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2. 发明申请

US20040254155A1 Porphyrins and metalloporphyrins for inhibiting heme iron uptake 失效
标题翻译：卟啉和金属卟啉抑制血红素摄取
公开(公告)号：US20040254155A1
公开(公告)日：2004-12-16
申请号：US10859810
申请日：2004-06-03
发明人： Jerry C. Bommer
IPC分类号： A61K031/555
CPC分类号： A61K31/555 , A61K31/409
摘要： The present invention provides a class of porphyrins and metal chelated porphyrins for use as inhibitors of heme iron uptake. The porphyrin/metal chelated porphyrin molecules of the invention are tetra-positively charged porphyrins based on meso-tetra(4-pyridyl)porphines. Several such agents are shown herein to cause inhibition of iron uptake in vivo and in vitro. The invention further provides therapeutic compositions including the porphyrins and/or metalloporphyrins of the invention. In addition, methods of inhibition of heme iron uptake in vivo are taught, as well as methods of treatment of diseases characterized by iron-overload. These methods include the administration of a porphyrin or metalloporphyrin in a therapeutic composition of the invention to prevent uptake of heme iron, thus preventing replenishment of a patient's iron stores.
摘要翻译：本发明提供了一类用作血红素铁摄取抑制剂的卟啉和金属螯合卟啉。本发明的卟啉/金属螯合卟啉分子是基于内消旋 - 四（4-吡啶基）卟吩的四正电荷卟啉。本文显示了几种这样的试剂以在体内和体外诱导铁吸收的抑制。本发明进一步提供包含本发明的卟啉和/或金属卟啉的治疗组合物。此外，还教导了在体内抑制血红素铁吸收的方法，以及治疗以铁过载为特征的疾病的方法。这些方法包括在本发明的治疗组合物中施用卟啉或金属卟啉以防止血红素铁的吸收，从而防止补充患者的铁存储。

3. 发明申请

US20040229796A1 Copper-dependent non-traditional pro-inflammatory cytokine export and methods, compositions and kits relating thereto 审中-公开
标题翻译：铜依赖性非传统促炎细胞因子出口及其相关的方法，组合物和试剂盒
公开(公告)号：US20040229796A1
公开(公告)日：2004-11-18
申请号：US10786223
申请日：2004-02-23
申请人： Maine Medical Center Research Institute
发明人： Thomas Maciag , Anna Mandinova , Lazar Mandinov , Igor Prudovsky , Stephen Bellum , Raffaella Soldi , Cinzia Bagala
IPC分类号： A61K038/17 , A61K031/555 , A61K031/195
CPC分类号： G01N33/6863 , A61K31/195 , A61K31/28 , A61K31/355 , A61K33/34 , A61K38/1738 , A61K45/06 , G01N33/6869 , G01N2333/545 , G01N2500/10
摘要： The present invention relates to the discovery that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation and/or administration to the cell of a truncated form of S100A13 lacking the basic residue portion. Further, copper chelation inhibits, inter alia, neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and the like, associated with vascular vessel injury. Thus, the present invention provides novel methods of preventing and treating, and for identifying novel compounds also useful as therapeutics for, such conditions.
摘要翻译：本发明涉及以下发现：通过对缺乏碱性残基部分的S100A13截短形式的细胞进行铜螯合和/或给药，可以抑制某些缺乏来自细胞的信号序列的促炎细胞因子的非传统出口。此外，铜螯合尤其抑制与血管损伤相关的新内膜形成，巨噬细胞浸润和相关炎症，细胞增殖，分泌细胞外基质，内膜增厚，外膜血管生成，再狭窄等。因此，本发明提供了预防和治疗以及用于鉴定也可用作这些病症的治疗剂的新化合物的新方法。

4. 发明申请

US20040220167A1 Methods of treating neuralgic pain 审中-公开
标题翻译：治疗神经痛的方法
公开(公告)号：US20040220167A1
公开(公告)日：2004-11-04
申请号：US10428266
申请日：2003-05-02
发明人： Nasrollah Samiy
IPC分类号： A61K031/409 , A61K031/555
CPC分类号： A61K31/409 , A61K31/555
摘要： A method of treating pain in a subject is disclosed which consists of administering a pharmaceutically effective amount of a porphyrin compound. In particular, the porphyrin is a green porphyrin and the pain is associated with a nerve injury pain or neuralgia.
摘要翻译：公开了治疗受试者疼痛的方法，其包括施用药学有效量的卟啉化合物。特别地，卟啉是绿色的卟啉，并且疼痛与神经损伤疼痛或神经痛有关。

