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1. 发明公开

EP4370959A1 OPTICAL SCAN MULTIPLIER AND USES THEREOF 审中-公开
公开(公告)号：EP4370959A1
公开(公告)日：2024-05-22
申请号：EP22842871.0
申请日：2022-07-14
申请人： Trustees of Boston University
发明人： XIAO, Sheng , MERTZ, Jerome Charles
IPC分类号： G02B21/00 , G02B26/12 , G02B27/58
CPC分类号： G02B26/105 , G02B21/0048

2. 发明公开

EP4359839A1 RESCAN OPTICAL SYSTEM, MICROSCOPE AND METHOD 审中-公开
公开(公告)号：EP4359839A1
公开(公告)日：2024-05-01
申请号：EP22733756.5
申请日：2022-06-20
申请人： Confocal.nl B.V.
发明人： LAMPAERT, Stefan Georges Emile , MANDERS, Erik Martinus Marie , STERL, Florian Frederik
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , G02B21/0084 , G02B21/0032

3. 发明公开

EP3326018A1 SYSTEMS AND METHODS FOR THREE-DIMENSIONAL IMAGING 审中-实审
公开(公告)号：EP3326018A1
公开(公告)日：2018-05-30
申请号：EP16745297.8
申请日：2016-07-15
申请人： The Trustees of Columbia University in the City of New York
发明人： HILLMAN, Elizabeth Marjorie Clare
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , G02B21/002 , G02B21/0024
摘要： Methods, devices and systems for up to three-dimensional scanning of target regions at high magnification are disclosed.

4. 发明公开

EP3283917A1 VERFAHREN UND VORRICHTUNG ZUM UNTERSUCHEN EINER PROBE 有权
标题翻译：测试样品的方法和装置
公开(公告)号：EP3283917A1
公开(公告)日：2018-02-21
申请号：EP16719278.0
申请日：2016-04-13
申请人： Leica Microsystems CMS GmbH
发明人： FAHRBACH, Florian , KNEBEL, Werner
IPC分类号： G02B21/06 , G02B21/00 , G02B21/16
CPC分类号： G02B21/0032 , G02B21/002 , G02B21/0048 , G02B21/0076 , G02B21/06 , G02B21/16 , G02B21/367
摘要： The invention relates to a method for examining a sample, in which method the sample is illuminated in an illumination plane along an illumination strip by means of an illuminating light beam which widens along the illumination strip, and in which the illumination strip is projected into a detection plane by detection light originating from the illumination strip being focused in the detection plane, and in which the detection light is detected by a detector. The method is characterized in that the detector is a slit detector, and the direction of the slit width of the slit detector is oriented at an angle different from zero degrees with respect to the direction of the longitudinal extent of the image of the illumination strip in the detection plane. The invention further relates to a device for carrying out this type of method.

5. 发明公开

EP2589214A4 A SYSTEM FOR SYNCHRONIZATION IN A LINE SCANNING IMAGING MICROSCOPE 有权转让
公开(公告)号：EP2589214A4
公开(公告)日：2017-10-25
申请号：EP11801247
申请日：2011-06-29
申请人： GE HEALTHCARE BIO-SCIENCES CORP
发明人： BULA WITOLD , FOMITCHOV PAVEL A , GOODSON STEVE , MEI ERWEN , ZHANG YANG
IPC分类号： H04N1/047 , G02B21/00 , G02B26/10 , G03B9/36
CPC分类号： H04N5/04 , G02B21/0048 , H04N1/113 , H04N1/195 , H04N2201/04715 , H04N2201/04755
摘要： A line confocal microscope system, comprising a scanning unit in the form of a mechanically driven scanning unit with a controllable a scanning trajectory and a two dimensional sensor unit operated in a rolling line shutter mode in synchronization with the scanning unit, wherein the scanning trajectory is set to have an acceleration part outside the field of view of the sensor unit.

