专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

101. 发明授权

EP0552489B1 Peptide, production and use thereof 失效
标题翻译：肽，其制备及其使用
公开(公告)号：EP0552489B1
公开(公告)日：1998-03-04
申请号：EP92121908.5
申请日：1992-12-23
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： Kitada, Chieko , Ohtaki, Tetsuya , Fujino, Masahiko
IPC分类号： C07K5/02 , C07K7/02 , C07K14/575 , A61K38/00
CPC分类号： C07K5/021 , A61K38/00 , C07K5/0202 , C07K7/02 , C07K14/57536

102. 发明公开

EP0784478A1 INHIBITION OF ENDOTHELIN-1 TO REDUCE INFLAMMATORY PROCESSES 失效
标题翻译：内皮素-1的抑制TO REDUCE炎性过程
公开(公告)号：EP0784478A1
公开(公告)日：1997-07-23
申请号：EP95933865.0
申请日：1995-09-12
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BRIGHAM & WOMEN'S HOSPITAL
发明人： RUSSELL, Mary, E. , SAYEGH, Mohamed , WATSCHINGER, Bruno
IPC分类号： G01N33 , A61K38 , A61K39 , A61K45 , A61K48 , A61K49 , A61P37 , A61P43 , C07K14 , C07K16 , C12N15
CPC分类号： G01N33/5088 , A61K38/00 , A61K48/00 , C07K14/57536 , C07K14/723 , C07K16/2869 , G01N2333/5754 , G01N2800/245
摘要： The vasoactive and mitogenic peptide, endothelin-1 (ET-1) is upregulated within grafts, and methods of diagnosing and treating graft rejection, arteriosclerosis, and other cell-mediated inflammatory conditions are provided. These methods involve identifying and reducing expression of ET-1.

103. 发明公开

EP0679658A4 ENDOTHELIN-ANTAGONIZING PEPTIDE. 失效
标题翻译： ENDOTHELINANTAGONISIERENDES PEPTID。
公开(公告)号：EP0679658A4
公开(公告)日：1997-06-04
申请号：EP95904339
申请日：1994-06-23
申请人： KYOWA HAKKO KOGYO KK
发明人： SHIBATA KENJI , SUZAWA TOSHIYUKI , YAMASAKI MOTOO , TANAKA TAKEO , TSUKUDA EIJI , YAMADA KOJI , OHNO TETSUJI
IPC分类号： A61K38/00 , C07K7/06 , C07K14/575 , C07K7/08
CPC分类号： C07K7/06 , A61K38/00 , C07K14/57536
摘要： An endothelin-antagonizing peptide compound represented by general formula (I) and a pharmacologically acceptable salt thereof: R -R -R -R -R -R -R -R -R -R -R -R -Phe-R -R -R -R -R -Ile-R -Z wherein R is X -Gly, X (a), X -SCH2CO or hydrogen; R is Asn, Asp, Phe, Tyr, Ser or a single bond; R is Trp, Ile, Pro, Ala or a single bond; R is His, Lys, Gly, Trp, Ala or a single bond; R is Gly, Thr, Trp, Val or a single bond; R is Gly, Thr, Asn, Tyr, Asp or a single bond; R is Ala, Ser, Asn, Asp, Tyr, Phe or a single bond; R is Pro, Ala, Arg or a single bond; R is (b), (c) or a single bond; R is Trp or Ala; R is Val, Pro or a single bond; R is Tyr or a single bond; R is Ala, MeAla, Ser or Cys; R is His or Trp; R is Leu or Nva; R is Asp, Thr, Asn, Ser, Gly or Glu; R is Ile, Leu, Cha, Abu, Thi, Met, Tyr, MeLeu, MeIle, Phg or Nle; R is Trp, Phe or Tyr; and Z is hydroxy, lower alkoxy or amino.
摘要翻译：通式（I）所示的内皮缩血管肽拮抗肽化合物及其药理学上可接受的盐：R 1 -R 2 -R 3 -R 4 -R 5 -R 6 - [R <7> -R <8> -R <9> -R <10> -R <11> -R <12> -Phe-R <14> -R <15> -R <16> -R <17 R 18 -Ile-R 20 -Z其中R 1是X 1 -Gly，X 3（a），X 2 -SCH 2 CO或氢; R 2是Asn，Asp，Phe，Tyr，Ser或单键; R 3是Trp，Ile，Pro，Ala或单键; R 4是His，Lys，Gly，Trp，Ala或单键; R 5是Gly，Thr，Trp，Val或单键; R 6是Gly，Thr，Asn，Tyr，Asp或单键; R 7是Ala，Ser，Asn，Asp，Tyr，Phe或单键; R 8是Pro，Ala，Arg或单键; R 9是（b），（c）或单键; R 10是Trp或Ala; R 11是Val，Pro或单键; R 12是Tyr或单键; R 14是Ala，MeAla，Ser或Cys; R 15是His或Trp; R 16是Leu或Nva; R 17是Asp，Thr，Asn，Ser，Gly或Glu; R 18是Ile，Leu，Cha，Abu，Thi，Met，Tyr，MeLeu，MeIle，Phg或Nle; R 20是Trp，Phe或Tyr; Z是羟基，低级烷氧基或氨基。

