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11. 发明公开

EP0242445A2 Dual laser excitation from single laser source 失效
标题翻译： Vorrichtung mit zwei aus einer einzigen Quelle stammendenLasererregungsbündeln。
公开(公告)号：EP0242445A2
公开(公告)日：1987-10-28
申请号：EP86117397.9
申请日：1986-12-13
申请人： Becton Dickinson and Company
发明人： Chupp, Vernon L.
IPC分类号： G01N15/14 , G01N21/64 , H01S3/13 , H01S3/23
CPC分类号： H01S3/2383 , G01N15/1427 , G01N21/53 , G01N21/6428 , G01N2015/1438 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , G01N2021/6421 , H01S3/0809 , H01S3/13 , H01S2301/08
摘要： A dual laser excitation apparatus comprises a first laser (12) for providing a first beam of light with a plurality of energy lines. A filter or wavelength disperser (18) is included for dividing the first beam of light into two portions. One of these portions of the light beam is spectrally separated and at least one separated line is directed to a first area of illumination (28). A second laser (29) is positioned to receive the other portion of the divided light beam and is adapted to be energized thereby. The second laser (29) produces a second beam of light directed to a second area of illumination (34). Such a dual laser excitation apparatus is well suited for flow cytometry purposes.
摘要翻译：双激光激发装置包括用于向多个能量线提供第一光束的第一激光器（12）。包括滤光器或波长分散器（18），用于将第一光束分成两部分。光束的这些部分中的一个被光谱分离，并且至少一个分开的线指向第一照明区域（28）。第二激光器（29）被定位成接收分割的光束的另一部分并且适于由此激励。第二激光器（29）产生指向第二照明区域（34）的第二光束。这种双激光激发装置非常适用于流式细胞术。

12. 发明公开

EP3240472A1 DEVICES AND METHODS FOR FRACTIONATED PHOTOACOUSTIC FLOW CYTOMETRY 有权
标题翻译：用于分级光声流动细胞计数的装置和方法
公开(公告)号：EP3240472A1
公开(公告)日：2017-11-08
申请号：EP15876378.9
申请日：2015-12-31
申请人： Bioventures, LLC.
发明人： ZHAROV, Vladimir Pavlovich
IPC分类号： A61B5/00 , A61B6/00 , A61B8/08
CPC分类号： A61B5/0095 , A61B8/4461 , A61B8/4477 , A61B2560/04 , A61B2562/0204 , G01N15/1056 , G01N15/1434 , G01N15/1459 , G01N15/1463 , G01N15/1475 , G01N2015/1006 , G01N2015/1438 , G01N2015/1477
摘要： A fractionated photoacoustic flow cytometry (PAFC) system and methods for the in vivo detection of target objects in biofluidic systems (e.g., blood, lymph, urine, or cerebrospinal fluid) of a living organism is described. The fractionated system includes a fractionated laser system, a fractionated optical system, a fractionated acoustic system, and combinations thereof. The fractionated laser system includes at least one laser or laser array for pulsing a target object within the circulatory vessel with fractionated focused laser beams. The fractionated optical system separates one or several laser beams into multiple beams in a spatial configuration on the skin above the circulatory vessel of the living organism. The fractionated acoustic system includes multiple focused ultrasound transducers for receiving photoacoustic signals emitted by the target object in response to the fractionated laser beams. The target objects have intrinsic photoacoustic contrast or may be labeled with photoswitchable or spaser-based probes. Fractioned beams may be used also for diagnostics with other spectroscopic methods (e.g., fluorescence, Raman or scattering) and energy sources both coherent and conventional such as lamp and LED in the broad spectral range from 10 Å to 1 cm (e.g., X-ray, UV, visible, NIR or microwaves) in continuous wave and pulse modes.

