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1. 发明授权

US06768921B2 Electrical impedance method and apparatus for detecting and diagnosing diseases 有权
公开(公告)号：US06768921B2
公开(公告)日：2004-07-27
申请号：US09749613
申请日：2000-12-28
申请人： Leslie W. Organ , Kenneth C. Smith , Reza Safaee-Rad , Milan Graovac , George P. Darmos , Ilya Gavrilov
发明人： Leslie W. Organ , Kenneth C. Smith , Reza Safaee-Rad , Milan Graovac , George P. Darmos , Ilya Gavrilov
IPC分类号： A61B505
CPC分类号： A61B5/0536 , A61B5/04085 , A61B2562/0209 , A61B2562/046
摘要： The present invention relates to an improved method and apparatus for detecting and diagnosing disease states in a living organism by using a plurality of electrical impedance measurements. In particular, the invention provides for an improved electrode array for diagnosing the presence of a disease state in the human breast, and discloses a method of application of the array to the breast that ensures that the multiplicity of impedance measurements obtained from a first body part correspond as precisely and reproducibly as possible to the multiplicity of impedance measurements that are obtained from another, homologous, second body part. A number of diagnostic methods based on homologous electrical difference analysis are disclosed, including the calculation of a number of metrics used to indicate disease states by comparison with pre-established threshold values, and the construction of a number of graphical displays for indicating the location of disease to a body part sector.

2. 发明申请

US20050004490A1 Electrical impedance method and apparatus for detecting and diagnosing diseases 审中-公开
标题翻译：用于检测和诊断疾病的电阻抗方法和装置
公开(公告)号：US20050004490A1
公开(公告)日：2005-01-06
申请号：US10841468
申请日：2004-05-10
申请人： Leslie Organ , Kenneth Smith , Reza Safaee-Rad , Milan Graovac , George Darmos , Ilya Gavrilov
发明人： Leslie Organ , Kenneth Smith , Reza Safaee-Rad , Milan Graovac , George Darmos , Ilya Gavrilov
IPC分类号： A61B5/05 , A61B5/0408 , A61B5/0478 , A61B5/053 , A61B5/04 , A61B19/00 , G01R35/00 , G01D18/00
CPC分类号： A61B5/0536 , A61B5/04085 , A61B2562/046
摘要： The present invention relates to an improved method and apparatus for detecting and diagnosing disease states in a living organism by using a plurality of electrical impedance measurements. In particular, the invention provides for an improved electrode array for diagnosing the presence of a disease state in the human breast, and discloses a method of application of the array to the breast that ensures that the multiplicity of impedance measurements obtained from a first body part correspond as precisely and reproducibly as possible to the multiplicity of impedance measurements that are obtained from another, homologous, second body part. A number of diagnostic methods based on homologous electrical difference analysis are disclosed, including the calculation of a number of metrics used to indicate disease states by comparison with pre-established threshold values, and the construction of a number of graphical displays for indicating the location of disease to a body part sector.
摘要翻译：本发明涉及通过使用多个电阻抗测量来检测和诊断活体中疾病状态的改进方法和装置。特别地，本发明提供了用于诊断人乳房中疾病状态的改善的电极阵列，并且公开了将阵列应用于乳房的方法，其确保从第一身体部位获得的多个阻抗测量值尽可能精确地和可重复地对应于从另一个同源的第二身体部分获得的多个阻抗测量。公开了基于同源电差分析的许多诊断方法，包括通过与预先建立的阈值比较来计算用于指示疾病状态的多个度量，以及用于指示位置的多个图形显示器的构造疾病到身体部位。

3. 发明申请

US20080076998A1 Breast electrode array and method of analysis for detecting and diagnosing diseases 审中-公开
标题翻译：乳房电极阵列及其分析方法，用于检测和诊断疾病
公开(公告)号：US20080076998A1
公开(公告)日：2008-03-27
申请号：US11896532
申请日：2007-09-04
申请人： Leslie Organ , Reza Safaee-Rad , Milan Graovac , Kenneth Smith , Joel Ironstone
发明人： Leslie Organ , Reza Safaee-Rad , Milan Graovac , Kenneth Smith , Joel Ironstone
IPC分类号： A61B5/04
CPC分类号： A61B5/053 , A61B5/061 , A61B2562/046
摘要： A breast electrode array and method of analysis for detecting and diagnosing diseases. In particular, the electrode array has a body, a plurality of flexible arms extending from the body, and a plurality of outer electrodes provided by the plurality of flexible arms, and a plurality of inner electrodes provided on at least one of the flexible arms and positioned partway between the body and the outer electrodes, and the outer electrodes and the inner electrodes are arranged on the arms to obtain impedance measurements between respective electrodes. Diagnostic methods based on homologous electrical difference analysis are also provided, utilizing the different topologies created by the inner and outer electrodes when taking impedance measurements.
摘要翻译：一种乳房电极阵列及其分析方法，用于检测和诊断疾病。特别地，电极阵列具有主体，从主体延伸的多个柔性臂和由多个柔性臂设置的多个外部电极，以及多个内部电极，设置在至少一个柔性臂和位于主体和外部电极之间，并且外部电极和内部电极布置在臂上以获得各个电极之间的阻抗测量。还提供了基于同源电差分析的诊断方法，利用内外电极在进行阻抗测量时产生的不同拓扑结构。

