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1. 发明授权

US06855293B1 Fluids manipulation device with format conversion 失效
标题翻译：具有格式转换的流体操纵装置
公开(公告)号：US06855293B1
公开(公告)日：2005-02-15
申请号：US09936881
申请日：2000-03-22
申请人： Roland Zengerle , Nicolaus Hey , Holger Gruhler , Michael Freygang , Martin Mueller
发明人： Roland Zengerle , Nicolaus Hey , Holger Gruhler , Michael Freygang , Martin Mueller
IPC分类号： G01N33/53 , B01J4/00 , B01J19/00 , B01L3/02 , C40B60/14 , F04B19/00 , G01N1/00 , G01N1/28 , G01N33/48 , G01N33/566 , G01N35/10 , G01N37/00 , B01L3/00 , B01L9/00 , B01L11/00 , G01N15/06
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , C40B60/14 , F04B19/006 , G01N35/1067 , G01N2035/1041 , G01N2035/1069 , Y10T436/2575
摘要： A fluid management apparatus includes a substrate having a first surface and a second surface opposite to the first surface. A plurality of fluid inlets, which are preferably media reservoirs, are formed in a first pattern in the first surface of the substrate. A plurality of fluid outlets, which are preferably nozzles, are arranged in a second pattern, which is different from the first pattern, in the second surface of the substrate. A plurality of fluid ducts formed in the substrate for connecting respective fluid inlets with respective fluid outlets are provided so that a format conversation from the fluid inlets to the fluid outlets is effected. The fluid outlets have opening cross-sections smaller than that of the fluid inlets. Furthermore, the fluid inlets may be arranged in the raster scheme of microtiter plates.
摘要翻译：流体管理装置包括具有第一表面和与第一表面相对的第二表面的基底。在衬底的第一表面中以第一图案形成多个流体入口，其优选地是介质储存器。优选地，喷嘴的多个流体出口在基板的第二表面中以与第一图案不同的第二图案布置。形成在衬底中的多个流体管道，用于将相应的流体入口与相应的流体出口连接，从而实现从流体入口到流体出口的格式对话。流体出口具有小于流体入口的开口横截面。此外，流体入口可以以微量滴定板的光栅方案排列。

2. 发明授权

US06416294B1 Microdosing device 失效
标题翻译：微量滴定装置
公开(公告)号：US06416294B1
公开(公告)日：2002-07-09
申请号：US09582917
申请日：2000-08-07
申请人： Roland Zengerle , Michael Freygang , Nicolaus Hey , Holger Gruhler
发明人： Roland Zengerle , Michael Freygang , Nicolaus Hey , Holger Gruhler
IPC分类号： F09B1700
CPC分类号： G01N35/1016 , B01J2219/00351 , B01J2219/00378 , B01L3/0203 , B01L3/0268 , B01L2400/0481 , C40B60/14 , F04B43/046 , G01F11/08 , G01N2035/00237
摘要： A volume sensor-free microdosing device comprises a pressure chamber which is at least partly delimited by a displacer, an actuating device for actuating the displacer, the volume of the pressure chamber being adapted to the changed by actuating the displacer, a media reservoir which is in fluid communication with the pressure chamber, an outlet opening which is in fluid communication with the pressure chamber, and a control mechanism. The control mechanism drives the microdosing device in such a way that a small change of volume of the pressure chamber volume is effected per unit time by a movement of the displacer from a first position to a predetermined second position, the second position of the displacer defining a larger volume of the pressure chamber than the first position, so as to suck a fluid volume into the pressure chamber, and that, in a second phase, a large volume change of the pressure chamber volume is effected per unit time by a movement of the displacer from the second position to the first position, so as to eject a defined fluid volume from the outlet opening in this way.
摘要翻译：无体积传感器的微量计量装置包括至少部分地由置换器限定的压力室，用于致动置换器的致动装置，压力室的体积适于通过致动置换器而改变;介质储存器，与压力室流体连通，与压力室流体连通的出口和控制机构。控制机构以这样一种方式驱动微量计量装置，使得通过置换器从第一位置到预定的第二位置的运动，每单位时间实现压力室体积的小的变化，位移器的第二位置限定比第一位置更大的压力室体积，以便将流体体积吸入压力室，并且在第二阶段中，通过运动使单位时间内每单位时间内容积变化的压力室体积所述置换器从所述第二位置到所述第一位置，以便以这种方式从所述出口开口排出限定的流体体积。