104. 发明公开

EP0767801A1 ENDOTHELIN ANTAGONISTS II 失效
标题翻译：内皮素拮抗剂
公开(公告)号：EP0767801A1
公开(公告)日：1997-04-16
申请号：EP95915024.0
申请日：1995-04-05
申请人： WARNER-LAMBERT COMPANY
发明人： CODY, Wayne, Livingston , DOHERTY, Annette, Marian , TOPLISS, John, Gordon
IPC分类号： A61K38 , A61K31 , A61P1 , A61P3 , A61P5 , A61P9 , A61P11 , A61P13 , A61P15 , A61P25 , A61P35 , C07C233 , C07C237 , C07D219 , C07D335 , C07D521 , C07K5 , C07K7 , C07K14
CPC分类号： C07K14/57536 , A61K38/00
摘要： Novel antagonists of endothelin containing an N-terminal fragment (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, metabolic, endocrinological, neurological disorders especially cerebral vasospasm, stroke, and head injury, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease, restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, and diabetes.

105. 发明授权

EP0468337B1 DNA coding for a human vasoconstrictive peptide and use thereof 失效
标题翻译：编码人，血管收缩肽，并且其使用DNA
公开(公告)号：EP0468337B1
公开(公告)日：1997-03-05
申请号：EP91111815.6
申请日：1991-07-16
申请人： Takeda Chemical Industries, Ltd.
发明人： Onda, Haruo , Ohkubo, Shoichi , Kosaka, Takuo
IPC分类号： C07K14/575 , C12N15/12 , C12P21/02 , A61K38/00
CPC分类号： C07K14/57536 , A61K38/00

106. 发明授权

EP0499266B1 Endothelin antagonist 失效
标题翻译：内皮素拮抗剂
公开(公告)号：EP0499266B1
公开(公告)日：1996-07-10
申请号：EP92102498.0
申请日：1992-02-14
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： Wakimasu, Mitsuhiro , Kikuchi, Takashi , Kubo, Kazuki
IPC分类号： C07K14/575 , A61K38/22
CPC分类号： C07K14/57536 , A61K38/00

107. 发明公开

EP0574530A4 ENDOTHELIN ANTAGONISTS 失效
标题翻译：内皮素拮抗剂
公开(公告)号：EP0574530A4
公开(公告)日：1996-04-03
申请号：EP92908614
申请日：1992-03-09
申请人： RES CORP TECHNOLOGIES INC
发明人： ANDERSEN THOMAS T , SPINELLA MICHAEL J
IPC分类号： A61K38/00 , C07K14/575 , A61K37/02 , C07K7/10
CPC分类号： C07K14/57536 , A61K38/00

