outer tube.
摘要翻译：公开了一种血管内治疗辅助装置，其在过滤器在血管内治疗辅助装置取回期间未被治疗装置捕获。治疗辅助装置包括：柔性轴; 固定在轴上的过滤器，其可以以伞状的方式打开和关闭; 线性支撑构件，其将过滤器的开口部侧的端部连接到轴的一部分，使得可以通过向近侧施加外力来关闭过滤器; 弹性体构件，其由形成有贯通孔（A）的弹性体构成，弹性体构件相对于过滤器的开口部配置在基端侧，使得轴穿过贯通孔（A），其中，外侧当过滤器关闭时，形成有贯通孔（A）的端面的直径大于过滤器的开口部侧的外径; 以及形成有贯通孔（B）的外管，该外管相对于过滤器的开口部配置在基端侧，使得轴以能够移动的状态穿过贯通孔（B）轴在纵向方向; 其中所述弹性体构件固定在所述外管的远侧。

7. 发明公开

EP3088014A1 MEDICAL DEVICE 有权
标题翻译： MEDIZINISCHE VORRICHTUNG
公开(公告)号：EP3088014A1
公开(公告)日：2016-11-02
申请号：EP14875327.0
申请日：2014-12-19
申请人： Terumo Kabushiki Kaisha
发明人： ANZAI, Takao , NISHIDA, Kaori
IPC分类号： A61L33/00 , A61L29/00 , A61L31/00
CPC分类号： A61L33/0035 , A61L31/048 , A61L31/16 , A61L33/0023 , A61L33/064 , A61L33/068 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2420/02 , C08L33/12
摘要： The invention relates to a medical device including a base member and a coating layer containing an antithrombogenic material and covering a surface of the base member. The antithrombogenic material contains a copolymer having a repeating unit (A) represented by the following formula (1) :

wherein R 11 is a hydrogen atom or a methyl group, Z is an oxygen atom or -NH-, R 12 is a C 1-6 alkylene group, R 13 and R 14 are each independently a C 1-4 alkyl group, and R 15 is a C 1-2 alkylene group, and a repeating unit (B) represented by the following formula (2):

wherein R 21 is a hydrogen atom or a methyl group, R 22 is a C 1-6 alkylene group, and R 23 is a C 1-4 alkyl group. The repeating unit (A) is contained in a proportion of 1 to 7 mol% based on all the structural units of the copolymer. The invention makes it possible to provide a medical device having excellent antithrombogenicity even under severe use conditions prone to thrombus formation.
摘要翻译：本发明涉及一种医疗装置，其包括基底构件和包含抗血栓形成材料并覆盖基底构件的表面的涂层。抗血栓形成材料含有具有由下式（1）表示的重复单元（A）的共聚物：其中R 11是氢原子或甲基，Z是氧原子或-NH-，R 12是C 1 -6亚烷基，R 13和R 14各自独立地为C 1-4烷基，R 15为C 1-2亚烷基，以及由下式（2）表示的重复单元（B）：其中 R 21是氢原子或甲基，R 22是C 1-6亚烷基，R 23是C 1-4烷基。重复单元（A）的含量相对于共聚物的全部结构单元为1〜7摩尔％。本发明使得即使在易于血栓形成的严重使用条件下也能提供具有优异抗凝血性的医疗装置。

8. 发明授权

EP1020495B1 ION COMPLEX, COATING MATERIAL, AND COATING METHOD 有权
标题翻译：离子复合物，涂层材料及涂装工艺
公开(公告)号：EP1020495B1
公开(公告)日：2004-09-22
申请号：EP99933116.8
申请日：1999-07-27
申请人： Mebiol Inc. , TERUMO KABUSHIKI KAISHA
发明人： YOSHIOKA, Hiroshi , MORI, Yuichi , KUBOTA, Sunao
IPC分类号： C08L101/00 , C09D201/00 , A61L33/00 , C09D201/02 , C09D105/10
CPC分类号： A61L33/00 , A61L33/0011 , A61L33/0035 , A61L33/062 , C09D201/02 , Y10T428/31 , Y10T428/31504 , Y10T428/31855
摘要： An ion complex which comprises a water-insoluble polyion (P) and a water-soluble polyion (A) and which is insoluble in water and soluble in water-containing organic solvents. The ion complex is suitable for use as a coating material to be applied to various ionic substances (e.g., a substance having physiological activity such as anticoagulant or antibacterial activity).

9. 发明公开

EP1439212A1 HYDROPHILIC MATERIAL AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：水蛭素材ZER SEINER HERSTELLUNG
公开(公告)号：EP1439212A1
公开(公告)日：2004-07-21
申请号：EP02772971.4
申请日：2002-10-03
申请人： TORAY INDUSTRIES, INC.
发明人： SUGAYA, Hiroyuki , EIKA, Yoshihiro , UENO, Yoshiyuki
IPC分类号： C09K3/00 , B01D71/68 , B01D69/08 , A61M1/18
CPC分类号： B01D67/0088 , A61L33/0035 , A61M1/3673 , B01D67/0011 , B01D67/009 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/30 , B01D2323/34 , B01D2325/28 , B01D2325/36 , C08L81/06 , C08L39/06
摘要： The present invention relates to a hydrophilic substance production method characterized in that polyvinylpyrrolidone-containing material wetted with an aqueous solution of a cationic polymer is treated with radiation. The invention makes it possible to produce material for blood treatment that prevents adsorption of blood platelets.
摘要翻译：亲水性物质的制造方法技术领域本发明涉及亲水性物质的制造方法，其特征在于，用阳离子性聚合物的水溶液润湿的含有聚乙烯吡咯烷酮的物质用辐射处理本发明使得可以生产防止血小板吸附的血液处理材料。

10. 发明授权

EP2683420B1 IMPROVEMENTS TO IMMOBILISED BIOLOGICAL ENTITIES 有权转让
公开(公告)号：EP2683420B1
公开(公告)日：2018-05-23
申请号：EP12708138.8
申请日：2012-03-09
申请人： W. L. Gore & Associates, Inc.
发明人： LEONTEIN, Karin , ANTONI, Per , NYSTRÖM, Daniel , BEGOVAC, Paul , PIETRZAK, Krzysztof
IPC分类号： A61L27/34 , A61L31/10 , A61L33/00
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.

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