5. 发明申请

US20040220165A1 Process for asymmetrically hydrogenating keto carboxylic esters 审中-公开
标题翻译：不对称氢化酮羧酸酯的方法
公开(公告)号：US20040220165A1
公开(公告)日：2004-11-04
申请号：US10772198
申请日：2004-02-04
发明人： John Meurig Thomas , Brian F. G. Johnson , Robert Raja , Matthew David Jones
IPC分类号： A61K031/555 , A61K009/14
CPC分类号： B01J31/1616 , B01J29/0308 , B01J29/06 , B01J31/1805 , B01J31/182 , B01J31/2291 , B01J31/2295 , B01J2231/643 , B01J2231/645 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C67/31 , C07F15/006 , C07F15/0073 , C07C69/732
摘要： The present invention relates to a process for preparing enantiomerically enriched null- and null-hydroxycarboxylic esters from the corresponding ketocarboxylic esters and also to catalysts usable therefor.
摘要翻译：本发明涉及从相应的酮羧酸酯制备对映体富集的α-和β-羟基羧酸酯的方法，以及可用于其的催化剂。

6. 发明申请

US20040219138A1 Combinations of superoxide dismutase mimetics and opioids 审中-公开
标题翻译：超氧化物歧化酶模拟物和阿片样物质的组合
公开(公告)号：US20040219138A1
公开(公告)日：2004-11-04
申请号：US10738578
申请日：2003-12-16
申请人： MetaPhore Pharmaceuticals, Inc. , Pharmacia Corporation
发明人： Daniela Salvemini
IPC分类号： A61K038/44 , A61K031/555 , A61K031/485
CPC分类号： C07F13/005 , A61K31/555
摘要： Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and opioids are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions.

7. 发明申请

US20040192664A1 Copper-carbene complexes and their use 审中-公开
标题翻译：铜 - 卡宾络合物及其用途
公开(公告)号：US20040192664A1
公开(公告)日：2004-09-30
申请号：US10752353
申请日：2004-01-06
发明人： Klaus Kunz , Ulrich Scholz , Oliver Gaertzen , Dirk Ganzer , Joachim Wesener
IPC分类号： A61K031/555 , C07F001/08
CPC分类号： C07F1/08
摘要： The invention relates to copper-carbene complexes, to a process for preparing them and to their use in catalytic coupling reactions.
摘要翻译：本发明涉及铜 - 卡宾络合物，其制备方法及其在催化偶合反应中的应用。

8. 发明申请

US20040171600A1 Antimicrobial compositions 失效
标题翻译：抗微生物组合物
公开(公告)号：US20040171600A1
公开(公告)日：2004-09-02
申请号：US10469772
申请日：2003-09-04
发明人： Toshimasa Ohnishi , Ikuya Tanaka
IPC分类号： A61K031/555 , A61K031/549 , A61K031/53 , A61K031/444
CPC分类号： A01N43/88 , A01N59/20 , A01N59/16 , A01N47/12 , A01N47/04 , A01N43/80 , A01N43/70 , A01N43/40 , A01N37/34 , A01N31/16 , A01N2300/00
摘要： This invention concerns antimicrobial compositions that are useful for industrial applications. More specifically, it concerns antimicrobial compositions that, by combining 3-benzonullbnullthiene-2-yl-5,6-dihydro-1,4,2-oxathiazine-4-oxide and one or more of 1-nullnull(3-iodo-2-propynyl)oxynullmethoxynull-4-methoxy benzene, 1-chloro-4-nullnull(3-iodo-2-propynyl)oxynullmethoxynullbenzene, Zinc 2-pyridine thiol-1-oxide, Copper 2-pyridine thiol-1-oxide, 2-pyridine thiol-1-oxide sodium salt, 2,2-dithio-bis(pyridine-1-oxide), 2-methylthio-4-t-butyl amino-6-cyclopropyl amino-s-triazine, 3-iodo-2-propynyl butylcarbamate (IPBC), 2-(n-octyl)-3(2H)-isothiazolone (OIT), 4,5-dichloro-2-(n-octyl)-3(2H)-isothiazolone (DCOIT), 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile (chlorothalonil), 1,1-dichloro-N-null(dimethylamino)sulfonylnull-1-fluoro-N-phenyl-methanesulfenamide (dichlofluanid), or 1,1-dichloro-N-null(dimethylamino)sulfonylnull-1-fluoro-N-(4-methylphenyl)-methanesulfenamide (tolylfluanid) have the synergistic effect of these compounds.
摘要翻译：本发明涉及可用于工业应用的抗微生物组合物。更具体地说，它涉及通过将3-苯并[b]噻吩-2-基-5,6-二氢-1,4,2-氧噻嗪-4-氧化物与一个或多个1 - [[（ 3-碘-2-丙炔基）氧基]甲氧基] -4-甲氧基苯，1-氯-4 - [[（3-碘-2-丙炔基）氧基]甲氧基]苯，2-吡啶硫醇-1-氧化物，2-吡啶硫醇-1-氧化铜，2-吡啶硫醇-1-氧化物钠盐，2,2-二硫代双（吡啶-1-氧化物），2-甲硫基-4-叔丁基氨基-6- 环丙基氨基-s-三嗪，3-碘-2-丙炔基丁基氨基甲酸酯（IPBC），2-（正辛基）-3（2H） - 异噻唑酮（OIT），4,5-二氯-2-（正辛基） -3（2H） - 异噻唑酮（DCOIT），2,4,5,6-四氯-1,3-苯二甲腈（百菌清），1,1-二氯-N - [（二甲基氨基）磺酰基] -1-氟-N - 苯基 - 甲磺酰胺（二氯氟烷）或1,1-二氯-N - [（二甲基氨基）磺酰基] -1-氟-N-（4-甲基苯基） - 甲磺酰胺（甲苯基氟烷）具有这些化合物的协同作用。