108. 发明公开

EP0692976A1 CHELATING AGENTS OF THE TYPE XN 1?S 1?O 1? FOR RADIOACTIVE ISOTOPES, METAL COMPLEXES THEREOF, AND THEIR USE IN DIAGNOSIS AND THERAPY 失效
标题翻译：螯合型XN 1 S 1 2 O 1？ FOR放射性同位素，它们的金属配合物及其用途的诊断与治疗
公开(公告)号：EP0692976A1
公开(公告)日：1996-01-24
申请号：EP94912441.0
申请日：1994-03-29
申请人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN
发明人： HILGER, Christoph-Stephan , DINKELBORG, Ludger , KRAMP, Wolfgang , SCHIER, Hans-Martin
IPC分类号： A61K51 , C07B59 , C07C323 , C07C391 , C07D333 , C07F13 , C07J1 , C07K7 , C07K14
CPC分类号： C07K14/57536 , A61K51/0478 , A61K51/088 , A61K2121/00 , A61K2123/00 , C07B59/001 , C07B59/008 , C07C323/59 , C07C323/60 , C07D333/34 , C07F13/005
摘要： Novel bifunctional chalcogenic-atom-discontinuous chelating agents, pharmaceutical preparations containing them, their use in radio diagnosis and radio therapy, and methods of preparing them. The invention concerns compounds of the general formula (I): M-L, in which M is a radioisotope of Tc or Re, and L is a ligand of general formula (II). Surprisingly, it has been found that the bifunctional chalcogenic-atom-discontinuous chelating agents described, and their coupling products with specifically enriching compounds, are eminently suitable for use in the production of radiodiagnostic or radiotherapeutic compounds.

109. 发明公开

EP0587541A1 Process to purify the big-endothelin protein 失效
标题翻译： Verfahren zur Reinigung des Big-Endothelin Proteins。
公开(公告)号：EP0587541A1
公开(公告)日：1994-03-16
申请号：EP93830361.7
申请日：1993-09-03
申请人： TECNOGEN S.C.P.A.
发明人： Fassina, Giorgio, c/o TECNOGEN ScpA , Merli, Silvia, c/o TECNOGEN ScpA
IPC分类号： C07K3/12 , C07K3/20 , C12N15/10
CPC分类号： C07K14/57536
摘要： A process to purify Big-Endothelin (Big-ET) from crude extracts comprising the steps as follows:

to express Big-ET protein in host cells using genetic engineering methods;
to lyse said host cells and to treat them with a proteolytic enzyme in order to obtain a proteolysed extract;
to load said proteolysed extract to an affinity chromatography column, prepared by immobilizing a Big-ET specific ligand, said ligand comprising Big-ET hydropathically complementary peptides, consisting of D configuration amino acids, said column equilibrated with a suitable saline buffer;
to wash out the not specifically bonded material from said column by a suitable washing buffer;
to elute the specifically retained material into said column by a suitable elution buffer.
摘要翻译：从粗提取物中纯化大内皮素（Big-ET）的方法，包括以下步骤：使用基因工程方法在宿主细胞中表达大ET蛋白; 裂解所述宿主细胞并用蛋白水解酶处理以获得蛋白水解的提取物; 将所述蛋白水解的提取物加载到通过固定Big-ET特异性配体制备的亲和层析柱，所述配体包含由D构型氨基酸组成的Big-ET亲水互补肽，所述柱用合适的盐水缓冲液平衡; 通过合适的洗涤缓冲液从所述柱中洗去未特异结合的材料; 通过合适的洗脱缓冲液将特定保留的物质洗脱到所述柱中。

110. 发明公开

EP0584290A1 ENDOTHELIN ANTAGONISTS 失效
标题翻译：内皮素拮抗剂。
公开(公告)号：EP0584290A1
公开(公告)日：1994-03-02
申请号：EP92923584.0
申请日：1992-04-24
申请人： WARNER-LAMBERT COMPANY
发明人： CODY, Wayne, Livingston , DePUE, Patricia , DOHERTY, Annette, Marian , TAYLOR, Michael, Douglas
IPC分类号： A61K38 , A61P3 , A61P9 , A61P11 , A61P13 , A61P15 , A61P25 , C07K5 , C07K7 , C07K14
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1016 , C07K14/57536
摘要： On décrit de nouveaux antagonistes d'endothéline, ainsi que des procédés de préparation de ces antagonistes et des compositions pharmaceutiques les contenant, ces antagonistes pouvant être utilisés pour le traitement de l'hypertension artérielle, l'infarctus du myocarde, les troubles d'origine métabolique, endocrinologique et neurologique, l'insuffisance cardiaque congestive, le choc endotoxique, l'hémorragie sous-arachnoïdienne, les arythmies, l'asthme, l'insuffisance rénale aiguë, la prééclampsie et le diabète.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式