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11. 发明公开

EP3071589A1 METHOD FOR REDUCING COLOUR OF A BIOTECHNOLOGICAL LIQUID 有权
标题翻译： VERFAHREN ZUR REDUZIERUNG DER FARBE EINER BIOTECHNOLOGISCHENFLÜSSIGKEIT
公开(公告)号：EP3071589A1
公开(公告)日：2016-09-28
申请号：EP14802704.8
申请日：2014-11-05
申请人： Kemira OYJ
发明人： HOLAPPA, Susanna , RECKTENWALD, Michael
IPC分类号： C07K1/00
CPC分类号： C07K1/30 , C07K1/14 , C12N9/96
摘要： The invention relates to a method for reducing colour of a biotechnological liquid. In the method a biotechnological liquid comprising colour forming substances is obtained and a high-basicity aluminium compound, which has a basicity of at least 0%, is added and mixed to the biotechnological liquid. Precipitate and/or flocks comprising colour forming substances are allowed to form, and the precipitate and/or flocks are separated from the biotechnological liquid.
摘要翻译：本发明涉及一种降低生物技术液体颜色的方法。在该方法中，获得包含成色物质的生物技术液体，并且将碱度至少为0％的高碱度铝化合物加入并混合到生物技术液体中。允许形成包含成色物质的沉淀物和/或绒毛，并将沉淀物和/或绒毛与生物技术液体分离。

12. 发明公开

EP2953965A4 PROTEIN PURIFICATION METHODS 审中-公开
标题翻译： PROTEINAUFREINIGUNGSVERFAHREN
公开(公告)号：EP2953965A4
公开(公告)日：2016-09-14
申请号：EP14749299
申请日：2014-02-05
申请人： AGENCY SCIENCE TECH & RES
发明人： GAGNON PETER STANLEY
IPC分类号： C07K1/30 , B01D15/36 , C01D3/04 , C01D5/00 , C07C43/10 , C07C53/126 , C07C211/14 , C07C229/16 , C07D219/10 , C07D233/88 , C07D279/18
CPC分类号： C07K1/303 , B01D15/36 , C07K1/30 , C07K16/00 , C07K16/2863 , C07K16/32
摘要： A method for the purification of a desired protein from a protein preparation includes conditioning the protein preparation by treatment with soluble organic multivalent ions, immobilized organic multivalent ions, or both, optionally in the presence of supersaturated allantoin, thereby removing at least 90% of chromatin, then (1) precipitating the desired protein with a nonionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration to provide a precipitate of the desired protein; or (2) precipitating the desired protein with a nonionic organic polymer in the absence of non-precipitating salts at greater than physiological concentration to provide a precipitate and subsequently washing the precipitate with a nonionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration.
摘要翻译：用于从蛋白质制剂中纯化所需蛋白质的方法包括通过用可溶性有机多价离子，固定的有机多价离子或两者进行处理来调节蛋白质制剂，任选地在过饱和尿囊素存在下，从而除去至少90％的染色质，然后（1）在非蛋白沉淀盐存在下，用非离子有机聚合物在大于生理浓度下沉淀所需蛋白质以提供所需蛋白质的沉淀物; 或者（2）在不存在非沉淀盐的情况下用非离子有机聚合物在大于生理浓度下沉淀所需蛋白质以提供沉淀物，随后在非蛋白沉淀盐存在下用非离子有机聚合物洗涤沉淀物大于生理浓度。

13. 发明授权

EP2280004B1 PHARMACEUTICAL FORMULATIONS COMPRISING INSULIN COMPLEXED WITH A DIKETOPIPERAZINE 有权
标题翻译：药物组合物含有胰岛素络合哌嗪
公开(公告)号：EP2280004B1
公开(公告)日：2016-04-20
申请号：EP10075476.1
申请日：2000-06-29
申请人： MannKind Corporation
发明人： Steiner, Solomon S , Woods, Rodney J , Sulner, Joseph W
IPC分类号： A61K47/00 , C07D241/08 , A61K38/28 , A61K9/00 , A61K9/16 , C07K14/605 , C07K14/62 , C07K1/30 , A61K47/22 , A61K9/14 , A61K47/48 , B82Y5/00 , C07K1/32
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/14 , A61K9/145 , A61K9/1617 , A61K9/1676 , A61K38/28 , A61K47/6949 , B82Y5/00 , C07D241/08 , C07K1/30 , C07K1/32 , C07K14/605 , C07K14/62 , Y10S514/866