13. 发明公开

EP2724146A4 ABSORBANCE SPECTRUM SCANNING FLOW CYTOMETRY 有权转让
标题翻译：吸收光谱吸收流动细胞计数
公开(公告)号：EP2724146A4
公开(公告)日：2015-05-13
申请号：EP12803171
申请日：2012-05-31
申请人： BECTON DICKINSON CO
发明人： NORTON PIERCE O , CHEN YONG QIN
IPC分类号： G01N21/64 , G01N15/00 , G01N15/10 , G01N15/14
CPC分类号： G01N21/6428 , G01N15/1434 , G01N15/1436 , G01N15/1459 , G01N21/64 , G01N2015/0065 , G01N2015/1006 , G01N2015/1438 , G01N2015/1477 , G01N2021/6417 , G01N2021/6439 , G01N2201/06113 , G01N2201/0633 , G01N2201/068
摘要： The present invention provides systems and methods for analyzing the excitation spectra of fluorescent particles in a flowing stream. The system uses a white light laser and color separation optics to provide a spatially-distributed, continuous color-spectrum excitation light system that is used to illuminate a region of a flowing stream. A particle that passes through the detection region traverses the full dispersed spectrum of excitation light, and the fluorescence emissions from the particle are continuously measured as it passes through the detection region. The measured fluorescence emissions at each wavelength of excitation light, which changes through full spectrum of the excitation light as the particle passes through the detection region, provides the excitation spectrum of the particle.

15. 发明公开

EP2732395A4 COMPENSATION OF MOTION-RELATED ERROR IN A STREAM OF MOVING MIRCO-ENTITIES 有权
标题翻译：运动误差的A POWER表征移动单位MICRO
公开(公告)号：EP2732395A4
公开(公告)日：2015-03-11
申请号：EP12826436
申请日：2012-08-24
申请人： SONY CORP , SONY CORP AMERICA
发明人： DURACK GARY , FLEISCHER STEPHEN D , HATCHER JEREMY , ROBERTS DAVID , ZORDAN MICHAEL
IPC分类号： G06F19/00 , G01N15/14 , G06F19/10
CPC分类号： G01N15/1404 , G01N15/1427 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1075 , G01N2015/1415 , G01N2015/1438 , G01N2015/1477 , G01N2015/149
摘要： Apparatus and methods for detecting, characterizing, and compensating motion-related error of moving micro-entities are described. Motion-related error may occur in streams of moving micro-entities, and may represent a deviation in and expected arrival time or an uncertainty in position of a micro-entity within the stream. Motion-related error of micro-entities is observed in a flow cytometer, e.g., as pulse jitter, and is found to have a functional dependence on a parameter of the system. The pulse jitter can be compensated, according to one embodiment, by adjusting data acquisition observation windows. For the flow cytometer, a reduction of pulse jitter can improve measurement accuracy, resolution of doublets, system throughput, and enable an increase in an interrogation region for probing the micro-entities.

16. 发明公开

EP2053381A3 Optical detection method and optical detection apparatus for a fine particle 审中-公开
标题翻译：用于微粒的光学检测方法和光学检测装置
公开(公告)号：EP2053381A3
公开(公告)日：2014-10-22
申请号：EP08167349.3
申请日：2008-10-23
申请人： Sony Corporation
发明人： Shinoda, Masataka , Imanishi, Shingo
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1425 , G01N15/1434 , G01N15/1459 , G01N2015/1006 , G01N2015/1438
摘要： Disclosed herein is an optical detection method and optical detection apparatus, the apparatus including: a light irradiation section (4) configured to irradiate a laser beam (5) upon one of fine particles (3) which are successively fed in a flow path (2); and a light detection section (9) configured to detect fluorescent light and/or scattered light (10) generated from any of the fine particles (3) upon which the laser beam (5) is irradiated; the method including the steps of: irradiating a laser beam (5) upon one of fine particles (3) which are successively fed in a flow path (2); and detecting fluorescent light and/or scattered light (10) generated from the fine particle (3); wherein the laser beam (5) being formed as a pulse laser beam whose pulse intensity is modulated such that one laser beam or two or more laser beams (5) having different wavelengths are irradiated by a plural number of times upon one fine particle (3) with the intensity varied.

17. 发明公开

EP2051061A3 Optical measuring device, optical measuring apparatus and fine particle measuring apparatus using optical measuring device 有权
标题翻译：光学测量装置，光学测量和细轨与所述光学测量装置
公开(公告)号：EP2051061A3
公开(公告)日：2014-09-24
申请号：EP08253274.8
申请日：2008-10-08
申请人： Sony Corporation
发明人： Furuki, Motohiro , Shinoda, Masataka , Imanishi, Shingo
IPC分类号： G01N15/14 , B01L9/00 , B01L3/00 , G01N21/64
CPC分类号： G01N15/1484 , B01L3/5027 , B01L9/527 , B01L2200/0647 , B01L2300/0816 , G01N15/1434 , G01N15/1459 , G01N21/6428 , G01N2015/1006 , G01N2015/1438
摘要： Disclosed herein is an optical measuring device, including: a plurality of microfluidic channels extending in parallel to each other; and a scanning section configured to scan a plurality of measuring light beams in a scanning direction in which the microfluidic channels are juxtaposed to optically measure fine particles introduced into the microfluidic channels.

