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21. 发明授权

EP2274027B1 PROCEDE DE FABRICATION D'UN DISPOSITIF D'EJECTION JETABLE 有权
标题翻译：方法制造注射装置ENWEG-
公开(公告)号：EP2274027B1
公开(公告)日：2017-01-18
申请号：EP09730853.0
申请日：2009-04-08
申请人： Primequal S.A.
发明人： WEILL, David , CHASSOT, Pierre-Yves
IPC分类号： A61M5/178 , A61M5/315 , A61M5/50 , A61M5/24
CPC分类号： A61M5/31581 , A61C5/62 , A61M5/1782 , A61M5/24 , A61M5/3129 , A61M5/3148 , A61M5/31526 , A61M5/31595 , A61M5/502 , A61M2005/2407 , A61M2005/2492 , A61M2005/3114 , A61M2005/341 , Y10T29/49826 , Y10T29/53

22. 发明公开

EP3021901A1 DRIVE MECHANISM 审中-公开
标题翻译：驱动机制
公开(公告)号：EP3021901A1
公开(公告)日：2016-05-25
申请号：EP14750324.7
申请日：2014-07-17
申请人： SANOFI
发明人： OAKLEY, Tom , SCHUMANN, Matt , PAWULSKI, Mark
IPC分类号： A61M5/20 , A61M5/315
CPC分类号： A61M5/31526 , A61M5/20 , A61M5/31535 , A61M5/31536 , A61M5/31551 , A61M5/31553 , A61M5/31558 , A61M5/31563 , A61M5/31578 , A61M5/31583 , A61M2005/3126
摘要： A drive mechanism (11) for a delivery device comprising —a drive member (17) for driving a piston rod (13); —a moveable dose setting member (19, 35) being decoupled from the drive member (17) in a dose setting state; the dose setting member (19, 35) being moveable in a drive direction in a dose delivery state, wherein the movement of the dose setting member (19, 35) is transferred to the drive member (17); and —a dose control means (49) being coupled to the dose setting member (19, 35) by a rack-and-pinion means (51, 67) in such a manner that the movement of the dose setting member (19, 35) is transferred to a movement of the dose control means (49), wherein the movement of the dose setting member (19, 35) is stopped when the dose control means (49) reaches an end position.
摘要翻译：一种用于输送装置的驱动机构（11），包括：用于驱动活塞杆（13）的驱动构件（17） - 在剂量设定状态下，可移动剂量设定构件（19,35）与驱动构件（17）分离; 所述剂量设定构件（19,35）在剂量输送状态下沿驱动方向可移动，其中所述剂量设定构件（19,35）的所述移动被传递至所述驱动构件（17）; 以及 - 剂量控制装置（49），其通过齿条 - 齿轮装置（51,67）以这样的方式联接到剂量设定构件（19,35），使得剂量设定构件（19,35 ）转移到剂量控制装置（49）的运动，其中剂量设定构件（19,35）的运动在剂量控制装置（49）到达终点位置时停止。

23. 发明公开

EP2950858A1 DOSING INJECTOR 审中-公开
标题翻译：配量注射器
公开(公告)号：EP2950858A1
公开(公告)日：2015-12-09
申请号：EP14703749.3
申请日：2014-01-29
申请人： ALLERGAN, INC.
发明人： FRANKLIN, Ethan
IPC分类号： A61M5/315
CPC分类号： A61M5/31526 , A61M5/31581 , A61M5/31595 , A61M2005/31508
摘要： A metered dose syringe includes a barrel having an open end and a opposing spaced apart port adapted to receive a needle. A plunger rod is provided and slidably disposed within the barrel through the barrel open end. Structure interconnected with the barrel and the plunger rod is provided for enabling stepwise movement of the plunger rod within the barrel. A syringe within the scope of our present invention permits injection of repeated and accurate doses due to the physical stops or dosage administered indicators.
摘要翻译：定量剂量注射器包括具有开口端和适于接收针的相对的间隔开端口的针筒。柱塞杆设置并且可滑动地设置在筒内通过筒开口端。提供与筒和柱塞杆相互连接的结构，用于使柱塞杆能够在筒内逐步移动。在我们的本发明范围内的注射器由于物理停止或剂量给予指示剂而允许注射重复的和精确的剂量。

