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91. 发明授权

EP2307921B1 LASER SCANNING MICROSCOPE FOR SCANNING ALONG A 3D TRAJECTORY 有权转让
标题翻译：激光扫描显微镜中采样沿三维TRAIN
公开(公告)号：EP2307921B1
公开(公告)日：2016-09-07
申请号：EP09785758.5
申请日：2009-07-14
申请人： Femtonics Kft.
发明人： VIZI, E. Szilveszter , KATONA, Gergely , RÓZSA, J. Balázs
IPC分类号： G02B21/00 , G01N21/64
CPC分类号： G02B21/0048 , G02B21/006 , G02B21/0084

92. 发明公开

EP3035101A1 SCANNING APPARATUS AND CONFOCAL OBSERVATION APPARATUS 无效转让
标题翻译： ABTASTUNGSVORRICHTUNG UND VORRICHTUNG ZUR KONFOKALEN BEOBACHTUNG
公开(公告)号：EP3035101A1
公开(公告)日：2016-06-22
申请号：EP15199858.0
申请日：2015-12-14
申请人： Olympus Corporation
发明人： YAMAZAKI, Kentaro
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , G02B21/0032 , G02B21/0044 , G02B26/0833
摘要： A scanning apparatus includes a light source, spatial light modulation means that modulates an incident beam of light on a first reflection surface, an illumination lens that irradiates the spatial light modulation means with a beam of light from the light source and that refracts a principal ray of a beam of light modulated by the spatial light modulation means so that an angle between the principal ray and an optical axis of the illumination lens (33) decreases, and a first reflector that directs, toward the illumination lens, a beam of light by reflecting the beam of light multiple times between the illumination lens and a front focal plane of the illumination lens, the beam of light being modulated by the spatial light modulation means and entering through the illumination lens.
摘要翻译：一种扫描装置，包括光源，调制第一反射面上的入射光束的空间光调制装置，以及来自光源的光束照射空间光调制装置并折射主光线的照明透镜由所述空间光调制装置调制的光束使得所述主光线和所述照明透镜（33）的光轴之间的角度减小，并且所述第一反射器朝向所述照明透镜引导光束，所述第一反射器通过在照明透镜和照明透镜的前焦面之间多次反射光束，光束被空间光调制装置调制并通过照明透镜进入。

93. 发明授权

EP2278375B1 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：对于患者的身体的选定部分的成像共焦显微镜
公开(公告)号：EP2278375B1
公开(公告)日：2016-03-30
申请号：EP10013218.2
申请日：2004-05-20
申请人： LUCID, INC.
发明人： Fox, William, J. , Distasio, Christopher, C. , Grodevant, Scott, R.
IPC分类号： G02B21/00 , G02B7/00 , G02B21/36 , A61B5/103
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362

94. 发明公开

EP2881727A1 SPECTRAL ANALYSIS DEVICE USING CONFOCAL MICROSCOPE OR MULTIPHOTON MICROSCOPE OPTICAL SYSTEM, SPECTRAL ANALYSIS METHOD, AND SPECTRAL ANALYSIS COMPUTER PROGRAM 无效转让
标题翻译：与具有共焦显微镜或AND的光学系统的双光子激发显微术，光谱分析SPEKTRALANALYSECOMPUTERPROGRAMM光谱分析
公开(公告)号：EP2881727A1
公开(公告)日：2015-06-10
申请号：EP13825513.8
申请日：2013-05-16
申请人： Olympus Corporation
发明人： YAMAGUCHI, Mitsushiro
IPC分类号： G01N21/64 , G02B21/06 , G02B21/26
CPC分类号： G01J1/18 , G01B11/14 , G01N21/6458 , G01N2001/282 , G01N2035/0493 , G02B21/00 , G02B21/0048 , G02B21/0076 , G02B21/06 , G02B21/26 , G02B27/1006
摘要： There is provided an optical analysis technique using the optical system of a confocal microscope or a multiphoton microscope for optical analysis techniques, such as the scanning molecule counting method, FCS, FIDA and PCH, in which it is enabled to judge whether or not a predetermined condition in the optical system is realized before performing a light intensity measurement. In the inventive optical analysis technique of measuring light intensity from a light detection region placed in a sample solution and analyzing the light intensity, there is performed a process of judging if a light detection region is placed in the sample solution and a measurement of the light intensity from the light detection region can be performed, and/or, the position or its area of the light detection region relative to the sample container in which a light intensity measurement can be performed based on the magnitude of signal intensity outputted by a photodetector during moving the position of the light detection region relative to the sample container.
摘要翻译：有使用共焦显微镜的光学系统或光学分析技术，：诸如扫描分子计数法，FCS，FIDA和PCH，其被使能以判断光子显微镜设置在光学分析技术是否经过了规定在光学系统的条件进行光强度的测量之前被实现。在从样品溶液中放置一个光检测区域测量光强度和分析所述光强度的本发明的光学分析技术，存在被执行。如果光检测区域是在样品溶液放置并在光的测量判断的处理从光检测区域的强度可以进行，和/或，位置或它的相对于样品容器，其中，光强度的测量可以基于信号强度的大小由一个光检测器中输出的要执行的光检测区域的面积移动相对于样品容器中的光检测区域的位置。

