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11. 发明授权

EP0181437B1 Process and apparatus for chemical analysis by liquid cromatography 失效
标题翻译：液相色谱法化学分析的方法和装置
公开(公告)号：EP0181437B1
公开(公告)日：1992-09-30
申请号：EP85109352.6
申请日：1985-07-25
申请人： CARLO ERBA STRUMENTAZIONE S.p.A.
发明人： Trisciani, Adriano , Carera, Rosolino
IPC分类号： G01N30/36 , G01N30/22
CPC分类号： G01N30/22 , Y10T436/255

12. 发明授权

EP3759382B1 SYSTEM AND VALVE FOR LIQUID CHROMATOGRAPHY 有权转让
公开(公告)号：EP3759382B1
公开(公告)日：2024-05-15
申请号：EP19757919.6
申请日：2019-02-22
IPC分类号： F16K11/074 , G01N30/20 , G01N30/22 , G01N30/32 , G01N30/36 , G01N30/38 , G01N30/34
CPC分类号： G01N30/20 , G01N30/32 , G01N2030/20120130101 , G01N2030/20220130101 , G01N2030/32820130101

13. 发明公开

EP4198508A1 CHROMATOGRAPHIC ANALYSIS WITH LOW PRESSURE DUAL GRADIENT REFOCUSING 审中-实审
公开(公告)号：EP4198508A1
公开(公告)日：2023-06-21
申请号：EP23156161.4
申请日：2017-09-26
申请人： Evosep ApS
发明人： VORM, Ole , BACHE, Nicolai
IPC分类号： G01N30/32 , G01N30/34 , G01N30/08 , G01N30/20 , G01N30/22 , B01D15/18 , B01D15/16 , G01N30/46 , G01N30/72
摘要： There is provided a system for separation of analytes in a solution. The system encompasses a cartridge or trapping column enclosing a sorbent for binding the analytes in the solution and a conduit establishing a fluid link to a valve having a holding-loop to achieve elution through the cartridge at low pressures. Prior to entry into the loop, the eluent is diluted or modified by a confluent flow stream. The valve is switchable to a position following the elution from the cartridge for emptying the holding loop through an outlet port at high pressures comparable to those required for chromatographic columns. The system may use parallel gradient formation/elution to stagger analyses so that essentially the only analytical phase that hinders a 100% duty cycle is the time required for moving the first analyte from the valve and to the detector.

14. 发明授权

EP3405273B1 SYSTEMS AND DEVICES ADDRESSING SOLVENT EXTRACTION PROBLEMS IN CHROMATOGRAPHY 有权
公开(公告)号：EP3405273B1
公开(公告)日：2021-10-13
申请号：EP17741908.2
申请日：2017-01-19
发明人： TARAFDER, Abhijit , IRANETA, Pamela, C.
IPC分类号： B01D17/12 , G01N1/34 , G01N35/04 , B01D15/14 , B01D15/18 , G01N30/22 , G01N30/24 , G01N30/20 , G01N30/08 , B01D15/12 , G01N30/34 , B01D15/40 , G01N30/06

15. 发明公开

EP3380462A1 METHODS FOR ANALYSIS AND RESOLUTION OF PREPARATIONS OF DIANHYDROGALACTITOL AND DERIVATIVES OR ANALOGS THEREOF 有权
公开(公告)号：EP3380462A1
公开(公告)日：2018-10-03
申请号：EP16869177.2
申请日：2016-11-22
申请人： Del Mar Pharmaceuticals (BC) Ltd.
发明人： XU, Qiang
IPC分类号： C07D303/14 , C07D301/02 , G01N30/22
CPC分类号： G01N30/22 , C07D303/14 , G01N30/30 , G01N30/7233 , G01N30/74 , G01N30/88 , G01N2030/027 , G01N2030/324 , G01N2030/8872
摘要： An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC employing a reverse phase amide column with ELSD detection; the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.

16. 发明公开

EP3365672A1 SYSTEMS, METHODS AND DEVICES FOR DECREASING SOLUBILITY PROBLEMS IN CHROMATOGRAPHY 有权
公开(公告)号：EP3365672A1
公开(公告)日：2018-08-29
申请号：EP16858096.7
申请日：2016-10-19
申请人： Waters Technologies Corporation
发明人： TARAFDER, Abhijit
IPC分类号： G01N30/16 , G01N30/20 , G01N30/22 , G01N30/38
CPC分类号： G01N30/06 , G01N30/20 , G01N30/88 , G01N2030/207
摘要： A significant reduction in extra-column band broadening can be achieved by decoupling the injection system from the main solvent flow line. In addition, by decoupling the injection system from the main solvent flow line, additional components (e.g., filters, valves, etc.) can be introduced into the chromatography system without increasing the negative band broadening effects. Systems and methods herein provide not only for such decoupling but also for filtering precipitates from the system. As a result, a larger volume of sample can be injected into the present systems without compromising separation yield. In addition, an increase the column loading per batch, an increase the overall yield of separations, and greater system efficiency (i.e., less time lost for cleaning and maintenance) can be realized.

