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1. 发明授权

US06762050B2 Manufacture of a microsensor device and a method for evaluating the function of a liquid by the use thereof 有权
标题翻译：微传感器装置的制造和使用该液体的功能的评价方法
公开(公告)号：US06762050B2
公开(公告)日：2004-07-13
申请号：US09870588
申请日：2001-06-01
申请人： Hitoshi Fukushima , Tatsuya Shimoda , Hywel Morgan
发明人： Hitoshi Fukushima , Tatsuya Shimoda , Hywel Morgan
IPC分类号： C12M136
CPC分类号： G01N33/54366 , B01J2219/00378 , B01J2219/00653 , B01J2219/00659 , B41J2/01 , C12Q1/6834 , C40B60/14
摘要： In order to form organic thin films on electrodes, a solution of a material for the organic thin film is accurately printed via an ink-jet onto the surface of microelectrodes as required, thereby producing a high density array of microelectrodes. Further, a solution of a sample substance or a liquid substance to be sensed is ejected into air via an ink-jet nozzle to fall to the surface of organic thin membranes on the microelectrodes so that the sample can be evaluated.
摘要翻译：为了在电极上形成有机薄膜，根据需要，通过喷墨将有机薄膜的材料溶液精确地印刷到微电极的表面上，从而产生高密度的微电极阵列。此外，待检测的样品物质或液体物质的溶液通过喷墨嘴喷射到空气中以落在微电极上的有机薄膜表面上，从而可以评估样品。

2. 发明授权

US06586233B2 Convectively driven PCR thermal-cycling 失效
公开(公告)号：US06586233B2
公开(公告)日：2003-07-01
申请号：US09802549
申请日：2001-03-09
申请人： William J. Benett , James B. Richards , Fred P. Milanovich
发明人： William J. Benett , James B. Richards , Fred P. Milanovich
IPC分类号： C12M136
CPC分类号： B01L7/52 , B01L2400/0445
摘要： A polymerase chain reaction system provides an upper temperature zone and a lower temperature zone in a fluid sample. Channels set up convection cells in the fluid sample and move the fluid sample repeatedly through the upper and lower temperature zone creating thermal cycling.

3. 发明授权

US06429007B1 Nucleic acid amplification reaction station for disposable test devices 有权
标题翻译：一次性试验装置的核酸扩增反应站
公开(公告)号：US06429007B1
公开(公告)日：2002-08-06
申请号：US09420140
申请日：1999-10-18
申请人： Bryan W. Kluttz , Geoff A. McKinley , Fabio Gennari , Michel Guy , Christopher Cotter , Luigi Catanzariti , Louis Graziano , Bruno Colin , Cecile Jaravel , Jacques Dachaud
发明人： Bryan W. Kluttz , Geoff A. McKinley , Fabio Gennari , Michel Guy , Christopher Cotter , Luigi Catanzariti , Louis Graziano , Bruno Colin , Cecile Jaravel , Jacques Dachaud
IPC分类号： C12M136
CPC分类号： C12Q1/6848 , B01L3/502 , B01L7/52 , B01L7/525 , B01L2200/026 , B01L2200/16 , B01L2300/044 , B01L2300/0809 , B01L2300/0825 , B01L2300/0861 , B01L2300/087 , B01L2300/1822 , B01L2400/0487 , B01L2400/049 , B01L2400/0633 , B01L2400/0644 , B01L2400/0655 , G01N35/026 , G01N2035/0436
摘要： An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature. A pneumatic system is also provided that assists in fluid transfer of a reaction solution from the first chamber to the second chamber.
摘要翻译：用于在一次性测试装置中进行核酸扩增反应的仪器。测试装置包括含有第一核酸扩增试剂（例如引物和核苷酸）的第一反应室和含有或与第二核酸扩增试剂（例如，扩增酶如 RT）。仪器包括接收测试装置的支撑结构。温度控制系统将第一反应室保持在第一升高温度，同时将第二核酸扩增试剂保持在低于第一温度的第二温度，以便保留第二核酸扩增试剂。致动器在测试装置中的流体导管上操作，以在第一温度下在第一反应室中发生反应之后使第一和第二反应室彼此流体连通。还提供了一种有助于将反应溶液从第一室流体转移到第二室的气动系统。

