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1. 发明授权

US06808627B2 Dialyzing apparatus 失效
标题翻译：透析器
公开(公告)号：US06808627B2
公开(公告)日：2004-10-26
申请号：US10073027
申请日：2002-02-12
申请人： Keizoh Kawaguchi
发明人： Keizoh Kawaguchi
IPC分类号： B01D6128
CPC分类号： A61M1/14 , A61M2230/04 , A61M2230/20 , A61M2230/005
摘要： A dialyzing apparatus including a dialyzer which removes water from blood of a patient at a water-remove rate, an arteriosclerosis-related-information obtaining device which obtains arteriosclerosis-related information that is related to a degree of arteriosclerosis of the patient, and a water-remove-rate display device which displays a target value of the water-remove rate based on the arteriosclerosis-related information obtained by the arteriosclerosis-related-information obtaining device.
摘要翻译：一种透析装置，包括透析器，其以去水率从患者的血液中除去水分，获得与患者的动脉硬化相关的动脉硬化相关信息的动脉硬化相关信息获取装置，以及水 - 基于由动脉硬化相关信息获取装置获得的与动脉硬化相关的信息显示除水率的目标值的去除率显示装置。

2. 发明授权

US06355161B1 Bottles for dialysis machines and method for automatically identifying such bottles 有权
标题翻译：用于透析机的瓶子和用于自动识别这种瓶子的方法
公开(公告)号：US06355161B1
公开(公告)日：2002-03-12
申请号：US09549897
申请日：2000-04-14
申请人： Dilip H. Shah , Gary Howell , Kenneth E. Pawlak , Masatoshi Ozono , Wade Fournier , Mete Alpan
发明人： Dilip H. Shah , Gary Howell , Kenneth E. Pawlak , Masatoshi Ozono , Wade Fournier , Mete Alpan
IPC分类号： B01D6128
CPC分类号： A61M1/1656 , A61J3/002 , A61J2205/30 , A61M1/1666 , A61M1/1668 , A61M1/169 , A61M2205/17 , A61M2205/505 , A61M2205/6036 , A61M2205/6045 , A61M2205/6063
摘要： A set of bottles for containing dialysate chemical formulations, chemical cleaning agents or the like is described. The chemical formulation bottles come in two varieties, sodium bicarbonate and liquid acid formulations, each bottle having a slightly different shape. The different shapes cooperate with a bottle mounting structure in the dialysis machine to insure that bottles are correctly installed on their respective bottle opening mechanism. The bottles also have a detection feature comprising either a raised rim or groove extending around the periphery of the bottle. A sensor assembly in the bottle mounting and opening system detects the detection feature. The detection feature is used by the machine to distinguish between dialysate formulation bottles and chemical cleaning bottles, which do not have the detection feature. The detection feature prevents unintentional installation of the chemical bottle on the opening mechanism for the dialysate chemical formulation bottles. A chemical loading system for use with the bottles, and having a detection system for detecting the detection feature is also described. The detection system can be either a mechanical detection system or an optical detection system.
摘要翻译：描述了一组用于容纳透析液化学制剂，化学清洁剂等的瓶子。化学制剂瓶有两个品种：碳酸氢钠和液体酸配方，每个瓶子的形状略有不同。不同的形状与透析机中的瓶子安装结构配合，以确保瓶子正确地安装在它们各自的开瓶机构上。瓶子还具有检测特征，其包括围绕瓶的周边延伸的凸缘或凹槽。瓶子安装和打开系统中的传感器组件检测检测特征。机器使用检测特征来区分不具有检测特征的透析液制剂瓶和化学清洁瓶。检测功能可防止化学瓶无意安装在透析液化学制剂瓶的开启机构上。还描述了一种用于瓶子的化学装载系统，并具有用于检测检测特征的检测系统。检测系统可以是机械检测系统或光学检测系统。

