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91. 发明公开

EP3218352A4 METHODS FOR LIQUID CHROMATOGRAPHY CALIBRATION FOR RAPID LABELED N-GLYCANS 无效
公开(公告)号：EP3218352A4
公开(公告)日：2018-07-18
申请号：EP15859131
申请日：2015-11-12
申请人： WATERS TECHNOLOGIES CORP
发明人： MORRIS MICHAEL F , LAUBER MATTHEW A , BROUSMICHE DARRYL W
IPC分类号： C07C217/08 , B01D15/30 , C07D215/48 , C07H15/26 , G01N30/02 , G01N30/04 , G01N30/62 , G01N30/88 , G01N33/68
CPC分类号： G01N30/02 , B01D15/305 , C07D215/48 , C07H15/26 , G01N30/04 , G01N30/88 , G01N33/6842 , G01N2030/027 , G01N2030/047 , G01N2030/626 , G01N2030/8836 , G01N2400/00 , G01N2440/38
摘要： Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to produce the rapid labeled dextran ladder.

92. 发明公开

EP3203227A4 CHRONIC HEART DISEASE PATIENT SPECIFIC BIOMARKER COMPOSITION AND USE THEREOF 有权
公开(公告)号：EP3203227A4
公开(公告)日：2018-06-06
申请号：EP14903169
申请日：2014-09-30
申请人： BGI SHENZHEN CO LTD , BGI SHENZHEN
发明人： FENG QIANG , LIU ZHIPENG , MENG NAN , WANG JUN
IPC分类号： G01N30/02 , G01N30/62 , G01N33/48
CPC分类号： G01N30/02 , G01N30/62 , G01N33/48
摘要： The present invention relates to a disease-specific metabolite profile, and particularly to a biomarker composition obtained by screening from blood plasma-specific profiles of coronary heart disease subjects. The present invention also relates to a use of the biomarker compositions in risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease, and to a method for risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease. The biomarker composition as provided by the present invention can be used for early diagnosis of coronary heart disease and has high sensitivity, good specificity and good application prospects.

93. 发明公开

EP3320325A1 DIFFERENTIAL VISCOMETER WITH SOLVENT COMPRESSIBILITY CORRECTION 有权
标题翻译：具有溶剂可压缩性校正的微分粘度计
公开(公告)号：EP3320325A1
公开(公告)日：2018-05-16
申请号：EP16822077.0
申请日：2016-07-08
申请人： Wyatt Technology Corporation
发明人： TRAINOFF, Steven
IPC分类号： G01N11/04 , G01N11/08 , G01N21/41 , G01N30/02 , G01N30/62
CPC分类号： G01N11/08 , G01N30/32 , G01N30/62 , G01N30/64
摘要： An improved version of the capillary bridge viscometer that compensates for the effect of solvent compressibility is disclosed. A novel, yet simple and inexpensive modification to a conventional capillary bridge viscometer design can improve its ability to reject pump pulses by more than order of magnitude. This improves the data quality and allows for the use of less expensive pumps. A pulse compensation volume is added such that it transmits pressure to the differential pressure transducer without sample flowing there through. The pressure compensation volume enables the cancelation of the confounding effects of pump pulses in a capillary bridge viscometer.

94. 发明公开

EP3203227A1 CHRONIC HEART DISEASE PATIENT SPECIFIC BIOMARKER COMPOSITION AND USE THEREOF 有权
标题翻译：慢性心脏病患者特异性生物标志物组合物及其用途
公开(公告)号：EP3203227A1
公开(公告)日：2017-08-09
申请号：EP14903169.2
申请日：2014-09-30
申请人： BGI Shenzhen Co., Limited , BGI Shenzhen
发明人： FENG, Qiang , LIU, Zhipeng , MENG, Nan , WANG, Jun
IPC分类号： G01N30/02 , G01N30/62 , G01N33/48
CPC分类号： G01N30/02 , G01N30/62 , G01N33/48
摘要： The present invention relates to a disease-specific metabolite profile, and particularly to a biomarker composition obtained by screening from blood plasma-specific profiles of coronary heart disease subjects. The present invention also relates to a use of the biomarker compositions in risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease, and to a method for risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease. The biomarker composition as provided by the present invention can be used for early diagnosis of coronary heart disease and has high sensitivity, good specificity and good application prospects.
摘要翻译：本发明涉及疾病特异性代谢物谱，并且具体涉及通过从冠状动脉心脏病对象的血浆特异性谱中筛选获得的生物标志物组合物。本发明还涉及生物标志物组合物在冠心病的风险评估，诊断，早期诊断或病理分期中的用途，以及用于冠心病的风险评估，诊断，早期诊断或病理分期的方法。本发明提供的生物标志物组合物可用于冠心病的早期诊断，灵敏度高，特异性好，应用前景好。

