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11. 发明授权

EP2893032B1 METHODS AND COMPOSITION FOR DETECTING INTESTINAL CELL-BARRIER DYSFUNCTION 有权转让
标题翻译：检测肠道细胞屏障功能障碍的方法和组合物
公开(公告)号：EP2893032B1
公开(公告)日：2018-01-17
申请号：EP13834474.2
申请日：2013-09-05
申请人： Maximus Diagnostic Technologies LLC
发明人： IRVIN, Randall, Thomas , LIU, Julia , DAVIS, Elisabeth, Melika
IPC分类号： C12Q1/37 , C07K14/81 , G01N33/573
CPC分类号： A61K49/0056 , A61B5/0068 , A61B5/0084 , A61K49/0041 , C07K14/8128 , G01N33/573 , G01N2333/96413 , G01N2333/96469 , G01N2800/065
摘要： Methods for detecting intestinal cell barrier dysfunction in a patient are disclosed. In one method, patient intestinal epithelial cells (IECs), oropharyngeal epithelial cells (OECs) or buccal epithelial cells (BECs) are stained with detectable probes specific against caspase-1 and caspase-3&7, and the cells are viewed for the presence of elevated levels of caspase-1, as evidence by a significantly higher ratio of caspase-1 marker to caspase-3&7, as an indicator of cell barrier dysfunction. In a second method, in situ images of a patient's IEC's, OECs or BECs are obtained by probe-based confocal laser endomicroscopy (pCLE), and images are analyzed for density of cell gaps. Also disclosed is a probe composition for use in detecting intestinal cell barrier dysfunction.

12. 发明公开

EP3255413A1 MEASUREMENT DEVICE 审中-公开
标题翻译：测量装置
公开(公告)号：EP3255413A1
公开(公告)日：2017-12-13
申请号：EP16746527.7
申请日：2016-01-29
申请人： Nitto Denko Corporation
发明人： IHARA, Terukazu , NISHIO, Hajime , HATAKEYAMA, Yoshiharu , YANO, Chiharu , NAKANO, Junko
IPC分类号： G01N21/41
CPC分类号： G01N21/554 , C12Y304/22065 , G01N21/41 , G01N33/54373 , G01N33/573 , G01N2333/96413
摘要： The present invention provides a measurement device which is compact and portable and is simply operated, and which is capable of quantifying the amount of an object to be inspected with high sensitivity and high accuracy. A measurement device of the present invention includes an SPR sensor cell, a light source, and a light receiving element. The SPR sensor cell includes a plurality of optical waveguides. At least one of the plurality of optical waveguides forms a detection unit together with a metal layer onto which a recognition substance for an object to be inspected is fixed, and at least another one of the plurality of optical waveguides forms a reference unit together with a metal layer free of the recognition substance.
摘要翻译：本发明提供一种小型且便携且操作简单，且能够高灵敏度且高精度地量化被检查物的量的测量装置。本发明的测量装置包括SPR传感器单元，光源和光接收元件。 SPR传感器单元包括多个光波导。多个光波导中的至少一个光波导与金属层一起形成检测单元，在该金属层上固定有用于被检查对象的识别物质，并且多个光波导中的至少另一个与参考单元一起形成参考单元不含识别物质的金属层。

13. 发明授权

EP2179053B1 BESTIMMUNG DER AKTIVITÄT VON PROTEASEN 有权
标题翻译： BESTIMMUNG DERAKTIVITÄTVON PROTEASEN
公开(公告)号：EP2179053B1
公开(公告)日：2017-06-07
申请号：EP08784292.8
申请日：2008-07-07
申请人： Papst Licensing GmbH & Co. KG
发明人： HOFER, Hans Werner , MEIER, Hans Jörg
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N2333/96413

14. 发明公开

EP2496942A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
标题翻译：方法和组合物诊断和预后肾损伤和肾功能衰竭的
公开(公告)号：EP2496942A1
公开(公告)日：2012-09-12
申请号：EP10829198.0
申请日：2010-11-05
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , G01N33/6893 , G01N2333/96413 , G01N2800/347 , G01N2800/56 , Y02A90/26
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cathepsin B, Renin, Dipeptidyl Peptidase IV, Neprilysin, Beta-2-microglobulin, Carbonic anhydrase IX, and C-X-C motif chemokine 2 as diagnostic and prognostic biomarkers in renal injuries.