14. 发明公开

EP2889307A4 ALPHA-CONOTOXIN PEPTIDE, AND MEDICAL COMPOSITION AND PURPOSE THEREOF 有权
标题翻译： ALPHA芋螺毒素肽，药物组合物，它目的
公开(公告)号：EP2889307A4
公开(公告)日：2016-04-13
申请号：EP13828357
申请日：2013-06-18
申请人： UNIV HAINAN
发明人： LUO SULAN , ZHANGSUN DONGTING , WU YONG , ZHU XIAOPENG , HU YUANYAN , BING HUI , MCINTOSH J MICHAEL
IPC分类号： C07K7/08 , A61K38/10 , A61K38/17 , A61P25/04 , A61P25/16 , A61P25/28 , A61P25/34 , A61P25/36 , A61P29/00 , C07K1/04 , C07K1/06 , C07K1/16 , C07K14/435 , C07K19/00 , C12N1/19 , C12N1/21 , C12N15/12 , C12N15/63
CPC分类号： C07K14/43504 , A61K38/00 , C07K1/061 , C07K1/16 , C07K1/30 , C07K2319/00 , G01N33/5032 , G01N33/944 , G01N2333/70571 , G01N2500/04
摘要： The present invention provides a novel ±-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The ±-conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as ±3²2 nAChRs, ±6/±3²2²3 nAChR or ±3²4 nAChR or ±6/±3²4 nAChR), has activity for treatment of neuralgia, addiction, Parkinson's disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.

15. 发明授权

EP1561756B1 METHOD OF PURIFYING PROTEIN 有权
标题翻译：方法蛋白质纯化
公开(公告)号：EP1561756B1
公开(公告)日：2015-12-23
申请号：EP03795400.5
申请日：2003-09-11
申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人： TAKEDA, Kozo , OCHI, Norimichi , ISHII, Kimie , MATSUHASHI, Manabu , IMAMURA, Akinori
IPC分类号： C07K16/06 , C07K14/52 , C07K16/26 , C07K16/28 , C07K16/30 , C07K1/22 , C07K1/32 , C07K1/34 , C07K14/535
CPC分类号： C07K1/30 , C07K1/22 , C07K1/34 , C07K14/535 , C07K16/065 , C07K16/26 , C07K16/2866 , C07K16/2896 , C07K16/3061 , C07K2317/24
摘要： The present invention provides a simpler and less expensive method for purifying physiologically active proteins, especially antibodies, which can ensure removal of impurities such as DNA contaminants and viruses, and which can minimize a loss of physiologically active proteins. Means for Solving the Problems: A method for removing impurities in a physiologically active protein-containing sample, which comprises the following steps: 1) allowing the physiologically active protein-containing sample to be converted into an aqueous solution of low conductivity at a pH below the isoelectric point of the physiologically active protein; and 2) removing the resulting particles.

16. 发明授权

EP2250182B1 ISOLATION OF DNA, RNA AND PROTEIN FROM A SINGLE SAMPLE 有权转让
标题翻译：来自个体样品的DNA，RNA和蛋白质分离
公开(公告)号：EP2250182B1
公开(公告)日：2015-12-02
申请号：EP09707278.9
申请日：2009-02-05
申请人： GE Healthcare Bio-Sciences Corp.
发明人： TAKKELLAPATI, Sudhakar, Rao , FARCHAUS, Joseph W.
IPC分类号： C07H21/00 , C07K1/18 , C07K1/20 , C07K1/30 , C12N15/10
CPC分类号： C07H21/00 , C07K1/18 , C07K1/20 , C07K1/30 , C12N15/101

17. 发明授权

EP2560682B1 ANTIBODY PREPARATIONS 有权
标题翻译：抗体组合物
公开(公告)号：EP2560682B1
公开(公告)日：2015-10-21
申请号：EP11715567.1
申请日：2011-04-21
申请人： Biotest AG
发明人： MÖLLER, Wolfgang , RUDNICK, Dieter , MANEG, Oliver , RODEMER, Michael , GERMER, Matthias , BRAUN, Veit
IPC分类号： A61K39/395 , A61K9/08 , A61L2/10 , C07K16/06 , A61P31/00
CPC分类号： C07K16/1275 , A61K9/0019 , A61K39/395 , A61K39/39591 , A61K47/183 , A61K2039/507 , C07K1/30 , C07K16/065 , C07K16/121 , C07K16/1232 , C07K16/125 , C07K16/1267 , C07K16/14 , C07K2317/21 , C07K2317/76

