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31. 发明授权

EP0687501B1 Magnetic material separating method and device making use of a pipette device 失效
标题翻译：在使用中磁分离的方法和装置的移液管。
公开(公告)号：EP0687501B1
公开(公告)日：1998-09-09
申请号：EP95109144.6
申请日：1995-06-13
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： Tajima, Hideji
IPC分类号： G01N35/00 , G01N33/543 , B01L3/02
CPC分类号： B03C1/288 , B01L3/021 , B03C2201/18 , G01N21/76 , G01N33/54326 , G01N35/0098 , Y10S436/807 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/25375 , Y10T436/2575

32. 发明公开

EP0760478A2 Light obstruction device for microplates 失效
标题翻译：用于微板的光快门装置
公开(公告)号：EP0760478A2
公开(公告)日：1997-03-05
申请号：EP96113569.6
申请日：1996-08-23
申请人： IATRON LABORATORIES, INC. , PRECISION SYSTEM SCIENCE CO., LTD.
发明人： Tajima, Hideji , Nagaoka Nobuo , Ogasawara, Minoru , Tanaka, Mitsunao
IPC分类号： G01N21/76 , G01N21/25 , G01N35/02
CPC分类号： G01N35/028 , G01N21/255
摘要： A light-emission measuring apparatus which is capable of eliminating various secondary problems in addition to shutting off strong light from the external and preventing crosstalk. The light-emission measuring apparatus is equipped with a box-type carrier 9 having an open top surface and made to accommodate a microplate 7 comprising a plurality of wells. The box-type carrier is disposed to be movable horizontally. A light-obstruction plate having a light-receiving hole 11 is disposed above the box-type carrier to be movable vertically. The light-obstruction plate 5 is brought into tight contact with a circumference of the box-type carrier 9 to establish a black box when being moved downwardly. Further, the light-receiving hole 11 of the light-obstruction plate 5 has a cylindrical projecting bottom surface 12 so that its bottom surface side outer circumference comes into tight contact with a circumference 13 of an opening of a well top surface of the microplate 7.

33. 发明公开

EP2275821A1 Container 失效
标题翻译：容器
公开(公告)号：EP2275821A1
公开(公告)日：2011-01-19
申请号：EP10176863.8
申请日：1996-07-31
申请人： Precision System Science Co., Ltd
发明人： Tajima, Hideji
IPC分类号： G01N35/02 , G01N1/10 , G01N33/543 , G01N21/03 , G01N21/11 , G01N35/04 , G01N35/10
CPC分类号： B01L3/0275 , B01L3/5085 , G01N2035/0436 , G01N2035/1053
摘要： A container has a base member, and plural vessels arranged along a line or lines in the base member, wherein the plural vessels comprise the necessary number of vessels for treatment, vessels for measuring light being able to couple with an optical measuring apparatus or an optical receiving unit in a light shielded state, or hole parts holding it, vessels accommodating or hole parts holding a pipette tip, tubes for PCR or hole parts holding it, or, vessels being contained in the solid phase or hole parts holding it, according to the process. Thus, the process from beginning to the optical measurement can be completed by only one container.
摘要翻译：容器具有基部构件和多个容器，所述多个容器沿着基部构件中的一条或多条线排列，其中多个容器包括必要数量的用于治疗的容器，用于测量光的容器能够与光学测量装置或光学测量装置接收单元或保持它的孔部分，容纳或容纳移液管尖端的孔部分的容器，用于PCR的管或用于保持它的孔部分，或容纳在固相中的容器或容纳它的孔部分，根据该过程。因此，从开始到光学测量的过程只能由一个容器来完成。