15. 发明公开

EP2179053A2 BESTIMMUNG DER AKTIVITÄT VON PROTEASEN 有权
标题翻译： BESTIMMUNG DERAKTIVITÄTVON PROTEASEN
公开(公告)号：EP2179053A2
公开(公告)日：2010-04-28
申请号：EP08784292.8
申请日：2008-07-07
申请人： Papst Licensing GmbH & Co. KG
发明人： HOFER, Hans, Werner , MEIER, Hans, Jörg
IPC分类号： C12Q1/37 , C12M1/36
CPC分类号： C12Q1/37 , G01N2333/96413
摘要： A method and apparatuses for determining the total content of proteases by means of measuring their enzyme activity after previous deinhibition is disclosed. In biological samples, lysosomal proteases are completely (e.g. in blood serum) or partly (e.g. in tissue homogenates) inhibited. A method proposed for the deinhibition entails immersing a solid support material (e.g. nylon or nitrocellulose) as plastic strip to which is linked, covalently or by adsorption, an inhibitor-binding substance which binds the inhibitor corresponding to the protease more strongly than the protease in the sample for measurement. After the deinhibition has taken place, the plastic strip is removed from the liquid sample for measurement, and the sample for measurement is passed on for measurement of the enzyme activity. Fluorogenic substrates from which the fluorogen 7-amino-4-trifluoromethylcoumarin is eliminated proved to be particularly advantageous for the activity measurement. These substrates make it possible for the sensitivity on measurement in microtitre plates with a fluorescence reader to be at least 10 times higher compared with conventional AMC substrates in blood serum, and thus for the fluorimetric determination of such enzyme activities in blood serum to be efficient with this measuring arrangement which is widely used in clinical laboratories.
摘要翻译：提供了一种测定蛋白酶活性的方法。排除荧光素7-氨基-4-三氟甲基香豆素的荧光底物被证明对于活性测量是特别有利的。这些底物使得可以用荧光读数器在微量滴定板中进行测量，并因此用于荧光测定血清中的这些酶活性。

16. 发明公开

EP0948639A4 IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION 失效
标题翻译：细胞在急LEUKOZYTENZUBEREITUNG鉴定
公开(公告)号：EP0948639A4
公开(公告)日：2001-12-19
申请号：EP97913899
申请日：1997-10-29
申请人： COULTER INT CORP
发明人： KUYLEN NAZLE , CREWS HAROLD R , JAFFE GERALD E , BARCELON MARIA , LUCAS FRANCIS J , GARCIA NANCY M
IPC分类号： G01N33/48 , C12Q1/26 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/574 , G01N33/58 , C12Q1/00 , C12Q1/04 , C12Q1/42 , G01N15/14 , G01N21/64
CPC分类号： C12Q1/34 , C12Q1/26 , C12Q1/37 , G01N33/574 , G01N33/582 , G01N2333/95 , G01N2333/96413 , G01N2333/96466 , G01N2333/96469 , G01N2800/52
摘要： The necessity to detect blast cells in a patient sample to determine a treatment regime for leukemia has long been desired. The present invention relates to a method and assay reagents for identification of blast cells in a fluid sample. The method further enables the determination of the lineage of the blast cells. The new method provides a determination of blast cells in less time than prior art methods.

17. 发明授权

EP2977760B1 BIOMARKER FOR DIAGNOSING LIVER CANCER 有权
公开(公告)号：EP2977760B1
公开(公告)日：2018-05-30
申请号：EP14767707.4
申请日：2014-03-17
申请人： Seoul National University R&DB Foundation
发明人： KIM, Youngsoo , YOON, Junghwan , KIM, Hyunsoo , JIN, Jonghwa
IPC分类号： G01N33/574 , G01N33/53 , G01N33/48 , G01N33/50
CPC分类号： G01N33/57438 , G01N33/5079 , G01N2333/9015 , G01N2333/90206 , G01N2333/96413
摘要： The present invention relates to a biomarker for diagnosis or prognosis of liver cancer which is at least one member selected from the group consisting of ACADVL, ANLN, BASP1, MTHFD1, CAPN1, C4A, FLNB and PABPC1, and a measurement kit, a composition and a method which are for diagnosis or prognosis of liver cancer which include the same. The biomarker according to the present disclosure enables, with high accuracy and sensitivity, an early diagnosis of or monitoring of hepatocellular carcinoma and effective prognosis or assessment of progression of disease. In addition, simple and effective diagnosis of or monitoting of liver cancer is possible by noninvasive tests using blood, urine or the like, and thus the present invention will be very effective in the early detection of liver cancer at home or general clinic through a development of, for example, point of care testing (POCT).