9. 发明申请

US20040166181A1 Compositions, methods, and kits for weight loss and inhibiting the loss of lean body mass 审中-公开
标题翻译：用于减肥和抑制瘦体重丧失的组合物，方法和试剂盒
公开(公告)号：US20040166181A1
公开(公告)日：2004-08-26
申请号：US10722368
申请日：2003-11-24
申请人： Shaklee Corporation
发明人： John C. Hegenauer , Haruna Yamaguchi , Winnie Wai-Yi Chan , Elaine L. Bagwell , Cindy Latham , Jeffrey M. Avila
IPC分类号： A61K035/78 , A61K031/555
CPC分类号： A61K36/80 , A61K33/24 , A61K36/03 , A61K36/11 , A61K36/13 , A61K36/185 , A61K36/28 , A61K36/29 , A61K36/31 , A61K36/38 , A61K36/48 , A61K36/74 , A61K36/896 , A61K38/02 , A61K2300/00
摘要： Disclosed are combinations of soy protein and chromium in amounts effective to inhibit the loss of lean body mass of a subject under caloric restriction. Further combinations include corosolic acid and optionally additional chromium. Still further combinations include a dietary composition of Fucus vesiculosus, Gambogia garcinia, Apis mellifica, Badiaga, Calcarea carbonica, Passiflora incarnata, Baryta carbonica, Calcarea fluorica, Lycopodium clavatum, Berberis vulgaris, Leptandra virginica, Thuja occidentalis, Galium aparine, Urtica urens, Histaminum muriaticum, and Sabadilla. Compositions of the disclosed soy protein, chromium, and corosolic acid combinations are disclosed as are kits containing the disclosed combinations as well as methods of using the disclosed combinations and compositions for weight loss and the inhibition of the loss of lean body mass in a subject during weight loss.
摘要翻译：公开了大量蛋白质和铬的组合，其量有效地抑制受热量限制下受试者的瘦体重的损失。其他组合包括科罗索酸和任选的另外的铬。还有更多的组合包括伏丝孢菌（Fucus vesiculosus），甘草甘草（Gambogia garcinia），蚜虫（Apis mellifica），Badiaga，碳酸钙，西伯利亚百里香，白云母，氟碳酸钙， muriaticum和Sabadilla。所披露的大豆蛋白，铬和科罗索酸组合的组合物作为包含所公开的组合的试剂盒以及使用所公开的组合和组合物用于体重减轻和抑制受试者体内瘦体重的丧失的方法被公开减肥

10. 发明申请

US20040166116A9 Polypeptides containing polymorphisms of the repeated regions of pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, their use in diagnostics, and in immunogenic compositions 有权
标题翻译：含有百日咳博德特氏菌，百日咳博德特氏菌和支气管炎博德特氏菌的重复区域的多态性的多肽，其在诊断中的用途和免疫组成
公开(公告)号：US20040166116A9
公开(公告)日：2004-08-26
申请号：US10302896
申请日：2002-11-25
发明人： Nicole Guiso-Maclouf , Caroline Boursaux-Eude
IPC分类号： A61K031/555 , A01N055/02 , A61K039/00 , A61K039/38
CPC分类号： C07K14/235 , A61K39/00 , C12Q1/689 , Y10S435/975
摘要： Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin of B. parapertussis) is invariant, whereas the pertactin of B. pertussis varies mostly in region I and B. bronchiseptica varies in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
摘要翻译：百日咳素（PRN）是由百日咳博德特氏菌，百日咳博德特氏菌和支气管炎博德特氏菌（Bordetella bronchiseptica）表达的外膜蛋白，其对博德氏菌感染具有保护性免疫力。百日咳杆菌的免疫显性和免疫保护性表位包括两个重复的区域I和II。这两个重复区域的比较显示副百日咳杆菌的百日咳杆菌是不变的，而百日咳杆菌的百日咳杆菌在区域I和B中主要变化。支气管炎在重复区域I和II中都不同。含有这些区域中含有变体序列的pertactins和pertactin片段的组合物可用作免疫原性组合物。

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