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1. 发明授权

EP0840886B1 MICROSCALE LIQUID HANDLING SYSTEM 失效
标题翻译： SYSTEM FOR液体运输微量的
公开(公告)号：EP0840886B1
公开(公告)日：2010-04-07
申请号：EP96926099.1
申请日：1996-07-19
申请人： NORTHEASTERN UNIVERSITY
发明人： KARGER, Barry, L. , FORET, Frantisek , ZAVRACKY, Paul, M. , MCGRUER, E., Nicol , XUE, Qifeng , DUNAYEVSKIY, Yuriy, M.
IPC分类号： G01N1/14 , G01N30/04 , H01J49/04
CPC分类号： H01J49/165 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00932 , B01L3/0268 , B01L3/502715 , B01L2300/0803 , B01L2300/0816 , B01L2400/027 , B01L2400/0421 , B33Y80/00 , G01N30/466 , G01N30/6095 , G01N30/7266 , G01N2030/027 , G01N2030/285 , G01N2030/628 , G01N2035/1044 , H01J49/0445 , Y10T436/117497 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , G01N30/34
摘要： A microscale fluid handling system (10) that permits the efficient transfer of nanoliter to picoliter quantities of a fluid sample from the spatially concentrated environment of a microfabricated chip to 'off-chip' analytical or collection devices (23) for further off-chip sample manipulation and analysis is disclosed. The fluid handling system (10) is fabricated in the form of one or more channels (12), in any suitable format, provided in a microchip body or substrate of silica, polymer or other suitable non-conductive material, or of stainless steel, noble metal, silicon or other suitable conductive or semi-conductive material. The microchip fluid handling system (10) includes one or more exit ports (16) integral with the end of one or more of the channels (12) for consecutive or simultaneous off-chip analysis or collection of the sample. The exit port or ports (16) may be configured, for example, as an electrospray interface for transfer of a fluid sample to a mass spectrometer (23).

2. 发明授权

EP0966022B1 Multi-inlet mass spectrometer 有权
标题翻译：多入口质谱仪
公开(公告)号：EP0966022B1
公开(公告)日：2007-05-30
申请号：EP99304746.3
申请日：1999-06-17
申请人： Micromass UK Limited
发明人： Bateman, Robert Harold , Hickson, John Anthony David
IPC分类号： H01J49/04
CPC分类号： H01J49/0431 , G01N30/466 , G01N30/7266 , G01N2030/628 , H01J49/107

3. 发明授权

EP0875759B1 Methods for screening compound libraries 失效
标题翻译：一种用于筛选化学化合物文库的方法
公开(公告)号：EP0875759B1
公开(公告)日：2006-10-25
申请号：EP98401455.5
申请日：1998-06-15
申请人： Hindsgaul, Ole , Schriemer, David C.
发明人： Hindsgaul, Ole , Schriemer, David C.
IPC分类号： G01N33/68 , G01N33/543 , G01N33/538
CPC分类号： G01N33/6845 , B01J2219/00585 , B01J2219/00704 , B01J2219/00707 , B01J2219/00731 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/12 , C40B40/18 , G01N30/466 , G01N30/7266 , G01N33/538 , G01N33/54306 , G01N33/54366 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N33/6851 , G01N2030/628 , H01J49/00 , H01J49/0036 , Y10T436/24

4. 发明公开

EP1529211A1 SYSTEMS AND METHODS FOR HIGH-THROUGHPUT MICROFLUIDIC SAMPLE ANALYSIS 审中-公开
标题翻译：装置和方法的高通量微流体样品分析
公开(公告)号：EP1529211A1
公开(公告)日：2005-05-11
申请号：EP03785129.2
申请日：2003-08-08
申请人： Nanostream, Inc.
发明人： GREGORI, Matthew, M. , COVINGTON, Joseph, F. , HOBBS, Steven, E.
IPC分类号： G01N30/72
CPC分类号： G01N30/466 , B01L3/5027 , G01N30/7266 , G01N30/84 , G01N2030/628 , G01N2030/8411 , H01J49/04
摘要： Systems and methods for collecting the output of multiple simultaneously operated chromatography columns and providing the outputs to a single mass spectrometer are provided. Such systems utilize predetermined lengths of microfluidic tubing that act as storage buffers for the substantially all of the output of each column, preserving all data and, because the storage buffers are microfluidic, there is minimal diffusion between sample bands and solvent and signal clarity is preserved.

