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11. 发明公开

EP0723421A1 ULTRASONIC THERAPY AND ASSESSMENT APPARATUS AND METHOD 失效
标题翻译：设备和方法处理和评价。利用超声
公开(公告)号：EP0723421A1
公开(公告)日：1996-07-31
申请号：EP94900592.0
申请日：1993-11-08
申请人： ORTHOLOGIC CORP.
发明人： KAUFMAN, Jonathan J. , CHIABRERA, Alessandro
IPC分类号： A61M11 , A61B8 , A61B17 , A61H23 , A61M15 , A61N7 , G01N29 , A61J7 , A61M16
CPC分类号： A61M15/00 , A61B8/0875 , A61J7/0481 , A61M15/008 , A61M15/009 , A61M2016/0039 , A61M2016/0042 , A61M2205/35 , A61M2205/3561 , A61M2205/52 , A61N7/00 , G01N29/30 , G01N29/348 , G01N29/449 , G01N2291/02483 , Y10S128/925
摘要： Non-invasive therapeutic treatment and/or quantitative evaluation of musculoskeletal tissue are performed in vivo by subjecting musculoskeletal tissue (11) to an ultrasonic acoustic signal pulse excitation, involving a composite sine wave signal consisting of plural discrete frequencies that are spaced in the ultrasonic region to approximately 2 MHZ, and repeated substantially in the range of 1 Hz to 1000 Hz. In a quantitative evaluation, the signal is supplied to one of two transducers (12, 13) on opposite sides of the tissue, and the signal received by the other transducer is processed (14): (a) to obtain an averaged per-pulse signal, and (b) to produce a Fourier transform of the averaged per-pulse tissue transmittal signal. In a separate operation, the same transducers are subjected to the same excitation, reception and processing, using a medium of known acoustic properties and path length to produce a reference Fourier transform. In a therapeutic treatment, the transducer (12) excited by the composite sine wave signal, is applied for a time period and magnitude.

12. 发明公开

EP1539214A4 THROMBIN PEPTIDE DERIVATIVES 审中-公开
标题翻译： THROMBINPEPTIDDERIVATE
公开(公告)号：EP1539214A4
公开(公告)日：2008-01-02
申请号：EP03784751
申请日：2003-07-01
申请人： ORTHOLOGIC CORP
发明人： CARNEY DARRELL H
IPC分类号： A61K38/00 , A61K38/48 , C07K20060101 , C07K7/08 , C12N9/74
CPC分类号： C12N9/6429 , A61K38/00 , C12Y304/21005
摘要： Disclosed are thrombin peptide derivatives comprising a polypeptide having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Xaa-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Xaa is alanine, glycine, serine, or an S-protected cysteine. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

13. 发明公开

EP0843573A1 ULTRASONIC BONE THERAPY APPARATUS AND METHOD 失效
标题翻译： DEVICE AND METHOD FOR骨疗法利用超声
公开(公告)号：EP0843573A1
公开(公告)日：1998-05-27
申请号：EP95937426.0
申请日：1995-10-04
申请人： ORTHOLOGIC CORP.
发明人： KAUFMAN, Jonathan, J. , CHIABRERA, Allessandro, E.
IPC分类号： A61N1 , A61H23 , A61N7 , A61B17 , A61F2
CPC分类号： A61N7/00 , A61B2017/0015 , A61B2017/00172 , A61F2002/2864
摘要： This invention is a method of ultrasonic bone therapy that subjects a bone (10) to an ultrasonic excitation pulse signal of finite duration, supplied to a transducer (14) next to the bone, and involving a sinusoidal signal in the ultrasonic region to approximately 2 Mhz peculiarly modulated by a sinusoidal signal with frequency between 0 Hz and about 25 kHz; the excitation signal is repeated in the range of 1 Hz to 5000 Hz. The exposure time for therapy is chosen to be in the range of 5 minutes to 1 hour, for 1 time to 3 times a day, for a period of days as necessary for healing or for promoting bone growth and ingrowth. An apparatus for implementing the above method for ultrasonic bone therapy is disclosed comprising a transducer (14) having a transmitting and a receiving element, a special waveform signal generator (20), and a computer (16) for performing the necessary operations defining a preferred treatment regime.

