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11. 发明授权

EP0731720B1 CARDIOPULMONARY BYPASS SYSTEM FOR CLOSED-CHEST INTERVENTION 失效
标题翻译：体外循环对于运行CLOSE胸
公开(公告)号：EP0731720B1
公开(公告)日：2002-04-10
申请号：EP95902513.1
申请日：1994-11-10
申请人： HEARTPORT, INC.
发明人： STEVENS, John, H. , STERMAN, Wesley, D. , MACHOLD, Timothy, R. , GIFFORD, Hanson, S.
IPC分类号： A61M37/00
CPC分类号： A61M25/10 , A61B2018/00232 , A61B2018/00261 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0125 , A61M25/0147 , A61M25/0152 , A61M25/0155 , A61M25/0158 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/1077 , A61M2210/125
摘要： The invention provides a system and method for establishing cardiopulmonary bypass and performing an interventional procedure in a patient's heart or great vessel with a minimum of arterial and venous penetrations. In one embodiment, a bypass cannula (180) configured for introduction into a patient's artery includes a blood flow lumen (188) which may be connected to a cardiopulmonary bypass system (92, 94, 96, 100). A catheter shaft (202) is coupled to the bypass cannula, usually within the blood flow lumen, and has a member (216) at its distal end for performing an interventional procedure within the heart or great vessel. In a particular embodiment, the catheter shaft has an expandable member such as an inflatable balloon disposed near its distal for occluding the ascending aorta so as to substantially block all blood flow therethrough for a plurality of cardiac cycles. The catheter shaft has an inner lumen (212) through which cardio-plegic fluid may be delivered upstream of the occluding member to infuse cardio-plegic fluid into the coronary arteries for arresting the heart. The blood flow lumen in the bypass cannula is connected to a cardiopulmonary bypass system, which receives deoxygenated blood from the patient's venous system, oxygenates the blood, and delivers the oxygenated blood to the patient's arterial system through the blood flow lumen.

12. 发明公开

EP0921831A1 MULTI-LUMEN CATHETER AND METHOD OF MANUFACTURE 失效
标题翻译：多腔导管作为和方法
公开(公告)号：EP0921831A1
公开(公告)日：1999-06-16
申请号：EP97930012.0
申请日：1997-06-17
申请人： HEARTPORT, INC.
发明人： CORVI, Timothy, J. , STEVENS, John, H.
IPC分类号： A61F2 , A61M1 , A61M25 , A61B17 , A61B19 , A61M29
CPC分类号： A61M25/0012 , A61B17/3417 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61B2090/064 , A61B2090/306 , A61F2/2427 , A61M1/3653 , A61M1/3659 , A61M25/0009 , A61M25/0032 , A61M25/0041 , A61M25/0045 , A61M25/005 , A61M25/0054 , A61M25/0125 , A61M25/0133 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M25/1027 , A61M2025/0002 , A61M2025/0031 , A61M2025/0034 , A61M2025/0046 , A61M2025/0078 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2205/11 , A61M2205/366 , A61M2210/125 , A61M2210/127
摘要： A multi-lumen catheter (10) having a reinforcing member (42) wrapped around at least one of the lumens (40) in a helical manner. An inflation lumen (43) is positioned outside the reinforcing member (42) for inflating a balloon (11) carried by the catheter (10). A two-lumen extrusion (339A) is bonded to the reinforced lumen (337A) to form the multi-lumen catheter. The multi-lumen catheter is particularly useful as an aortic occlusion catheter.

13. 发明公开

EP0719161A1 ENDOVASCULAR SYSTEM FOR ARRESTING THE HEART 失效
标题翻译：血管内系统，用于生成人工心脏仍然有效
公开(公告)号：EP0719161A1
公开(公告)日：1996-07-03
申请号：EP94927997.0
申请日：1994-09-01
申请人： HEARTPORT, INC.
发明人： EVARD, Philip, C , MACHOLD, Timothy, R. , STEVENS, John, H.
IPC分类号： A61F2 , A61M1 , A61M25 , A61M29
CPC分类号： A61M25/10 , A61B2018/00232 , A61B2018/00261 , A61F2/2427 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0125 , A61M25/0662 , A61M2025/0078 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2202/047 , A61M2210/125 , A61M2210/127
摘要： The invention provides an endovascular device (20) for partitioning the ascending aorta and a system for arresting the heart to facilitate the performance of precedures such as heart valve replacement or coronary artery bypass grafting without the need for a thoracotomy. According to the invention, an endovascular device (20) for partitioning a patient's ascending aorta comprises a flexible shaft (22) having a distal end (24), a proximal end (26), and a first inner lumen (29) therebetween with an opening (31) at the distal end (24). The shaft (22) may have a preshaped distal portion (32) with a curvature generally corresponding to the curvature of the patient's aortic arch. Expandable means (28) are disposed near the distal end (24) of the shaft (22) proximal to the opening (31) in the first inner lumen (29) for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles. Means (90) for delivering cardioplegic fluid may be connected to the proximal end (26) of the device to infuse cardioplegic fluid into the coronary arteries for arresting the heart. The endovascular device of the invention is readily positionable in the ascending aorta, resists displacement caused by systolic blood flow, and maintains axial alignment with the center of the ascending aorta and aortic valve.