34. 发明公开

EP2259070A2 Container 失效
标题翻译： Gefäss
公开(公告)号：EP2259070A2
公开(公告)日：2010-12-08
申请号：EP10176871.1
申请日：1996-07-31
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： Tajima, Hideji
IPC分类号： G01N35/02 , G01N1/10 , G01N33/543 , G01N21/03 , G01N21/11 , B01L3/00 , B01L3/02
CPC分类号： B01L3/0275 , B01L3/5085 , G01N2035/0436 , G01N2035/1053
摘要： It is an object of the present invention to provide a container which can execute a reliable work of dispensing and/or agitating on the occasion of aspirating and/or discharging a sample and/or a reagent in a container, by aspirating or discharging in a predetermined quantity without blockading the front end portion of the liquid sucking/discharging line. It is another object of the present invention to provide a container having a simple structure which can realize a high precision inspection for all of the quantity by aspirating all of the quantity in the container, by being capable of discharging all of the quantity in the container without necessity of the surplus of the samples and/or reagents and by treating all of the quantity as a fixed quantity.
The present invention is a container comprising a gap part formed to have a smaller width than a caliber of a front end portion of a liquid sucking/discharging line adapted to be inserted therein and pulled out thereof, at an inside bottom part thereof. The gap part is formed to be a shape being capable of aspirating and discharging all of the quantity of liquid through the front end portion even in a state that the front end portion is disposed in contact with the inside bottom part. On the occasion of discharging, the container is formed so that reaction between a sample and a reagent can be uniformed by discharging and diffusing aspirated liquid.
摘要翻译：本发明的目的是提供一种容器，其能够在吸入和/或排出容器中的样品和/或试剂的情况下通过吸入或排出在罐中进行抽吸或排出来执行分配和/或搅拌的可靠工作而不堵塞液体吸入/排出管线的前端部分。本发明的另一个目的是提供一种具有简单结构的容器，其能够通过吸出容器中的所有数量来实现所有量的高精度检查，通过能够排出容器中的所有数量不需要剩余的样品和/或试剂，并且将所有数量作为固定量处理。本发明是一种容器，其包括间隙部分，其形成为具有比其插入其中并被拉出的液体吸入/排出管线的前端部分的口径的宽度小的内部底部部分。间隙部分形成为即使在前端部与内底部接触的状态下也能够通过前端部吸引和排出全部液体的形状。在排出时，形成容器，使得样品和试剂之间的反应可以通过排出和扩散吸入的液体而均匀化。

35. 发明授权

EP1256808B1 CONTAINER TRANSFER AND PROCESSING SYSTEM 无效
标题翻译：集装箱中转和处理系统
公开(公告)号：EP1256808B1
公开(公告)日：2007-09-05
申请号：EP01900785.5
申请日：2001-01-16
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, Hideji
IPC分类号： G01N35/04 , B01L3/00 , B01L11/00 , G01N35/00 , G01N35/02 , B01L7/00 , G01F23/30 , G01F23/68
CPC分类号： B01L9/543 , G01N35/0099 , G01N35/028 , G01N35/04 , G01N35/1074 , G01N2035/0425 , G01N2035/0441 , G01N2035/0444 , Y10T436/113332
摘要： A container transfer and processing system, comprising a simultaneous transfer means capable of simultaneously feeding a specified quantity of plate-shaped containers each having specified quantity of storage parts or a specified quantity of chip plaques each storing specified quantity of pipet chips along a specified route, a container working device performing various types of works for the containers in the route, contents therein, or the containers out of the route or the contents thereof, an individual transfer means capable of individually transferring the containers or chip plaques between any positions in the area including the route of the simultaneous transfer means and the container mounting position on the container working device, and a control part performing the transfer of both transfer means and the control of the operation of the container working device.

36. 发明授权

EP0763739B1 METHOD AND APPARATUS FOR LIQUID TREATMENT UTILIZING DISPENSER 失效
标题翻译：方法和设备流体处理由分发手段
公开(公告)号：EP0763739B1
公开(公告)日：2005-06-01
申请号：EP96906085.4
申请日：1996-03-19
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, Hideji, Precision System Science Co., Ltd.
IPC分类号： G01N33/543 , G01N33/553 , G01N35/10
CPC分类号： G01N35/1065 , B01L3/0275 , B01L3/0279 , B01L7/52 , B01L2300/0681 , B01L2300/087 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N35/0098 , G01N35/10 , G01N35/1079 , G01N2035/0405 , G01N2035/103 , G01N2035/1053 , G01N2035/1055

