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1. 发明授权

US06642395B1 Acetalsulfonate derivative, process for producing the same, and process for producing styrene oxide derivative 失效
标题翻译：乙醛磺酸酯衍生物，其制造方法，以及氧化苯乙烯衍生物的制造方法
公开(公告)号：US06642395B1
公开(公告)日：2003-11-04
申请号：US10130284
申请日：2002-05-29
申请人： Hiroyuki Mori , Hikari Morita , Yoshimasa Kobayashi
发明人： Hiroyuki Mori , Hikari Morita , Yoshimasa Kobayashi
IPC分类号： C07C30900
CPC分类号： C07C309/73 , C07C303/28 , C07C303/30 , C07C309/66 , C07D309/12
摘要： There are provided an acetalsulfonate derivative useful as an intermediate for medicines and agricultural chemicals, a process for industrially producing the derivative, and a process for industrially producing a styrene oxide derivative from the acetalsulfonate derivative or from a mandelic acid derivative. A process for producing an acetalsulfonate derivative which comprises a first step of esterifying a mandelic acid derivative to form a mandelic ester derivative, a second step of protecting the mandelic ester derivative by an acetal to form an acetal derivative, a third step of reducing the acetal derivative to form an ethanediol derivative and a fourth step of reacting the ethanediol derivative with a sulfonyl chloride derivative. A process for producing a styrene oxide derivative which comprises a deprotecting step of deacetalizing the acetalsulfonate derivative and a step of epoxidizing the sulfonate derivative obtained in the deprotecting step with the aid of a base catalyst.
摘要翻译：提供了可用作药物和农药的中间体的乙缩醛磺酸酯衍生物，工业生产该衍生物的方法，以及从乙醛磺酸酯衍生物或扁桃酸衍生物工业生产苯氧乙烯衍生物的方法。乙缩醛磺酸酯衍生物，其包括酯化扁桃酸衍生物以形成扁桃酸酯衍生物的第一步骤，通过缩醛保护扁桃酸酯衍生物以形成缩醛衍生物的第二步骤，将缩醛衍生物还原形成乙二醇的第三步骤衍生物和使乙二醇衍生物与磺酰氯衍生物反应的第四步。一种氧化苯乙烯衍生物的制造方法，其包括脱乙酰化缩醛化衍生物的脱保护工序和在脱保护工序中得到的磺酸酯衍生物借助碱催化剂进行环氧化的工序。

2. 发明授权

US06504050B1 Process for the preparation of 2-acrylamido-2-methyl-1-propanesulfonic acid 有权
标题翻译： 2-丙烯酰氨基-2-甲基-1-丙磺酸的制备方法
公开(公告)号：US06504050B1
公开(公告)日：2003-01-07
申请号：US10096070
申请日：2002-03-13
申请人： Prashant Purushottam Barve , Sunil Shankar Joshi , Ravindra William Shinde , Milind Yashwant Gupte , Chandrashekhar Narayan Joshi , Shrikant Madhukar Ghike , Raghavendra Venkatrao Naik , Rajendra Anantrao Kulkarni , Aruna Narayan Bote
发明人： Prashant Purushottam Barve , Sunil Shankar Joshi , Ravindra William Shinde , Milind Yashwant Gupte , Chandrashekhar Narayan Joshi , Shrikant Madhukar Ghike , Raghavendra Venkatrao Naik , Rajendra Anantrao Kulkarni , Aruna Narayan Bote
IPC分类号： C07C30900
CPC分类号： C07C303/02 , C07C309/15
摘要： The present invention provides a process for the preparation of highly pure 2-acrylamido-2-methyl-1-propanesulfonic acid in high yield, with improved appearance, by the reaction of acrylonitrile with more than 98% sulfuric acid or oleum and liquefied isobutylene in presence of weak inorganic acids or organic sulfonic acids.
摘要翻译：本发明提供了通过丙烯腈与大于98％的硫酸或发烟硫酸和液化的异丁烯的反应，以高产率制备高纯度2-丙烯酰氨基-2-甲基-1-丙磺酸的方法，存在弱无机酸或有机磺酸。

