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1. 发明公开

EP1011782A1 ANTEGRADE CARDIOPLEGIA CATHETER AND METHOD 失效
标题翻译：导管装运顺行停搏
公开(公告)号：EP1011782A1
公开(公告)日：2000-06-28
申请号：EP98918616.8
申请日：1998-04-22
申请人： HEARTPORT, INC.
发明人： ST. GOAR, Frederick, G. , STEVENS, John, H. , GIFFORD, Hanson, S., III , GRIFFITH, Bartley, P.
IPC分类号： A61M29/00
CPC分类号： A61M25/1011 , A61M25/0032 , A61M25/10 , A61M2025/0003 , A61M2025/0031 , A61M2025/0036 , A61M2025/1052 , A61M2025/1095 , A61M2025/1097 , A61M2210/125 , A61M2210/127
摘要： A cardioplegia catheter (20) is configured to extend into the ascending aorta with a proximal portion of the shaft (26) extending into a left chamber of the heart through the aortic valve, and out of the heart through a penetration in a wall thereof. The cardioplegia catheter has an occlusion member (28) thereof. The cardioplegia catheter has an occlusion member (28) configured to occlude the ascending aorta between the brachycephalic artery, and the coronary ostia. An arterial return cannula delivers oxygenated blood to the arterial system downstream of the occlusion member, while cardioplegia fluid is delivered through a lumen in the cardioplegia catheter (20) upstream of the occlusion member to induce cardioplegia arrest.

2. 发明公开

EP0805701A1 RETROGRADE DELIVERY CATHETER AND METHOD FOR INDUCING CARDIOPLEGIC ARREST 失效
标题翻译：导管为诱导心脏骤停BY停跳液逆行灌注和方法
公开(公告)号：EP0805701A1
公开(公告)日：1997-11-12
申请号：EP95943417.0
申请日：1995-12-08
申请人： HEARTPORT, INC.
发明人： BOYD, Stephen, W. , STEVENS, John, H. , EVARD, Philip, C. , ADAMS, Craig, L.
IPC分类号： A61B17 , A61F2 , A61M1 , A61M25 , A61M29
CPC分类号： A61B17/29 , A61B17/320016 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61F2/2412 , A61F2/2427 , A61F2/2433 , A61F2/2436 , A61M1/3653 , A61M1/3659 , A61M25/0032 , A61M25/0041 , A61M25/0125 , A61M25/0147 , A61M25/0152 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M2025/0031 , A61M2025/004 , A61M2025/0078 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2205/11 , A61M2205/366 , A61M2210/125 , A61M2210/127
摘要： A retrograde delivery catheter (10) includes at its distal end a balloon (11) configured to occlude the coronary sinus (21) of a patient's heart, and has a length and flexibility which allow the distal end to be positioned in the coronary sinus (21) with the proximal end extending trans-luminal to a peripheral vein such as an internal jugular vein (44) and out of the body through a puncture (24) therein. The delivery catheter (20) has a delivey lumen (128) extending between its proximal and distal ends which is configured to allow a cardioplegia fluid to be delivered at a flow rate of at least 200 ml/min with a pump pressure less than 300 mm Hg, thereby allowing cardioplegia arrest to be maintained using a blood cardioplegia fluid without causing excessive hemolysis. In a method of inducing cardioplegia arrest according to the invention, the patient is placed on cardiopulmonary bypass (18), the coronary arteries (50, 51) are isolated from remainder of the arterial system, and the delivery catheter (10) is positioned trans-luminal in the coronary sinus (21) from a peripheral vein.