24. 发明授权

EP1944050B1 Improvements in and relating to drive mechanisms suitable for use in drug delivery devices 有权转让
标题翻译：改进和与适用于药物输送装置中使用的驱动装置连接
公开(公告)号：EP1944050B1
公开(公告)日：2015-07-08
申请号：EP08006911.5
申请日：2004-03-03
申请人： DCA Design International Limited
发明人： Veasey, Robert Frederick , Langley, Christopher Nigel , Wimpenny, Steven
IPC分类号： A61M5/315 , A61M5/24 , A61M5/32
CPC分类号： A61M5/31528 , A61M5/24 , A61M5/2422 , A61M5/31501 , A61M5/31511 , A61M5/31526 , A61M5/31533 , A61M5/31541 , A61M5/3155 , A61M5/31551 , A61M5/3156 , A61M5/31583 , A61M5/31585 , A61M5/31593 , A61M2205/581 , A61M2205/582
摘要： The invention relates to a drive mechanism for use in a drug delivery device for dispensing a medicinal product comprising: a housing (154) having an external thread (150); a piston rod (20") having a generally circular section; a dose dial sleeve (70"'), which is threadedly engaged with the external thread (150) of the housing (154) and being rotatable with respect to the housing (154); a drive sleeve (30'), located between the housing (154) and the piston rod (20"), a clutch means (60"") located between the drive sleeve (30') and the dose dial sleeve (70"'), in which e) when the dose dial sleeve (70"') and the drive sleeve (30') are de-coupled by the said clutch means (60""), rotation of said dose dial sleeve (70"') with respect to the said drive sleeve (30') is allowed; and f) when the dose dial sleeve (70"') and drive sleeve (30') are coupled by the said clutch means (60""), rotation of the dose dial sleeve (70"') with respect to the said drive sleeve (30') is prevented, A nut (40') is located between the drive sleeve (30') and the housing (154), the nut (40') having a thread that is engaged with a thread of the drive sleeve (30') and the nut (40') and the housing (154) being keyed together by means of longitudinally directed splines to prevent rotation between the nut (40') and the housing (154) while allowing relative longitudinal movement therebetween.

25. 发明公开

EP2821089A1 Syringe with alternatively selectable graduations 有权转让
标题翻译： Spritze mit alternativwählbarenAbstufungen
公开(公告)号：EP2821089A1
公开(公告)日：2015-01-07
申请号：EP14175061.2
申请日：2014-06-30
申请人： VLOW Medical B.V.
发明人： Verhoeven, Franciscus Maria , van den Houdt, Andreas Adrianus Lambertus , de Beer, Angelinus Quirinus Maria
IPC分类号： A61M5/315 , A61M5/31
CPC分类号： A61M5/3135 , A61M5/31505 , A61M5/31526 , A61M5/31536 , A61M5/31568 , A61M5/31573 , A61M5/31581 , A61M5/31595 , A61M2005/3126 , A61M2005/31508
摘要： A syringe (100) having a longitudinal axis (L), comprising:
- a barrel assembly (200) including:
- a barrel (210), extending longitudinally between a proximal end (212a) and a distal end (212b),
- a collar (220), provided at the proximal end (212a) of the barrel (210), and defining a reading window (226);