37. 发明公开

EP1512369A1 PORTABLE TERMINAL DEVICE AND LIFE STYLE-RELATED DISEASE PATIENT-MEDICAL INSTITUTION COOPERATION SYSTEM 审中-公开
标题翻译：便携式终端设备及系统医学研究所和病人之间的合作，生活方式相关疾病
公开(公告)号：EP1512369A1
公开(公告)日：2005-03-09
申请号：EP03733314.3
申请日：2003-06-06
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, Hideji, Precision System Science Co., Ltd.
IPC分类号： A61B5/00 , A61B5/22 , G06F17/60 , H04M1/00
CPC分类号： G06Q50/22 , A61B5/0002 , G06F19/00 , G06F19/324 , G06F19/3418 , G06F19/3475 , G06F19/3481 , G06Q10/10 , G16H10/40 , G16H10/60 , G16H15/00 , G16H40/63
摘要： There is provided a portable terminal device, and a lifestyle-related disease patient - medical institution cooperation system, which collects a user's biological data and life data, so that it is possible to quickly receive advice from a specialist, and data accumulation and analysis over a long period is possible, to accurately comprehend deviations in lifestyle habits and the life of a patient, and to give a highly reliable medical service.
The invention is a terminal device which can be carried by the user, comprising: a measuring unit which measures the user's in-vivo substance so as to obtain biological data; an input unit which can input life data including at least the user's food intake contents; a data storage unit which readably stores basic data including the biological data and the life data, and a display unit which displays the data.
摘要翻译：提供了一种便携式终端设备，以及生活习惯病的患者 - 医疗机构合作系统，收集用户的生物数据和寿命数据，所以也有可能从一个专家迅速获得建议和数据的积累和分析过长时间是可能的，准确地设置在生活习惯和病人的生活理解的偏差，并给予高度可靠的医疗服务。本发明是可以由用户携带，其包括终端设备：测量单元，其测量用户的生物体内物质，以便获得生物数据; 与可在用户的食物摄取内容的输入数据寿命包括至少输入单元; 数据存储单元，其存储可读基本数据包括生物数据和所述寿命数据;以及显示单元，其显示所述数据。

38. 发明公开

EP1371965A1 SMALL OBJECT IDENTIFYING DEVICE AND ITS IDENTIFYING METHOD 有权
标题翻译： EINRICHTUNG ZUM IDENTIFIZIEREN KLEINER OBJEKTE UND IDENTIFIZIERUNGSVERFAHREN
公开(公告)号：EP1371965A1
公开(公告)日：2003-12-17
申请号：EP02711227.5
申请日：2002-01-25
申请人： PRECISION SYSTEM SCIENCE CO., LTD. , The Furukawa Electric Co., Ltd. , Fi-Techno Co., Ltd.
发明人： NOGUCHI, Masahisa c/o FI-Techno Co., Ltd. , TSUKII, Ken c/o The Furukawa Electric Co., Ltd. , TAJIMA, Hideji Precision System Science Co., Ltd.
IPC分类号： G01N15/14 , G01N37/00 , G01N21/64 , G01N21/78 , G01N33/543
CPC分类号： G01N15/1456 , G01N2015/1488 , G01N2015/1497
摘要： In relation to a small object identifying device and its identifying method, there is provided a small object identifying device and its identifying method which can identify easily, reliably and efficiently a large number of small objects from several tens, to several hundreds, to several thousands, to more than several tens of thousands, without stopping in the case of identifying several kinds of small objects.
This has a construction comprising: a dispersion step for dispersing a large quantity of several kinds of small objects labeled by a combination of the presence/absence or measure of label elements of several kinds; a measuring step for distributing and associating kinds of the label elements to two or more measurement points, and measuring the presence/absence or the measure of the label elements of the kinds which have been associated with respective measurement points, for each of the dispersed small objects, at respective measurement points having a relative temporal relationship between measurement points; and an identifying step for associating the measurement results measured at each measurement point, based on the temporal relationship and a positional relationship between the measurement points to thereby identify the small objects.
摘要翻译：关于小对象识别装置及其识别方法，提供了一种小对象识别装置及其识别方法，其可以容易地，可靠地和有效地识别从数十到数百到数千个的小型对象在几个小物体识别的情况下，不得停止。这种结构包括：分散步骤，用于分散由几种标签元素的存在/不存在或测量的组合标记的大量几种小物体; 测量步骤，用于将标签元素的种类分配和关联到两个或更多个测量点，并且测量与各个测量点相关联的种类的标签元素的存在/不存在或测量，对于每个分散的小在各测量点处具有测量点之间的相对时间关系; 以及识别步骤，用于根据时间关系和测量点之间的位置关系来关联在每个测量点处测量的测量结果，从而识别小物体。

