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1. 发明授权

EP1165610B1 PEPTIDE USEFUL IN TREATING MULTIPLE SCLEROSIS AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：肽用于治疗多发性硬化症及其药物组合物
公开(公告)号：EP1165610B1
公开(公告)日：2006-01-11
申请号：EP99915734.0
申请日：1999-03-29
申请人： TECNOGEN S.C.P.A.
发明人： MARINO, Maria , IPPOLITO, Agostino , FASSINA, Giorgio
IPC分类号： C07K14/47 , A61K38/17
CPC分类号： C07K14/4713 , A61K38/00
摘要： A peptide compound useful in treating the Multiple Sclerosis selected from the group comprising: R-Asn-Gly-Val-Gly-His-Gly-Phe-Gly-Asn-Gly-Val-Gly-Pro-Gly-Thr-Gly-Pro-Gly-Ser-Gly-R' (I) (SEQ ID NO: 1); R-Gly-Pro-Gly-Val-Gly-Phe-Gly-Lys-Gly-Ile-Gly-Thr-Gly-Arg-Gly-Pro-Gly-Pro-Gly-Gln-R' (II) (SEQ ID NO: 2); R-Gln-Gly-Pro-Gly-Pro-Gly-Arg-Gly-Thr-Gly-Ile-Gly-Lys-Gly-Phe-Gly-Val-Gly-Pro-Gly-R' (III) (SEQ ID NO:3); and R-Gly-Ser-Gly-Pro-Gly-Thr-Gly-Pro-Gly-Val-Gly-Asn-Gly-Gly-Phe-Gly-His-Gly-Val-Gly-Asn-R' (IV) (SEQ ID NO:4) where R is H- or COCH3, R' is COOH or CONH2 and each amino acid has L or D configuration. A pharmaceutical composition comprising the same.

2. 发明授权

EP0670889B1 MOBILE-MODULE PLANT FOR THE DEVELOPEMENT AND THE PRODUCTION OF BIOTECHNOLOGICAL PRODUCTS ON A PILOT SCALE 失效
标题翻译：移动模块化系统的开发VERSUCHSMASSTAB的研制与生产生物技术产品
公开(公告)号：EP0670889B1
公开(公告)日：1998-08-19
申请号：EP93912873.2
申请日：1993-05-29
申请人： SNAMPROGETTIBIOTECNOLOGIE S.P.A , TECNOGEN S.C.P.A.
发明人： CASSANI, Giovanni, Rodolfo , LANI, Marina, Barbara
IPC分类号： C12M1/00 , B01L11/00
CPC分类号： B01J19/004 , B01L9/54 , C12M23/44 , C12M23/52
摘要： A mobile-module plant (1) for the developement and the production of biotechnological products on a pilot scale comprising equipments for the production, separation, purification and finishing of said products (11, 17, 18, 19, 20; 40, 47, 48, 50, 52, 54; 71-76, 82, 86, 89, 92, 95, 98) and auxiliary equipments (102; 107, 109, 110; 112; 113; 119; 123; 129; 134; 135; 141-143), wherein (i) said plant (1) consists of at least two mobile modules (2; 3; 4; 5; 8) suitable for being connected together and integrated one with the other, (ii) each of said mobile modules (2; 3; 4; 5; 8) comprises a movable container (6), (iii) at least one of said movable containers (6) is provided with a preselected own set of said equipments (11, 17, 18, 19, 20; 40, 47, 48, 50, 52, 54; 71-76, 82, 86, 89, 92, 95, 98; 102; 107, 109, 110; 112; 113; 119; 123; 129; 134; 135; 141-143), and (iv) at least one of said movable containers (6) is aseptic.

3. 发明公开

EP0460569A1 PROCESS FOR IDENTIFYING POLYNUCLEOTIDE SEQUENCES AND DEVICE SUITABLE THEREFOR 失效
标题翻译： Verfahren zur Identifizierung von Polynukleotidsequenzen und Vorrichtungdafür。
公开(公告)号：EP0460569A1
公开(公告)日：1991-12-11
申请号：EP91109023.1
申请日：1991-06-03
申请人： TECNOGEN S.C.P.A.
发明人： CORTI, ANGELO
IPC分类号： C12Q1/68
CPC分类号： G01N33/54366 , C12Q1/6816 , C12Q1/6834 , C12Q2563/131 , C12Q2563/125 , C12Q2537/125
摘要： There is described a process for identifying polynucleotide sequences consisting in hybridizing in one single capsule polynucleotide molecules which comprise said sequences with at least one reagent, also of polynucleotide nature, having sequence complementary to the polynucleotide to be detected.
The process herein disclosed is exceptionally simple and it can be carried out also in unspecialized laboratories by means of a kit.
摘要翻译：描述了一种鉴定多核苷酸序列的方法，所述多核苷酸序列在一个单一胶囊多核苷酸分子中杂交，所述多核苷酸分子包含所述序列与至少一种具有与待检测的多核苷酸互补的序列的多核苷酸性质的试剂。本文公开的方法非常简单，并且也可以通过试剂盒在非特异性实验室中进行。