5. 发明公开

EP1067380A1 Verfahren mit Vorrichtung zum Parallel-Analysieren von kolloidalen Teilchen mit Feldflussfraktionierung 审中-公开
公开(公告)号：EP1067380A1
公开(公告)日：2001-01-10
申请号：EP00113189.5
申请日：2000-07-03
申请人： BASF AKTIENGESELLSCHAFT
发明人： Schuch, Horst, Dr. , Schrof, Wolfgang, Dr.
IPC分类号： G01N30/00
CPC分类号： G01N30/0005 , G01N2030/628 , G01N30/466
摘要： Die vorliegende Erfindung betrifft eine Vorrichtung zur gleichzeitigen Untersuchung von mindestens zwei Proben mittels der Methode der Feldfluß-Fraktionierung, wobei die Vorrichtung mindestens die folgenden Elemente aufweist:

a) eine Quelle für einen definierten Flüssigkeitsstrom, vorzugsweise eine Pumpe,
b) mindestens zwei Trennkanäle mit je mindestens einem Einlaß und mindestens einem Auslaß zum Durchleiten der mindestens zwei Proben durch je einen der mindestens zwei Trennkanäle,
c) mindestens eine steuerbare Einheit, die mit den mindestens zwei Trennkanälen über deren je mindestens einen Auslaß verbunden ist, und die die mindestens zwei durch je einen der mindestens zwei Trennkanäle durchleitbaren Proben getrennt voneinander an mindestens eine an die steuerbare Einheit sich anschließende Einheit weiterleiten kann.

Ferner betrifft die vorliegende Erfindung ein entsprechendes Verfahren und die Verwendung des erfindungsgemäßen Verfahrens und/oder der erfindungsgemäßen Vorrichtung zur Fraktionierung von Teilchen, insbesondere von kolloidalen Teilchen, nach ihrem Durchmesser oder nach anderen Eigenschaften, insbesondere nach der chemischen Zusammensetzung oder der Dichte oder der Ladung oder nach Kombinationen daraus.
摘要翻译：为了使用现场流分馏技术同时分析至少两个样品，该设备具有供给以确定载流子流动的供给，优选泵（1）。至少两个分离通道（2），每个具有至少一个入口（4）和至少一个出口，分别通过每个通道取两个样品。至少一个受控单元连接到通道出口，以允许单独的样品流被引导至至少一个控制下的另外的单元。该装置使用流场流分馏或沉降场流分馏，或热或电泳场流分馏。受控单元具有一个或多个多口阀（5,7），随后是测量单元（6）和/或检测器。至少两个分离通道布置在夹层结构中。膜同时覆盖至少两个通道，其还承载通道入口。包括多个分析的独立权利要求，其中至少两个样品沿其轴向同时进入分离的通道。力作用在流动通道上，与其轴向取向成直角，样品通过控制传递到另一个工位。通道上的垂直力通过流动。

6. 发明公开

EP1007212A2 APPARATUS AND METHODS FOR DROPLET MICROCHEMISTRY 有权
标题翻译：用于液滴微量化的装置和方法
公开(公告)号：EP1007212A2
公开(公告)日：2000-06-14
申请号：EP98945763.5
申请日：1998-08-20
申请人： Hunter, Ian W.
发明人： Hunter, Ian W.
IPC分类号： B01L3/02 , G01N35/02 , B01L3/00
CPC分类号： B01L3/0262 , B01F5/0085 , B01F13/0059 , B01J19/0046 , B01J2219/00515 , B01J2219/00518 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00657 , B01J2219/00659 , B01J2219/00702 , B01L3/0268 , B01L3/505 , B01L3/5085 , B01L3/5088 , B01L2300/0812 , B01L2300/0845 , G01N30/24 , G01N30/7233 , G01N30/84 , G01N2030/628 , G01N2030/8417 , G01N2035/1037
摘要： An apparatus and methods for performing microchemical manipulation and analysis of liquid samples. One or more droplets of liquid are loaded serially or in parallel onto a flexible member which may be a fiber or a tape, and are retained on the flexible member by virtue of surface adhesion. Microchemical operations may be performed on these droplets, the operations including mixing, dilution, concentration, heating, cooling, filtering, and analyzing, where the analyzing may include chemical, biochemical, optical, or other physical analyses.
摘要翻译：用于进行微量化学操作和液体样品分析的装置和方法。一个或多个液滴被顺序地或平行地加载到柔性构件上，该柔性构件可以是纤维或带，并且由于表面粘附而保持在柔性构件上。可以对这些液滴进行微量化学操作，操作包括混合，稀释，浓缩，加热，冷却，过滤和分析，其中分析可以包括化学，生物化学，光学或其他物理分析。