18. 发明公开

EP3234177A1 ACTIVITY ASSAY FOR BOND FORMING ENZYMES 无效
标题翻译：活性测定法用于结合成形酶
公开(公告)号：EP3234177A1
公开(公告)日：2017-10-25
申请号：EP15813326.4
申请日：2015-12-14
申请人： F. Hoffmann-La Roche AG
发明人： BOENITZ-DULAT, Mara , KOPETZKI, Erhard , KRATZSCH, Peter , SCHATTE, Martin
IPC分类号： C12Q1/37
CPC分类号： G01N33/5302 , A61K38/00 , C12Q1/005 , C12Q1/37 , G01N2333/90 , G01N2333/96413
摘要： Herein is reported a method for the detection of a sortase in a sample, comprising the following steps: a) incubating the sample with a first substrate comprising an immobilization tag and a second substrate comprising a detectable label, whereby in the presence of a sortase in the sample a conjugate comprising the immobilization tag and the detectable label is formed, b) immobilizing the conjugate of step a) via/using the immobilization tag to a solid phase, c) detecting the immobilized conjugate via/using the detectable label and thereby detecting the sortase in the sample.
摘要翻译：本文报道了用于检测样品中分选酶的方法，其包括以下步骤：a）将样品与包含固定标签的第一底物和包含可检测标记物的第二底物温育，由此在分选酶存在形成包含固定标签和可检测标记物的缀合物的样品，b）通过/使用固定标签将步骤a）的缀合物固定到固相上，c）通过/使用可检测标记物检测固定缀合物，从而检测样本中的分拣机。

19. 发明公开

EP2977760A4 BIOMARKER FOR DIAGNOSING LIVER CANCER 有权
标题翻译：生物标志物诊断肝癌的研究
公开(公告)号：EP2977760A4
公开(公告)日：2017-02-15
申请号：EP14767707
申请日：2014-03-17
申请人： UNIV SEOUL NAT R & DB FOUND
发明人： KIM YOUNGSOO , YOON JUNGHWAN , KIM HYUNSOO , JIN JONGHWA
IPC分类号： G01N33/574 , G01N33/48 , G01N33/50 , G01N33/53
CPC分类号： G01N33/57438 , G01N33/5079 , G01N2333/9015 , G01N2333/90206 , G01N2333/96413
摘要： The present invention relates to a biomarker for diagnosis or prognosis of liver cancer which is at least one member selected from the group consisting of ACADVL, ANLN, BASP1, MTHFD1, CAPN1, C4A, FLNB and PABPC1, and a measurement kit, a composition and a method which are for diagnosis or prognosis of liver cancer which include the same. The biomarker according to the present disclosure enables, with high accuracy and sensitivity, an early diagnosis of or monitoring of hepatocellular carcinoma and effective prognosis or assessment of progression of disease. In addition, simple and effective diagnosis of or monitoting of liver cancer is possible by noninvasive tests using blood, urine or the like, and thus the present invention will be very effective in the early detection of liver cancer at home or general clinic through a development of, for example, point of care testing (POCT).

20. 发明公开

EP2893032A4 METHODS AND COMPOSITION FOR DETECTING INTESTINAL CELL-BARRIER DYSFUNCTION 有权转让
标题翻译：方法和组合物功能障碍肠屏障的检测
公开(公告)号：EP2893032A4
公开(公告)日：2016-08-10
申请号：EP13834474
申请日：2013-09-05
申请人： LIU JULIA
发明人： IRVIN RANDALL THOMAS , LIU JULIA , DAVIS ELISABETH MELIKA
IPC分类号： C12Q1/37 , C07K14/81 , G01N33/573
CPC分类号： A61K49/0056 , A61B5/0068 , A61B5/0084 , A61K49/0041 , C07K14/8128 , G01N33/573 , G01N2333/96413 , G01N2333/96469 , G01N2800/065
摘要： Methods for detecting intestinal cell barrier dysfunction in a patient are disclosed. In one method, patient intestinal epithelial cells (IECs), oropharyngeal epithelial cells (OECs) or buccal epithelial cells (BECs) are stained with detectable probes specific against caspase-1 and caspase-3&7, and the cells are viewed for the presence of elevated levels of caspase-1, as evidence by a significantly higher ratio of caspase-1 marker to caspase-3&7, as an indicator of cell barrier dysfunction. In a second method, in situ images of a patient's IEC's, OECs or BECs are obtained by probe-based confocal laser endomicroscopy (pCLE), and images are analyzed for density of cell gaps. Also disclosed is a probe composition for use in detecting intestinal cell barrier dysfunction.

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