专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100151541A1 NOVEL POLYPEPTIDE HAVING ESTERASE ACTIVITY AND RECOMBINANT ESTERASE AND USE THEREOF 有权
标题翻译：具有蛋白酶活性的新型多肽和重组蛋白酶及其用途
公开(公告)号：US20100151541A1
公开(公告)日：2010-06-17
申请号：US12159547
申请日：2006-12-08
申请人： Gerhard Steinbauer , Micheal Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Marcel Wubbolts , Joannes Kierkels , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
发明人： Gerhard Steinbauer , Micheal Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Marcel Wubbolts , Joannes Kierkels , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
IPC分类号： C12P7/62 , C12N9/16 , C07H21/04
CPC分类号： C12N9/18 , C12P7/02 , C12P41/005
摘要： Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.
摘要翻译：多肽和具有酯酶活性的重组蛋白质，其表现出氨基酸序列SEQ。 ID。 1及其用途。

2. 发明授权

US07473792B2 Process for transition metal-catalyzed asymmetric hydrogenation of acrylic acid derivatives, and a novel catalyst system for asymmetric transition metal catalysis 有权
标题翻译：用于过渡金属催化的丙烯酸衍生物的不对称氢化方法，以及用于不对称过渡金属催化的新型催化剂体系
公开(公告)号：US07473792B2
公开(公告)日：2009-01-06
申请号：US11666922
申请日：2005-12-05
申请人： Jeroen Boogers , Ulfried Felfer , Martina Kotthaus , Andreas H. M. De Vries , Johannes G. De Vries , Laurent Lefort , Gerhard Steinbauer
发明人： Jeroen Boogers , Ulfried Felfer , Martina Kotthaus , Andreas H. M. De Vries , Johannes G. De Vries , Laurent Lefort , Gerhard Steinbauer
IPC分类号： C07F15/00 , B01J31/00 , C07C57/02
CPC分类号： C07C51/36 , B01J31/1865 , B01J31/187 , B01J31/24 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07C67/303 , C07C57/36 , C07C57/58 , C07C53/128 , C07C59/64
摘要： A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C1-C6-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.
摘要翻译： R 1为H或任选取代的烷基，芳基或杂芳基的式（I）的丙烯酸衍生物的过渡金属催化不对称氢化的方法，R 2为任选取代的烷基，芳基或杂芳基，R 3为是H或C 1 -C 6烷基，其包括在一个或多个氢供体存在下，任选地在溶剂中使式（I）化合物氢化，使用包含过渡金属钌，铑和铱以及式（II）的手性磷配体的组合，其中Cn与两个氧原子和磷原子一起形成任选取代的具有2至6个碳原子的环，R 4是任选取代的烷基，芳基，烷氧基或芳氧基或NR5R6，其中R5和R6各自独立地为H或任选取代的烷基，芳基，芳烷基或烷芳基，或与氮原子一起形成 g和其中R是任选取代的烷基或芳基的式（III）的非手性膦配体与相应的式（IV）化合物反应，其中R 1，R 2和R 3各自如上所定义，以及一种用于不对称过渡金属催化的新型催化剂体系。

3. 发明申请

US20070293691A1 Process for Transition Metal-Catalyzed Asymmetric Hydrogenation of Acrylic Acid Derivatives, and a Novel Catalyst System for Asymmetric Transition Metal Catalysis 有权
标题翻译：过渡金属催化非对称氢化丙烯酸衍生物的方法，以及用于不对称过渡金属催化的新型催化剂体系
公开(公告)号：US20070293691A1
公开(公告)日：2007-12-20
申请号：US11666922
申请日：2005-12-05
申请人： Jeroen Boogers , Ulfried Felfer , Martina Kotthaus , Andreas H.M. De Vries , Johannes De Vries , Laurent Lefort , Gerhard Steinbauer
发明人： Jeroen Boogers , Ulfried Felfer , Martina Kotthaus , Andreas H.M. De Vries , Johannes De Vries , Laurent Lefort , Gerhard Steinbauer
IPC分类号： C07C57/07 , B01J31/24 , C07F17/02 , C07B53/00
CPC分类号： C07C51/36 , B01J31/1865 , B01J31/187 , B01J31/24 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07C67/303 , C07C57/36 , C07C57/58 , C07C53/128 , C07C59/64
摘要： A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C1-C6-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.
摘要翻译： R 1为H或任选取代的烷基，芳基或杂芳基的式（I）的丙烯酸衍生物的过渡金属催化不对称氢化的方法，R 2为任选取代的烷基，芳基或杂芳基，R 3为是H或C 1 -C 6 - 烷基，其包括任选地在溶剂中，在一种或多种存在下将式（I）的化合物氢化氢供体，使用包含来自钌，铑和铱的过渡金属的催化剂体系和式（II）的手性磷配体的组合，其中Cn与两个氧原子和磷原子一起，形成具有2至6个碳原子的任选取代的环，R 4是任选取代的烷基，芳基，烷氧基或芳氧基或NR 5 R 6，其中R 5和R 6可各自独立地为H或任选取代的烷基，芳基，芳烷基或烷芳基，或者连同硝化可以形成环，和其中R是任选取代的烷基或芳基的式（III）的非手性膦配体与其中R 1，R 2和R 3各自相应的式（Ⅳ）化合物反应如上所定义，以及用于不对称过渡金属催化的新型催化剂体系。