3. 发明授权

EP0732890B1 DEVICE FOR INTRACARDIAC PROCEDURES 失效
标题翻译： DEVICE心脏手术INTRA
公开(公告)号：EP0732890B1
公开(公告)日：2004-09-29
申请号：EP95901941.5
申请日：1994-11-18
申请人： HEARTPORT, INC.
发明人： STERMAN, Wesley, D. , GARRISON, Michi, E. , GIFFORD, Hanson, S., III , STEVENS, John, H.
IPC分类号： A61B8/12 , A61F2/24 , A61M5/00
CPC分类号： A61M39/0247 , A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/00637 , A61B2017/00663 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61F2/2427 , A61F2/2496 , A61M25/1011 , A61M2025/0003 , A61M2025/028 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , Y10S623/904 , A61M2230/005
摘要： The invention provides devices and methods for performing less invasive surgical procedures with an organ or vessel. One embodiment provides a method of closed chest surgical intervention within an internal cavity of a patient's heart. The patient's heart is arrested and cardiopulmonary by-pass is established. A scope (25) extending through a percutaneous intercostal penetration in the patient's chest is used to view an internal portion of the patient's chest. The penetration is formed in a wall of the heart using a cutter (110) introduced through the percutaneous penetration. An interventional tool is then introduced through a cannula (22) positioned in the penetration. The interventional tool is inserted through the penetration to perform a surgical procedure within the internal cavity under visualization by a scope (25). A cutting tool is introduced into the patient's left atrium from a right portion of the patient's chest to remove the patient's mitral valve. A replacement valve (36) is then introduced through the intercostal space and through the penetration in the heart, and the replacement valve is attached in the mitral valve position.

4. 发明公开

EP0841963A1 CARDIOPLEGIA CATHETER SYSTEM 失效
标题翻译：搏导管系统
公开(公告)号：EP0841963A1
公开(公告)日：1998-05-20
申请号：EP95941419.0
申请日：1995-11-21
申请人： HEARTPORT, INC.
发明人： ST. GOAR, Frederick, G. , PETERS, William, S. , EVARD, Philip, C. , BOYD, Stephen, W. , ADAMS, Craig, L. , MUELLER, Richard, L., Jr. , STEVENS, John, H.
IPC分类号： A61F2 , A61M1 , A61M25 , A61B17 , A61M29
CPC分类号： A61M25/0068 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61F2/2427 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/005 , A61M25/008 , A61M25/01 , A61M25/0125 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M2025/0031 , A61M2025/0034 , A61M2025/0036 , A61M2025/004 , A61M2025/0057 , A61M2025/0078 , A61M2025/0087 , A61M2025/028 , A61M2025/1047 , A61M2025/1077 , A61M2205/11 , A61M2205/366 , A61M2210/125
摘要： A catheter system is provided for accessing the coronary ostia (176, 180) transluminal from a peripheral arterial access site, such as the femoral artery, and for inducing cardioplegia arrest by direct infusion of cardioplegia solution into the coronary arteries. In a first embodiment, the catheter system is in the form of a single perfusion catheter (20) with multiple distal branches (24, 26, 28) for engaging the coronary ostia (176, 180). In a second embodiment, multiple perfusion catheters (82, 84) are delivered to the coronary ostia (176, 180) through a single arterial cannula (104). In a third embodiment, multiple perfusion catheters (112, 114, 116) are delivered to the coronary ostia (176, 180) through a single guiding catheter (126). In a fourth embodiment, multiple catheters (140, 142, 144) are delivered to the coronary ostia (176, 180) through a single guiding catheter (130) which has distal exit ports (134, 136, 138) that are arranged to direct the perfusion catheters into the coronary ostia (176, 180). In each embodiment, the catheters (20) are equipped with an occlusion means (30, 50) at the distal end of the catheter (20) for closing the coronary ostia (176, 180), and isolating the coronary arteries from the systemic blood flow.