95. 发明公开

EP2752655A1 METHOD FOR DETECTING TARGET PARTICLES 无效转让
标题翻译：检测目标粒子的方法
公开(公告)号：EP2752655A1
公开(公告)日：2014-07-09
申请号：EP12828423.9
申请日：2012-06-28
申请人： Olympus Corporation
发明人： HANASHI Takuya
IPC分类号： G01N21/64
CPC分类号： G01N33/543 , G01N15/1456 , G01N21/6408 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6458 , G01N33/54326 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G02B21/0032 , G02B21/0048 , G02B21/0076 , G02B21/26
摘要： This method for detecting a target particle comprises (a) a step for preparing a solution containing a target particle, a luminescent probe that binds to the target particle and a particle for separation and recovery, or containing the target particle bound to the luminescent probe, the luminescent probe and the particle for separation and recovery, and forming a complex composed of the target particle, the luminescent probe and the particle for separation and recovery in the solution, (b) a step for recovering the particle for separation and recovery from the solution by solid-liquid separation treatment following step (a) and preparing a sample solution containing the particle for separation and recovery, and (c) a step for calculating the number of molecules of the complex present in the sample solution according to a scanning molecule counting method, wherein the particles for separation and recovery bind to a complex composed of the target particles and the luminescent probe.
摘要翻译：该检测目标粒子的方法包括：（a）制备含有目标粒子，与目标粒子和分离回收用粒子结合的发光探针，或者含有结合于发光探针的目标粒子的溶液的工序; 发光探针和分离回收用颗粒之间形成由目标颗粒，发光探针和分离回收用颗粒组成的复合体的工序，（b）从所述溶液中回收分离回收用颗粒的工序（a）工序后，通过固液分离处理，制备含有分离回收用颗粒的试样溶液，（c）根据扫描分子算出试样溶液中存在的配合物的分子数的步骤计数方法，其中用于分离和回收的颗粒结合由目标颗粒和发光探针组成的复合物。

96. 发明授权

EP2491451B1 VORRICHTUNG UND VERFAHREN ZUM ABLENKEN EINES LICHTSTRAHLS IN ZWEI UNTERSCHIEDLICHE RICHTUNGEN UND SCAN-MIKROSKOP 失效
标题翻译：设备和方法在两个不同的方向和扫描显微镜偏转的光束
公开(公告)号：EP2491451B1
公开(公告)日：2013-08-14
申请号：EP10757056.6
申请日：2010-08-27
申请人： Leica Microsystems CMS GmbH
发明人： FEHRER, Dirk-Oliver , BÖHM, Ingo
IPC分类号： G02B26/10 , G02B21/00 , G02B7/182 , G02B26/08
CPC分类号： G02B21/0048 , G02B7/1821 , G02B26/101

97. 发明授权

EP1636625B1 CONFOCAL MICROSCOPE FOR IMAGING OF SELECTED LOCATIONS OF THE BODY OF A PATIENT 有权
标题翻译：共焦显微镜图的患者的身体的选定点
公开(公告)号：EP1636625B1
公开(公告)日：2013-07-10
申请号：EP04753135.5
申请日：2004-05-20
申请人： LUCID, INC.
发明人： FOX, William, J. , DISTASIO, Christopher, C. , GRODEVANT, Scott, R.
IPC分类号： G02B21/00 , G02B7/00 , G02B21/36
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362