7. 发明公开

EP0966022A2 Multi-inlet mass spectrometer 有权
标题翻译： Mehrfachprobeninlassmassenspektrometer
公开(公告)号：EP0966022A2
公开(公告)日：1999-12-22
申请号：EP99304746.3
申请日：1999-06-17
申请人： Micromass Limited
发明人： Bateman, Robert Harold , Hickson, John Anthony David
IPC分类号： H01J49/04
CPC分类号： H01J49/0431 , G01N30/466 , G01N30/7266 , G01N2030/628 , H01J49/107
摘要： An electrospray and/or APCI mass spectrometer has an evacuated chamber 8, a sampling region 7 where the pressure is greater than in said evacuated chamber 8, a sampling orifice 5 communicating between said sampling region 7 and said evacuated chamber 8, and a mass analyzer which receives at least some charged particles along a first axis 37 through said sampling orifice 5 from said sampling region 7 into said evacuated chamber 8. A plurality of charged-particle jet generation means 1, 38-40 each of which is supplied with a fluid to be analyzed each generate a jet aligned with a jet axis 3; 45; 46; 47, of charged particles derived from said fluid, and are disposed so that each charged-particle jet generation means 1; 38-40 has a different jet axis 3; 45; 46; 47 and so that all said jet axes 3, 45-47 intersect said first axis 37 within said sampling region 7. Jet selecting means 4 comprising a hollow member 36 is disposed so that the intersections of said jet axis 3; 45; 46; 47 and said first axis 37 are within its interior, said hollow member 36 having at least a first aperture 49 alignable with said jet axis 3; 45; 46; 47 through which at least some charged particles comprised in a said charged-particle jet may enter the interior of said hollow member 36 and travel to said first axis 37. There is also means for aligning said first aperture 49 in said hollow member 36 with each said jet axis 3; 45; 46; 47 in turn, thereby allowing in turn at least some charged particles comprised in each said jet to enter the interior of said hollow member 36 to pass through said sampling orifice 5 to said evacuated chamber 8, and subsequently to be mass analyzed by said mass analyzer.
摘要翻译：电喷雾和/或APCI质谱仪具有真空室8，其中压力大于所述真空室8中的采样区域7，在所述采样区域7和所述抽真空室8之间连通的采样孔5和质量分析器其将沿着第一轴线37的至少一些带电粒子从所述采样区域7通过所述采样孔5接收到所述真空室8中。多个带电粒子射流产生装置1,38-40中的每一个被供应流体要分析，每个都产生与喷射轴3对准的射流; 45; 46; 47，来自所述流体的带电粒子，并且被设置成使得每个带电粒子射流产生装置1; 38-40具有不同的喷射轴3; 45; 46; 并且使得所有所述喷射轴3至45-47与所述采样区域7内的所述第一轴线37相交。包括中空部件36的喷射选择装置4设置成使得所述喷射轴线3的相交; 45; 46; 47和所述第一轴37在其内部，所述中空构件36具有至少一个可与所述喷射轴线3对准的第一孔49; 45; 46; 包括在所述带电粒子射流中的至少一些带电粒子可以通过其进入到所述中空构件36的内部并行进到所述第一轴线37.还有用于将所述中空构件36中的所述第一孔49与每个所述喷射轴3; 45; 46; 从而允许包括在每个所述射流中的至少一些带电粒子进入所述中空构件36的内部，以通过所述取样孔5到达所述真空室8，随后通过所述质量分析器进行质量分析。

