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1. 发明申请

US20040161456A1 Delivery and activation through liposome incorporation of diaminocyclohexane platinum(II) complexes 失效
标题翻译：通过二氨基环己烷铂（II）配合物的脂质体掺入递送和活化
公开(公告)号：US20040161456A1
公开(公告)日：2004-08-19
申请号：US10750382
申请日：2003-12-30
申请人： Board of Regents, The University of Texas System
发明人： Roman Perez-Soler , Abdul R. Khokhar
IPC分类号： A61K009/127 , A61K031/28
CPC分类号： A61K31/282 , A61K9/127
摘要： Antitumor compositions are disclosed, as well as methods of preparing the compositions and methods of using them to inhibit tumor growth in mammals. The invention can take advantage of intraliposomal conversion of a platinum complex having the formula 1 where R1 is diaminocycloalkyl, and R2 and R3 each have the formula 2 where R4, R5, and R6 are each independently hydrocarbon moieties having from 1 to about 10 carbon atoms, into a complex having the formula R1nullPtnullX2 nullnull(II) where X is halogen.
摘要翻译：公开了抗肿瘤组合物，以及制备组合物的方法和使用它们抑制哺乳动物肿瘤生长的方法。本发明可以利用具有下式的铂络合物的脂内酯转化：其中R 1是二氨基环烷基，R 2和R 3各自具有下式其中R 4，R 5和R 6各自独立地是具有1至约10个碳原子的烃部分，具有式R1-Pt-X2（Ⅱ）的络合物，其中X是卤素。

2. 发明申请

US20040122087A1 Dermatological composition containing urea 有权
标题翻译：含尿素的皮肤病学组成
公开(公告)号：US20040122087A1
公开(公告)日：2004-06-24
申请号：US10328368
申请日：2002-12-23
申请人： Bradley Pharmaceuticals, Inc.
发明人： Bradley P. Glassman , Dileep Bhagwat , Daniel Glassman
IPC分类号： A61K031/32 , A61K031/28 , A61K031/30 , A61K031/17
CPC分类号： A61Q19/00 , A61K8/19 , A61K8/27 , A61K8/42 , A61K31/17 , A61K31/28 , A61K31/30 , A61K31/32 , Y10S514/844 , A61K2300/00
摘要： Described are dermatological compositions for treating, protecting and re-epitheliazing cutaneous wounds and damaged skin, such compositions including about 21 to about 40% urea and trace amounts of zinc, copper and manganese in the form of their respective pharmaceutically acceptable salts.
摘要翻译：描述了用于治疗，保护和重新上皮皮肤伤口和受损皮肤的皮肤病学组合物，所述组合物包括其各自的药学上可接受的盐形式的约21至约40％的尿素和痕量的锌，铜和锰。

3. 发明申请

US20040097423A1 Platinum complexes as antitumor agents in combination with biochemical modulation 失效
标题翻译：铂复合物作为抗肿瘤剂与生化调节相结合
公开(公告)号：US20040097423A1
公开(公告)日：2004-05-20
申请号：US10655657
申请日：2003-09-05
申请人： Board of Regents, The University of Texas System
发明人： Zahid H. Siddik , Abdul R. Khokhar
IPC分类号： A61K038/05 , A61K031/555 , A61K031/28
CPC分类号： C07F15/0093
摘要： The present invention concerns the use of methods and compositions for the treatment of cancer and other hyperproliferative diseases. In certain embodiments, methods are described for the treatment of cancer and/or hyperproliferative diseases by administration of compositions containing at least one platinum complex alone or in combination with a modulator of glutathione. In particular, the methods may be used to treat cisplatin or carboplatin resistant tumor cells.
摘要翻译：本发明涉及用于治疗癌症和其它过度增生性疾病的方法和组合物的用途。在某些实施方案中，描述了通过施用含有至少一种铂络合物单独或与谷胱甘肽调节剂组合的组合物来治疗癌症和/或过度增殖性疾病的方法。特别地，该方法可用于治疗顺铂或卡铂抗性肿瘤细胞。

4. 发明申请

US20040029852A1 Ruthenium (ii) compounds for use in the therepy of cancer 失效
标题翻译：钌（ii）用于癌症的化合物
公开(公告)号：US20040029852A1
公开(公告)日：2004-02-12
申请号：US10312940
申请日：2003-08-15
发明人： Robert Edward Morris , Peter John Sadler , Duncan Jodrell , Haimei Chen
IPC分类号： C07F015/00 , A61K031/555 , A61K031/28
CPC分类号： C07F17/02 , A61K33/24 , C07F15/0046
摘要： Compounds which may be used in the treatment and/or prevention of cancer have the formula (I): wherein R1 and R2 together with the ring to which they are bound represent a saturated or unsaturated carbocyclic or heterocyclic group.
摘要翻译：可用于治疗和/或预防癌症的化合物具有式（I）：其中R 1和R 2与它们所连接的环一起代表饱和或不饱和的碳环或杂环基团。