98. 发明公开

EP2491451A1 VORRICHTUNG UND VERFAHREN ZUM ABLENKEN EINES LICHTSTRAHLS IN ZWEI UNTERSCHIEDLICHE RICHTUNGEN UND SCAN-MIKROSKOP 失效
标题翻译：设备和方法在两个不同的方向和扫描显微镜偏转的光束
公开(公告)号：EP2491451A1
公开(公告)日：2012-08-29
申请号：EP10757056.6
申请日：2010-08-27
申请人： Leica Microsystems CMS GmbH
发明人： FEHRER, Dirk-Oliver , BÖHM, Ingo
IPC分类号： G02B26/10 , G02B21/00 , G02B7/182 , G02B26/08
CPC分类号： G02B21/0048 , G02B7/1821 , G02B26/101
摘要： The invention relates to a device (20) for deflecting a light beam in two different directions comprising a mirror (22), a first and a second rotating actuator element (24). The first rotating actuator element (24) rotates about a first axis (54) depending on a first control signal. The second rotating actuator element (26) is arranged along the first axis (54) opposite of the first rotating actuator element (24) and rotates about the first axis (54) depending on a second control signal. A first spring element (28) is connected to the first rotating actuator element (24) and is connected outside of the first axis (54) at a predetermined distance thereto to the mirror (22). A second spring element (30) is connected to the second rotating actuator element (26) and the mirror (22).

99. 发明公开

EP2359178A1 VERFAHREN UND VORRICHTUNG ZUR DYNAMISCHEN VERLAGERUNG EINES LICHTSTRAHLS GEGENÜBER EINER DEN LICHTSTRAHL FOKUSSIERENDEN OPTIK 有权
标题翻译：方法和装置到任何光束聚焦镜头的光束的动态重定位
公开(公告)号：EP2359178A1
公开(公告)日：2011-08-24
申请号：EP09799610.2
申请日：2009-12-16
申请人： Deutsches Krebsforschungszentrum
发明人： ENGELHARDT, Johann
IPC分类号： G02B26/10 , G02B21/00
CPC分类号： G02B21/0048 , G02B26/101
摘要： In order to dynamically shift a light beam (7) relative to an optic which focuses the light beam so that an object can be scanned by the focused light beam (7) in a two-dimensional scanning field, the light beam (7) is deflected in two different directions relative to the optical axis of the optic to two points one after the other per direction, said deflections being done by two deflection angles (31 and 32 or 33 and 34) which change dynamically independent of one another.

100. 发明公开

EP2093600A4 LASER SCAN CONFOCAL MICROSCOPE 审中-公开
标题翻译：激光共聚焦显微镜
公开(公告)号：EP2093600A4
公开(公告)日：2011-06-08
申请号：EP07850946
申请日：2007-12-20
申请人： NIPPON KOGAKU KK
发明人： YOSHIDA YUKI , AIKAWA NAOSHI
IPC分类号： G02B21/00 , G02B26/10
CPC分类号： G02B21/0032 , G02B21/00 , G02B21/0024 , G02B21/0048 , G02B21/0076 , G02B21/16 , G02B26/105 , G02B27/0025 , G02B27/0081
摘要： Fluorescence is generated from an irradiated point on an inspection surface of a sample (7) and the fluorescence is collected by an objective lens (6). Here, because of the magnification chromatic aberration of the objective lens 86, the fluorescence going out from the objective lens (6) travels along a path shifted from the irradiation light and changed substantially into a non-scan light by a galvano-scanner (5). The fluorescence passes through a dichroic mirror (4) and comes into deflection means (9) as 2-dimensional deflection means after light of unnecessary wavelength is removed by a filter (8). The deflection means (9) is driven in synchronization with the galvano-scanner (5) by a computer (10) and corrects the shift and inclination of the optical axis generated by the magnification chromatic aberration of the objective lens (6). After the shift and inclination of the optical axis are corrected, the fluorescence forms an image of the irradiation point of the inspection surface of the sample (7) on a pin hole of a pin hole plate (12) by using a collective lens (11). Thus, it is possible to provide a laser scan confocal microscope capable of correcting the peripheral light reduced by the magnification chromatic aberration by using an optical system even if the used objective lens has the magnification chromatic aberration.

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