17. 发明公开

EP3092483A4 MASS-SPECTROMETER SYSTEMS AND METHODS 有权
标题翻译： MASSENSPEKTROMETERSYSTEME UND VERFAHREN
公开(公告)号：EP3092483A4
公开(公告)日：2017-07-05
申请号：EP15735600
申请日：2015-01-09
申请人： PUREHONEY TECH INC
发明人： OZBAL CAN
IPC分类号： G01N30/06 , G01N30/20 , G01N30/22
CPC分类号： G01N33/6848 , G01N1/34 , G01N33/9446 , G01N35/1097 , G01N2001/4088
摘要： Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
摘要翻译：本公开的实施方式提出了用于使用质谱的自动化生物样品分析的新颖系统，装置和方法。在一些实施例中，从样本引入到数据报告的时间花费相对短的时间量（例如几分钟）。在一些实施方案中，待分析的生物样品是血液样品。对于许多应用来说，只有一滴血就足够了。通过使用具有独特分子量的标准混合物，可以在单个MS运行（例如）中执行目标分析物的定量分析，从而不需要创建和分析标准曲线。这种实施例的一个优点可以在于，系统，设备和方法可以消除批量创建的需要，因为可以消除创建和分析标准曲线的分摊时间和努力的要求。

18. 发明公开

EP3092483A1 MASS-SPECTROMETER SYSTEMS AND METHODS 有权
标题翻译： MASSENSPEKTROMETERSYSTEME UND VERFAHREN
公开(公告)号：EP3092483A1
公开(公告)日：2016-11-16
申请号：EP15735600.7
申请日：2015-01-09
申请人： Purehoney Technologies, Inc.
发明人： OZBAL, Can
IPC分类号： G01N30/06 , G01N30/20 , G01N30/22
CPC分类号： G01N33/6848 , G01N1/34 , G01N33/9446 , G01N35/1097 , G01N2001/4088
摘要： Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
摘要翻译：本公开的实施方案提出了使用质谱法进行自动化生物样品分析的新颖系统，装置和方法。在一些实施例中，从采样引入到数据报告的时间需要较短的时间（例如，几分钟）。在一些实施方案中，要分析的生物样品是血液样品。对于许多应用，只有一滴血可能就足够了。通过使用具有独特分子量的标准品的混合物，可以在单个MS运行（例如）中执行目标分析物的定量分析，从而无需创建和分析标准曲线。这样的实施例的一个优点可能在于，可以消除系统，设备和方法不需要批量创建，因为可以消除创建和分析标准曲线的时间和精力的分摊的要求。

19. 发明公开

EP3014262A1 COMPENSATION FOR CHROMATOGRAPHY COLUMN VOLUME VARIATIONS 有权
标题翻译： KOMPENSATIONFÜRVOLUMENVARIATIONEN EINERCHROMATOGRAFIESÄULE
公开(公告)号：EP3014262A1
公开(公告)日：2016-05-04
申请号：EP14814033.8
申请日：2014-06-17
申请人： Waters Technologies Corporation
发明人： GERHARDT, Geoff , GILAR, Martin , BUNNER, Bernard
IPC分类号： G01N30/02 , G01N30/22 , G01R35/00
CPC分类号： G01N30/8668 , G01N30/6095 , G01N30/8665 , G01N2030/027
摘要： Provided are systems and methods for adapting to volume variations in microfluidic chromatography columns. A column is calibrated by comparing a parameter of the column with a same parameter of a reference column and generating, by a processor, an adjustment factor in response to the comparison between the parameter of the column with a same parameter of the reference column. Volume differences between the calibrated column and the reference column are compensated for by integrating the generated adjustment factor into a sample separation involving the calibrated column.
摘要翻译：提供了适应微流体色谱柱体积变化的系统和方法。通过将列的参数与参考列的相同参数进行比较来校准列，并且响应于列的参数与参考列的相同参数之间的比较，由处理器生成调整因子。通过将生成的调整因子整合到涉及校准色谱柱的样品分离中来补偿校准色谱柱和参考色谱柱之间的体积差异。

20. 发明授权

EP2071327B1 Probengeber für die Hochleistungsflüssigkeitschromatographie 有权
标题翻译：自动进样器用于高性能液相色谱法
公开(公告)号：EP2071327B1
公开(公告)日：2016-02-10
申请号：EP08019968.0
申请日：2008-11-14
申请人： Dionex Softron GmbH
发明人： Hochgraeber, Hermann , Ruegenberg, Gervin
IPC分类号： G01N30/20 , G01N30/22 , G01N35/10
CPC分类号： G01N30/20 , G01N30/22 , G01N35/1097 , G01N2030/201 , G01N2030/202

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