4. 发明申请

US20060151815A1 Weighted gradient method and system for diagnosing disease 有权
标题翻译：加权梯度法和诊断疾病系统
公开(公告)号：US20060151815A1
公开(公告)日：2006-07-13
申请号：US11287470
申请日：2005-11-28
申请人： Milan Graovac , James Martens , Zoran Pavlovic , Joel Ironstone
发明人： Milan Graovac , James Martens , Zoran Pavlovic , Joel Ironstone
IPC分类号： H01L29/80
CPC分类号： A61B5/0536 , A61B5/055
摘要： A method for detecting and diagnosing disease states in a body part is described. The method starts with a preparatory step of modeling the body part as a grid of many finite elements, then calculating an electrical property between two finite elements at which current from two corresponding electrodes flows through the body part. This is termed the weight (influence) of the element. With this baseline information, electrical impedance measurements made at the plurality of electrodes on the periphery of the body part can be used in a diagnostic module to calculate a Weighted Element Value (WEVal) for each element. In a preferred embodiment of invention, the difference in WEVal magnitude between corresponding elements of homologous body parts serves as an indicator of the presence of disease.
摘要翻译：描述了用于检测和诊断身体部位中的疾病状态的方法。该方法从将身体部分建模为许多有限元的网格的准备步骤开始，然后计算两个有限元素之间的电气特性，在两个有限元素之间，来自两个相应电极的电流流过身体部分。这被称为元件的重量（影响）。利用该基线信息，可以在诊断模块中使用在身体部位的周边上的多个电极处进行的电阻抗测量来计算每个元件的加权元素值（WEVal）。在本发明的优选实施方案中，同源体部分的相应元件之间的WEVal量值的差异用作疾病存在的指标。

5. 发明申请

US20080064979A1 SYSTEM AND METHOD FOR PREBALANCING ELECTRICAL PROPERTIES TO DIAGNOSE DISEASE 审中-公开
标题翻译：用于预测电学特性以诊断疾病的系统和方法
公开(公告)号：US20080064979A1
公开(公告)日：2008-03-13
申请号：US11684994
申请日：2007-03-12
申请人： Zoran Pavlovic , Milan Graovac , Joel Ironstone
发明人： Zoran Pavlovic , Milan Graovac , Joel Ironstone
IPC分类号： A61B5/05
CPC分类号： A61B5/053
摘要： A system and method for diagnosing the possibility of disease by making electrical measurements in one of a first body part and a second substantially similar body part are described. The present invention balances out differences between homologous body parts that are due to natural factors unrelated to disease, such as differences in size or symmetry between left and right breasts. Once data are prebalanced, statistical analyses can be performed on the data to diagnose disease. The system includes a normalizing module for obtaining a normalizing factors database from a screening population group to account for differences in spatial separation of impedance measurements. Once a set of normalizing factors is obtained, a prebalancing factor can be obtained that can further be used to adjust raw electrical measurements. Normalizing factors are applied to a smaller subset of measurements that are likely to better represent the body part as a whole.: This set of measurements is reduced further by eliminating a set of the measurements that can be biased by a presence of a disease in a body part. The remaining measurements for each body part are then averaged to obtain an overall measure of a body part electrical property. The quotient between these measures is then used to adjust raw measurements. The adjusted measurements remove the imbalance that might exist due to natural differences between body parts. Adjusted measurements are then used as an input to other methods to obtain more accurate disease diagnostics.
摘要翻译：描述了通过在第一主体部分和第二基本上相似的身体部分中的一个中进行电测量来诊断疾病可能性的系统和方法。本发明平衡了归因于与疾病无关的自然因素的同源身体部位之间的差异，例如左乳房和右乳房之间的尺寸或对称性的差异。一旦数据进行前期平衡，就可以对数据进行统计分析以诊断疾病。该系统包括归一化模块，用于从筛选群体组获得归一化因子数据库，以解决阻抗测量的空间分离的差异。一旦获得了一组归一化因子，就可以获得可以进一步用于调整原始电气测量的预平衡因子。将归一化因子应用于可能更好地代表整体身体部位的较小的测量子集。通过消除可以通过在一种疾病中存在疾病而偏倚的一组测量来进一步降低该组测量值身体的一部分。然后对每个身体部位的剩余测量值进行平均，以获得身体部位电气性质的总体度量。然后使用这些措施之间的商来调整原始测量。调整后的测量可以消除由于身体部位之间的自然差异而可能存在的不平衡。然后将调整后的测量值用作其他方法的输入，以获得更准确的疾病诊断。