4. 发明授权

US06399395B1 Device and method of applying microdroplets to a substrate 失效
标题翻译：将微滴施加到基底的装置和方法
公开(公告)号：US06399395B1
公开(公告)日：2002-06-04
申请号：US09416129
申请日：1999-10-12
申请人： Roland Zengerle , Nicolaus Hey , Holger Gruhler , Michael Freygang , Martin Müller
发明人： Roland Zengerle , Nicolaus Hey , Holger Gruhler , Michael Freygang , Martin Müller
IPC分类号： C12M136
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , C40B60/14 , F04B19/006 , G01N35/1067 , G01N2035/1041 , G01N2035/1069 , Y10T436/2575
摘要： A device for applying microdroplets to a substrate includes a dosing head having a nozzle orifice and a liquid storage area in fluid communication with the orifice. A drive applies an acceleration to the dosing head. A quantity of liquid in the storage area cannot follow the acceleration due to its inertia. This inertia causes microdroplets to be driven out of the nozzle onto the substrate. In one embodiment, the dosing head includes a plurality of nozzle orifices each having an associated liquid storage area, so that a plurality of different analytes are deposited on the substrate.
摘要翻译：用于将微滴施加到基底的装置包括具有喷嘴孔口和与孔口流体连通的液体储存区域的计量头。驱动器对加药头施加加速度。存储区域中的液体量由于其惯性而不能跟随加速度。该惯性导致微滴从喷嘴驱动到基板上。在一个实施例中，计量头包括多个具有相关联的液体储存区域的喷嘴孔，使得多个不同的分析物沉积在基底上。

5. 发明授权

US06399363B1 Method of permeant removal from cell suspension in a porous container 失效
标题翻译：从多孔容器中的细胞悬浮液去除透过物的方法
公开(公告)号：US06399363B1
公开(公告)日：2002-06-04
申请号：US09635036
申请日：2000-08-04
申请人： Roy H. Hammerstedt , Rupert P. Amann
发明人： Roy H. Hammerstedt , Rupert P. Amann
IPC分类号： C12M136
CPC分类号： A01N1/0205 , A01N1/0221 , A01N1/0242 , A01N1/0268
摘要： An apparatus in which cryoprotectant in cryopreserved samples is removed with the use of turbulence and convective-dispersion around the cells within the primary cryopreservation container. Convective-dispersion is applied via the combined action of gravity and pulsatile transmembrane flow of buffer through the pores of containers fabricated from appropriate membrane material. By using mechanical forces to aid the process of cryoprotectant removal, the benefits of slow cryoprotectant removal are retained while the actual removal time is markedly decreased.
摘要翻译：使用低温保藏容器内的细胞周围的湍流和对流分散来除去冷冻保存的冷冻保护剂的装置。通过缓冲液的重力和脉冲跨膜流的组合作用通过由合适的膜材料制成的容器的孔施加对流分散。通过使用机械力来帮助冷冻保护剂去除的过程，保留缓慢冷冻保护剂去除的好处，而实际的去除时间显着降低。

6. 发明授权

US06225109B1 Genetic analysis device 失效
标题翻译：遗传分析装置
公开(公告)号：US06225109B1
公开(公告)日：2001-05-01
申请号：US09321170
申请日：1999-05-27
申请人： Robert D. Juncosa , Rene Bongard , Johannes Dapprich , Richard Scribner
发明人： Robert D. Juncosa , Rene Bongard , Johannes Dapprich , Richard Scribner
IPC分类号： C12M136
CPC分类号： B01L3/5025 , B01L3/502707 , B01L3/50855 , B01L2200/0689 , B01L2300/069 , B01L2300/0809 , B01L2300/0822 , B01L2300/0825 , B01L2300/0877 , B01L2400/0406
摘要： A genetic analysis device particularly for determining the presence or absence of Single Nucleotide Polymorphisms (SNPs) within specific sequences of DNA. The device includes a housing, at least one glass slide member, and an elastomeric member with channels thereon. Oligo arrays are spotted on the glass slide member(s) and subjected to DNA samples, reagents or the like. A plurality of openings or ports allow entry of samples, reagents or wash materials, while a plurality of exit ports or openings allow removal of such materials. The assay devices can be used for multiple samples or a single sample. A plurality of synthesis devices can be positioned in a support base in order to allow sampling in an automated manner. The synthesis devices can be provided in a 96 well microtiter format.
摘要翻译：特别用于确定DNA特定序列内单核苷酸多态性（SNP）的存在或不存在的遗传分析装置。该装置包括壳体，至少一个玻璃滑动构件和在其上具有通道的弹性构件。将寡核苷酸阵列点在玻片载体上并进行DNA样品，试剂等。多个开口或端口允许样品，试剂或洗涤材料进入，而多个出口或开口允许去除这些材料。测定装置可用于多个样品或单个样品。可以将多个合成装置定位在支撑基座中，以便以自动方式进行采样。合成装置可以以96孔微量滴定法形式提供。