5. 发明申请

US20040009964A1 Compositions and methods for the treatment of matrix metalloproteinase-related diseases 审中-公开
标题翻译：用于治疗基质金属蛋白酶相关疾病的组合物和方法
公开(公告)号：US20040009964A1
公开(公告)日：2004-01-15
申请号：US10391054
申请日：2003-03-18
申请人： BioInterface Technologies, Inc.
发明人： Christopher J. Capelli
IPC分类号： A61K031/555 , A61K031/28 , A61K033/38
CPC分类号： A61K33/38
摘要： The present invention relates to the use of water-soluble photo-stable silver thiosulfate ion complexes that are antimicrobially active and inhibit the activity of metalloproteinases. The present invention describes incorporation of these complexes into medical devices and/or wound dressings to prevent or treat symptomology related to microbial infections and/or conditions of excessive tissue destruction. In particular, these complexes may be useful in the treatment of rheumatoid arthritis and/or osteoarthritis in the prevention and treatment of articular bone joint degradation and subsequent reductions in joint swelling and pain.
摘要翻译：本发明涉及抗微生物活性并抑制金属蛋白酶活性的水溶性光稳定性硫代硫酸银离子络合物的用途。本发明描述了将这些复合物掺入到医疗装置和/或伤口敷料中以预防或治疗与微生物感染和/或过度组织破坏的条件相关的症状。特别地，这些复合物可用于治疗类风湿性关节炎和/或骨关节炎，以预防和治疗关节骨关节退化，随后减少关节肿胀和疼痛。

6. 发明申请

US20030224061A1 Oral composition with insulin-like activities and methods of use 失效
标题翻译：具有胰岛素样活性的口服组合物和使用方法
公开(公告)号：US20030224061A1
公开(公告)日：2003-12-04
申请号：US10163254
申请日：2002-06-04
发明人： Linda M. Pacioretty , John G. Babish
IPC分类号： A61K033/26 , A61K031/385 , A61K031/28 , A61K031/185
CPC分类号： A61K31/28 , A23L33/10 , A23L33/16 , A23V2002/00 , A61K31/185 , A61K31/385 , A61K33/24 , Y10S514/866 , Y10S514/904 , Y10S514/905 , Y10S514/909 , A61K2300/00 , A23V2250/1636 , A23V2250/026 , A23V2250/0644 , A23V2250/1586 , A23V2250/0612
摘要： An orally administered, novel dietary supplement or therapeutic composition capable of insulin-like activity in animals, preferably humans, is provided. Contained in the composition are therapeutically effective amounts of vanadyl sulfate, alpha-lipoic acid, taurine, and chromium carnitine. The composition is preferably orally administered on a daily basis for at least about 4 weeks and can be used by normal, healthy individuals as well as diabetics.
摘要翻译：提供了一种口服给药的新型膳食补充剂或能够在动物，优选人类中具有胰岛素样活性的治疗组合物。组合物中含有治疗有效量的硫酸氧钒，α-硫辛酸，牛磺酸和铬肉碱。组合物优选每天口服给药至少约4周，并且可由正常健康个体以及糖尿病患者使用。

7. 发明申请

US20030216359A1 Combination chemotherapy 审中-公开
公开(公告)号：US20030216359A1
公开(公告)日：2003-11-20
申请号：US10429840
申请日：2003-05-05
申请人： University of Pittsburgh of the Commonwealth System of Higher Education
发明人： Candace S. Johnson , Donald L. Trump
IPC分类号： A61K033/24 , A61K031/675 , A61K031/704 , A61K031/66 , A61K031/56 , A61K031/28
CPC分类号： A61K45/06 , A61K31/337 , A61K31/573 , A61K31/59 , A61K31/675 , A61K33/24 , A61K31/55 , A61K31/335 , A61K2300/00
摘要： This invention relates to combination chemotherapy, particularly involving vitamin D or a derivative thereof. In one aspect, the invention provides a method of killing a cell by first administering to the cell vitamin D (or a derivative) and subsequently administering to the cell a cytotoxic agent. Where this strategy is applied to an intact tumor, the present invention provides a method of retarding the growth of the tumor by first administering vitamin D (or a derivative) to the tumor and subsequently administering the cytotoxic agent. A further aspect of the invention concerns a method of treating prostate cancer within a patient by co-administration of vitamin D (or a derivative) and a glucocorticoid to the patient. In yet a further aspect, the invention provides an improved method of treating a patient with vitamin-D involving the adjunctive administration of zoledronate.