95. 发明授权

EP2417447B1 MODULAR GAS CHROMATOGRAPH 有权
标题翻译：模块气体色谱
公开(公告)号：EP2417447B1
公开(公告)日：2016-06-22
申请号：EP09787696.5
申请日：2009-04-06
申请人： Thermo Fisher Scientific S.p.A
发明人： ZILIOLI, Giacinto , PELAGATTI, Stefano , MAGNI, Paolo
IPC分类号： G01N30/88 , G01N30/24 , G01N30/62 , G01N30/02
CPC分类号： G01N30/88 , G01N30/24 , G01N30/62 , G01N2030/025 , G01N2030/8881

96. 发明授权

EP1634055B1 METHOD FOR VERIFYING THE INTEGRITY OF THERMAL DESORPTION SAMPLING TUBES 有权转让
标题翻译：验证取样管的完整性，为热解吸法
公开(公告)号：EP1634055B1
公开(公告)日：2014-04-23
申请号：EP04776120.0
申请日：2004-05-24
申请人： PerkinElmer Health Sciences, Inc.
发明人： TIPLER, Andrew , DELORENZO, Frank
IPC分类号： G01N30/06 , G01N30/08 , G01N30/12 , G01N30/62 , G01N1/22 , G01N33/00
CPC分类号： G01N33/0011 , G01N1/2214 , G01N30/06 , G01N2030/085 , G01N2030/128 , G01N2030/625 , Y10T436/11 , Y10T436/2575

97. 发明公开

EP2653863A1 Self-referencing radiation detector for use with a radiopharmaceutical quality control testing system 有权转让
标题翻译： Selbstreferenziertes放射线检测方法用于与放射性药物质量控制测试系统中使用的
公开(公告)号：EP2653863A1
公开(公告)日：2013-10-23
申请号：EP13002032.4
申请日：2013-04-18
申请人： ABT Molecular Imaging, Inc.
发明人： Giamis, Anthony M.
IPC分类号： G01N30/62
CPC分类号： G01N30/62 , G01N2030/77
摘要： A self-referencing radiation detector to test the radiochemical purity of a sample radiopharmaceutical solution. In some embodiments, the self-referencing radiation detector measures the radioactivity of a sample radiopharmaceutical solution before the sample radiopharmaceutical solution is passed through a high performance liquid chromatography column. The radiation detector then measures the radioactivity of each separated molecularly distinct species from the high performance liquid chromatography column. The radiochemical purity of the sample radiopharmaceutical solution is calculated by comparing the measured radioactivity of separated molecularly distinct species from said high performance liquid chromatography column to the measured radioactivity of the sample radiopharmaceutical solution before the sample radiopharmaceutical solution is passed through the high performance liquid chromatography column.
摘要翻译：一种自引用辐射检测器，以测试样品放射性药物溶液的无线电化学纯度。在一些实施方案中，自参考辐射检测器测量样品的放射性药物溶液之前的样品溶液的放射性药物的放射性是通过高效液相色谱柱。放射线检测器然后测量从高性能液相色谱柱每个分离分子不同种类的放射性。样品放射性药物溶液的无线电化学纯度通过从所述高效液相色谱柱样品放射性药物溶液通过高效液相色谱柱之前分离分子不同种类的测量放射性比较的样品的放射性药物溶液的测量的放射性计算，

