专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2172776A1 Method to diagnose heart muscle damage 失效
标题翻译： Verfahren zur Bestimm Hertz-Muskel-Schaden
公开(公告)号：EP2172776A1
公开(公告)日：2010-04-07
申请号：EP09016084.7
申请日：1997-12-15
申请人： Biosite Incorporated
发明人： Buechler, Kenneth F. , McPherson, Paul H.
IPC分类号： G01N33/68 , G01N33/545 , G01N33/543
CPC分类号： G01N33/54366 , G01N33/6887 , G01N33/6893 , G01N2333/4712 , G01N2800/32 , G01N2800/324 , Y10S435/96 , Y10S435/962 , Y10S435/975 , Y10S436/808 , Y10S436/811 , Y10S436/824 , Y10S530/81 , Y10S530/811 , Y10S530/829 , Y10S530/83 , Y10S530/841
摘要： A method for the diagnosis of heart muscle damage comprising:
using an immunoassay system to determine the amount of cardiac troponin I in a blood, plasma, or serum sample supspected of containing troponin from damaged heart muscle, said system comprising (a) formation of an antibody conjugate comprising an antibody coupled to a signal generating element, said antibody being capable of specifically binding to cardiac specific regions of the troponin I complexes and of unbound troponin I, (b) formation of a reaction mixture comprising said whole blood, plasma or serum sample incubated with said antibody conjugate, (c) application of said reaction mixture to a surface to which is bound at least one capture antibody capable of specifically binding to cardiac specific regions of troponin I, said capture antibody binding said antibody conjugate, whereby the immobilized conjugate produces a detectable signal upon formation of sandwich complexes, and (d) relating of the detectable signal to the amount of cardiac troponin I present in said sample, wherein said antibody is insensitive with respect to the free troponin I and cardiac troponin I complexed with troponin C and troponin T, i.e. yields an assay response for said free and complexed forms of cardiac troponin I that is the same within a factor of 2; and
relating the amount of cardiac troponin I present in said sample to the occurrence or non-occurrence of heart muscle damage.
摘要翻译：一种用于诊断心脏肌肉损伤的方法，包括：使用免疫测定系统来测定血液，血浆或血清样品中含有肌钙蛋白的损伤心脏肌肉中肌钙蛋白I的量，所述系统包括（a）形成抗体结合物，其包含与信号产生元件偶联的抗体，所述抗体能够特异性结合肌钙蛋白I复合物和未结合的肌钙蛋白I的心脏特异性区域，（b）形成包含所述全血，血浆或血清的反应混合物样品与所述抗体缀合物孵育，（c）将所述反应混合物施用于结合有至少一种能够特异性结合肌钙蛋白I的心脏特异性区域的捕获抗体的表面，所述捕获抗体结合所述抗体缀合物，由此固定化共轭物在形成夹心复合物时产生可检测的信号，和（d）将可检测信号与t相关他存在于所述样品中的心肌肌钙蛋白I的量，其中所述抗体相对于与肌钙蛋白C和肌钙蛋白T复合的游离肌钙蛋白I和心肌肌钙蛋白I不敏感，即产生所述游离和复合形式的心肌肌钙蛋白I的测定响应在2的范围内是相同的; 并将所述样品中存在的心肌肌钙蛋白I的量与心肌损伤的发生或不发生相关联。

2. 发明公开

EP1602929A3 Methods for monitoring the status of assays 审中-公开
标题翻译：监测状态检测方法
公开(公告)号：EP1602929A3
公开(公告)日：2007-09-05
申请号：EP05076405.9
申请日：1999-01-04
申请人： Biosite Incorporated
发明人： Buechler, Kenneth F. , Anderberg, Joseph M. , McPherson, Paul H.
IPC分类号： G06F19/00 , G01N33/53 , G01N33/558 , G01N33/559
CPC分类号： G01N33/54306 , G01N11/04 , G01N33/53 , G01N35/00693 , G01N2011/008 , G01N2021/6439 , G01N2035/00702 , Y10S435/805 , Y10S435/81 , Y10S435/967 , Y10S435/97 , Y10S435/971 , Y10S436/805 , Y10S436/81 , Y10S436/818
摘要： The invention relates in part to a method of smoothing assay signal determinations in an assay device. The device has a reaction chamber and a diagnostic lane. An unreactive label is provided in the reaction chamber and then the diagnostic lane is observed for label signal. The signal from the label id subjected to smoothing.

3. 发明公开

EP1657543A1 Fluorometer system 审中-公开
标题翻译：荧光计免疫测定
公开(公告)号：EP1657543A1
公开(公告)日：2006-05-17
申请号：EP05076963.7
申请日：1998-12-15
申请人： Biosite Incorporated
发明人： Buechler, Kenneth F. , Anderberg, Joseph M. , McPherson, Paul H.
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , Y10T436/112499 , Y10T436/115831
摘要： A fluorometer for sensing the fluorescence of a sample utilizes an optical energy source for exciting a sample to be tested and an optical energy detector for detecting the emitted energy from the excited sample. Drive electronics are used for positioning the sample with respect to the optical components allowing a plurality of sample regions to be tested. A processor is utilized to control the operation of the test in accordance with test instructions and for processing the emitted energy detected from the sample to determine test results. A ROM chip socket accepts a plurality of ROM chips, wherein each ROM chip stores test data sets for one or more test types to be performed. ROM chips can be swapped to allow the fluorometer to be configured and reconfigured to perform a plurality of different tests. A communications interface facilitates the sharing of test information between the fluorometer and external entities.
摘要翻译：用于感测样品荧光的荧光计利用用于激发被测样品的光能源和用于检测被激发样品发射的能量的光能检测器。驱动电子器件用于相对于光学部件定位样品，允许测试多个样品区域。使用处理器来根据测试指令控制测试的操作，并且用于处理从样品检测到的发射能量以确定测试结果。 ROM芯片插座接受多个ROM芯片，其中每个ROM芯片存储要执行的一种或多种测试类型的测试数据集。可以交换ROM芯片以允许荧光计被配置和重新配置以执行多个不同的测试。通信接口有助于在荧光计和外部实体之间共享测试信息。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式