14. 发明公开

EP0723421A4 ULTRASONIC THERAPY AND ASSESSMENT APPARATUS AND METHOD 失效
标题翻译：设备和方法处理和评价。利用超声
公开(公告)号：EP0723421A4
公开(公告)日：1998-02-04
申请号：EP94900592
申请日：1993-11-08
申请人： ORTHOLOGIC CORP
发明人： KAUFMAN JONATHAN J , CHIABRERA ALESSANDRO
IPC分类号： A61M11/08 , A61B8/00 , A61B8/08 , A61B17/56 , A61H23/02 , A61J7/04 , A61M15/00 , A61M16/00 , A61N7/00 , G01N29/30 , G01N29/34
CPC分类号： A61M15/00 , A61B8/0875 , A61J7/0481 , A61M15/008 , A61M15/009 , A61M2016/0039 , A61M2016/0042 , A61M2205/35 , A61M2205/3561 , A61M2205/52 , A61N7/00 , G01N29/30 , G01N29/348 , G01N29/449 , G01N2291/02483 , Y10S128/925

15. 发明授权

EP0481761B1 Medical treatment device 失效
标题翻译：一种医疗治疗装置
公开(公告)号：EP0481761B1
公开(公告)日：1996-05-29
申请号：EP91309538.6
申请日：1991-10-16
申请人： OrthoLogic Corp.
发明人： Lamond, Donald R. , Heinzelman, Bert
IPC分类号： A61N2/00
CPC分类号： A61N2/02 , A61G13/0045 , A61G13/12 , A61G13/1235 , A61G13/124 , A61G13/1245

16. 发明公开

EP0481761A2 Medical treatment device 失效
标题翻译： Einrichtung und Verfahren zur medizinischen Behandlung。
公开(公告)号：EP0481761A2
公开(公告)日：1992-04-22
申请号：EP91309538.6
申请日：1991-10-16
申请人： OrthoLogic Corp.
发明人： Lamond, Donald R. , Heinzelman, Bert
IPC分类号： A61N2/00
CPC分类号： A61N2/02 , A61G13/0045 , A61G13/12 , A61G13/1235 , A61G13/124 , A61G13/1245
摘要： A medical treatment device (20) is disclosed which includes a medical treatment element (36,38) and resilient securing members (32,34) which adjust or deform to conform to the particular dimensions of that part of the patient's anatomy which is to be treated. The resilient securing members (32, 34) move or deform outwardly away from the patient (22) as the device is applied to conform to the size of the patient and ensure that the patient is centered within the treatment device. The medical treatment elements (36,38) are thus accurately positioned with respect to the patient (22). This is particularly important in treatments involving the application of magnetic fields to the patient (22). In addition, the disclosed medical device (20) is relatively comfortable and can be worn by a patient (22) for a relatively long period of time.
The invention also extends to the method of applying the medical treatment device (20) to the patient (22).
摘要翻译：公开了一种治疗装置（20），其包括医疗处理元件（36,38）和弹性固定构件（32,34），其被调节或变形以符合患者解剖结构的该部分的特定尺寸对待。随着装置被施加以符合患者的尺寸并且确保患者在治疗装置内居中，弹性固定构件（32,34）向外远离病人（22）移动或变形。因此医疗处理元件（36,38）相对于患者（22）精确定位。这在涉及向患者（22）施加磁场的治疗中尤其重要。此外，所公开的医疗装置（20）相对舒适并且可以由患者（22）佩戴较长时间段。本发明还延伸到将医疗装置（20）应用于患者（22）的方法。