3. 发明授权

US06776908B1 Micro-equilibrium dialysis vertically-loaded apparatus 有权
标题翻译：微量平衡透析垂直装载装置
公开(公告)号：US06776908B1
公开(公告)日：2004-08-17
申请号：US09672323
申请日：2000-09-28
申请人： Michael J. Banker , Timothy J. Zuzel , John A. Williams
发明人： Michael J. Banker , Timothy J. Zuzel , John A. Williams
IPC分类号： B01D6128
CPC分类号： B01L3/50255 , B01D61/28 , B01L2300/0829
摘要： An improved device for equilibrium dialysis procedures utilizing a dialysis membrane inserted in a gap in and separating all of any number of test wells contained in the dialysis block into at least a donating and receiving side which can be accessed and manipulated at any time during testing from the top of the device is described. The device may be constructed from a series of nine blocks of virgin teflon, cut and made flat to achieve certain dimensions ideal for making the device compatible with standard 96-well format laboratory equipment and conducive to robotic automation. The bars are placed side-by-side and connected by a pair of alignment pins along which the bars can slide on a horizontal plane relative to one another, individually or collectively, to aid in assembly, usage and cleaning. The bars are further held together during usage by a clamping mechanism to prevent any leakage of the sample being tested. Such wells are formed in an 8×12 array such that a diameter of each of the wells of a particular row corresponds to and overlaps with the separation gap between successive rows of the bars. The dialysis membranes are inserted into the gaps during assembly of the device, with one membrane inserted between each of the eight gaps formed between the nine rows of bars. The advantages of an equilibrium dialysis apparatus constructed in this manner include decreased cost, increased efficiency and ease in testing, and increased flexibility in testing methods.
摘要翻译：一种用于平衡透析程序的改进装置，其利用透析膜插入间隙中并将包含在透析块中的任何数量的测试孔分离成至少一个捐赠和接受侧，其可以在测试期间的任何时间被访问和操纵描述设备的顶部。该设备可以由一系列九块先进的特氟隆构成，切割并制成平坦的，以达到使设备与标准96孔格式实验室设备兼容并有利于机器人自动化的理想选择。杆被并排放置，并通过一对对准销连接，沿着该对定位销可以单独地或共同地在一个水平面上滑动杆，以帮助组装，使用和清洁。在使用期间，通过夹紧机构将条保持在一起以防止被测样品的任何泄漏。这样的阱以8×12阵列形成，使得特定行的每个孔的直径对应于并连续的条列之间的间隔。在组装装置过程中将透析膜插入到间隙中，其中一个膜插入在九排条之间形成的八个间隙中的每一个之间。以这种方式构建的平衡透析装置的优点包括降低成本，提高效率和易于测试，以及增加测试方法的灵活性。

4. 发明授权

US06605218B2 Dialyzers for blood treatment and processes for production thereof 有权
标题翻译：用于血液处理的透析器及其生产方法
公开(公告)号：US06605218B2
公开(公告)日：2003-08-12
申请号：US09736373
申请日：2000-12-15
申请人： Hidetoshi Kozawa , Hidekazu Nakashima , Shigehisa Wada
发明人： Hidetoshi Kozawa , Hidekazu Nakashima , Shigehisa Wada
IPC分类号： B01D6128
CPC分类号： B01D67/0088 , A61M1/16 , B01D63/021 , B01D67/009 , B01D67/0095 , B01D69/02 , B01D69/084 , B01D2325/36 , B01D2325/38
摘要： A dialyzer for blood treatment includes a semipermeable membrane which is made of a hydrophobic polymer and a hydrophilic polymer, and has a water permeating performance drying of ½ or higher relative to that before drying. The dialyzer has a vitamin B12 clearance not smaller than 135 ml/min per 1.6 m2 or the amount of the hydrophilic polymer eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer for blood treatment is light-weight, easy to handle, and exhibits a reduced elution of the hydrophilic polymer procedures for producing a dialyzer containing the semipermeable membrane and a process for producing a hollow fiber membrane for use in blood treatment as described.
摘要翻译：用于血液处理的透析器包括由疏水性聚合物和亲水性聚合物制成的半透膜，并且相对于干燥前的水渗透性能干燥为1/2以上。透析器的维生素B12清除率不低于每平方米135ml / min，或从半透膜洗脱的亲水性聚合物的量不高于10ppm。用于血液处理的透析器重量轻，易于处理，并且亲水性聚合物方法的洗脱减少，用于生产含有半透膜的透析器和用于生产如上所述血液处理的中空纤维膜的方法。

5. 发明授权

US06814864B1 Extra-corporeal blood purification device 有权
标题翻译：超身体血液净化装置
公开(公告)号：US06814864B1
公开(公告)日：2004-11-09
申请号：US10111771
申请日：2002-04-29
申请人： Olivier Favre , Francesco Di Lella
发明人： Olivier Favre , Francesco Di Lella
IPC分类号： B01D6128
CPC分类号： A61M1/3441 , A61M1/3434 , A61M1/3437 , A61M1/3639 , A61M1/3663 , A61M1/3672 , A61M2205/707 , A61M2205/7563 , Y10S210/929
摘要： An extra-corporeal blood purification device includes a blood filter, and elements for measuring at least one parameter affected by filter resistance to liquid flow, elements for determining at least a threshold value of the parameter, elements for comparing the parameter with the threshold value, exchange control elements for calculating the distribution between the respective flow rates through connecting ducts, capable of reducing the difference between the value of the measured parameter and the threshold value.
摘要翻译：一种体外血液净化装置包括血液过滤器和用于测量受到对液体流动的过滤阻力影响的至少一个参数的元件，用于确定参数的至少阈值的元件，用于将参数与阈值进行比较的元件，交换控制元件，用于计算通过连接管道的相应流量之间的分布，能够减小测量参数的值与阈值之间的差异。