14. 发明授权

EP0819013B1 SYSTEM FOR PERFORMING ENDOVASCULAR PROCEDURES 失效
标题翻译：系统进行endovasculaar程序
公开(公告)号：EP0819013B1
公开(公告)日：2004-06-23
申请号：EP96908744.4
申请日：1996-03-11
申请人： HEARTPORT, INC.
发明人： STEVENS, John, H. , PETERS, William, S. , STERMAN, Wesley, D. , GIFFORD, Hansen, S., III
IPC分类号： A61M29/00 , A61M25/00 , A61M25/10
CPC分类号： A61M25/1011 , A61M25/0041 , A61M25/0152 , A61M2025/0161
摘要： This invention is a system for inducing cardio-plegia arrest and performing an endovascular procedure within the heart or blood vessels of a patient. An endo-aortic partitioning catheter (10) has an inflatable balloon (11) which occludes the ascending aorta (12) when inflated. Cardio-plegia fluid may be infused through a lumen of the endo-aortic partitioning catheter (39) to stop the heart while the patient's circulatory system is supported on cardiopulmonary bypass. One or more endovascular devices (500) are introduced through an internal lumen (40) of the endo-aortic partitioning catheter (30) to perform a diagnostic or therapeutic endovascular procedure within the heart or blood vessels of the patient. Surgical procedures such as coronary artery bypass surgery or heart valve replacement may be performed in conjunction with the endovascular procedure while the heart is stopped. Embodiments of the system are described for performing, e.g., fiberoptic angioscopy of structures within the heart and its blood vessels, and valvuloplasty for correction of valvular stenosis.
摘要翻译：本发明是一种用于诱导心脏 - 心脏骤停并在患者的心脏或血管内执行血管内手术的系统。内 - 主动脉分隔导管（10）具有可膨胀气囊（11），其在充气时阻塞升主动脉（12）。可以通过主动脉分隔导管（39）的内腔注入心血液，以在体外循环支持患者的循环系统时阻止心脏。通过内主动脉分隔导管（30）的内腔（40）引入一个或多个血管内装置（500）以在患者的心脏或血管内执行诊断或治疗性血管内手术。当心脏停止时，可以结合血管内手术进行外科手术，如冠状动脉搭桥手术或心脏瓣膜置换术。该系统的实施例被描述用于执行例如心脏及其血管内的结构的纤维血管镜检查以及用于矫正瓣膜狭窄的瓣膜成形术。

15. 发明授权

EP0684781B1 SYSTEM FOR PERFORMING THORACOSCOPIC CARDIAC BYPASS PROCEDURES 失效
标题翻译： SYSTEM FOR胸腔镜心脏搭桥手术
公开(公告)号：EP0684781B1
公开(公告)日：2002-12-11
申请号：EP94906572.6
申请日：1994-01-10
申请人： HEARTPORT, INC.
发明人： STERMAN, Wesley, D. , SIEGEL, Lawrence, C. , CURTIS, Patricia, E. , STEVENS, John, H. , MACHOLD, Timothy, R.
IPC分类号： A61B1/00
CPC分类号： A61M39/0247 , A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/00637 , A61B2017/00663 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61F2/2427 , A61M25/1011 , A61M2025/0003 , A61M2025/028 , A61M2039/0273 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M2230/005
摘要： A method for closed chest cardiac surgical intervention relies on viewing the cardiac region through a thoracoscope (34) or other viewing scope and endovascularly partitioning the patient's arterial system at a location within the ascending aorta. The cardiopulmonary bypass (56) and cardioplegia can be induced, and a variety of surgical procedures performed on the stopped heart using percutaneously introduced tools. The method of the present invention will be particularly suitable for forming coronary artery bypass grafts, where an arterial blood source is created using least invasive surgical techniques, and the arterial source is connected to a target location within a coronary artery while the patient is under cardiopulmonary bypass and cardioplegia.