6. 发明申请

US20050075579A1 Diagnosis of disease by determination of electrical network properties of a body part 审中-公开
标题翻译：通过确定身体部位的电网特性来诊断疾病
公开(公告)号：US20050075579A1
公开(公告)日：2005-04-07
申请号：US10809473
申请日：2004-03-26
申请人： Adam Semlyen , Milan Graovac
发明人： Adam Semlyen , Milan Graovac
IPC分类号： A61B5/053 , A61B5/05
CPC分类号： A61B5/0536
摘要： A system and method for detecting and diagnosing disease states in a body part is described. The method is based on a set of electrical impedance measurements taken on the surface of a body part and a representation of the body part in the form of a network of impedances that would result in the same surface measurements as the actual body part. The system includes an electrical data unit for measuring electrical data of the body part, the electrical data unit having a plurality of Ne electrodes. The system also includes a network module for representing the body part by a network, the network having external nodes and internal nodes connected by current pathways. The system further includes an electrical properties module for determining electrical properties of the pathways using the measured electrical data, and a diagnosis module for utilizing the electrical properties to diagnose the possibility of disease in the body part. It is well known, for example, that tissue electrical impedance changes with malignancy.
摘要翻译：描述了用于检测和诊断身体部位中的疾病状态的系统和方法。该方法基于在身体部分的表面上进行的一组电阻抗测量，以及将导致与实际身体部分相同的表面测量的阻抗网络形式的身体部分的表示。该系统包括用于测量身体部位的电气数据的电气数据单元，该电子数据单元具有多个Ne电极。该系统还包括用于通过网络表示身体部位的网络模块，该网络具有通过当前路径连接的外部节点和内部节点。该系统还包括用于使用所测量的电气数据确定通路的电气特性的电气特性模块，以及用于利用电气特性来诊断身体部位疾病可能性的诊断模块。众所周知，例如，组织电阻抗随恶性变化而变化。

7. 发明授权

US08103337B2 Weighted gradient method and system for diagnosing disease 有权
标题翻译：加权梯度法和诊断疾病系统
公开(公告)号：US08103337B2
公开(公告)日：2012-01-24
申请号：US11287470
申请日：2005-11-28
申请人： Milan Graovac , James Martens , Zoran Pavlovic , Joel Ironstone
发明人： Milan Graovac , James Martens , Zoran Pavlovic , Joel Ironstone
IPC分类号： A61B5/05 , G06T17/00 , G09G5/02
CPC分类号： A61B5/0536 , A61B5/055
摘要： A method for detecting and diagnosing disease states in a body part is described. The method starts with a preparatory step of modeling the body part as a grid of many finite elements, then calculating an electrical property between two finite elements at which current from two corresponding electrodes flows through the body part. This is termed the weight (influence) of the element. With this baseline information, electrical impedance measurements made at the plurality of electrodes on the periphery of the body part can be used in a diagnostic module to calculate a Weighted Element Value (WEVal) for each element. In a preferred embodiment of invention, the difference in WEVal magnitude between corresponding elements of homologous body parts serves as an indicator of the presence of disease.
摘要翻译：描述了用于检测和诊断身体部位中的疾病状态的方法。该方法从将身体部分建模为许多有限元的网格的准备步骤开始，然后计算两个有限元素之间的电气特性，在两个有限元素之间，来自两个相应电极的电流流过身体部分。这被称为元件的重量（影响）。利用该基线信息，可以在诊断模块中使用在身体部位的周边上的多个电极处进行的电阻抗测量来计算每个元件的加权元素值（WEVal）。在本发明的优选实施方案中，同源体部分的相应元件之间的WEVal量值的差异用作疾病存在的指标。