39. 发明公开

EP1162444A1 CONCENTRATION DEVICE USING MAGNETIC PARTICLES AND METHOD THEREFOR 审中-公开
标题翻译：设备用于专注度提高了其使用磁性粒子及其方法
公开(公告)号：EP1162444A1
公开(公告)日：2001-12-12
申请号：EP00900434.2
申请日：2000-01-18
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, Hideji, Precision System Science Co., Ltd.
IPC分类号： G01N1/28 , G01N1/00 , G01N30/00 , G01N30/48 , B03C1/00 , C12Q1/68
CPC分类号： G01N1/40 , B03C1/28 , B03C1/288 , G01N35/0098 , Y10T436/25375
摘要： The invention relates to a concentration device using magnetic particles and a method therefor aimed at performing concentration of a large volume of liquid efficiently and reliably with a simple structure and on a small device scale. The construction involves having: a liquid suction passage in which liquid can pass through only in a suction direction; a liquid discharge passage in which liquid can pass through only in a discharge direction; a magnetic force device which can exert a magnetic field from outside of the liquid passage on at least one liquid passage thereof or remove the magnetic field, and which can separate magnetic particles having directly or indirectly captured a target substance suspended in the liquid by having the magnetic particles adhere to the inner wall of the liquid passage; a storage section communicated with each liquid passage, for storing the sucked liquid; and a pressure adjustment device for sucking and discharging the liquid by adjusting the pressure in the storage section.
摘要翻译：本发明利用在以简单的结构和小规模设备上高效且可靠地进行大体积的液体的浓度为此针对磁性颗粒和方法涉及一种浓缩装置。该构造涉及具有：其中的液体的液体吸入通道可以通过只在吸引方向; 在其中的液体的液体排出通道可以穿过仅在排出方向; 磁力装置，其可以从液体通道的外部上的至少一个液体通道施加磁场或其除去磁场，并且其可以分离磁性粒子具有由具有直接或间接地捕捉悬浮在液体中的目标物质磁性颗粒附着于液体通道的内壁; 与每个液体通道连通，用于存储所吸入的液体的存储部分; 和用于抽吸并通过调节在所述存储部分中的压力排出所述液体的压力调整装置。

40. 发明公开

EP0885958A1 METHOD FOR TREATING BIOPOLYMERS, MICROORGANISMS OR MATERIALS BY USING MORE THAN ONE TYPE OF MAGNETIC PARTICLES 失效
标题翻译：生物聚合物的处理方法，微生物或其他材料不止一种类型的磁性粒子的使用。
公开(公告)号：EP0885958A1
公开(公告)日：1998-12-23
申请号：EP97903600.1
申请日：1997-02-24
申请人： PRECISION SYSTEM SCIENCE CO., LTD.
发明人： TAJIMA, Hideji-Precision System Science Co., Ltd.
IPC分类号： C12N15/10 , C12Q1/02 , C12Q1/68 , C12Q1/70 , G01N33/53 , B03C1/015 , C12N13/00
CPC分类号： C12N15/1013 , C12Q1/6834 , G01N33/54333 , Y10S435/82
摘要： The method of processing biopolymers, microorganisms and substances by using two or more kinds of magnetic particles according to this invention can automatically and consistently perform a series of processes, such as extraction, isolation or measurement of DNA and the like, by a combined use of at least two or more kinds of magnetic particles and can also prevent cross-contamination completely.
The processing method of this invention is performed in the following manner. Biopolymers, microorganisms or substances are bound to magnetic particles by using a pipette tip removably mounted to the front end of a pipette nozzle of a transfer pipette to perform a purification process such as capturing of cells or dissolving of cell nuclei or protein to extract DNA and the like. The extracted DNA and the like are amplified as required and then particular DNA and the like are isolated by binding them, through the use of the pipette tip, to other magnetic particles that are coated with antibody, probe, biotin or streptavidin. Then, the isolated particular DNA and the like are assayed by chemiluminescence, fluorescence or coloring reaction.
摘要翻译：通过使用两种或更多种磁性颗粒的雅丁本发明可以自动一致执行的一系列过程，：如提取，分离或DNA的测量等处理所述的生物聚合物，微生物和物质，由组合使用的方法至少两种或更多种磁性颗粒，因此可以防止交叉污染完全。本发明的处理方法，在下面的方式进行。生物聚合物，微生物或物质通过使用可拆卸地安装到移液管的吸移管嘴的前端的移液管尖端来执行纯化过程结合到磁性粒子：例如细胞的捕获或细胞核或蛋白质提取DNA的溶解和等。所提取的DNA等根据需要进行放大，然后特定DNA等被通过结合它们，通过使用移液管尖端的，到其他磁性粒子分离的涂覆有抗体一样，样品，生物素或链霉。然后，分离的特定DNA和等通过化学发光，荧光或显色反应进行测定。

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