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    • 31. 发明公开
    • MEASURING INSTRUMENT
    • 测量仪器
    • EP0838678A1
    • 1998-04-29
    • EP96923050.7
    • 1996-07-10
    • PRECISION SYSTEM SCIENCE CO., LTD.
    • TAJIMA, Hideji Precision System Science Co., Ltd.
    • G01N21/75
    • G01N21/76G01N21/75
    • This invention provides a measuring apparatus that allows measurements of light in various inspections based on different light generating principles to be performed by a single measuring apparatus and thus widens the range of reagents that can be used, increasing the versatility of this single measuring apparatus and significantly enhancing its usefulness for users and reagent manufacturers.
      The measuring apparatus of this invention comprises: a light receiving unit and/or a light receiving unit holder connected to a light measuring device; a nozzle holder holding a nozzle for injecting reagents including luminescent reagents into a container; and a container containing a specimen and/or a container holder; wherein the container or container holder and the light receiving unit or light receiving unit holder, and/or the nozzle holder are coupled together to form an enclosed space shielded from external light.
    • 本发明提供了一种测量装置,其允许基于不同光产生原理的各种检查中的光的测量由单个测量装置执行,并因此扩大了可以使用的试剂的范围,增加了该单个测量装置的通用性并且显着 增强了用户和试剂制造商的实用性。 本发明的测量装置包括:与光测量装置连接的光接收单元和/或光接收单元支架; 保持喷嘴的喷嘴座,用于将包括发光试剂的试剂注入容器; 和容纳样本和/或容器保持器的容器; 其中所述容器或容器保持器和所述光接收单元或所述光接收单元保持器和/或所述喷嘴保持器联接在一起以形成与外部光屏蔽的封闭空间。
    • 33. 发明公开
    • Container
    • Gefäss
    • EP2259070A2
    • 2010-12-08
    • EP10176871.1
    • 1996-07-31
    • PRECISION SYSTEM SCIENCE CO., LTD.
    • Tajima, Hideji
    • G01N35/02G01N1/10G01N33/543G01N21/03G01N21/11B01L3/00B01L3/02
    • B01L3/0275B01L3/5085G01N2035/0436G01N2035/1053
    • It is an object of the present invention to provide a container which can execute a reliable work of dispensing and/or agitating on the occasion of aspirating and/or discharging a sample and/or a reagent in a container, by aspirating or discharging in a predetermined quantity without blockading the front end portion of the liquid sucking/discharging line. It is another object of the present invention to provide a container having a simple structure which can realize a high precision inspection for all of the quantity by aspirating all of the quantity in the container, by being capable of discharging all of the quantity in the container without necessity of the surplus of the samples and/or reagents and by treating all of the quantity as a fixed quantity.
      The present invention is a container comprising a gap part formed to have a smaller width than a caliber of a front end portion of a liquid sucking/discharging line adapted to be inserted therein and pulled out thereof, at an inside bottom part thereof. The gap part is formed to be a shape being capable of aspirating and discharging all of the quantity of liquid through the front end portion even in a state that the front end portion is disposed in contact with the inside bottom part. On the occasion of discharging, the container is formed so that reaction between a sample and a reagent can be uniformed by discharging and diffusing aspirated liquid.
    • 本发明的目的是提供一种容器,其能够在吸入和/或排出容器中的样品和/或试剂的情况下通过吸入或排出在罐中进行抽吸或排出来执行分配和/或搅拌的可靠工作 而不堵塞液体吸入/排出管线的前端部分。 本发明的另一个目的是提供一种具有简单结构的容器,其能够通过吸出容器中的所有数量来实现所有量的高精度检查,通过能够排出容器中的所有数量 不需要剩余的样品和/或试剂,并且将所有数量作为固定量处理。 本发明是一种容器,其包括间隙部分,其形成为具有比其插入其中并被拉出的液体吸入/排出管线的前端部分的口径的宽度小的内部底部部分。 间隙部分形成为即使在前端部与内底部接触的状态下也能够通过前端部吸引和排出全部液体的形状。 在排出时,形成容器,使得样品和试剂之间的反应可以通过排出和扩散吸入的液体而均匀化。
    • 37. 发明公开
    • SMALL OBJECT IDENTIFYING DEVICE AND ITS IDENTIFYING METHOD
    • EINRICHTUNG ZUM IDENTIFIZIEREN KLEINER OBJEKTE UND IDENTIFIZIERUNGSVERFAHREN
    • EP1371965A1
    • 2003-12-17
    • EP02711227.5
    • 2002-01-25
    • PRECISION SYSTEM SCIENCE CO., LTD.The Furukawa Electric Co., Ltd.Fi-Techno Co., Ltd.
    • NOGUCHI, Masahisa c/o FI-Techno Co., Ltd.TSUKII, Ken c/o The Furukawa Electric Co., Ltd.TAJIMA, Hideji Precision System Science Co., Ltd.
    • G01N15/14G01N37/00G01N21/64G01N21/78G01N33/543
    • G01N15/1456G01N2015/1488G01N2015/1497
    • In relation to a small object identifying device and its identifying method, there is provided a small object identifying device and its identifying method which can identify easily, reliably and efficiently a large number of small objects from several tens, to several hundreds, to several thousands, to more than several tens of thousands, without stopping in the case of identifying several kinds of small objects.
      This has a construction comprising: a dispersion step for dispersing a large quantity of several kinds of small objects labeled by a combination of the presence/absence or measure of label elements of several kinds; a measuring step for distributing and associating kinds of the label elements to two or more measurement points, and measuring the presence/absence or the measure of the label elements of the kinds which have been associated with respective measurement points, for each of the dispersed small objects, at respective measurement points having a relative temporal relationship between measurement points; and an identifying step for associating the measurement results measured at each measurement point, based on the temporal relationship and a positional relationship between the measurement points to thereby identify the small objects.