7. 发明授权

US06818435B2 Microfluidics devices and methods for performing cell based assays 失效
标题翻译：用于进行基于细胞的测定的微流体装置和方法
公开(公告)号：US06818435B2
公开(公告)日：2004-11-16
申请号：US09858558
申请日：2001-05-15
申请人： Bruce L. Carvalho , Norman F. Sheppard, Jr. , Christina Feakes , Gregory J. Kellogg
发明人： Bruce L. Carvalho , Norman F. Sheppard, Jr. , Christina Feakes , Gregory J. Kellogg
IPC分类号： C12M136
CPC分类号： B01L3/50273 , B01F5/0647 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L7/525 , B01L2200/0605 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/10 , B01L2400/0406 , B01L2400/0409 , B01L2400/0677 , B01L2400/0688 , B01L2400/088 , G01N21/07 , G01N35/00069 , G01N2035/00495 , G01N2035/00504 , G01N2035/00514 , G01N2035/00524 , Y10T436/111666
摘要： This invention provides methods and apparatus for performing microanalytic analyses and procedures, particularly miniaturized cell based assays. These methods are useful for performing a variety of cell-based assays, including drug candidate screening, life sciences research, and clinical and molecular diagnostics.
摘要翻译：本发明提供了用于进行微量分析分析和程序，特别是基于小型化的基于细胞的测定的方法和装置。这些方法对于进行各种基于细胞的测定是有用的，包括药物候选筛选，生命科学研究以及临床和分子诊断。

8. 发明授权

US06599735B1 Continuous fermentation system 失效
标题翻译：连续发酵系统
公开(公告)号：US06599735B1
公开(公告)日：2003-07-29
申请号：US09684855
申请日：2000-10-06
申请人： Attila Bartók , Thorsten Mueh , Markus Rueckel
发明人： Attila Bartók , Thorsten Mueh , Markus Rueckel
IPC分类号： C12M136
CPC分类号： C12M41/48 , C12M25/18 , C12M25/20 , C12M37/02 , C12M41/12 , C12P21/02 , Y10S435/81
摘要： A fermentation assembly comprising: (a) a vessel for culturing living cells; (b) at least two storage flasks in fluid communication with the vessel for supply of liquids and a first transport means for transferring the liquids from the storage flasks to the vessel; (c) individual appliances operably connected to the transport means for monitoring the supply of the contents of the storage flasks to the vessel; (d) a harvest flask in fluid communication with the vessel and a second transport means for transferring the fermentation broth from the vessel to the harvest flask; and (e) a device operably connected to the first transport means for controlling and maintaining a constant dilution rate in the vessel with varying rates of individual supply of liquid from the storage flasks to the vessel is disclosed.
摘要翻译：一种发酵装置，包括：（a）用于培养活细胞的容器; （b）至少两个与所述容器流体连通以供应液体的储存瓶和用于将所述液体从所述储存瓶转移到所述容器的第一输送装置; （c）可操作地连接到运输工具上用于监测储存瓶的内容物供应给容器的各种设备; （d）与容器流体连通的收获瓶和用于将发酵液从容器转移到收获瓶的第二输送装置; 公开了一种可操作地连接到第一输送装置上的装置，用于控制和保持容器中恒定的稀释速率，其中液体从储存瓶到容器的单独供应速率变化不大。

9. 发明授权

US06582954B2 Biopolymer detector 失效
公开(公告)号：US06582954B2
公开(公告)日：2003-06-24
申请号：US10062132
申请日：2002-01-30
申请人： Keiichi Sato , Mitsuhiro Tachibana , Toshiki Morita , Motonao Nakao
发明人： Keiichi Sato , Mitsuhiro Tachibana , Toshiki Morita , Motonao Nakao
IPC分类号： C12M136
CPC分类号： C12Q1/6825
摘要： Disclosed is a biopolymer (DNA) detector capable of performing overall analysis including an unreacted sample without needing any complex work such as washing or the like. A DNA probe 66 is fixed to an electrode plate 22, and the electrode plate 22 is displaced by applying a DC voltage between electrode plates 22 and 23. Thus, sample DNA 63 to be detected can be separated. It becomes possible to obtain a clearer result by performing analysis based on a ratio of an entire reaction system.

10. 发明授权

US06576459B2 Sample preparation and detection device for infectious agents 失效
公开(公告)号：US06576459B2
公开(公告)日：2003-06-10
申请号：US09815624
申请日：2001-03-23
申请人： Robin R. Miles , Amy W. Wang , Christopher K. Fuller , Asuncion V. Lemoff , Kerry A. Bettencourt , June Yu
发明人： Robin R. Miles , Amy W. Wang , Christopher K. Fuller , Asuncion V. Lemoff , Kerry A. Bettencourt , June Yu
IPC分类号： C12M136
CPC分类号： B01L3/5027 , B01F13/0059 , B01F13/0076 , B01L7/52 , B01L2200/10 , B01L2400/0424 , B01L2400/043 , G01N1/4077 , G01N15/0656 , G01N2015/0088 , Y10S435/81 , Y10S435/962
摘要： A sample preparation and analysis device which incorporates both immunoassays and PCR assays in one compact, field-portable microchip. The device provides new capabilities in fluid and particle control which allows the building of a fluidic chip with no moving parts, thus decreasing fabrication cost and increasing the robustness of the device. The device can operate in a true continuous (not batch) mode. The device incorporates magnetohydrodynamic (MHD) pumps to move the fluid through the system, acoustic mixing and fractionation, dielectropheretic (DEP) sample concentration and purification, and on-chip optical detection capabilities.

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