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1. 发明申请

US20090209030A1 Thermal Cycler 审中-公开
标题翻译：热循环仪
公开(公告)号：US20090209030A1
公开(公告)日：2009-08-20
申请号：US12415623
申请日：2009-03-31
申请人： William J. Benett , James B. Richards , Paul L. Stratton , Elizabeth K. Wheeler , Peter Krulevitch , Steve Visuri , John M. Dzenitis
发明人： William J. Benett , James B. Richards , Paul L. Stratton , Elizabeth K. Wheeler , Peter Krulevitch , Steve Visuri , John M. Dzenitis
IPC分类号： C12M1/02 , H05K3/00
CPC分类号： B01L7/52 , B01L3/5082 , B01L2200/12 , B01L2300/123 , B01L2300/1827 , B01L2300/1844 , Y10T29/49124
摘要： A thermalcycler is constructing with a first thermalcycler body section of a flexible circuit material or a circuit board material. The first thermalcycler body section has a first face. A first cavity portion is formed in the first face. A second thermalcycler body section is constructed of a flexible circuit material or a circuit board material. The second thermalcycler body section has a second face. A second cavity portion is formed in the second face. When the first cavity portion and the second cavity portion are positioned together they form a cavity. A thermalcycler unit is positioned in the cavity. The first thermalcycler body section and the second thermalcycler body section are connected together with the first face and the face opposed to each other and the thermalcycler unit operatively connected to the first cavity portion and the second cavity portion.
摘要翻译：热循环器正在构造具有柔性电路材料或电路板材料的第一热循环体主体部分。第一热循环体主体部分具有第一面。第一空腔部分形成在第一面中。第二个热循环器主体部分由柔性电路材料或电路板材料构成。第二热循环器本体部分具有第二面。第二空腔部分形成在第二面中。当第一空腔部分和第二空腔部分位于一起时，它们形成空腔。热循环器单元位于空腔中。第一热循环器主体部分和第二热循环器主体部分与第一面和彼此相对的面连接在一起，并且热循环器单元可操作地连接到第一腔部分和第二腔部分。

2. 发明授权

US06586233B2 Convectively driven PCR thermal-cycling 失效
公开(公告)号：US06586233B2
公开(公告)日：2003-07-01
申请号：US09802549
申请日：2001-03-09
申请人： William J. Benett , James B. Richards , Fred P. Milanovich
发明人： William J. Benett , James B. Richards , Fred P. Milanovich
IPC分类号： C12M136
CPC分类号： B01L7/52 , B01L2400/0445
摘要： A polymerase chain reaction system provides an upper temperature zone and a lower temperature zone in a fluid sample. Channels set up convection cells in the fluid sample and move the fluid sample repeatedly through the upper and lower temperature zone creating thermal cycling.

3. 发明授权

US06503750B1 PCR thermocycler 有权
公开(公告)号：US06503750B1
公开(公告)日：2003-01-07
申请号：US09200309
申请日：1998-11-25
申请人： William J. Benett , James B. Richards
发明人： William J. Benett , James B. Richards
IPC分类号： C12M134
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00828 , B01J2219/00873 , B01J2219/00961 , B01L3/5027 , B01L2300/1827 , B01L2300/1838
摘要： A sleeve-type silicon polymerase chain reaction (PCR) chamber or thermocycler having improved thermal performance. The silicon sleeve reaction chamber is improved in thermal performance by etched features therein that reduce thermal mass and increase the surface area of the sleeve for cooling. This improved thermal performance of the thermocycler enables an increase in speed and efficiency of the reaction chamber. The improvement is accomplished by providing grooves in the faces of the sleeve and a series of grooves on the interior surfaces that connect with grooves on the faces of the sleeve. The grooves can be anisotropically etched in the silicon sleeve simultaneously with formation of the chamber.