    • 关于小对象识别装置及其识别方法,提供了一种小对象识别装置及其识别方法,其可以容易地,可靠地和有效地识别从数十到数百到数千个的小型对象 在几个小物体识别的情况下,不得停止。 这种结构包括:分散步骤,用于分散由几种标签元素的存在/不存在或测量的组合标记的大量几种小物体; 测量步骤,用于将标签元素的种类分配和关联到两个或更多个测量点,并且测量与各个测量点相关联的种类的标签元素的存在/不存在或测量,对于每个分散的小 在各测量点处具有测量点之间的相对时间关系; 以及识别步骤,用于根据时间关系和测量点之间的位置关系来关联在每个测量点处测量的测量结果,从而识别小物体。
    • 38. 发明公开
    • CONCENTRATION DEVICE USING MAGNETIC PARTICLES AND METHOD THEREFOR
    • 设备用于专注度提高了其使用磁性粒子及其方法
    • EP1162444A1
    • 2001-12-12
    • EP00900434.2
    • 2000-01-18
    • PRECISION SYSTEM SCIENCE CO., LTD.
    • TAJIMA, Hideji, Precision System Science Co., Ltd.
    • G01N1/28G01N1/00G01N30/00G01N30/48B03C1/00C12Q1/68
    • G01N1/40B03C1/28B03C1/288G01N35/0098Y10T436/25375
    • The invention relates to a concentration device using magnetic particles and a method therefor aimed at performing concentration of a large volume of liquid efficiently and reliably with a simple structure and on a small device scale. The construction involves having: a liquid suction passage in which liquid can pass through only in a suction direction; a liquid discharge passage in which liquid can pass through only in a discharge direction; a magnetic force device which can exert a magnetic field from outside of the liquid passage on at least one liquid passage thereof or remove the magnetic field, and which can separate magnetic particles having directly or indirectly captured a target substance suspended in the liquid by having the magnetic particles adhere to the inner wall of the liquid passage; a storage section communicated with each liquid passage, for storing the sucked liquid; and a pressure adjustment device for sucking and discharging the liquid by adjusting the pressure in the storage section.
    • 本发明利用在以简单的结构和小规模设备上高效且可靠地进行大体积的液体的浓度为此针对磁性颗粒和方法涉及一种浓缩装置。 该构造涉及具有:其中的液体的液体吸入通道可以通过只在吸引方向; 在其中的液体的液体排出通道可以穿过仅在排出方向; 磁力装置,其可以从液体通道的外部上的至少一个液体通道施加磁场或其除去磁场,并且其可以分离磁性粒子具有由具有直接或间接地捕捉悬浮在液体中的目标物质 磁性颗粒附着于液体通道的内壁; 与每个液体通道连通,用于存储所吸入的液体的存储部分; 和用于抽吸并通过调节在所述存储部分中的压力排出所述液体的压力调整装置。
    • 39. 发明公开
    • METHOD FOR TREATING BIOPOLYMERS, MICROORGANISMS OR MATERIALS BY USING MORE THAN ONE TYPE OF MAGNETIC PARTICLES
    • 生物聚合物的处理方法,微生物或其他材料不止一种类型的磁性粒子的使用。
    • EP0885958A1
    • 1998-12-23
    • EP97903600.1
    • 1997-02-24
    • PRECISION SYSTEM SCIENCE CO., LTD.
    • TAJIMA, Hideji-Precision System Science Co., Ltd.
    • C12N15/10C12Q1/02C12Q1/68C12Q1/70G01N33/53B03C1/015C12N13/00
    • C12N15/1013C12Q1/6834G01N33/54333Y10S435/82
    • The method of processing biopolymers, microorganisms and substances by using two or more kinds of magnetic particles according to this invention can automatically and consistently perform a series of processes, such as extraction, isolation or measurement of DNA and the like, by a combined use of at least two or more kinds of magnetic particles and can also prevent cross-contamination completely.
      The processing method of this invention is performed in the following manner. Biopolymers, microorganisms or substances are bound to magnetic particles by using a pipette tip removably mounted to the front end of a pipette nozzle of a transfer pipette to perform a purification process such as capturing of cells or dissolving of cell nuclei or protein to extract DNA and the like. The extracted DNA and the like are amplified as required and then particular DNA and the like are isolated by binding them, through the use of the pipette tip, to other magnetic particles that are coated with antibody, probe, biotin or streptavidin. Then, the isolated particular DNA and the like are assayed by chemiluminescence, fluorescence or coloring reaction.
    • 通过使用两种或更多种磁性颗粒的雅丁本发明可以自动一致执行的一系列过程,:如提取,分离或DNA的测量等处理所述的生物聚合物,微生物和物质,由组合使用的方法 至少两种或更多种磁性颗粒,因此可以防止交叉污染完全。 本发明的处理方法,在下面的方式进行。 生物聚合物,微生物或物质通过使用可拆卸地安装到移液管的吸移管嘴的前端的移液管尖端来执行纯化过程结合到磁性粒子:例如细胞的捕获或细胞核或蛋白质提取DNA的溶解和 等。 所提取的DNA等根据需要进行放大,然后特定DNA等被通过结合它们,通过使用移液管尖端的,到其他磁性粒子分离的涂覆有抗体一样,样品,生物素或链霉。 然后,分离的特定DNA和等通过化学发光,荧光或显色反应进行测定。