6. 发明公开

EP3198324A1 RESOLUTION ENHANCEMENT FOR LINE SCANNING EXCITATION MICROSCOPY SYSTEMS AND METHODS 有权转让
标题翻译：线扫描激发显微系统和方法的分辨率增强
公开(公告)号：EP3198324A1
公开(公告)日：2017-08-02
申请号：EP15775866.5
申请日：2015-09-22
申请人： The United States Of America,As Represented By The Secretary, Department Of Health & Human Services
发明人： SHROFF, Hari , YORK, Andrew , GIANNINI, John , KUMAR, Abhishek
IPC分类号： G02B21/00 , G02B27/58
CPC分类号： G02B21/0076 , G02B21/0032 , G02B21/0036 , G02B21/0048 , G02B26/101 , G02B27/58
摘要： A resolution enhancement technique for a line scanning confocal microscopy system that generates vertical and horizontal line scanning patterns onto a sample is disclosed. The line scanning confocal microscopy system is capable of producing line scanning patterns through the use of two alternative pathways that generate either the vertical line scanning pattern or horizontal line scanning pattern.
摘要翻译：公开了一种线扫描共焦显微系统的分辨率增强技术，该系统在样品上产生垂直和水平线扫描图案。线扫描共聚焦显微镜系统能够通过使用产生垂直线扫描图案或水平线扫描图案的两种替代路径产生线扫描图案。

7. 发明公开

EP3179288A1 LICHTFELD-BILDGEBUNG MIT SCANOPTIK 有权
标题翻译：使用SCANOPTIK进行光场成像
公开(公告)号：EP3179288A1
公开(公告)日：2017-06-14
申请号：EP16200973.2
申请日：2016-11-28
申请人： Carl Zeiss Microscopy GmbH
发明人： SINGER, Wolfgang , WOLLESCHENSKY, Ralf , KLEPPE, Ingo , JABBOUR, Toufic , GÖLLES, Michael , WICKER, Kai
IPC分类号： G02B27/00 , G02B21/36
CPC分类号： G02B21/367 , G02B21/0048 , G02B21/008 , G02B21/025 , G02B21/26 , G02B27/0075 , G06T7/557 , G06T2207/10028 , G06T2207/10052 , G06T2207/10056 , G06T2207/10148 , G06T2207/20221 , G06T2207/30024 , H04N13/221 , H04N13/254
摘要： Eine optische Vorrichtung umfasst eine Lichtquelle und einen Detektor (118), sowie einem Probenhalter, der eingerichtet ist, um ein Objekt (250) in dem optischen Pfad (161) von Licht zu fixieren. Eine Scanoptik (114, 115, 116, 122) ist eingerichtet, um für eine Vielzahl von Scanposition in jeweils selektiv Licht, welches aus unterschiedlichen Winkelbereichen vom Objekt (250) einfällt, auf den Detektor (118) zu lenken. Basierend auf einem dreidimensionalen Lichtfeld, welches durch entsprechende Messdaten der Vielzahl von Scanposition (290) repräsentiert wird, wird eine räumlich aufgelöste Abbildung des Objekts (250) erzeugt, die mindestens zwei Bilder aus unterschiedlichen Objektebenen des Objekts umfasst.
摘要翻译：一种光学装置包括光源和检测器（118）以及被配置为将物体（250）固定在光的光路（161）中的样品保持器。扫描光学器件（114,115,116,122）被布置成将光线引导到检测器（118）上以用于从物体（250）的不同角度范围入射的选择性光中的多个扫描位置。根据一个维光场3，它是由多个扫描位置（290）的对应的测量数据所表示的，产生所述对象（250），其包括所述对象的不同对象平面中的至少两个图像的空间分辨图像。

8. 发明公开

EP3095004A1 LIGHT SHEET GENERATOR 审中-公开
标题翻译： LICHTFOLIENGENERATOR
公开(公告)号：EP3095004A1
公开(公告)日：2016-11-23
申请号：EP15737356.4
申请日：2015-01-13
申请人： Applied Scientific Instrumentation, Inc.
发明人： RONDEAU, Gary, D.
IPC分类号： G02B26/10
CPC分类号： G02B21/0048 , G02B21/0032 , G02B21/0076 , G02B21/06 , G02B21/10 , G02B21/16 , G02B21/367 , G02B26/0833 , G02B27/30
摘要： Systems and methods for generating light sheets suitable for use in single plane illumination microscopy may include a series of chambers in sequential communication with each other, the series of chambers including an optics system configured to convert a beam of light, such as a laser beam, into a planar light sheet. The series of chambers may include chambers having respective long axes oriented at an acute angle to each other to form a compact zig-zag pattern.
摘要翻译：用于产生适合用于单平面照明显微镜的光片的系统和方法可以包括彼此连续通信的一系列室，所述一系列室包括被配置为将诸如激光束的光束转换的光学系统，成平面光照片。一系列腔室可以包括具有彼此成锐角定向的相应长轴的腔室，以形成紧凑的锯齿形图案。

