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1. 发明授权

EP0678577B1 Method for the production of recombinant human LH-RH receptor proteins in specific CHO cell lines. 失效
标题翻译：一种用于在特定细胞系CHO生产重组人LH-RH受体蛋白质的过程。
公开(公告)号：EP0678577B1
公开(公告)日：2004-09-08
申请号：EP95105801.5
申请日：1995-04-19
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： Onda, Haruo , Ohkubo, Shoichi , Hinuma, Shuji , Sawada, Hidekazu
IPC分类号： C12N5/10 , C07K14/72 , C07K7/23 , C12Q1/00
CPC分类号： C07K7/23 , A61K38/00 , A61K39/00 , C07K14/723

2. 发明公开

EP1179540A1 NOVEL POLYPEPTIDE 审中-公开
标题翻译：新型多肽
公开(公告)号：EP1179540A1
公开(公告)日：2002-02-13
申请号：EP00929805.0
申请日：2000-05-19
申请人： Takeda Chemical Industries, Ltd.
发明人： Itoh, Yasuaki , Mogi, Shinichi , Tanaka, Hideyuki , Ohkubo, Shoichi , Ogi, Kazuhiro
IPC分类号： C07K14/47 , C12P21/02 , C07K16/18 , C12P21/08 , G01N33/50 , G01N33/15 , G01N33/563 , A61K38/16 , A61K39/395
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , C07K16/18
摘要： The present invention relates to a novel secretory protein or salts thereof, methods of manufacturing the protein, a pharmaceutical composition comprising the protein, an antibody to the protein, screening methods/screening kits for a compound or salts thereof that promotes or inhibits activities of the protein, etc.
The protein of the present invention can be used as prophylactic/therapeutic agents for various diseases such as cancer, immunologicl diseases, pulmonary dysfunction, liver dysfunction, infection or gastrointestinal disorders, etc. The antibody of the present invention can be used for quantification of the protein of the present invention in the test solution. Furthermore, the protein of the present invention is useful as the reagent for screening a compound that either promotes or inhibits activities of the protein of the present invention.
摘要翻译：本发明涉及新的分泌蛋白或其盐，制备该蛋白的方法，包含该蛋白的药物组合物，该蛋白的抗体，用于促进或抑制该蛋白活性的化合物或其盐的筛选方法/筛选试剂盒蛋白质等。本发明的蛋白质可以用作各种疾病例如癌症，免疫疾病，肺功能障碍，肝功能障碍，感染或胃肠疾病等的预防/治疗剂。可以使用本发明的抗体用于定量测试溶液中本发明的蛋白质。此外，本发明的蛋白质可用作筛选促进或抑制本发明蛋白质活性的化合物的试剂。

3. 发明公开

EP1233025A1 Receptor expression cells and use thereof 失效
标题翻译： Rezeptorexprimierende Zellen und deren Verwendungen
公开(公告)号：EP1233025A1
公开(公告)日：2002-08-21
申请号：EP02009520.4
申请日：1995-04-19
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： Onda, Haruo , Ohkubo, Shoichi , Hinuma, Shuji , Sawada, Hidekazu
IPC分类号： C07K14/705 , C07K7/23 , C12N15/00
CPC分类号： C07K7/23 , A61K38/00 , A61K39/00 , C07K14/723
摘要： Disclosed are CHO cells which are capable of continued production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to early provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, a pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.
摘要翻译：公开了能够连续产生人LH-RH受体蛋白质或其细胞膜级分的CHO细胞; 重组人LH-RH受体蛋白或其部分肽; 通过使化合物与CHO细胞或其细胞膜级分或重组人LH-RH受体蛋白或其部分肽接触来筛选对LH-RH受体具有亲和性的化合物的方法; 套件进行筛选; 通过筛选方法获得的对LH-RH受体具有亲和力的化合物或用于筛选的试剂盒; 和含有该化合物的药物组合物，从而能够早期提供例如前列腺癌，子宫癌，乳腺癌，垂体瘤，子宫内膜异位症，子宫肌瘤或早熟青春期的预防或治疗组合物。它们也可用作妊娠控制组合物，例如避孕或月经周期控制组合物。