3. 发明授权

US06441230B1 Triphos polymer compounds and acylation agent useful in their preparation 有权
标题翻译： Triphos聚合物化合物和酰化剂可用于其制备
公开(公告)号：US06441230B1
公开(公告)日：2002-08-27
申请号：US09781356
申请日：2001-02-12
申请人： Niels Christian Schiødt , Finn Joensen
发明人： Niels Christian Schiødt , Finn Joensen
IPC分类号： C07C30900
CPC分类号： B01J31/1658 , B01J31/06 , B01J31/20 , B01J31/2404 , B01J2231/321 , B01J2531/0247 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/828 , C07C7/163 , C07C45/50 , C07C45/68 , C07C309/65 , C07C381/00 , C07C2531/24 , C07C49/80 , C07C47/02
摘要： Material and process of preparing such material, of the formula where R1 is a linker and C(R2P(R3)2)3 group is a triphos moiety; and wherein R1 is selected from branched and linear alkyl group and alkyl carbonyl group optionally substituted with functional groups comprising carbonyl, alkoxy, hydroxy, amino, nitro, carboxylic or sulfonic acid and esters or amides thereof; R2 are methylene (CH2) or substituted methylene groups; R3 are linear or branched alkyl or phenyl or substituted phenyl groups; polymer is any polymer containing aromatic groups, comprising polystyrene, poly-vinyl pyridine, poly pyrrole, poly pyrrolidone or derivatives thereof. The material impregnated with a transition metal has catalytic properties. The preparation of the material involves the use of an acylating agent having the formula CF3SO3C(O)C(H2X)3 or an anhydride thereof, where X is a halogen.
摘要翻译：制备这种材料的材料和方法，其中R1是连接基，C（R2P（R3）2）3基团是三磷键部分; 并且其中R 1选自支链和直链烷基，和任选被包括羰基，烷氧基，羟基，氨基，硝基，羧酸或磺酸的官能团取代的烷基羰基和其酯或酰胺; R2是亚甲基（CH2）或取代亚甲基; R3是直链或支链烷基或苯基或取代的苯基; 聚合物是含有芳族基团的任何聚合物，包括聚苯乙烯，聚乙烯基吡啶，聚吡咯，聚吡咯烷酮或其衍生物。用过渡金属浸渍的材料具有催化性能。该材料的制备涉及使用具有式CF 3 SO 3 C（O）C（H 2 X）3的酰化剂或其酸酐，其中X为卤素。

4. 发明授权

US06337421B1 Purification of alkanesulphonic acids 失效
标题翻译：烷基磺酸的纯化
公开(公告)号：US06337421B1
公开(公告)日：2002-01-08
申请号：US09627002
申请日：2000-07-27
申请人： Christian Gancet
发明人： Christian Gancet
IPC分类号： C07C30900
CPC分类号： C07C303/44 , C07C309/04
摘要： In order to reduce the content of sulphuric acid in an alkanesulphonic acid, an aqueous solution of the latter is brought into contact with a basic anion-exchange resin. The invention relates more particularly to the purification of 70% methanesulphonic acid.
摘要翻译：为了降低链烷磺酸中硫酸的含量，后者的水溶液与碱性阴离子交换树脂接触。本发明更具体地涉及70％甲磺酸的纯化。

5. 发明授权

US06326512B1 Method of producing an optically active &bgr;-hydroxy sulfonic acid compound by catalytic asymmetric hydrogenation 失效
标题翻译：通过催化不对称氢化制备光学活性β-羟基磺酸化合物的方法
公开(公告)号：US06326512B1
公开(公告)日：2001-12-04
申请号：US09584747
申请日：2000-06-01
申请人： Masato Kitamura , Masahiro Yoshimura , Naoki Kanda , Ryoji Noyori
发明人： Masato Kitamura , Masahiro Yoshimura , Naoki Kanda , Ryoji Noyori
IPC分类号： C07C30900
CPC分类号： C07C303/22 , C07C303/32 , C07C309/24
摘要： Disclosed is a method of producing an optically active &bgr;-hydroxy sulfonic acid compound comprising hydrogenating a &bgr;-keto sulfonic acid compound represented by formula 1: where R1 represents an alkyl or a phenyl group, which may be substituted, and R2 represents sodium or an alkyl group, in an acidic solvent, in the presence of an asymmetric catalyst comprising a complex of bivalent Ru, having 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl as a ligand, to produce a compound represented by formula 2: where R1 and R2 are as defined above, and * designates an asymmetric carbon atom.
摘要翻译：公开了一种制备光学活性β-羟基磺酸化合物的方法，包括氢化由式1表示的β-酮磺酸化合物：其中R 1表示可被取代的烷基或苯基，R 2表示钠或烷基，在酸性溶剂中，在包含具有2,2'-双（二苯基膦基）-1,1'-联萘作为配体的二价Ru的络合物的不对称催化剂的存在下，制备由式 2：其中R1和R2如上所定义，*表示不对称碳原子。