4. 发明授权

US06699713B2 Polymerase chain reaction system 有权
标题翻译：聚合酶链反应体系
公开(公告)号：US06699713B2
公开(公告)日：2004-03-02
申请号：US09752794
申请日：2000-12-29
申请人： William J. Benett , James B. Richards , Paul L. Stratton , Dean R. Hadley , Fred P. Milanovich , Phil Belgrader , Peter L. Meyer
发明人： William J. Benett , James B. Richards , Paul L. Stratton , Dean R. Hadley , Fred P. Milanovich , Phil Belgrader , Peter L. Meyer
IPC分类号： C12M134
CPC分类号： C12M1/34 , B01L7/52
摘要： A portable polymerase chain reaction DNA amplification and detection system includes one or more chamber modules. Each module supports a duplex assay of a biological sample. Each module has two parallel interrogation ports with a linear optical system. The system is capable of being handheld.
摘要翻译：便携式聚合酶链反应DNA扩增和检测系统包括一个或多个室模块。每个模块支持生物样品的双相测定。每个模块具有两个具有线性光学系统的并行询问端口。该系统能够被手持。

5. 发明授权

US06893863B2 PCR thermocycler 失效
标题翻译： PCR热循环仪
公开(公告)号：US06893863B2
公开(公告)日：2005-05-17
申请号：US10260120
申请日：2002-09-27
申请人： William J. Benett , James B. Richards
发明人： William J. Benett , James B. Richards
IPC分类号： B01J19/00 , B01L3/00 , B01L7/00 , C12M1/34
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00828 , B01J2219/00873 , B01J2219/00961 , B01L3/5027 , B01L2300/1827 , B01L2300/1838
摘要： A sleeve-type silicon polymerase chain reaction (PCR) chamber or thermocycler having improved thermal performance. The silicon sleeve reaction chamber is improved in thermal performance by etched features therein that reduce thermal mass and increase the surface area of the sleeve for cooling. This improved thermal performance of the thermocycler enables an increase in speed and efficiency of the reaction chamber. The improvement is accomplished by providing grooves in the faces of the sleeve and a series of grooves on the interior surfaces that connect with grooves on the faces of the sleeve. The grooves can be anisotropically etched in the silicon sleeve simultaneously with formation of the chamber.
摘要翻译：具有改进的热性能的套筒型硅聚合酶链反应（PCR）室或热循环仪。通过其中的蚀刻特征，硅套筒反应室的热性能得到改善，其降低热质量并增加用于冷却的套筒的表面积。热循环仪的这种改进的热性能使得能够提高反应室的速度和效率。通过在套筒的表面上设置凹槽和在内表面上与套筒表面上的凹槽连接的一系列凹槽来实现改进。在形成腔室的同时，可以在硅套管中各向异性地蚀刻凹槽。

6. 发明授权

US5859887A Nuclear fuel assembly support grid 失效
标题翻译：核燃料组件支撑电网
公开(公告)号：US5859887A
公开(公告)日：1999-01-12
申请号：US879538
申请日：1997-06-20
申请人： James B. Richards
发明人： James B. Richards
IPC分类号： G21C3/352 , G21C3/34
CPC分类号： G21C3/352 , G21Y2002/206 , G21Y2002/303 , G21Y2004/301 , Y02E30/40
摘要： A nuclear fuel assembly support grid formed from a lattice structure having an egg-crate design with the interior lattice straps joined to a perimeter strap generally at least three locations along its length; with at least two of those locations being affixed by shear joints. The shear joints are formed from weld tabs extending from the ends of the interior lattice straps, at appropriate locations, which fit into corresponding slots in the perimeter strap. The weld tabs are then brazed or welded, as appropriate to the base metals being joined, after being inserted. The weld segments can be designed with twist tabs at their end, that can be deformed after being inserted into the corresponding slots in the peripheral strap, to hold the fixture in place while it is being bonded. In another embodiment, the interior lattice straps are joined to the perimeter strap by two shear joints formed respectively at the very top and bottom of the interface.
摘要翻译：由具有卵盒设计的格子结构形成的核燃料组件支撑格栅，内部格子带通常沿着其长度连接至周边带至少三个位置; 其中至少两个位置由剪切接头固定。剪切接头由在内部格子带的端部延伸的焊接片形成，该适配位置适合于周边带中相应的槽。然后在插入之后，焊接接头被钎焊或焊接，适合于被接合的基底金属。焊接部分可以在其端部设计有扭曲突出部，其可以在插入到周边带中的相应狭槽中之后变形，以将固定装置固定在其上。在另一个实施例中，内部格子带通过分别形成在界面的最上面和底部的两个剪切接头连接到周边带上。

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