6. 发明授权

US06187190B1 Apparatus for molecular weight separation 失效
标题翻译：分子量分离装置
公开(公告)号：US06187190B1
公开(公告)日：2001-02-13
申请号：US09474851
申请日：1999-12-30
申请人： Richard D. Smith , Chuanliang Liu
发明人： Richard D. Smith , Chuanliang Liu
IPC分类号： B01D6128
CPC分类号： B01D61/243 , B01D61/28 , G01N2001/4016
摘要： The present invention relates generally to an apparatus and method for separating high molecular weight molecules from low molecular weight molecules. More specifically, the invention relates to the use of microdialysis for removal of the salt (low molecular weight molecules) from a nucleotide sample (high molecular weight molecules) for ESI-MS analysis. The dialysis or separation performance of the present invention is improved by (1) increasing dialysis temperature thereby increasing desalting efficiency and improving spectrum quality; (2) adding piperidine and imidazole to the dialysis buffer solution and reducing charge states and further increasing detection sensitivity for DNA; (3) using low concentrations (0-2.5 mM NH4OAc) of dialysis buffer and shifting the DNA negative ions to higher charge states, producing a nearly 10-fold increase in detection sensitivity and a slightly decreased desalting efficiency, (4) conducting a two-stage separation or (5) any combination of (1), (2), (3) and (4).
摘要翻译：本发明一般涉及从低分子量分子中分离高分子量分子的装置和方法。更具体地，本发明涉及使用微量透析从ESI-MS分析的核苷酸样品（高分子量分子）中除去盐（低分子量分子）。通过（1）增加透析温度从而提高脱盐效率和提高光谱质量，提高本发明的透析或分离性能; （2）向透析缓冲液中加入哌啶和咪唑，降低电荷状态，进一步提高DNA的检测灵敏度; （3）使用透析缓冲液的低浓度（0-2.5mM NH 4 OAc），并将DNA负离子转移到较高的电荷状态，检测灵敏度增加近10倍，脱盐效率稍微降低，（4）级分离或（5）（1），（2），（3）和（4）的任何组合。

7. 发明授权

US06821421B2 Hemodialyzing unit for adjusting dialytic fluid to low flow rate 失效
公开(公告)号：US06821421B2
公开(公告)日：2004-11-23
申请号：US10196316
申请日：2002-07-16
申请人： Tomoaki Murakami
发明人： Tomoaki Murakami
IPC分类号： B01D6128
CPC分类号： A61M1/16 , A61M1/1601 , A61M1/1645 , A61M1/165 , A61M1/3663 , A61M2205/3334 , A61M2205/50
摘要： A hemodialyzing unit includes a dialytic fluid supply line for feeding a dialytic fluid from a dialytic fluid supply/discharge unit to a dialyzer, a dialytic fluid discharge line for feeding a dialytic fluid discharged from the dialyzer to the dialytic fluid supply/discharge unit, and a bypass line for connecting both lines at an intermediate portion of each. A flow rate adjusting member is provided to a downstream supply line between a coupling portion for coupling the dialytic fluid supply line to the bypass line and the dialyzer. A wider range of treatments such as CHD (or CHDF), SHD (or SHDF), and HD (or HDF) can be conducted without employing a device for the exclusive use of the CHD or CHDF.

8. 发明授权

US06458275B1 Multi-well equilibrium dialysis system 失效
标题翻译：多孔平衡透析系统
公开(公告)号：US06458275B1
公开(公告)日：2002-10-01
申请号：US09586985
申请日：2000-06-05
申请人： Ashok Kumar Shukla , Mukta M Shukla , Amita M Shukla
发明人： Ashok Kumar Shukla , Mukta M Shukla , Amita M Shukla
IPC分类号： B01D6128
CPC分类号： B01L3/5025 , B01D61/18 , B01D61/28 , B01L3/50255
摘要： This invention relates to an equilibrium dialysis system in a multi-well format for the simultaneous preparation of multiple samples. Such an equilibrium dialysis system can be used for protein binding assays, molecule-molecule interaction studies, tissue cultures and many other biological and chemical applications. The equilibrium dialysis system described herein has at least 96 wells for the simultaneous preparation of 96 samples and can also be made in 96-well, 384-well, 1536-well or other multi-well formats.
摘要翻译：本发明涉及用于同时制备多个样品的多孔格式的平衡透析系统。这种平衡透析系统可用于蛋白质结合测定，分子 - 分子相互作用研究，组织培养和许多其他生物和化学应用。本文描述的平衡透析系统具有用于同时制备96个样品的至少96个孔，并且还可以在96孔，384孔，1536孔或其它多孔形式中制备。

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