5. 发明公开

EP0837712A1 DEVICES AND METHODS FOR PORT-ACCESS MULTIVESSEL CORONARY ARTERY BYPASS SURGERY 失效
标题翻译：装置和方法多VASCULAREN端口访问搭桥术冠状动脉
公开(公告)号：EP0837712A1
公开(公告)日：1998-04-29
申请号：EP96916899.0
申请日：1996-05-31
申请人： HEARTPORT, INC.
发明人： BOYD, Stephen, W. , RAPACKI, Alan, R. , VASKA, Matthias , DONLON, Brian, S. , PETERS, Williams, S. , STEVENS, John, H.
IPC分类号： A61B1 , A61B17 , A61B18 , A61B19 , A61F2 , A61F7 , A61M1 , A61M25
CPC分类号： A61F7/10 , A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/2804 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/36 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/00637 , A61B2017/00663 , A61B2017/0237 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2912 , A61B2017/2927 , A61B2017/2932 , A61B2017/2943 , A61B2017/306 , A61B2017/308 , A61B2017/320056 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61B2090/306 , A61B2217/005 , A61F2/2427 , A61F2007/0001 , A61F2007/0054 , A61F2007/101 , A61M25/1011 , A61M39/0247 , A61M2025/0003 , A61M2025/028 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M2230/005
摘要： Surgical methods and instruments are disclosed for performing port-access or closed-chest coronary artery bypass (CABG) surgery in multivessel coronary artery disease. In contrast to standard open-chest CABG surgery, which requires a median sternotomy or other gross thoracotomy to expose the patient's heart, post-access CABG surgery is performed through small incisions or access ports made through the intercostal spaces between the patient's ribs, resulting in greatly reduced pain and morbidity to the patient. In situ arterial bypass grafts, such as the internal mammary arteries and/or the right gastroepiploic artery, are prepared for grafting by thoracoscopic or laparoscopic takedown techniques. Free grafts, such as a saphenous vein graft or a free arterial graft, can be used to augment the in situ arterial grafts. The graft vessels are anastomosed to the coronary arteries under direct visualization through a cardioscopic microscope inserted through an intercostal access port. Retraction instruments are provided to manipulate the heart within the closed chest of the patient to expose each of the coronary arteries for visualization and anastomosis. Disclosed are a tunneler and an articulated tunneling grasper for rerouting the graft vessels, and a finger-like retractor, a suction cup retractor, a snare retractor and a loop retractor for manipulating the heart. Also disclosed is a port-access topical cooling device for improving myocardial protection during the port-access CABG procedure. An alternate surgical approach using an anterior mediastinotomy is also described.

6. 发明公开

EP0819014A1 ENDOVASCULAR CARDIAC VENTING CATHETER AND METHOD 失效
标题翻译： ENDOVASKULÄRERKATHETER和方法来推导发自内心
公开(公告)号：EP0819014A1
公开(公告)日：1998-01-21
申请号：EP96908755.0
申请日：1996-03-12
申请人： HEARTPORT, INC.
发明人： STEVENS, John, H. , KRIER, Jeffrey, W. , VALLEY, Kirsten, L. , EVARD, Philip, C.
IPC分类号： A61F2 , A61M1 , A61M25 , A61M29
CPC分类号： A61M25/0041 , A61B2018/00232 , A61B2018/00261 , A61F2/2433 , A61F2/2436 , A61M1/3653 , A61M1/3659 , A61M25/007 , A61M25/0125 , A61M25/0662 , A61M25/10 , A61M29/02 , A61M2025/0004 , A61M2025/0078 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2210/125 , A61M2210/127
摘要： A venting catheter, system and method, are provided for withdrawing blood and other fluids from a patient's heart to facilitate decompressing the heart during cardioplegia arrest and cardiopulmonary bypass, without the need for a thoracotomy and without puncturing the aorta, pulmonary artery, or heart itself. The venting catheter (602) is configured to be introduced into a peripheral vein and intra-luminal advanced through the right side of the heart and into the pulmonary artery. The venting catheter includes a lumen (610) configured to withdraw blood at a rate of at least about 50 ml/min at a pressure of no less than about -350 mmHg. A flow directing means (615) is provided to facilitate guiding the catheter into the pulmonary artery by being carried by blood flow through the heart. The cardiac venting system may include, in addition to the cardiac venting catheter, a cardiopulmonary bypass system to maintain circulation of oxygenated blood, and means for arresting the patient's heart.