4. 发明申请

US20110301365A1 ALPHA-SUBSTITUTED ALPHA, BETA-UNSATURATED E- OR Z-ALDEHYDES, USE THEREOF, AND PROCESSES FOR THEIR PREPARATION ALPHA, BETA 审中-公开
标题翻译： ALPHA替代的阿尔法，β-不饱和的E-或Z-阿尔德，其使用及其制备方法ALPHA，BETA
公开(公告)号：US20110301365A1
公开(公告)日：2011-12-08
申请号：US13205498
申请日：2011-08-08
申请人： Gerhard STEINBAUER , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Anna Maria Cornelia Francisca Castelijns , Andreas Hendrikus Maria De Vries
发明人： Gerhard STEINBAUER , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Anna Maria Cornelia Francisca Castelijns , Andreas Hendrikus Maria De Vries
IPC分类号： C07D307/02 , C07C237/02
CPC分类号： C07C47/277 , C07C37/002 , C07C37/62 , C07C41/22 , C07C41/26 , C07C45/516 , C07C45/562 , C07C45/62 , C07C45/63 , C07C45/72 , C07C45/74 , C07C47/27 , C07C69/78 , C07C309/66 , C07C309/73 , C12P7/24 , C07C43/23 , C07C43/225 , C07C39/373 , C07C39/24
摘要： This invention relates to novel alpha-substituted α,β-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula in which R1 and R2 may be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and R3 and R4 may be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and R5 may be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals.
摘要翻译：本发明涉及下式的新型α-取代的α，β-不饱和的E-或Z-醛或其异构体混合物，其中R 1和R 2可以相同或不同并且各自为H或烃，其中烃可以具有一个或多个杂原子，R 3和R 4可以相同或不同，并且各自为烃，其中烃可以具有一个或多个杂原子，R 5可以相同或不同，为H或烃，其中烃可以具有一个或多个杂原子，以及其制备方法。本发明还涉及药物的其它中间体的制备和药物的制备。

5. 发明申请

US20080281125A1 Process for Preparing Enantiopure E-(2S)-Alkyl-5-Halopent-4-Enoic Acids and Esters 审中-公开
标题翻译：制备对映体（E）（2S） - 烷基-5-卤代-4-烯酸和酯的方法
公开(公告)号：US20080281125A1
公开(公告)日：2008-11-13
申请号：US11885740
申请日：2006-02-22
申请人： Markus Rossler , Gerhard Steinbauer , Peter Pojarliev
发明人： Markus Rossler , Gerhard Steinbauer , Peter Pojarliev
IPC分类号： C07C51/42
CPC分类号： C07C51/02 , C07B2200/07 , C07C51/412 , C07C51/43 , C07C57/52
摘要： A process for preparing enantiopure E-(2S)-alkyl-5-halopent-4-enoic acids and their esters of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-C4-alkyl and X is chlorine, bromine or iodine, in which the corresponding racemic 2-alkyl-5-halopent-4-enoic acid a) is reacted in a suitable solvent first with (S)-3-Methyl-2-phenylbutylamine, quinine or with N-methyl-D-glucamine, after which b) the corresponding (S)-3-Methyl-2-phenylbutylamine salt, quinine or glucamine salt of the (R)-pentenoic acid is precipitated and removed, and c) the remaining filtrate is mixed with a second chiral base or an inorganic salt, after which the corresponding salt of the (S)-pentenoic acid is precipitated and d) is then converted into the corresponding E-(2S)-alkyl-5-halo-4-pentenoic acid and subsequently where appropriate into the corresponding ester of the formula (I) in which R1 is C1-C4-alkyl.
摘要翻译：一种制备对映体育用的E-（2S） - 烷基-5-卤代-4-烯酸及其式（I）的酯的方法，其中R是C 1 -C 6 - 6个 - 烷基，R 1是H或C 1 -C 4 - 烷基，X是氯，溴或碘其中相应的外消旋的2-烷基-5-卤代-4-烯酸a）在合适的溶剂中首先与（S）-3-甲基-2-苯基丁胺，奎宁或与N-甲基-D-葡萄糖胺，然后b）相应的（S）-3-甲基-2-苯基丁胺盐，（R） - 戊烯酸的奎宁或葡糖胺盐沉淀并除去，和c）将剩余的滤液与第二手性碱或无机盐，然后将（S） - 戊烯酸的相应盐沉淀出来，然后将d）转化成相应的E-（2S） - 烷基-5-卤代-4-戊烯酸，随后适当地加入其中R 1为C 1 -C 4 - 烷基的式（I）的相应酯。