- a plunger (300) including:
- a longitudinally extending graduation portion (320) that is at least partially longitudinally slidably received in the barrel (210), and that provides for at least two mutually different visually readable graduations (324), which respective graduations extend along the longitudinal axis (L) and are alternatively selectable by rotation of the graduation portion around the longitudinal axis, such that a selected graduation (324) is visible through the reading window (226) when the plunger (300) is slid into and out of the barrel (210) during use.
摘要翻译：一种具有纵向轴线（L）的注射器（100），包括： - 枪管组件（200），其包括： - 在近端（212a）和远端（212b）之间纵向延伸的枪管（210）， - 设置在所述筒体（210）的近端（212a）处的凸缘（220），并且限定读取窗口（226）; - 柱塞（300），包括： - 纵向延伸的刻度部分（320），其至少部分地纵向可滑动地容纳在所述筒体（210）中，并且提供至少两个彼此不同的视觉可读刻度（324）刻度沿着纵向轴线（L）延伸，并且可选地通过刻度部分围绕纵向轴线的旋转来选择，使得当柱塞（300）被滑入时通过读取窗口（226）可见的所选择的刻度（324）并在使用过程中离开枪管（210）。

26. 发明公开

EP2817045A1 AN END OF DOSE INDICATOR 有权
标题翻译： END剂量显示技术
公开(公告)号：EP2817045A1
公开(公告)日：2014-12-31
申请号：EP13702468.3
申请日：2013-02-01
申请人： Novo Nordisk A/S
发明人： KIILERICH, Ebbe
IPC分类号： A61M5/315
CPC分类号： A61M5/5086 , A61M5/20 , A61M5/31526 , A61M5/31528 , A61M5/31535 , A61M5/3157 , A61M5/3158 , A61M5/486 , A61M2205/123 , A61M2205/581 , A61M2205/582
摘要： The present invention relates to a medical delivery apparatus which comprises a hollow container (2) filled with a liquid drug (3). The container (2) is closed at its distal end by a pierceable membrane (4) and provided with a plunger at its proximal open. Whenever a piston rod (20) moves the plunger (5) forward inside the container, a pressure is build up in the liquid drug (3) contained in the container (2). Further, a resilient element (33),such as a spring, is provided. This resilient element (33) can be activated to operate from a relaxed state to a tensed state upon activation of a dose injection mechanism during injection. The resilient element (33) is operated to its tensed state when during injection, the pressure is build up in the liquid drug (3) and secured in its tensed state as long as the pressure inside the container (2) is above a predetermined threshold value. When the pressure in the liquid drug (3) decreases below the predetermined threshold value, the tensed spring will operate into its relaxed state thereby providing an audible and/or tactile indication to the user that the pressure in the liquid drug (3) contained in the container (2) is below the predetermined threshold value.

27. 发明公开

EP2788054A1 ACCURATE DOSE CONTROL MECHANISMS AND DRUG DELIVERY SYRINGES 有权
标题翻译：机械师祖尔格兰德·德里奇（SPRITZE ZUR MEDIKAMENTENVERABREICHUNG）
公开(公告)号：EP2788054A1
公开(公告)日：2014-10-15
申请号：EP12809422.4
申请日：2012-12-06
申请人： Unitract Syringe Pty Ltd
发明人： SHETTY, Gautam N. , CASTAGNA, Lou
IPC分类号： A61M5/28 , A61M5/315
CPC分类号： A61M5/31526 , A61M5/28 , A61M5/31528 , A61M5/31575 , A61M5/31585 , A61M2005/3139 , A61M2005/3152 , F04C2270/041 , Y10T29/49826
摘要： A dose control mechanism for a syringe includes a plunger having a coarse pitch screw on its exterior surface, a housing having a corresponding coarse pitch guide along the interior surface of the housing, a screw having a fine pitch screw which interfaces with a fine pitch nut of an adapter, wherein the plunger has an internal annular space within which screw at least partially resides. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle. The syringe may be a fill-at-time-of-use syringe, a pre-filled syringe, or a safety syringe having integrated needle retraction or needle sheathing safety features, or a combination thereof. Methods of assembly, manufacturing, and operation are similarly disclosed.
摘要翻译：用于注射器的剂量控制机构包括在其外表面上具有粗螺旋螺杆的柱塞，具有沿着壳体内表面的相应的粗间距导向件的壳体，具有细间距螺钉的螺钉，其与细间距螺母的适配器，其中所述柱塞具有内部环形空间，螺杆至少部分地位于所述内部环形空间中。精确剂量的药物输送注射器包括这样的剂量控制机构，筒体，柱塞密封件和具有筒尖和针头的筒适配器组件。注射器可以是使用时间不长的注射器，预填充注射器或具有整体针回缩或针头护套安全特征的安全注射器，或其组合。类似地公开了组装，制造和操作的方法。