3. 发明授权

US06399395B1 Device and method of applying microdroplets to a substrate 失效
标题翻译：将微滴施加到基底的装置和方法
公开(公告)号：US06399395B1
公开(公告)日：2002-06-04
申请号：US09416129
申请日：1999-10-12
申请人： Roland Zengerle , Nicolaus Hey , Holger Gruhler , Michael Freygang , Martin Müller
发明人： Roland Zengerle , Nicolaus Hey , Holger Gruhler , Michael Freygang , Martin Müller
IPC分类号： C12M136
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , C40B60/14 , F04B19/006 , G01N35/1067 , G01N2035/1041 , G01N2035/1069 , Y10T436/2575
摘要： A device for applying microdroplets to a substrate includes a dosing head having a nozzle orifice and a liquid storage area in fluid communication with the orifice. A drive applies an acceleration to the dosing head. A quantity of liquid in the storage area cannot follow the acceleration due to its inertia. This inertia causes microdroplets to be driven out of the nozzle onto the substrate. In one embodiment, the dosing head includes a plurality of nozzle orifices each having an associated liquid storage area, so that a plurality of different analytes are deposited on the substrate.
摘要翻译：用于将微滴施加到基底的装置包括具有喷嘴孔口和与孔口流体连通的液体储存区域的计量头。驱动器对加药头施加加速度。存储区域中的液体量由于其惯性而不能跟随加速度。该惯性导致微滴从喷嘴驱动到基板上。在一个实施例中，计量头包括多个具有相关联的液体储存区域的喷嘴孔，使得多个不同的分析物沉积在基底上。

4. 发明授权

US06280148B1 Microdosing device and method for operating same 失效
标题翻译：微量滴定装置及其操作方法
公开(公告)号：US06280148B1
公开(公告)日：2001-08-28
申请号：US09367664
申请日：1999-08-17
申请人： Roland Zengerle , Michael Freygang , Manfred Stehr , Stephan Messner , Matthias Ashauer , Rainer Rossberg
发明人： Roland Zengerle , Michael Freygang , Manfred Stehr , Stephan Messner , Matthias Ashauer , Rainer Rossberg
IPC分类号： F04B4906
CPC分类号： H01L41/00 , B01J2219/00351 , B01J2219/00364 , B01J2219/00378 , B01L3/0265 , B01L3/0268 , B01L3/5027 , B01L2200/146 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0439 , B01L2400/0487 , B05B9/0413 , C40B60/14 , F04B19/006 , F04B43/046 , F04B2201/0201 , G01F11/08 , G01N35/00 , G01N2035/00237
摘要： A microdosing device comprises a pressure chamber which is at least partly delimited by a displacer, an actuating device for actuating the displacer, the volume of the pressure chamber being adapted to be changed by actuating the displacer, a media reservoir which is in fluid comunication with the pressure chamber via a first fluid line, and an outlet opening which is in fluid communication with the pressure chamber via a second fluid line. The microdosing device additionally comprises a means for detecting the respective position of the displacer and a control means which is connected to the actuating device and to the means for detecting the position of the displacer, said control means controlling the actuating device on the basis of the detected position of the displacer or on the basis of displacer positions detected during at least one preceding dosing cycle so as to cause the discharge of a defined volume of fluid from the outlet opening. The control means comprises means for controlling the actuating device with a signal of low edge steepness so as to cause the displacer to move from a first position to a predetermined second position, the second position of the displacer defining a larger volume of the pressure chamber than the first position. In addition, the control means comprises means for controlling the actuating device with a signal of high edge steepness so as to cause the displacer to move from the second position to the first position for discharging in this way a defined volume of fluid from the outlet opening.
摘要翻译：微量饮料装置包括至少部分地由置换器限定的压力室，用于致动置换器的致动装置，压力室的体积适于通过致动置换器来改变;压力室的体积可以通过流体通过与经由第一流体管线的压力室和通过第二流体管线与压力室流体连通的出口开口。微量计量装置还包括用于检测置换器的相应位置的装置和连接到致动装置的控制装置和用于检测置换器的位置的装置，所述控制装置基于检测置换器的位置，或者基于在至少一个以前的给料循环期间检测到的置换器位置，以便引起从出口开口排出限定体积的流体。控制装置包括用于利用低边缘陡度的信号来控制致动装置的装置，以便使置换器从第一位置移动到预定的第二位置，置换器的第二位置限定压力室的体积更大，第一名。此外，控制装置包括用于利用具有高边缘陡度的信号来控制致动装置的装置，以便使置换器从第二位置移动到第一位置，以这种方式从出口开口排出限定体积的流体。

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