4. 发明公开

EP1165610A1 PEPTIDES USEFUL IN TREATING MULTIPLE SCLEROSIS AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：肽用于治疗多发性硬化症及其药物组合物
公开(公告)号：EP1165610A1
公开(公告)日：2002-01-02
申请号：EP99915734.0
申请日：1999-03-29
申请人： TECNOGEN S.C.P.A.
发明人： MARINO, Maria , IPPOLITO, Agostino , FASSINA, Giorgio
IPC分类号： C07K14/47 , A61K38/17
CPC分类号： C07K14/4713 , A61K38/00
摘要： A peptide compound useful in treating the Multiple Sclerosis selected from the group comprising: R-Asn-Gly-Val-Gly-His-Gly-Phe-Gly-Asn-Gly-Val-Gly-Pro-Gly-Thr-Gly-Pro-Gly-Ser-Gly-R' (I) (SEQ ID NO: 1); R-Gly-Pro-Gly-Val-Gly-Phe-Gly-Lys-Gly-Ile-Gly-Thr-Gly-Arg-Gly-Pro-Gly-Pro-Gly-Gln-R' (II) (SEQ ID NO: 2); R-Gln-Gly-Pro-Gly-Pro-Gly-Arg-Gly-Thr-Gly-Ile-Gly-Lys-Gly-Phe-Gly-Val-Gly-Pro-Gly-R' (III) (SEQ ID NO:3); and R-Gly-Ser-Gly-Pro-Gly-Thr-Gly-Pro-Gly-Val-Gly-Asn-Gly-Gly-Phe-Gly-His-Gly-Val-Gly-Asn-R' (IV) (SEQ ID NO:4) where R is H- or COCH3, R' is COOH or CONH2 and each amino acid has L or D configuration. A pharmaceutical composition comprising the same.

5. 发明授权

EP0751225B1 Process for the identification of proteolytic activities and/or inhibitors thereof 失效
标题翻译：一种用于检测的蛋白水解活性和/或它们的抑制剂的方法
公开(公告)号：EP0751225B1
公开(公告)日：2001-03-28
申请号：EP96114931.7
申请日：1991-10-14
申请人： TECNOGEN S.C.P.A.
发明人： Fassina, Giorgio , Corti, Angelo
IPC分类号： C12Q1/37
CPC分类号： C07K14/525 , C07K14/001 , C07K14/57536

6. 发明授权

EP0481930B1 Nonlinear peptides hydropathycally complementary to known amino acid sequences, process for the production and uses thereof 失效
标题翻译：非线性肽与已知氨基酸序列hydropathically互补，制备方法及其用途
公开(公告)号：EP0481930B1
公开(公告)日：1997-06-18
申请号：EP91830428.8
申请日：1991-10-14
申请人： TECNOGEN S.C.P.A.
发明人： Fassina, Giorgio, c/o TECNOGEN Società Consortile , Corti, Angelo, c/o TECNOGEN Società Consortile
IPC分类号： C07K7/02 , C07K14/00 , C07K14/525 , C07K14/575 , G01N33/68
CPC分类号： C07K14/525 , C07K14/001 , C07K14/57536

7. 发明公开

EP0481930A2 Nonlinear peptides hydropathycally complementary to known amino acid sequences, process for the production and uses thereof 失效
标题翻译：和非线性肽与已知氨基酸序列hydropathically互补，制备方法及其用途。
公开(公告)号：EP0481930A2
公开(公告)日：1992-04-22
申请号：EP91830428.8
申请日：1991-10-14
申请人： TECNOGEN S.C.P.A.
发明人： Fassina, Giorgio, c/o TECNOGEN Società Consortile , Corti, Angelo, c/o TECNOGEN Società Consortile
IPC分类号： C07K7/02 , C07K15/00 , G01N33/68
CPC分类号： C07K14/525 , C07K14/001 , C07K14/57536
摘要： This invention relates to nonlinear peptides which are hydropathically complementary to known amino acid sequences and are covalently linked to an amino acid nucleus. Such molecules are employed both for affinity chromatography applications and for analytical procedures for determining peptide analytes in complex matrices. More particularly, peptides complementary to endothelin fragments are employed for the identification of proteolytic activities or of activities that inhibit proteolytic activities.
摘要翻译：本发明涉及非线性肽哪些是已知的氨基酸序列互补的hydropathically和共价连接到氨基酸的核。幅分子被用于亲和层析这两个应用程序和用于复杂基质确定性采矿肽分析物的分析方法。更具体地，涉及内皮素的片段互补的肽被用于或活动的蛋白水解活性的鉴定确实地抑制蛋白水解活性。