28. 发明公开

EP2221077A3 Improvements in and relating to a pen-type injector and method for assembling same 有权转让
标题翻译： Verbesserter Pen-Injektor和Fertigungsmethode
公开(公告)号：EP2221077A3
公开(公告)日：2013-03-13
申请号：EP10005508.6
申请日：2004-03-03
申请人： DCA Design International Limited
发明人： Veasey, Robert, Frederick , Langley, Christopher, Nigel , Wimpenny, Steven
IPC分类号： A61M5/315 , A61M5/24 , A61M5/32
CPC分类号： A61M5/31528 , A61M5/24 , A61M5/2422 , A61M5/31501 , A61M5/31511 , A61M5/31526 , A61M5/31533 , A61M5/31541 , A61M5/3155 , A61M5/31551 , A61M5/3156 , A61M5/31583 , A61M5/31585 , A61M5/31593 , A61M2205/581 , A61M2205/582
摘要： The invention relates to a pen-type injector comprising a housing (2, 2', 2", 2"'); a piston rod (32, 32', 32") having a screw thread; an insert (14, 14', 14"') located in the housing (2, 2', 2", 2"') and through which the piston rod (32, 32', 32") may rotate; a dose dial sleeve (50, 50', 50", 50"') rotatable with respect to the housing and the insert; and a drive sleeve (60, 60', 60") which is axially displaceable with respect to the housing. The maximum angular displacement of the dose dial sleeve with respect to the housing is determined by abutment of a radially directed lug (100) on the dose dial sleeve (50, 50', 50", 50"') with a catch means (102) on the insert (14, 14', 14"'). The invention relates to a method for assembling a pen-type injector, too.
摘要翻译：本发明涉及一种用于药物输送装置用于分配医药产品的驱动机构，包括：具有外螺纹（150）的壳体（154）; 具有大致圆形截面的活塞杆（20“）;与所述壳体（154）的外螺纹（150）螺纹接合且能够相对于壳体（154）旋转的剂量拨片套筒（70”'））; 位于所述壳体（154）和所述活塞杆（20“）之间的驱动套筒（30'），位于所述驱动套筒（30'）和所述剂量拨号套筒（70”）之间的离合器装置（60“ ），其中e）当所述剂量拨盘套筒（70“'）和所述驱动套筒（30'）通过所述离合器装置（60”）解耦时，所述剂量拨号套筒（70“'）的旋转相对于所述驱动套筒（30'）被允许; 以及f）当所述剂量拨盘套筒（70“'）和驱动套筒（30'）通过所述离合器装置（60”）联接时，剂量拨片套筒（70“'）相对于所述驱动器防止套筒（30'），螺母（40'）位于驱动套筒（30'）和壳体（154）之间，螺母（40'）具有与驱动套筒（30'）和螺母（40'）和壳体（154）通过纵向定向的花键键合在一起，以防止螺母（40'）和壳体（154）之间的旋转，同时允许它们之间的相对纵向运动。