6. 发明授权

US06765112B1 Fluorinated onium salts 有权
标题翻译：氟化鎓盐
公开(公告)号：US06765112B1
公开(公告)日：2004-07-20
申请号：US10396942
申请日：2003-03-25
申请人： James A. Schultz
发明人： James A. Schultz
IPC分类号： C07C30900
CPC分类号： C07C303/32 , C07F9/5407 , C07C309/06
摘要： A process that can be used for manufacturing a tetraalkylonium perfluoroalkylsulfonate is provided. The process comprises contacting a tetraalkylonium halide with a metal perfluoroalkyl sulfonate to produce a mixture; allowing the second mixture to produce an aqueous upper layer and a separate lower liquid layer; separating the lower liquid layer from the upper aqueous layers to produce a product layer; optionally washing the product layer with 1 to 10 volumes of water, based on the volume of the product layer at a temperature of about 50° C. to about 100° C. to produce a washed product layer; and drying the product layer or washed product.
摘要翻译：提供了可用于制备全烷基磺酸四烷基铵的方法。该方法包括使四烷基卤化铵与金属全氟烷基磺酸酯接触以产生混合物; 允许第二混合物产生水性上层和单独的下液体层; 将下部液体层与上部水层分离以产生产物层; 基于产物层的体积，在约50℃至约100℃的温度下，任选地用1至10体积的水洗涤产物层以产生洗涤的产品层; 并干燥产物层或洗涤的产品。

7. 发明授权

US06706916B1 Optically active amino acid derivatives and processes for the preparation of the same 失效
标题翻译：光学活性氨基酸衍生物及其制备方法
公开(公告)号：US06706916B1
公开(公告)日：2004-03-16
申请号：US09913822
申请日：2001-08-17
申请人： Haruyo Sato , Takae Ohno , Shiho Iwata
发明人： Haruyo Sato , Takae Ohno , Shiho Iwata
IPC分类号： C07C30900
CPC分类号： C07C227/32 , C07B2200/07 , C07C227/18 , C07C231/18 , C07C229/08 , C07C229/24 , C07C229/26 , C07C233/47 , C07C235/12
摘要： In producing optically-active amino acid benzyl esters by reacting optically-active amino acids with benzyl alcohols, hydrazines are present in the reaction system, or the compounds are reacted in the absence of oxygen, or the compounds are reacted in the absence of oxygen while hydrazines are present in the reaction system. The processes are simple and give optically-active amino acid benzyl esters of high optical purity.
摘要翻译：在光学活性氨基酸与苄醇反应制备光学活性氨基酸苄基酯时，肼在反应体系中存在，或者化合物在不存在氧的情况下反应，或者化合物在不存在氧的情况下反应，而肼存在于反应体系中。该方法简单，得到光学纯度高的光学活性氨基酸苄基酯。

8. 发明授权

US06610881B1 Method for producing sulfonated aryl phosphines 失效
标题翻译：制备磺化芳基膦的方法
公开(公告)号：US06610881B1
公开(公告)日：2003-08-26
申请号：US09937640
申请日：2001-12-12
申请人： Michael Riedel , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Ernst Wiebus , Carl D Frohning , Wilfried Fenske , Florian Rampf
发明人： Michael Riedel , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Ernst Wiebus , Carl D Frohning , Wilfried Fenske , Florian Rampf
IPC分类号： C07C30900
CPC分类号： B01J31/2404 , B01J31/2409 , B01J31/28 , B01J2231/321 , B01J2531/822 , B01J2531/96 , C07C45/50 , C07F9/5022 , C07F9/5054 , C07F9/5095 , C07C47/02
摘要： The invention relates to a method for producing sulfonated aryl phosphines by reacting aryl phosphines with oleum. After reacting the aryl phosphines with oleum, the sulfonation mixture is firstly diluted with water and an inert gas stream is then fed through the diluted sulfonation mixture until SO2 is no longer released from the diluted sulfonation mixture. Afterwards, the sulfonation mixture is subsequently processed in a usual manner. The invention also relates to a method for producing solutions of sulfonated aryl phosphines by reacting the aryl phosphines with oleum, diluting the sulfonation mixture with water, extracting the aqueous solution using an organic solution consisting of an amine, and subsequently carrying out a reextraction using an aqueous solution having an inorganic base. According to the invention, the solution containing aqueous sulfonated aryl phosphines is adjusted to a pH value of up to 3 by adding acid, and an inert gas stream is then fed through the aqueous solution until sulfur dioxide is no longer released. The invention additionally relates to an aqueous catalyst solution containing rhodium and an aqueous solution of sulfonated aryl phosphines, treated as defined by the invention, for carrying out the hydroformylation of olefinically unsaturated compounds, and relates to the use thereof for carrying out the same.
摘要翻译：本发明涉及通过使芳基膦与发烟硫酸反应制备磺化芳基膦的方法。在芳基膦与发烟硫酸反应之后，首先用水稀释磺化混合物，然后将惰性气体流通过稀释的磺化混合物，直到SO 2不再从稀释的磺化混合物中释放出来。之后，磺化混合物随后以常规方式进行处理。本发明还涉及通过使芳基膦与发烟硫酸反应制备磺化芳基膦的溶液的方法，将磺化混合物与水稀释，使用由胺构成的有机溶液萃取水溶液，然后使用具有无机碱的水溶液。根据本发明，通过加入酸将含有磺化芳基膦水溶液的溶液的pH值调至3，然后将惰性气体流通过该水溶液直至二氧化硫不再释放。本发明另外涉及含有铑的水性催化剂溶液和由本发明定义的磺化芳基膦的水溶液，用于进行烯属不饱和化合物的加氢甲酰化，并涉及其用于进行烯属不饱和化合物的加氢甲酰化。