18. 发明公开

EP2606337A2 DETECTOR ARRANGEMENT FOR A FLOW CYTOMETRY SYSTEM 有权
标题翻译：检测器装置用于流式细胞仪系统
公开(公告)号：EP2606337A2
公开(公告)日：2013-06-26
申请号：EP11818894.5
申请日：2011-08-22
申请人： Stratedigm Inc.
发明人： JAVADI, Shervin , KARUNARATNE, Arjuna
IPC分类号： G01N21/39 , G01N21/64
CPC分类号： G01N15/1434 , G01N15/1425 , G01N15/1459 , G01N2015/1438
摘要： Systems and methods for regarding a cytometry system are disclosed. The system can include a plurality lasers which are spatially separated from each other. Each laser can be assigned to a single detector. The single detector can process multiple events from each laser by digital switching of signal processing circuitry. Additional detectors can be assigned to receive light in a similar manner.

19. 发明公开

EP2545357A1 GENERATING PULSE PARAMETERS IN A PARTICLE ANALYZER 有权
标题翻译： GENERATING脉冲参数在颗粒分析器
公开(公告)号：EP2545357A1
公开(公告)日：2013-01-16
申请号：EP11710074.3
申请日：2011-03-09
申请人： Beckman Coulter, Inc.
发明人： LOFSTROM, Christopher, D. , FOX, Daniel, N. , THRASHER, Thomas, L. , NECKELS, David, C.
IPC分类号： G01N15/14
CPC分类号： G01N15/1429 , G01N15/1427 , G01N15/1459 , G01N2015/1438
摘要： A method is provided for generating measurement parameters for a particle sample in a particle analyzer. The method includes, interrogating the particle sample with a triggering interrogator and one or more secondary interrogators respectively positioned along a length of an interrogation area, generating respective pulses based upon the interrogation of a first particle from the particle sample, determining a primary pulse detection window based upon a triggering pulse, determining a search interval to find a secondary pulse based upon factors including the primary pulse detection window and a laser delay, adjusting the search interval for laser delay variation dynamically based on the interrogation of the first particle, identifying the secondary pulse in the adjusted search interval, and processing the secondary pulse to determine a peak value of the secondary pulse. Corresponding apparatus are also provided.

20. 发明公开

EP2327977A2 Particle analyzing apparatus and particle imaging method 审中-公开
标题翻译： Partikelanalysevorrichtung und Partikelabbildungsverfahren
公开(公告)号：EP2327977A2
公开(公告)日：2011-06-01
申请号：EP10193092.3
申请日：2010-11-30
申请人： Sysmex Corporation
发明人： Ozasa, Masatsugu , Kobayashi, Hiroyuki
IPC分类号： G01N15/14 , G01N21/64
CPC分类号： G01N15/1475 , G01N1/31 , G01N15/147 , G01N2015/0092 , G01N2015/1438
摘要： A particle Analyzing apparatus, comprising: a flow cell which forms a specimen flow including particles; first and second light sources; an irradiation optical system which applies lights emitted from the first and second light sources so that the lights are applied to the specimen flow; a detector which detects forward scattered light, the forward scattered light being emitted from the first light and scattered by the particle in the specimen flow, and generates a signal according to the detected scattered light; a light blocking member disposed between the flow cell and the detector; a controller which obtains characteristic parameters of the particle based on the signal from the detector; and an imaging device which captures an image of the particle in the specimen flow using the light from the second light source is disclosed. Particle imaging method is also disclosed.
摘要翻译：一种颗粒分析装置，包括：形成包含颗粒的样品流的流动池; 第一和第二光源; 照射光学系统，其施加从第一和第二光源发射的光，使得光被施加到样本流; 检测器，其检测前向散射光，前向散射光从第一光发射并由样品流中的粒子散射，并根据检测到的散射光产生信号; 设置在所述流动池和所述检测器之间的遮光构件; 控制器，其基于来自检测器的信号获得粒子的特征参数; 并且公开了使用来自第二光源的光来捕获样品流中的颗粒的图像的成像装置。还公开了粒子成像方法。

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