17. 发明公开

EP2282765A1 THROMBIN DERIVED PEPTIDES FOR SMOOTH MUSCLE RELAXATION 审中-公开
标题翻译：凝血酶原诉肽松弛平滑肌的
公开(公告)号：EP2282765A1
公开(公告)日：2011-02-16
申请号：EP09725708.3
申请日：2009-03-24
申请人： Orthologic Corp. , The Texas A&M University System
发明人： CARNEY, Darrell, H. , OLSZEWSKA-PAZDRAK, Barbara , FOSSUM, Theresa, W.
IPC分类号： A61K38/48 , A61P21/02
CPC分类号： A61K38/4833
摘要： Agonists of a non-proteolytically activated thrombin receptor, and more particularly, thrombin peptide derivatives, can be used in methods to cause smooth muscle relaxation. Compositions comprising thrombin peptide derivatives can be administered to a subject with a disease or disorder that can be ameliorated by relaxation of smooth muscle. Such compositions can also be administered to a subject to facilitate medical, diagnostic or surgical procedures.

18. 发明公开

EP2282754A2 METHOD OF TREATING PERIPHERAL ARTERIAL DISEASE 审中-公开
标题翻译：法外周动脉疾病的治疗
公开(公告)号：EP2282754A2
公开(公告)日：2011-02-16
申请号：EP09726377.6
申请日：2009-03-24
申请人： Orthologic Corp. , The Texas A&M University System
发明人： CARNEY, Darrell, H. , OLSZEWSKA-PAZDRAK, Barbara , FOSSUM, Theresa, W.
IPC分类号： A61K38/04 , A61K38/16 , A61P9/10
CPC分类号： A61K38/04 , A61K38/16
摘要： An agonist of a non-proteolytically activated thrombin receptor can be used in a method for treating peripheral arterial disease. The agonist can be a thrombin peptide derivative. In some embodiments, the peripheral arterial disease is characterized by intermittent claudication. The thrombin peptide derivatives to be used in the methods can have amino acid sequences similar to a region of thrombin. Usually, the thrombin peptide derivatives are 12-23 amino acid residues in length. In some cases, the thrombin peptide derivatives are dimers, and in particular, dimers that result from formation of a disulfide bond between two cysteine residues of peptide monomers.

19. 发明公开

EP2063910A2 METHOD OF TREATING ENDOTHELIAL DYSFUNCTION 审中-公开
标题翻译：方法内皮功能障碍的治疗
公开(公告)号：EP2063910A2
公开(公告)日：2009-06-03
申请号：EP07861354.4
申请日：2007-09-21
申请人： Orthologic Corp. , THE TEXAS A & M UNIVERSITY SYSTEM
发明人： CARNEY, Darrell, H. , OLSZEWSKA-PAZDRAK, Barbara , FOSSUM, Theresa, W.
IPC分类号： A61K38/48 , C12N9/74 , A61P9/08 , A61P9/10
CPC分类号： A61K38/10 , A61K38/16 , A61K38/18 , A61K38/4833 , C12N9/6429 , C12Y304/21005
摘要： Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.

20. 发明公开

EP1934262A1 ANTIBODIES TO COMPLEMENTARY PEPTIDES OF THROMBIN OR PORTIONS THEREOF 审中-公开
标题翻译：凝血酶抗体互补肽或其任何部分
公开(公告)号：EP1934262A1
公开(公告)日：2008-06-25
申请号：EP06803588.0
申请日：2006-09-14
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , Orthologic Corp.
发明人： FULLER, Gerald, M. , CARNEY, Darrell, H. , BERGMANN, John, S.
IPC分类号： C07K16/36 , C12N5/10 , A61K39/395 , G01N33/53 , A61P35/00 , A61P19/00 , A61P7/00 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2863 , C07K2317/34 , C07K2317/75 , C12N9/6429 , C12Y304/21005
摘要： Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subj ect in need of such treatment are disclosed.

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