9. 发明授权

US06518455B1 Process for preparing substituted aromatic and heteroaromatic aldehydes and carboxylic acids 失效
标题翻译：取代的芳族和杂芳族醛和羧酸的制备方法
公开(公告)号：US06518455B1
公开(公告)日：2003-02-11
申请号：US09473020
申请日：1999-12-28
申请人： Gerhard Steinbauer , Karlheinz Giselbrecht , Manfred Schöftner , Klaus Reiter
发明人： Gerhard Steinbauer , Karlheinz Giselbrecht , Manfred Schöftner , Klaus Reiter
IPC分类号： C07C30900
CPC分类号： C07C303/22 , C07C309/44 , C07C309/58
摘要： A process for preparing substituted aromatic and heteroaromatic aldehydes or carboxylic acids of the formula in which R1 and R2 are H, C1-C4 alkyl, C1-C4 alkoxy, OH, NO2, CN, COOH, CONH2, COOR, NH2, SO3H or halogen and R is C1-C4 alkyl and where R1 and R2 are not simultaneously H, X is C or N and Z is CHO or COOH, from the corresponding symmetric stilbene compounds of the formula in which R1, R2 and X are as defined above, by aqueous ozonolysis and subsequent isolation of an aldehyde or oxidation to give the corresponding carboxylic acid.
摘要翻译： R1和R2是H，C1-C4烷基，C1-C4烷氧基，OH，NO2，CN，COOH，CONH2，COOR，NH2，SO3H或卤素的取代芳族和杂芳族醛或羧酸的方法，以及 R是C1-C4烷基，其中R1和R2不同时为H，X为C或N，Z为CHO或COOH，R1，R2和X如上定义的式对应的对称二苯乙烯化合物，臭氧分解并随后分离醛或氧化，得到相应的羧酸。

10. 发明授权

US06479697B2 Process for the preparation of &agr;-(2-4-disulfophenyl)-N-tert-burtylnitrone and pharmaceutically acceptable salts thereof 失效
标题翻译：制备α-（2-4-二磺基苯基）-N-叔丁基硝酮的方法及其药学上可接受的盐
公开(公告)号：US06479697B2
公开(公告)日：2002-11-12
申请号：US09806832
申请日：2001-04-05
申请人： Henry Kruk , John McGinley , Sergei Pouhov , John Vajda , Jörgen Blixt
发明人： Henry Kruk , John McGinley , Sergei Pouhov , John Vajda , Jörgen Blixt
IPC分类号： C07C30900
CPC分类号： C07C303/22 , C07C303/32 , C07C309/46
摘要： A process for the preparation of &agr;-(2,4-disulfophenyl)-N-tert-butylnitrone diacids and pharmaceutically acceptable salts thereof by the reaction of the corresponding disulfophenyl aldehyde with N-tert-butylhydroxylammonium acetate is disclosed.
摘要翻译：公开了通过相应的二磺基苯基醛与N-叔丁基羟基乙酸铵的反应来制备α-（2,4-二磺基苯基）-N-叔丁基硝酮二酸及其药学上可接受的盐的方法。

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