6. 发明授权

US06346623B1 Method for producing substituted pyridine-carboxylic acids 有权
标题翻译：取代的吡啶羧酸的制备方法
公开(公告)号：US06346623B1
公开(公告)日：2002-02-12
申请号：US09701543
申请日：2000-11-30
申请人： Gerhard Steinbauer , Curt Zimmermann , Ernst Wressnegger , Erich Steinwender
发明人： Gerhard Steinbauer , Curt Zimmermann , Ernst Wressnegger , Erich Steinwender
IPC分类号： C07D21355
CPC分类号： C07D213/803 , C07D213/80
摘要： An improved process for the preparation of substituted pyridinecarboxylic acids (II), useful as herbicide intermediates, by ozonolysis of quinolines (I).
摘要翻译：通过喹啉（I）的臭氧分解制备用作除草剂中间体的取代的吡啶羧酸（II）的改进方法。

7. 发明授权

US08088955B2 Alpha-substituted α,β-unsaturated E- or Z-aldehydes, use thereof, and processes for their preparation α,β 失效
标题翻译： α-取代的α，β-不饱和的E-或Z-醛，其用途及其制备方法α，bgr;
公开(公告)号：US08088955B2
公开(公告)日：2012-01-03
申请号：US12668236
申请日：2008-07-11
申请人： Gerhard Steinbauer , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Anna Maria Cornelia Francisca Castelijns , Andreas Hendrikus Maria De Vries
发明人： Gerhard Steinbauer , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Anna Maria Cornelia Francisca Castelijns , Andreas Hendrikus Maria De Vries
IPC分类号： C07C47/27 , C07C45/00 , C07C309/01 , C07F7/02
CPC分类号： C07C47/277 , C07C37/002 , C07C37/62 , C07C41/22 , C07C41/26 , C07C45/516 , C07C45/562 , C07C45/62 , C07C45/63 , C07C45/72 , C07C45/74 , C07C47/27 , C07C69/78 , C07C309/66 , C07C309/73 , C12P7/24 , C07C43/23 , C07C43/225 , C07C39/373 , C07C39/24
摘要： This invention relates to novel alpha-substituted α,β-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula (I) in which R1 and R2 may be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and R3 and R4 may be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and R5 may be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals.
摘要翻译：本发明涉及式（I）的新型α-取代的α，β-不饱和的E-或Z-醛或其异构体混合物，其中R 1和R 2可以相同或不同并且各自为H或烃，其中烃可以具有一个或多个杂原子，并且R 3和R 4可以相同或不同，并且各自为烃，其中烃可以具有一个或多个杂原子，R 5可以相同或不同，为H或烃，其中烃可以具有一个或多个杂原子，其用途及其制备方法。本发明还涉及药物的其它中间体的制备和药物的制备。