7. 发明公开

EP0819013A1 SYSTEM AND METHODS FOR PERFORMING ENDOVASCULAR PROCEDURES 失效
标题翻译：用于进行血管内手术的系统和方法
公开(公告)号：EP0819013A1
公开(公告)日：1998-01-21
申请号：EP96908744.0
申请日：1996-03-11
申请人： HEARTPORT, INC.
发明人： STEVENS, John, H. , PETERS, William, S. , STERMAN, Wesley, D. , GIFFORD, Hansen, S., III
IPC分类号： A61F2 , A61M25
CPC分类号： A61M25/1011 , A61M25/0041 , A61M25/0152 , A61M2025/0161
摘要： This invention is a system for inducing cardio-plegia arrest and performing an endovascular procedure within the heart or blood vessels of a patient. An endo-aortic partitioning catheter (10) has an inflatable balloon (11) which occludes the ascending aorta (12) when inflated. Cardio-plegia fluid may be infused through a lumen of the endo-aortic partitioning catheter (39) to stop the heart while the patient's circulatory system is supported on cardiopulmonary bypass. One or more endovascular devices (500) are introduced through an internal lumen (40) of the endo-aortic partitioning catheter (30) to perform a diagnostic or therapeutic endovascular procedure within the heart or blood vessels of the patient. Surgical procedures such as coronary artery bypass surgery or heart valve replacement may be performed in conjunction with the endovascular procedure while the heart is stopped. Embodiments of the system are described for performing, e.g., fiberoptic angioscopy of structures within the heart and its blood vessels, and valvuloplasty for correction of valvular stenosis.
摘要翻译：本发明是一种用于诱导心脏 - 心脏骤停并在患者的心脏或血管内执行血管内手术的系统。内 - 主动脉分隔导管（10）具有可膨胀气囊（11），其在充气时阻塞升主动脉（12）。可以通过主动脉分隔导管（39）的内腔注入心血液，以在体外循环支持患者的循环系统时阻止心脏。通过内主动脉分隔导管（30）的内腔（40）引入一个或多个血管内装置（500）以在患者的心脏或血管内执行诊断或治疗性血管内手术。当心脏停止时，可以结合血管内手术进行外科手术，如冠状动脉搭桥手术或心脏瓣膜置换术。该系统的实施例被描述用于执行例如心脏及其血管内的结构的纤维血管镜检查以及用于矫正瓣膜狭窄的瓣膜成形术。

8. 发明授权

EP0819014B1 ENDOVASCULAR CARDIAC VENTING CATHETER 失效
标题翻译： ENDOVASKULÄRERKATHETER推导发自内心
公开(公告)号：EP0819014B1
公开(公告)日：2003-02-05
申请号：EP96908755.0
申请日：1996-03-12
申请人： HEARTPORT, INC.
发明人： STEVENS, John, H. , KRIER, Jeffrey, W. , VALLEY, Kirsten, L. , EVARD, Philip, C.
IPC分类号： A61M29/00 , A61M29/02
CPC分类号： A61M25/0041 , A61B2018/00232 , A61B2018/00261 , A61F2/2433 , A61F2/2436 , A61M1/3653 , A61M1/3659 , A61M25/007 , A61M25/0125 , A61M25/0662 , A61M25/10 , A61M29/02 , A61M2025/0004 , A61M2025/0078 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2210/125 , A61M2210/127
摘要： A venting catheter, system and method, are provided for withdrawing blood and other fluids from a patient's heart to facilitate decompressing the heart during cardioplegia arrest and cardiopulmonary bypass, without the need for a thoracotomy and without puncturing the aorta, pulmonary artery, or heart itself. The venting catheter (602) is configured to be introduced into a peripheral vein and intra-luminal advanced through the right side of the heart and into the pulmonary artery. The venting catheter includes a lumen (610) configured to withdraw blood at a rate of at least about 50 ml/min at a pressure of no less than about -350 mmHg. A flow directing means (615) is provided to facilitate guiding the catheter into the pulmonary artery by being carried by blood flow through the heart. The cardiac venting system may include, in addition to the cardiac venting catheter, a cardiopulmonary bypass system to maintain circulation of oxygenated blood, and means for arresting the patient's heart.