4. 发明公开

EP0468337A1 DNA coding for a human vasoconstrictive peptide and use thereof 失效
标题翻译： DNS，die ein menschliches，gefässverengendesPeptid kodiert，und dessen Verwendung。
公开(公告)号：EP0468337A1
公开(公告)日：1992-01-29
申请号：EP91111815.6
申请日：1991-07-16
申请人： Takeda Chemical Industries, Ltd.
发明人： Onda, Haruo , Ohkubo, Shoichi , Kosaka, Takuo
IPC分类号： C07K14/575 , C12N15/12 , C12P21/02 , A61K37/02
CPC分类号： C07K14/57536 , A61K38/00
摘要： Disclosed are (1) a DNA containing a cDNA segment coding for human endothelin-2 (SEQ ID NO:1), (2) a precursor of human endothelin-2 (SEQ ID NO:2), (3) a transformant carrying a DNA containing a cDNA segment coding for human endothelin-2, and (4) a method for preparing mature human endothelin-2 which comprises culturing the transformant described in (3), accumulating a protein in a culture medium, and collecting the same, whereby human endothelin-2 and the precursors thereof can be produced in large amounts.
摘要翻译：公开了（1）含有编码人内皮素-2（SEQ ID NO：1）的cDNA段的DNA，（2）人内皮素-2（SEQ ID NO：2）的前体，（3）含有编码人内皮素-2的cDNA片段的DNA，（4）成熟人内皮素-2的制备方法，其包括培养（3）所述的转化体，将培养基中的蛋白质聚集并收集，人内皮素-2及其前体可以大量生产。

5. 发明授权

EP0468337B1 DNA coding for a human vasoconstrictive peptide and use thereof 失效
标题翻译：编码人，血管收缩肽，并且其使用DNA
公开(公告)号：EP0468337B1
公开(公告)日：1997-03-05
申请号：EP91111815.6
申请日：1991-07-16
申请人： Takeda Chemical Industries, Ltd.
发明人： Onda, Haruo , Ohkubo, Shoichi , Kosaka, Takuo
IPC分类号： C07K14/575 , C12N15/12 , C12P21/02 , A61K38/00
CPC分类号： C07K14/57536 , A61K38/00

6. 发明公开

EP0678577A2 Method for the production of recombinant human LH-RH receptor proteins 失效
标题翻译：一种用于在特定细胞系CHO生产重组人LH-RH受体蛋白质的过程。
公开(公告)号：EP0678577A2
公开(公告)日：1995-10-25
申请号：EP95105801.5
申请日：1995-04-19
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： Onda, Haruo , Ohkubo, Shoichi , Hinuma, Shuji , Sawada, Hidekazu
IPC分类号： C12N15/12 , C12N5/10 , C07K14/72 , C07K7/23 , C12Q1/00 , A61K38/09
CPC分类号： C07K7/23 , A61K38/00 , A61K39/00 , C07K14/723
摘要： Disclosed are CHO cells which are capable of continued production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to early provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, a pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.
摘要翻译：公开的是CHO细胞，其能够持续产生人LH-RH受体蛋白质，或其细胞膜组份的的; 重组人LH-RH受体蛋白质或其部分肽; 用于通过接触与所述的CHO细胞或其细胞膜组份，或重组人LH-RH受体蛋白质或其部分肽的化合物筛选具有用于LH-RH受体的亲和性化合物的方法; 包筛选他们; 具有用于通过用于筛选或试剂盒的筛选方法获得的LH-RH受体的亲和力化合物; 和药物组合物含有该化合物，从而能够早期提供预防性或治疗性组合物，例如，前列腺癌，子宫癌，乳腺癌，垂体瘤一个，子宫内膜异位，子宫肌瘤或性早熟。因此，它们作为妊娠控制组合物中有用：如避孕或月经周期控制组合物。

7. 发明公开

EP0421284A1 Human endothelin-3 cDNA and use thereof 失效
标题翻译： Menschliches Endothelin-3 cDNA和seine Verwendung。
公开(公告)号：EP0421284A1
公开(公告)日：1991-04-10
申请号：EP90118627.0
申请日：1990-09-28
申请人： Takeda Chemical Industries, Ltd.
发明人： Onda, Haruo , Ohkubo, Shoichi
IPC分类号： C12N15/16 , C12P21/02 , C07K13/00 , C12N1/21 , C12N5/10
CPC分类号： C07K14/57536 , A61K38/00
摘要： A DNA comprising a cDNA coding for human endothelin-3 is disclosed. A precursor protein of human endothelin-3, a transformant transformed with the cDNA coding for human endothelin-3 and a method for producing endothelin-3 are also disclosed.
摘要翻译：公开了包含编码人内皮素-3的cDNA的DNA。还公开了人内皮素-3的前体蛋白，用编码人内皮素-3的cDNA转化的转化体和产生内皮素-3的方法。

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