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1. 发明授权

US06776908B1 Micro-equilibrium dialysis vertically-loaded apparatus 有权
标题翻译：微量平衡透析垂直装载装置
公开(公告)号：US06776908B1
公开(公告)日：2004-08-17
申请号：US09672323
申请日：2000-09-28
申请人： Michael J. Banker , Timothy J. Zuzel , John A. Williams
发明人： Michael J. Banker , Timothy J. Zuzel , John A. Williams
IPC分类号： B01D6128
CPC分类号： B01L3/50255 , B01D61/28 , B01L2300/0829
摘要： An improved device for equilibrium dialysis procedures utilizing a dialysis membrane inserted in a gap in and separating all of any number of test wells contained in the dialysis block into at least a donating and receiving side which can be accessed and manipulated at any time during testing from the top of the device is described. The device may be constructed from a series of nine blocks of virgin teflon, cut and made flat to achieve certain dimensions ideal for making the device compatible with standard 96-well format laboratory equipment and conducive to robotic automation. The bars are placed side-by-side and connected by a pair of alignment pins along which the bars can slide on a horizontal plane relative to one another, individually or collectively, to aid in assembly, usage and cleaning. The bars are further held together during usage by a clamping mechanism to prevent any leakage of the sample being tested. Such wells are formed in an 8×12 array such that a diameter of each of the wells of a particular row corresponds to and overlaps with the separation gap between successive rows of the bars. The dialysis membranes are inserted into the gaps during assembly of the device, with one membrane inserted between each of the eight gaps formed between the nine rows of bars. The advantages of an equilibrium dialysis apparatus constructed in this manner include decreased cost, increased efficiency and ease in testing, and increased flexibility in testing methods.
摘要翻译：一种用于平衡透析程序的改进装置，其利用透析膜插入间隙中并将包含在透析块中的任何数量的测试孔分离成至少一个捐赠和接受侧，其可以在测试期间的任何时间被访问和操纵描述设备的顶部。该设备可以由一系列九块先进的特氟隆构成，切割并制成平坦的，以达到使设备与标准96孔格式实验室设备兼容并有利于机器人自动化的理想选择。杆被并排放置，并通过一对对准销连接，沿着该对定位销可以单独地或共同地在一个水平面上滑动杆，以帮助组装，使用和清洁。在使用期间，通过夹紧机构将条保持在一起以防止被测样品的任何泄漏。这样的阱以8×12阵列形成，使得特定行的每个孔的直径对应于并连续的条列之间的间隔。在组装装置过程中将透析膜插入到间隙中，其中一个膜插入在九排条之间形成的八个间隙中的每一个之间。以这种方式构建的平衡透析装置的优点包括降低成本，提高效率和易于测试，以及增加测试方法的灵活性。

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