8. 发明公开

EP1621546A1 Peptide ligands specific to immonoglobulins 有权
标题翻译： Peptidische Ligande die eine spezifischeBindungsfähigkeitfürImmunoglobuline zeigen
公开(公告)号：EP1621546A1
公开(公告)日：2006-02-01
申请号：EP05076751.6
申请日：2005-07-28
申请人： TECNOGEN S.C.P.A.
发明人： Verdoliva, Antonio , Bellofiore, Piero , Cassani, Giovanni , Marasco, Daniela , Pedone, Carlo , Monti, Simona , Ruvo, Menotti
IPC分类号： C07K5/08 , C07K5/10 , C07K7/02 , C07K5/02 , C07K16/06 , G01N33/68
CPC分类号： C07K5/0821 , C07K5/0215 , C07K5/1013 , C07K7/02 , G01N33/6854 , H04B1/3827
摘要： A compound of formula:

(X 1 -X 2 -His-X 3 -CO) n -R (I)

where:

X 1 is H or an amino acid residue of cysteine (Cys) having L or D configuration, wherein each pair of amino acid residues of Cys, optionally present as X 1 , can be in the form of a cystine residue owing to an -S-S- bridge formed by the -SH functions of two Cys residues,
X 2 is an amino acid residue of tyrosine (Tyr) or of histidine (His) having L or D configuration,
X 3 is an amino acid residue of His or Tyr having L or D configuration, provided, however, that X 2 is Tyr when X 3 is His and X 2 is His when X 3 is Tyr,
His is an amino acid residue of histidine having L or D configuration,
n is an integer of from 1 to 4,
R when n is 1, is OH, a residue of a single amino acid, or a peptide chain comprising from 2 to 7 amino acids,

whereas,
when n is 2, 3 or 4, it is a group capable of forming a dimer, a trimer and, respectively, a tetramer.
摘要翻译：一个公式的组合：€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ（X 1 -X 2 -His-X 3 -CO）n -R€ƒ€ƒ€ƒ€ƒ（I ）其中：X 1是H或具有L或D构型的半胱氨酸（Cys）的氨基酸残基，其中任选以X 1表示的Cys的每对氨基酸残基可以是胱氨酸残基的形式，因为由两个Cys残基的-SH功能形成的-SS-桥，X 2是具有L或D构型的酪氨酸（Tyr）或组氨酸（His）的氨基酸残基，X 3是氨基酸res 2是Tyr 当X 3为His且X 3为Tyr时，X 2为His，His为具有L或D构型的组氨酸的氨基酸残基，n为1至4的整数，当n为1时为R，为OH，a为单个氨基酸的残基或包含2至7个氨基酸的肽链，€ƒ€ƒ，而当n为2,3或4时，它是能够形成二聚体，三聚体和/ 分别是四聚体。

9. 发明授权

EP0958829B1 Use of a peptide compound in the treatment of systemic lupus erythematosus 失效
标题翻译：使用肽化合物用于治疗SLE的
公开(公告)号：EP0958829B1
公开(公告)日：2004-05-19
申请号：EP98830310.3
申请日：1998-05-21
申请人： TECNOGEN S.C.P.A.
发明人： Marino, Maria , Rossi, Maria , Fassina, Giorgio
IPC分类号： A61K38/08 , A61K38/10
CPC分类号： A61K38/08 , A61K38/10

10. 发明公开

EP0587541A1 Process to purify the big-endothelin protein 失效
标题翻译： Verfahren zur Reinigung des Big-Endothelin Proteins。
公开(公告)号：EP0587541A1
公开(公告)日：1994-03-16
申请号：EP93830361.7
申请日：1993-09-03
申请人： TECNOGEN S.C.P.A.
发明人： Fassina, Giorgio, c/o TECNOGEN ScpA , Merli, Silvia, c/o TECNOGEN ScpA
IPC分类号： C07K3/12 , C07K3/20 , C12N15/10
CPC分类号： C07K14/57536
摘要： A process to purify Big-Endothelin (Big-ET) from crude extracts comprising the steps as follows:

to express Big-ET protein in host cells using genetic engineering methods;
to lyse said host cells and to treat them with a proteolytic enzyme in order to obtain a proteolysed extract;
to load said proteolysed extract to an affinity chromatography column, prepared by immobilizing a Big-ET specific ligand, said ligand comprising Big-ET hydropathically complementary peptides, consisting of D configuration amino acids, said column equilibrated with a suitable saline buffer;
to wash out the not specifically bonded material from said column by a suitable washing buffer;
to elute the specifically retained material into said column by a suitable elution buffer.
摘要翻译：从粗提取物中纯化大内皮素（Big-ET）的方法，包括以下步骤：使用基因工程方法在宿主细胞中表达大ET蛋白; 裂解所述宿主细胞并用蛋白水解酶处理以获得蛋白水解的提取物; 将所述蛋白水解的提取物加载到通过固定Big-ET特异性配体制备的亲和层析柱，所述配体包含由D构型氨基酸组成的Big-ET亲水互补肽，所述柱用合适的盐水缓冲液平衡; 通过合适的洗涤缓冲液从所述柱中洗去未特异结合的材料; 通过合适的洗脱缓冲液将特定保留的物质洗脱到所述柱中。

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