8. 发明申请

US20030171430A1 Remedies for cisplatin-tolerant cancer 失效
标题翻译：缓解顺铂耐药的疗法
公开(公告)号：US20030171430A1
公开(公告)日：2003-09-11
申请号：US10344239
申请日：2003-02-11
发明人： Shuichi Kishimoto , Shoji Fukushima , Yoshikazu Takeuchi
IPC分类号： A61K031/28 , A61K035/78
CPC分类号： A61K9/0019 , A61K9/08 , A61K9/10 , A61K31/282 , A61K47/14 , A61K47/24 , A61K47/44
摘要： Preparation of a lipophilic platinum complex being dissolved or suspended in an iodized poppyseed oil fatty acid ethyl ester is useful as an agent for treatment of cisplatin-resistant cancers.
摘要翻译：溶解或悬浮在碘化罂粟油脂肪酸乙酯中的亲脂性铂络合物的制备可用作治疗顺铂耐药性癌症的药剂。

9. 发明申请

US20030139352A1 Inhibitors of ABC drug transporters in cancer cells 审中-公开
标题翻译： ABC药物转运蛋白在癌细胞中的抑制剂
公开(公告)号：US20030139352A1
公开(公告)日：2003-07-24
申请号：US10159012
申请日：2002-05-30
发明人： Grant L. Schoenhard
IPC分类号： A61K031/7048 , A61K031/704 , A61K031/485 , A61K031/4745 , A61K031/337 , A61K031/65 , A61K031/17 , A61K031/28
CPC分类号： A61K45/06 , A61K31/485
摘要： The present invention relates to cancer, including in cancer and, in particular, to opioid compounds that are inhibitors of drug transporters of the ABC protein superfamily. The invention relates to methods of treating cancer using anti-tumor agents and opioid inhibitors of such transporters. The invention also relates to methods for selecting or designing compounds for the ability to inhibit drug transporter proteins and to methods of inhibiting drug transporter proteins. The invention concerns the new use of opioid receptor antagonists in the treatment of a cancer patient who has developed a resistance to a therapeutically active substance.
摘要翻译：本发明涉及癌症，包括癌症，特别是涉及作为ABC蛋白超家族的药物转运蛋白抑制剂的阿片类化合物。本发明涉及使用抗肿瘤剂和这种转运蛋白的阿片样物质抑制剂治疗癌症的方法。本发明还涉及用于选择或设计化合物以抑制药物转运蛋白的能力的方法和抑制药物转运蛋白的方法。本发明涉及阿片类受体拮抗剂在治疗对治疗活性物质具有抗性的癌症患者中的新用途。

10. 发明申请

US20030072785A1 Mixtures for stimulating glucose up-take 失效
标题翻译：用于刺激葡萄糖摄取的混合物
公开(公告)号：US20030072785A1
公开(公告)日：2003-04-17
申请号：US10260522
申请日：2002-10-01
申请人： UNILEVER PATENT HOLDINGS
发明人： Anna Louise Brown , Frederick William Cain , Ingrid Celestina Mohede , Preyesh Parmar , Julia Sarah Rogers , Ulrike Schmid
IPC分类号： A61K035/78 , A61K031/225 , A61K031/28 , A61K038/18
CPC分类号： A61K31/201 , A23L33/12
摘要： Our invention concerns a mixture of CLA glycerides, and/or CLA-fatty acids and or CLA-alkyl esters and another component, wherein the other component (nullcomponent A) is selected for its capacity to alleviate problems related to insulin resistance in mammals, using CLA rich diets and/or foods and/or food supplements using an appropriate in vitro test so that in at least one step of the in vitro test, as described in the text, an improvement in test results is obtained of at least 4% by the blend of the CLA derivative and component A when compared to the CLA derivative only. The inventon further concerns CLA rich dietic food, food supplements and foods containing the combination of CLA and component A as defined, while also the use of this combination for achieving an alleviation of insulin resistance is part of the invention.
摘要翻译：本发明涉及CLA甘油酯和/或CLA-脂肪酸和/或CLA-烷基酯和另一种组分的混合物，其中选择其它组分（=组分A）以减轻哺乳动物胰岛素抵抗相关问题的能力，使用CLA丰富的饮食和/或食物和/或食物补充剂，使用适当的体外试验，使得在体外试验的至少一个步骤中，如文中所述，获得的试验结果的改善至少为4％当与CLA衍生物相比时，通过CLA衍生物和组分A的共混物。本发明进一步涉及CLA富含脂肪的食物，食品添加剂和含有CLA和组分A的组合的食品，同时也使用这种组合来实现胰岛素抵抗的减轻是本发明的一部分。

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