9. 发明公开

EP3073309A1 LASER SCANNING MICROSCOPE 有权
标题翻译：激光扫描显微镜
公开(公告)号：EP3073309A1
公开(公告)日：2016-09-28
申请号：EP16158463.6
申请日：2007-06-20
申请人： Nikon Corporation
发明人： Okugawa, Hisashi
IPC分类号： G02B21/00 , G01N21/64 , G02B26/08 , G02B21/32
CPC分类号： G02B21/0076 , G01N21/6458 , G02B21/0032 , G02B21/0048 , G02B21/0064 , G02B21/32
摘要： A proposition of the present invention is to provide a laser scanning microscope capable of enhancing the degree of freedom of observation while keeping its structure simple. Accordingly, a laser scanning microscope (100) of the present invention includes a light source part (1), a spectroscopic unit (9) guiding light from the light source part (1) to a specimen plane (16) and guiding the light from the specimen plane (16) to a detector, light path switching units (10 and 13) switching a light path between the spectroscopic unit (9) and the specimen plane (16) to one among a plurality of light paths (R1 and R2) with different routes, and a plurality of light deflecting units (11 and 12) each disposed in each of the plurality of light paths.
摘要翻译：本发明的目的是提供一种激光扫描显微镜，其能够在保持其结构简单的同时增强观察的自由度。因此，本发明的激光扫描型显微镜（100）包括光源部（1），将来自光源部（1）的光导向试样面（16），并将来自光源部（16）至检测器，光路切换单元（10和13）将分光单元（9）和样品平面（16）之间的光路切换到多个光路（R1和R2）中的一个，具有不同的路径，以及多个光偏转单元（11和12），每个光偏转单元设置在多个光路中的每一个中。

10. 发明公开

EP3059577A1 PHOTOMETRIC ANALYSIS DEVICE EMPLOYING SINGLE LIGHT-EMITTING PARTICLE DETECTION, PHOTOMETRIC ANALYSIS METHOD, AND COMPUTER PROGRAM FOR PHOTOMETRIC ANALYSIS 审中-公开
标题翻译： WITH发光粒子，METHOD FOR光度分析和计算机程序个体的承认用于光度分析光分析装置
公开(公告)号：EP3059577A1
公开(公告)日：2016-08-24
申请号：EP14852119.8
申请日：2014-06-30
申请人： Olympus Corporation
发明人： TANABE, Tetsuya , KONDO, Seiji
IPC分类号： G01N21/64 , G02B21/00
CPC分类号： G01N15/06 , G01N21/64 , G01N2015/0065 , G01N2015/0687 , G01N2015/0693 , G02B21/0032 , G02B21/0048 , G02B21/008 , G02B21/0084 , G02B21/16 , G02B2207/114
摘要： In the scanning molecule counting method using optical measurement with a confocal or multiphoton microscope, there is provided a technique of computing a light-emitting particle concentration which changes with time and detecting a concentration change velocity or a reaction velocity. The inventive optical analysis technique of detecting light of light-emitting particles in a sample solution generates time series light intensity data of light from a light detection region detected with moving the position of the light detection region of the microscope in the sample solution; measures successively an interval of generation times of signals of the light-emitting particles detected in the time series light intensity data; and determines the concentration or concentration change velocity of the light-emitting particles, using the successively measured signal generation time intervals.
摘要翻译：在扫描分子使用光学测量用共聚焦或多光子显微镜计数法，提供了计算的发光粒子的浓度随时间变化和检测的浓度变化速度或反应速度的技术。从与移动在试样溶液中的显微镜的光检测区域的位置检测到的光检测区域检测发光粒子的光在样本溶液基因率时序光强度的光的数据的本发明的光学分析技术; 依次以在时间序列的光强度数据中检测到的发光颗粒的信号产生时间间隔的措施; 和确定性地雷发光粒子的浓度或浓度变化速度，使用顺序测量信号生成的时间间隔。

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