29. 发明授权

EP1601397B1 IMPROVEMENTS IN AND RELATING TO DRIVE MECHANISMS SUITABLE FOR USE IN DRUG DELIVERY DEVICES 有权转让
标题翻译：改进驱动机构与管理器件中的应用
公开(公告)号：EP1601397B1
公开(公告)日：2008-08-20
申请号：EP04716595.6
申请日：2004-03-03
申请人： DCA Design International Limited
发明人： VEASEY, Robert, Frederick , LANGLEY, Christopher Nigel , WIMPENNY, Steven
IPC分类号： A61M5/315 , A61M5/24 , A61M5/32
CPC分类号： A61M5/31528 , A61M5/24 , A61M5/2422 , A61M5/31501 , A61M5/31511 , A61M5/31526 , A61M5/31533 , A61M5/31541 , A61M5/3155 , A61M5/31551 , A61M5/3156 , A61M5/31583 , A61M5/31585 , A61M5/31593 , A61M2205/581 , A61M2205/582
摘要： The invention relates to a drive mechanism for use in a drug delivery device for dispensing a medicinal product comprising: a housing (154) having an external thread (150); a piston rod (20") having a generally circular section; a dose dial sleeve (70"'), which is threadedly engaged with the external thread (150) of the housing (154) and being rotatable with respect to the housing (154); a drive sleeve (30'), located between the housing (154) and the piston rod (20"), a clutch means (60"") located between the drive sleeve (30') and the dose dial sleeve (70"'), in which e) when the dose dial sleeve (70"') and the drive sleeve (30') are de-coupled by the said clutch means (60""), rotation of said dose dial sleeve (70"') with respect to the said drive sleeve (30') is allowed; and f) when the dose dial sleeve (70"') and drive sleeve (30') are coupled by the said clutch means (60""), rotation of the dose dial sleeve (70"') with respect to the said drive sleeve (30') is prevented, A nut (40') is located between the drive sleeve (30') and the housing (154), the nut (40') having a thread that is engaged with a thread of the drive sleeve (30') and the nut (40') and the housing (154) being keyed together by means of longitudinally directed splines to prevent rotation between the nut (40') and the housing (154) while allowing relative longitudinal movement therebetween.

30. 发明公开

EP1909870A1 DOSE MECHANISM FOR AN INJECTION DEVICE FOR LIMITING A DOSE SETTING CORRESPONDING TO THE AMOUNT OF MEDICAMENT LEFT 有权
标题翻译：剂量机构一起用于注射装置用于限制调整剂量根据余量药物
公开(公告)号：EP1909870A1
公开(公告)日：2008-04-16
申请号：EP06754730.7
申请日：2006-07-17
申请人： Novo Nordisk A/S
发明人： ENGGAARD, Christian, Peter , MØLLER, Claus, Schmidt , MARKUSSEN, Tom, Hede
IPC分类号： A61M5/315
CPC分类号： A61M5/31551 , A61M5/20 , A61M5/31505 , A61M5/31526 , A61M5/31528 , A61M5/31541 , A61M5/31553 , A61M5/3156 , A61M5/31571 , A61M5/31583 , A61M5/31586 , A61M5/31593 , A61M2005/202 , A61M2005/3151
摘要： A mechanism for preventing setting of a dose, which exceeds the amount of a medicament in a reservoir in an injection device. The device comprises a threaded piston rod, a limiter and a driver. The three elements are arranged such that during dose setting, the limiter is moved towards an end-of-contend position, wherein dose setting is limited. The invention comprises an accumulative and a non-accumulative embodiment. The invention further relates to a mechanism for prevention ejection of a dose exceeding the set dose.
摘要翻译：甲机构，用于防止剂量，超过的药物中的量在贮存器中的注射装置的设置。该装置包括一个带螺纹的活塞杆，一个限幅器和驱动器。这三个元件被布置在剂量设定期间搜索那样，限幅器被朝向在移动-的端抗衡位置，worin剂量设定是有限的。的累计本发明包括和非累积方式。本发明还涉及一种用于剂量超过所述设定剂量的预防喷出的机构。

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