8. 发明公开

EP0875759A2 Methods for screening compound libraries 失效
标题翻译： Verfahren zur Sichtung einer Bibliothek von chemischen Verbindungen
公开(公告)号：EP0875759A2
公开(公告)日：1998-11-04
申请号：EP98401455.5
申请日：1998-06-15
申请人： SYNSORB Biotech Inc.
发明人： Hindsgaul, Ole , Schriemer, David C.
IPC分类号： G01N33/566 , G01N33/543 , C12Q1/68 , H01J49/00
CPC分类号： G01N33/6845 , B01J2219/00585 , B01J2219/00704 , B01J2219/00707 , B01J2219/00731 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/12 , C40B40/18 , G01N30/466 , G01N30/7266 , G01N33/538 , G01N33/54306 , G01N33/54366 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N33/6851 , G01N2030/628 , H01J49/00 , H01J49/0036 , Y10T436/24
摘要： Disclosed are methods for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target receptor. Methods are also disclosed which permit a compound library to be rapidly screened to determine if any members of the library have a higher affinity for the target receptor relative to a pre-selected indicator compound.
摘要翻译：公开了使用正面色谱法与质谱联用筛选化合物文库的方法，以鉴定和排列与目标受体结合的文库的那些成员。还公开了允许快速筛选化合物文库以确定文库的任何成员相对于预选择的指示剂化合物对靶受体是否具有更高亲和力的方法。

9. 发明公开

EP2633305A1 AUTOMATED SYSTEM FOR SAMPLE PREPARATION AND ANALYSIS 有权
标题翻译：自动化系统ZUR PROBENVORBEREITUNG不动产
公开(公告)号：EP2633305A1
公开(公告)日：2013-09-04
申请号：EP11785837.3
申请日：2011-10-28
申请人： Thermo Fisher Scientific OY
发明人： DEWITTE, Robert , SIIDOROV, Juhani , NUOTIO, Vesa , SALMINEN, Raimo , VEHKOMAKI, Jarmo , SAUKKONEN, Jukka , OSTMAN, Bill , SENTENO, Joseph, M. , BRANN, John, Edward, III , HERMAN, Joseph, L. , ZONDERMAN, Jeffrey, A. , OLNEY, Terry, N.
IPC分类号： G01N30/06 , G01N30/72 , G01N30/86
CPC分类号： G01N30/7233 , G01N27/62 , G01N30/06 , G01N30/16 , G01N30/72 , G01N30/8658 , G01N30/88 , G01N35/00871 , G01N35/0092 , G01N35/026 , G01N35/08 , G01N2030/027 , G01N2030/067 , G01N2030/628 , G01N2030/8804 , G01N2030/8813 , G06F19/00 , H01J49/00 , H01J49/0031 , H01J49/0409 , H01J49/0413 , H01J49/0431 , H01J49/10 , Y10T436/24
摘要： A sample preparation and analysis system 10. The system 10 includes a housing 16 with a sample preparation station 12 and a sample analysis station 14 positioned within the housing 16. The sample analysis station 14 is spaced away from the sample preparation station 12. A transport assembly 50 is configured to move at least one sample within the housing 16 and between the sample preparation station 12 and the sample analysis station 14.
摘要翻译：样品制备和分析系统。系统10包括样品制备系统12和样品分析系统14.样品制备系统12根据从包含多个独特测定的数据库中选择的测定准备样品。样品分析系统14包括基于所选择的测定法动态可重新配置的分析器110，以便根据所选择的测定法分析所制备的样品。数据通信链路27将来自样品制备系统12的数据传送到样品分析系统14，以根据所选择的测定重新配置分析器110。

10. 发明公开

EP2038644A1 DETECTION APPARATUS AND METHODS 审中-公开
标题翻译：检测装置及方法
公开(公告)号：EP2038644A1
公开(公告)日：2009-03-25
申请号：EP07733297.1
申请日：2007-06-20
申请人： Smiths Detection-Watford Limited
发明人： MUNRO, William Angus
IPC分类号： G01N27/64 , G01N30/46
CPC分类号： G01N30/466 , G01N27/622 , G01N30/461 , G01N30/7206 , G01N2030/628
摘要： Detection apparatus including an IMS detector (1, 100) or the like has a gas inlet (10) with a gas flow path arrangement (40, 41, 102) by which sample gas is supplied to the detector. In one arrangement two regions (40 and 41) of a gas flow path arrangement are connected in parallel. The regions are provided by respective GC capillary tubing coils (40) and (41) coated internally with materials of different absorption characteristics so that the time taken for the chemical of interest to reach the detector (1) is different along the two coils, thereby giving responses in the detector at different times. Alternatively, two regions of a gas flow path could be provided by regions (104 and 106) arranged serially one after the other.

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