18. 发明公开

EP2755992A4 PLASMA PROTEIN FRACTIONATION BY SEQUENTIAL POLYACID PRECIPITATION 有权转让
标题翻译：序列多糖填充减少血浆
公开(公告)号：EP2755992A4
公开(公告)日：2015-04-29
申请号：EP12832274
申请日：2012-09-14
申请人： GE HEALTHCARE BIO SCIENCES AB
发明人： VAN ALSTINE JAMES , BERG MIKAEL , KJÖRNING JOHANNA , SHANAGAR JAMIL
IPC分类号： C07K1/30
CPC分类号： C07K1/30 , A61K35/16 , C07K1/303 , C07K14/75 , C07K14/76 , C07K16/18
摘要： There is a recognized need for novel, more simplified, approaches to isolation of plasma from whole blood, as well as a need to isolate cell-free plasma fractions containing different plasma proteins. Methods are divulged for use of aqueous phase systems, formed in blood or blood containing solutions via addition of a single polymer at relatively low concentration, to effect isolation (clarification) of plasma proteins from blood cells. Methods are also divulged to replace widely used Cohn-type plasma protein fractionation which is based on sequential addition of up to 40% (v/v) ethanol and other precipitants, with simple sequential addition of a polyacid. The latter results in isolation of plasma protein fractions (i.e. fibrinogen, immunoglobulin, albumin) in sequence similar to that obtained with Cohn Fractionation and therefore may be suitable for use to reduce solvent use and solvent-related process complications in existing plasma protein purification processes. It may also support use of polymeric film based containers in novel solvent free plasma fractionation processes. The methods disclosed may also be suitable for use in smaller scale plasma protein isolation, in research and diagnostic applications. The general methodologies are robust and can function over a broad range of process variables such as temperature and pH.

19. 发明公开

EP2731966A1 PROCEDE DE PREPARATION D'UN CONCENTRE D'IMMUNOGLOBULINES POLYVALENTES 有权
标题翻译：程序制备D'UNCENTRE D'IMMUNOGLOBULINES POLYVALENTES
公开(公告)号：EP2731966A1
公开(公告)日：2014-05-21
申请号：EP12733726.9
申请日：2012-07-11
申请人： Laboratoire Français du Fractionnement et des Biotechnologies
发明人： CHTOUROU, Abdessatar , BATAILLE, Damien , MICHAUX, Georges
IPC分类号： C07K16/06 , C07K1/36
CPC分类号： C07K1/36 , C07K1/165 , C07K1/30 , C07K16/06 , C07K16/065
摘要： The present application relates to a method for preparing a polyvalent-immunoglobulin concentrate, with a view to using same in therapeutics, from an initial blood plasma solution or an immunoglobulin-enriched plasma fraction, including the steps of: removing the protein contaminants by means of precipitation in caprylic acid so as to obtain a protease-free solution; and separating the protease-free solution by means of chromatography in a fluidized bed, said method making it possible to obtain a human polyvalent immunoglobulin concentrate at a yield of more than 4.5 grams of immunoglobulins per liter of blood plasma used.
摘要翻译：本申请涉及用于制备多价 - 免疫球蛋白浓缩物的方法，目的是将其用于来自初始血浆溶液或富含免疫球蛋白的血浆部分的治疗剂中，所述方法包括以下步骤：通过以下步骤去除蛋白质污染物：在辛酸中沉淀以获得不含蛋白酶的溶液; 并通过在流化床中色谱分离无蛋白酶溶液，所述方法使得可以以每升所用血浆中超过4.5克免疫球蛋白的产率获得人多价免疫球蛋白浓缩物。

20. 发明公开

EP2598516A2 PROCESS FOR PURIFYING PROTEINS 有权转让
标题翻译：方法蛋白质纯化
公开(公告)号：EP2598516A2
公开(公告)日：2013-06-05
申请号：EP11745810.9
申请日：2011-07-27
申请人： UCB Pharma, S.A.
发明人： WILD, Gavin, Barry
IPC分类号： C07K1/36 , C07K16/24 , C07K14/245
CPC分类号： C07K16/00 , C07K1/30 , C07K16/241 , C07K2317/14 , C07K2317/55 , C12N9/90 , C12P21/00
摘要： The present invention provides method for purifying a recombinant protein from a gram-negative bacterial host cell sample or extract thereof wherein said host cell expresses a recombinant protein and a recombinant disulphide isomerase DsbC; comprising: a. adjusting the pH of the host cell sample or extract thereof to a pH of 5 or less to precipitate the recombinant disulphide isomerase; and b. separating precipitated recombinant disulphide isomerase DsbC from the recombinant protein to produce a recombinant protein sample.

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