8. 发明申请

US20120220014A1 NOVEL POLYPEPTIDE HAVING ESTERASE ACTIVITY AND RECOMBINANT ESTERASE AND USE THEREOF 有权
标题翻译：具有蛋白酶活性的新型多肽和重组蛋白酶及其用途
公开(公告)号：US20120220014A1
公开(公告)日：2012-08-30
申请号：US13417734
申请日：2012-03-12
申请人： Gerhard Steinbauer , Michael Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Joannes Kierkels , Marcel Wubbolts , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
发明人： Gerhard Steinbauer , Michael Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Joannes Kierkels , Marcel Wubbolts , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
IPC分类号： C12N9/16 , C07H21/04
CPC分类号： C12N9/18 , C12P7/02 , C12P41/005
摘要： Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.
摘要翻译：多肽和具有酯酶活性的重组蛋白质，其表现出氨基酸序列SEQ。 ID。 1及其用途。

9. 发明授权

US08158393B2 Polypeptide having esterase activity and recombinant esterase and use thereof 有权
标题翻译：具有酯酶活性的多肽和重组酯酶及其用途
公开(公告)号：US08158393B2
公开(公告)日：2012-04-17
申请号：US12159547
申请日：2006-12-08
申请人： Gerhard Steinbauer , Micheal Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Marcel Wubbolts , Joannes Kierkels , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
发明人： Gerhard Steinbauer , Micheal Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Marcel Wubbolts , Joannes Kierkels , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
IPC分类号： C12P7/62 , C12N9/16
CPC分类号： C12N9/18 , C12P7/02 , C12P41/005
摘要： Method of resolving stereoselectively racemic 2-alkyl-5-halopent-4-ene-carboxylic esters of the formula (I) in which R is a C1-C6-alkyl radical, R1 is C1-C4-alkyl and X is chlorine, bromine or iodine, by contacting a racemic ester of formula (I) with a polypeptide or recombinant protein having esterase activity and exhibiting an amino acid sequence that is at least 98% identical to the amino acid sequence of SEQ. ID. No. 1.
摘要翻译：拆分式（I）的立体选择性外消旋的2-烷基-5-卤代-4-烯 - 羧酸酯的方法，其中R是C 1 -C 6 - 烷基，R 1是C 1 -C 4 - 烷基，X是氯，溴或碘，通过使式（I）的外消旋酯与具有酯酶活性的多肽或重组蛋白质接触，并显示与SEQ ID NO：1的氨基酸序列至少98％相同的氨基酸序列。 ID。 1号

10. 发明授权

US07550626B2 Process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids or carboxylic esters 失效
标题翻译：制备外消旋烷基-5-卤代-4-烯羧酸或羧酸酯的方法
公开(公告)号：US07550626B2
公开(公告)日：2009-06-23
申请号：US11995553
申请日：2006-07-03
申请人： Peter Pojarliev , Gerhard Steinbauer , Christian Burger
发明人： Peter Pojarliev , Gerhard Steinbauer , Christian Burger
IPC分类号： C07C69/62 , C07C53/15
CPC分类号： C07C51/09 , C07C67/32 , C07C67/343 , C07C57/52 , C07C69/65
摘要： A process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids and esters thereof of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-4-alkyl and X is chlorine, bromine or iodine, which comprises a) reacting a dialkyl alkylmalonate of the formula (II),in which R is as defined above and R2 is a C1-C4-alkyl radical, in the presence of a metal alkoxide of the formula MOR3, in which M may be Na, K or Li, and R3 is a C1-C4-alkyl radical, and in an organic solvent, with 1,3-dihalopropene to give the corresponding allylated malonate, then b) after full conversion, adding an inorganic salt and a C1-C6 alcohol to the reaction mixture, heating the reaction mixture to reflux temperature, then c) isolating the desired racemic ester of the formula (I) from the reaction mixture by extraction or direct distillation and d) if the racemic acid is the desired end product, hydrolyzing the ester function.
摘要翻译：制备式（I）的外消旋烷基-5-卤代-4-甲酸及其酯的方法，其中R是C1-C6-烷基，R1是H或C1-4 - 烷基，X是氯溴或碘，其包括：a）在式MOR 3的金属醇盐存在下使式（II）的烷基丙二酸二烷基酯（其中R如上定义，R 2是C 1 -C 4 - 烷基）其中M可以是Na，K或Li，R3是C1-C4-烷基，在有机溶剂中与1,3-二卤丙烯反应，得到相应的烯丙基化丙二酸酯，然后b）完全转化后，加入无机盐和C 1 -C 6醇反应混合物，将反应混合物加热至回流温度，然后c）通过萃取或直接蒸馏从反应混合物中分离所需的式（I）外消旋酯，和d）如果外消旋酸是所需的最终产物，水解酯的功能。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式