8. 发明申请

US20080249432A1 Diagnosis of Disease By Determination of Elctrical Network Properties of a Body Part 审中-公开
标题翻译：通过确定身体部位的电子网络特性来诊断疾病
公开(公告)号：US20080249432A1
公开(公告)日：2008-10-09
申请号：US10550759
申请日：2004-03-26
申请人： Adam Semlyen , Milan Graovac
发明人： Adam Semlyen , Milan Graovac
IPC分类号： A61B5/053
CPC分类号： A61B5/0536
摘要： A system and method for detecting and diagnosing disease states in a body part is described. The method is based on a set of electrical impedance measurements taken on the surface of a body part and a representation of the body part in the form of a network of impedances that would result in the same surface measurements as the actual body part. The system includes an electrical data unit for measuring electrical data of the body part, the electrical data unit having a plurality of Ne electrodes. The system also includes a network module for representing the body part by a network, the network having external nodes and internal nodes connected by current pathways. The system further includes an electrical properties module for determining electrical properties of the pathways using the measured electrical data, and a diagnosis module for utilizing the electrical properties to diagnose the possibility of disease in the body part. It is well known, for example, that tissue electrical impedance changes with malignancy.
摘要翻译：描述了用于检测和诊断身体部位中的疾病状态的系统和方法。该方法基于在身体部分的表面上进行的一组电阻抗测量，以及将导致与实际身体部分相同的表面测量的阻抗网络形式的身体部分的表示。该系统包括用于测量身体部分的电气数据的电气数据单元，该电子数据单元具有多个N电极。该系统还包括用于通过网络表示身体部位的网络模块，该网络具有通过当前路径连接的外部节点和内部节点。该系统还包括用于使用所测量的电气数据确定通路的电气特性的电气特性模块，以及用于利用电气特性来诊断身体部位疾病可能性的诊断模块。众所周知，例如，组织电阻抗随恶性变化而变化。

9. 发明申请

US20050197591A1 System and method for prebalancing electrical properties to diagnose disease 审中-公开
标题翻译：用于预测电气性能以诊断疾病的系统和方法
公开(公告)号：US20050197591A1
公开(公告)日：2005-09-08
申请号：US10790846
申请日：2004-03-03
申请人： Zoran Pavlovic , Milan Graovac , Joel Ironstone
发明人： Zoran Pavlovic , Milan Graovac , Joel Ironstone
IPC分类号： A61B5/00 , A61B5/05 , A61B5/053
CPC分类号： A61B5/053
摘要： A system and method for diagnosing the possibility of disease by making electrical measurements in one of a first body part and a second substantially similar body part are described. The present invention balances out differences between homologous body parts that are due to natural factors unrelated to disease, such as differences in size or symmetry between left and right breasts. Once data are prebalanced, statistical analyses can be performed on the data to diagnose disease. The system includes a normalizing module for obtaining a normalizing factors database from a screening population group to account for differences in spatial separation of impedance measurements. Once a set of normalizing factors is obtained, a prebalancing factor can be obtained that can further be used to adjust raw electrical measurements. Normalizing factors are applied to a smaller subset of measurements that are likely to better represent the body part as a whole. This set of measurements is reduced further by eliminating a set of the measurements that can be biased by a presence of a disease in a body part. The remaining measurements for each body part are then averaged to obtain an overall measure of a body part electrical property. The quotient between these measures is then used to adjust raw measurements. The adjusted measurements remove the imbalance that might exist due to natural differences between body parts. Adjusted measurements are then used as an input to other methods to obtain more accurate disease diagnostics.
摘要翻译：描述了通过在第一主体部分和第二基本上相似的身体部分中的一个中进行电测量来诊断疾病可能性的系统和方法。本发明平衡了归因于与疾病无关的自然因素的同源身体部位之间的差异，例如左乳房和右乳房之间的尺寸或对称性的差异。一旦数据进行前期平衡，就可以对数据进行统计分析以诊断疾病。该系统包括归一化模块，用于从筛选群体组获得归一化因子数据库，以解决阻抗测量的空间分离的差异。一旦获得了一组归一化因子，就可以获得可以进一步用于调整原始电气测量的预平衡因子。归一化因子被应用于可能更好地代表身体整体的较小的测量子集。通过消除可以通过身体部位中的疾病的存在而偏移的一组测量来进一步减少该组测量。然后对每个身体部位的剩余测量值进行平均，以获得身体部位电气性质的总体度量。然后使用这些措施之间的商来调整原始测量。调整后的测量可以消除由于身体部位之间的自然差异而可能存在的不平衡。然后将调整后的测量值用作其他方法的输入，以获得更准确的疾病诊断。

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