98. 发明公开

EP1756597A1 DEVICE FOR DETERMINING COMPOSITION OF A FLUID MIXTURE 审中-公开
标题翻译： DEVICE用于确定流体混合物的组成
公开(公告)号：EP1756597A1
公开(公告)日：2007-02-28
申请号：EP05745676.6
申请日：2005-05-03
申请人： KAM Controls Incorporated
发明人： MOHAJER, Kim , BROWNE, Edward, McChesney , KHAJEH, Abbas
IPC分类号： G01R27/32 , G01R27/26 , G01R27/08 , G01N33/20 , G01N30/62 , G01N30/95 , G01N37/00
CPC分类号： G01N22/00 , G01N33/2847 , G01R27/22
摘要： A method and apparatus are disclosed for determining the concentration of individual components within a fluid mixture by determining the permittivity of the individual components. The method and apparatus use a reference sensor and at least one measurement sensor positioned inside the same sensor device that is immersed in the fluid mixture to be measured. Signals, such as radio frequency or microwave, are sequentially transmitted at multiple, known, constant frequencies to and reflected from both the reference and measurement sensor(s). Permittivities of the individual components are determined from these transmitted and reflected signals and information about the concentration of the individual fluids and other compounds within the fluid mixture and the density of the fluid mixture are produced. Repetitive sampling and processing of these signals allow determination and real-time monitoring of the concentration of individual components within a mixture of fluids. The present invention provides self-calibration, accurate frequency maintenance and self-selection of an operating frequency range.

99. 发明公开

EP1194200A4 HIGH-THROUGHPUT PARALLEL LIQUID CHROMATOGRAPHY SYSTEM 有权
标题翻译：平行AUSGEFÜHRTEFLÜSSIGKEITSCHROMATOGRAPHIEVORRICHTUNG麻省理工HOHEM DURCHSATZ
公开(公告)号：EP1194200A4
公开(公告)日：2004-04-07
申请号：EP00925886
申请日：2000-04-20
申请人： ADVANCED BIOANALYTICAL SERVICE
发明人： CORSO THOMAS N , VAN PELT COLLEEN K
IPC分类号： G01N30/16 , G01N30/20 , G01N30/24 , G01N30/34 , G01N30/46 , G01N30/62 , B01D15/08
CPC分类号： G01N30/466 , B01J2219/00452 , B01J2219/00585 , B01J2219/00587 , B01J2219/00702 , G01N30/16 , G01N30/24 , G01N30/34 , G01N30/468 , G01N2030/202 , G01N2030/628
摘要： A high-throughput liquid chromatography system (10) capable of parallel separations for increased sample throughput is described. The system (10) comprises valves (24, 48) allowing for the use of multiple liquid chromatography columns (62, 64, 66, 68) and a single injector (58) and pumping system (12) while also minimizing extraneous plumbing and hardware. The system (10) is capable of injecting individual samples and directing them to one of a multiplicity of columns (62, 64, 66, 68) followed by selective output to a detector (73). The system (10) described allows for up to 16 columns, but the number may vary according to the application. The system (10) may be run in an isocratic or gradient mode. Whereas currently available multi-probe systems incorporate a separate injector for each column, the invention described here uses only one injector (58) and is independent of column number. This removes injector (58) variability along with reducing the amount of pluming and mechanical parts in the system (10) allowing for better separations while proving a more robust system (10).
摘要翻译：描述了能够并行分离以提高样品通量的高通量液相色谱系统。该系统包括允许使用多个液相色谱柱和单个注射器和泵送系统的阀，同时还使外部管道和硬件最小化。该系统能够注入单独的样品并将它们引导到多个色谱柱之一，然后选择性地输出到检测器。所描述的系统允许最多16列，但是数量可能根据应用而有所不同。系统可以以等度或梯度模式运行。虽然目前可用的多探针系统包括用于每列的单独的注射器，但是这里描述的本发明仅使用一个注射器，并且与柱号无关。这样可以减少喷射器的变化性，同时减少系统中的排气量和机械部件，从而实现更好的分离，同时提供更坚固的系统。该装置可以连接到现有的HPLC注射器，泵送和检测器技术。

100. 发明授权

EP0878222B1 SIMULATED MOVING BED SEPARATOR 失效
标题翻译：仿真流量床分选机
公开(公告)号：EP0878222B1
公开(公告)日：2004-03-31
申请号：EP96939326.3
申请日：1996-11-29
申请人： DAICEL CHEMICAL INDUSTRIES, LTD.
发明人： NAGAMATSU, Shinji , MURAZUMI, Koichi
IPC分类号： B01D15/02 , B01D15/08 , G01N30/44 , G01N30/46 , G01N30/62
CPC分类号： B01D15/1828 , B01D15/1842 , B01D2215/023
摘要： A quasi-moving bed separator which can monitor a concentration distribution of components in a circulating fluid flow passage in real time or can automatically determine an optimum operating condition. The separator comprises a concentration detector provided in the circulating fluid flow passage and concentration measuring means provided in a take-out port leading from the circulating fluid flow passage.

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