16. 发明公开

EP0836423A1 LESS INVASIVE DEVICES AND METHODS FOR TREATMENT OF CARDIAC VALVES 失效
标题翻译：微创装置和方法治疗心脏瓣膜
公开(公告)号：EP0836423A1
公开(公告)日：1998-04-22
申请号：EP96916756.0
申请日：1996-05-30
申请人： HEARTPORT, INC.
发明人： GARRISON, Michi, E. , DONLON, Brian, S. , DANIEL, S., Christopher , STEVENS, John, H.
IPC分类号： A61B17 , A61B19 , A61F2
CPC分类号： A61F2/2427 , A61B17/00234 , A61B17/0218 , A61B17/0293 , A61B90/40 , A61B2017/00243 , A61B2090/401 , A61F2/2403 , A61F2/2448 , A61F2/2466 , A61F2/2496
摘要： Device and methods are provided for less invasive surgical treatment of cardiac valves whereby the need for a gross thoracotomy or median sternotomy is eliminated. In one aspect of this invention, a delivery system (10) for a cardiac valve prosthesis such as an annuloplasty ring (90) or prosthetic valve (262) includes an elongated handle (28) configured to extend into the heart through an intercostal space from outside of the chest cavity, and a prosthesis holder (100) attached to the handle for releasably holding a prosthesis. The prosthesis holder (100) is attached to the handle (28) in such a way that the holder (100), prosthesis (90) and handle (28) have a profile with a height smaller than the width of an intercostal space when the adjacent ribs are unrectrated, preferably less than about 30 mm. In a further aspect, the invention provides a method for repairing or replacing a heart valve which includes the steps of introducing a prosthesis (262) through an intercostal space and through a penetration in a wall of the heart, and securing the prosthesis (262) to an interior wall of the heart, wherein each step is carried out without cutting, removing, or significantly retracting the ribs or sternum.

17. 发明公开

EP0822777A1 METHOD AND APPARATUS FOR THORACOSCOPIC INTRACARDIAC PROCEDURES 失效
标题翻译：方法和VORICHTUNG FOR THORASKOKOPISCHE和程序心内
公开(公告)号：EP0822777A1
公开(公告)日：1998-02-11
申请号：EP96909667.0
申请日：1996-03-12
申请人： HEARTPORT, INC.
发明人： STEVENS, John, H. , REITZ, Bruce, A. , ROTH, Alex, T. , PETERS, William, S. , GIFFORD, Hanson, S.
IPC分类号： A61B5 , A61B1 , A61B17 , A61B18 , A61B19 , A61F2 , A61M1
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/2909 , A61B17/320016 , A61B17/3211 , A61B17/3417 , A61B17/3468 , A61B18/1442 , A61B18/1482 , A61B18/1492 , A61B90/37 , A61B90/50 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00349 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00867 , A61B2017/00907 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/2946 , A61B2017/306 , A61B2017/3405 , A61B2017/3486 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00898 , A61B2018/00982 , A61B2018/1465 , A61F2/2427 , A61M25/1011 , A61M39/0247 , A61M2025/028 , A61M2039/0279 , A61M2039/0297 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , Y10S623/904
摘要： Devices, systems, and methods are provided for accessing the interior of the heart, and performing procedures therein while the heart is beating. A tubular access device (22) is positioned through an intercostal space and through a muscular wall of the heart. The access device (22) includes a balloon or flange for sealing (32) the penetration to prevent leakage of blood. An obturator (52) is positionable in the access device, and includes cutting means (60) located at its distal end. Elongated instruments are introduced through the access device to perform surgical procedures including septal device repair, ablation, and electrophysiological mapping.

18. 发明公开

EP0732890A1 DEVICES AND METHODS FOR INTRACARDIAC PROCEDURES 失效
标题翻译： DEVICE心脏手术INTRA
公开(公告)号：EP0732890A1
公开(公告)日：1996-09-25
申请号：EP95901941.0
申请日：1994-11-18
申请人： HEARTPORT, INC.
发明人： STERMAN, Wesley, D. , GARRISON, Michi, E. , GIFFORD, Hanson, S., III , STEVENS, John, H.
IPC分类号： A61B17 , A61B1 , A61B18 , A61B19 , A61F2 , A61M1 , A61M25
CPC分类号： A61M39/0247 , A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/00637 , A61B2017/00663 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61F2/2427 , A61F2/2496 , A61M25/1011 , A61M2025/0003 , A61M2025/028 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , Y10S623/904 , A61M2230/005
摘要： The invention provides devices and methods for performing less invasive surgical procedures with an organ or vessel. One embodiment provides a method of closed chest surgical intervention within an internal cavity of a patient's heart. The patient's heart is arrested and cardiopulmonary by-pass is established. A scope (25) extending through a percutaneous intercostal penetration in the patient's chest is used to view an internal portion of the patient's chest. The penetration is formed in a wall of the heart using a cutter (110) introduced through the percutaneous penetration. An interventional tool is then introduced through a cannula (22) positioned in the penetration. The interventional tool is inserted through the penetration to perform a surgical procedure within the internal cavity under visualization by a scope (25). A cutting tool is introduced into the patient's left atrium from a right portion of the patient's chest to remove the patient's mitral valve. A replacement valve (36) is then introduced through the intercostal space and through the penetration in the heart, and the replacement valve is attached in the mitral valve position.

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