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    • 8. 发明申请
    • (2,5-disubstituted-1,4-phenylene oxide) block or graft copolymer
    • (2,5-二取代-1,4-亚苯基氧化物)嵌段或接枝共聚物
    • US20020007020A1
    • 2002-01-17
    • US09818758
    • 2001-03-28
    • Hideyuki HigashimuraShuhei NamekawaShiro Kobayashi
    • C08G002/00C08G065/38C08G065/48C08L071/12
    • C08G65/485C08G61/12C08L71/123Y10T428/2982C08L2666/04
    • There is disclosed a (2,5-disubstituted-1,4-phenylene oxide) block copolymer which comprises one or more block structural units represented by formula (I) and at least one particular divalent structural unit in a molecule. There is also disclosed a (2,5-disubstituted-1,4-phenylene oxide) graft polymer which comprises one or more structural units of formula (IV), or three or more of structural unit of formula (IV) and particular divalent structural unit, in a molecule. 1 (wherein R1 represents an unsubstituted or substituted hydrocarbon group, and the two R1s may be the same or different; a represents a number average degree of polymerization and is 5 or more; R4 represents a trifunctional unsubstituted or substituted hydrocarbon group; U represents nullCOnull, nullOCOnull, or nullNHCOnull; and f is 1 or 0.)
    • 公开了一种(2,5-二取代-1,4-亚苯基氧化物)嵌段共聚物,其包含一个或多个由式(I)表示的嵌段结构单元和分子中至少一个特定的二价结构单元。 还公开了一种(2,5-二取代-1,4-亚苯基氧化物)接枝聚合物,其包含一种或多种式(IV)的结构单元,或三种或更多种式(IV)的结构单元和特定的二价结构 单位,分子。 (其中R1表示未取代或取代的烃基,并且两个R 1可以相同或不同; a表示数均聚合度,为5以上; R 4表示三官能的未取代或取代的烃基; U表示-CO - , - OCO-或-NHCO-; f为1或0)
    • 9. 发明申请
    • Ophthalmic biomaterials and preparation thereof
    • 眼科生物材料及其制备
    • US20040258727A1
    • 2004-12-23
    • US10855955
    • 2004-05-28
    • Lina LiuHeather D. Sheardown
    • C08G065/48C08L071/12A61F002/00
    • G02B1/043C08G77/045C08G77/12C08G77/18C08G77/44C08G77/70C08L83/04C08L83/10C08L2666/04
    • Composite interpenetrating network (IPN) of PDMS and PNIPAAM was formed to generate polymers with oxygen and glucose permeability as well as improved wettability compared to PDMS homopolymers and greater mechanical strength than PNIPAAM homopolymers. Transparent vinyl and hydroxyl terminated PDMS/PNIPAAM IPNs (PDMS-V and PDMS-OH IPNs respectively) were successfully synthesized. Transmission electron microscopy images verified the structure of the IPNs. Surface analysis suggested that PNIPAAM was present on the surface as well as in the bulk material. PDMS-OH IPNs generated from a PDMS-OH matrix cured in the presence of solvent had the highest glucose permeability at 10null7 cm2/s, comparable to that of the native cornea. The LCST phenomenon remained in these materials, although changes were not as abrupt as with pure PNIPAAM. These results suggest that these materials may be further developed as ophthalmic biomaterials or for controlled drug release applications.
    • 形成PDMS和PNIPAAM的复合互穿网络(IPN),以产生具有氧和葡萄糖渗透性的聚合物以及与PDMS均聚物相比改善的润湿性和比PNIPAAM均聚物更大的机械强度。 成功地合成了透明乙烯基和羟基封端的PDMS / PNIPAAM IPN(分别为PDMS-V和PDMS-OH IPN)。 透射电子显微镜图像验证了IPN的结构。 表面分析表明,PNIPAAM存在于表面以及散装材料中。 在溶剂存在下固化的PDMS-OH基质产生的PDMS-OH IPN具有与天然角膜相当的10 -7 cm 2 / s的最高葡萄糖透过率。 LCST现象仍然存在于这些材料中,尽管变化并不像纯PNIPAAM那样突然。 这些结果表明,这些材料可以进一步开发为眼科生物材料或用于受控药物释放应用。