9. 发明授权

EP0841963B1 CARDIOPLEGIA CATHETER SYSTEM 失效
标题翻译：搏导管系统
公开(公告)号：EP0841963B1
公开(公告)日：2004-03-10
申请号：EP95941419.4
申请日：1995-11-21
申请人： HEARTPORT, INC.
发明人： ST. GOAR, Frederick, G. , PETERS, William, S. , EVARD, Philip, C. , BOYD, Stephen, W. , ADAMS, Craig, L. , MUELLER, Richard, L., Jr. , STEVENS, John, H.
IPC分类号： A61M29/00 , A61M25/00 , A61M25/10
CPC分类号： A61M25/0068 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61F2/2427 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/005 , A61M25/008 , A61M25/01 , A61M25/0125 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M2025/0031 , A61M2025/0034 , A61M2025/0036 , A61M2025/004 , A61M2025/0057 , A61M2025/0078 , A61M2025/0087 , A61M2025/028 , A61M2025/1047 , A61M2025/1077 , A61M2205/11 , A61M2205/366 , A61M2210/125
摘要： A catheter system is provided for accessing the coronary ostia (176, 180) transluminal from a peripheral arterial access site, such as the femoral artery, and for inducing cardioplegia arrest by direct infusion of cardioplegia solution into the coronary arteries. In a first embodiment, the catheter system is in the form of a single perfusion catheter (20) with multiple distal branches (24, 26, 28) for engaging the coronary ostia (176, 180). In a second embodiment, multiple perfusion catheters (82, 84) are delivered to the coronary ostia (176, 180) through a single arterial cannula (104). In a third embodiment, multiple perfusion catheters (112, 114, 116) are delivered to the coronary ostia (176, 180) through a single guiding catheter (126). In a fourth embodiment, multiple catheters (140, 142, 144) are delivered to the coronary ostia (176, 180) through a single guiding catheter (130) which has distal exit ports (134, 136, 138) that are arranged to direct the perfusion catheters into the coronary ostia (176, 180). In each embodiment, the catheters (20) are equipped with an occlusion means (30, 50) at the distal end of the catheter (20) for closing the coronary ostia (176, 180), and isolating the coronary arteries from the systemic blood flow.

10. 发明授权

EP0719161B1 ENDOVASCULAR SYSTEM FOR ARRESTING THE HEART 失效
标题翻译：血管内系统，用于生成人工心脏仍然有效
公开(公告)号：EP0719161B1
公开(公告)日：2002-04-17
申请号：EP94927997.0
申请日：1994-09-01
申请人： HEARTPORT, INC.
发明人： EVARD, Philip, C , MACHOLD, Timothy, R. , STEVENS, John, H.
IPC分类号： A61M37/00
CPC分类号： A61M25/10 , A61B2018/00232 , A61B2018/00261 , A61F2/2427 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0125 , A61M25/0662 , A61M2025/0078 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2202/047 , A61M2210/125 , A61M2210/127
摘要： The invention provides an endovascular device (20) for partitioning the ascending aorta and a system for arresting the heart to facilitate the performance of precedures such as heart valve replacement or coronary artery bypass grafting without the need for a thoracotomy. According to the invention, an endovascular device (20) for partitioning a patient's ascending aorta comprises a flexible shaft (22) having a distal end (24), a proximal end (26), and a first inner lumen (29) therebetween with an opening (31) at the distal end (24). The shaft (22) may have a preshaped distal portion (32) with a curvature generally corresponding to the curvature of the patient's aortic arch. Expandable means (28) are disposed near the distal end (24) of the shaft (22) proximal to the opening (31) in the first inner lumen (29) for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles. Means (90) for delivering cardioplegic fluid may be connected to the proximal end (26) of the device to infuse cardioplegic fluid into the coronary arteries for arresting the heart. The endovascular device of the invention is readily positionable in the ascending aorta, resists displacement caused by systolic blood flow, and maintains axial alignment with the center of the ascending aorta and aortic valve.

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