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1. 发明专利

JP2013177434A Nanoparticle for protein drug delivery 审中-公开
标题翻译：用于蛋白质药物递送的纳米颗粒
公开(公告)号：JP2013177434A
公开(公告)日：2013-09-09
申请号：JP2013112996
申请日：2013-05-29
申请人： Nanomega Medical Corp , ナノメガメディカルコーポレーション , Hosheng Tu , チュ,シェン , Hsing Wen Sung , スン,シン−ウェン
发明人： TU HOSHENG , SUNG HSING WEN
IPC分类号： A61K9/16 , A61K38/28 , A61K47/34 , A61K47/36
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide nanoparticles for drug delivery for enhancing intestinal paracellular transportation or brain blood paracellular transportation of protein drugs.SOLUTION: Each nanoparticle includes: a first component comprising at least one bioactive agent; a negatively charged second component such as a poly-γ-glutamic acid; and a third component comprising a low molecular weight chitosan. In the nanoparticle, the first and second components occupy the center region, and the third component occupies the region on the surface.
摘要翻译：要解决的问题：提供用于药物递送的纳米颗粒，用于增强蛋白质药物的细胞旁细胞运输或脑血液旁分泌运输。解决方案：每个纳米颗粒包括：包含至少一种生物活性剂的第一组分; 带负电的第二组分如聚-γ-谷氨酸; 和包含低分子量壳聚糖的第三组分。在纳米颗粒中，第一和第二组分占据中心区域，第三组分占据表面上的区域。

2. 发明授权

US08579846B2 Ocular implant systems 有权
标题翻译：眼植入系统
公开(公告)号：US08579846B2
公开(公告)日：2013-11-12
申请号：US13301648
申请日：2011-11-21
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61B19/00 , A61F11/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.
摘要翻译：公开了用于治疗眼部疾病的植入物和方法。一个植入物具有管状构件，其具有入口端和出口端以及与其连接的切割构件。管状构件构造成延伸穿过眼睛组织，使得入口端和出口端分别位于眼睛的前房和生理流出路径中。期望地，切割构件被配置为在眼组织中进行切口以接收管状构件的至少一部分。一种方法包括使用植入物远端部分将具有近端和远端的植入物引入前房和穿透眼组织。植入物从前房进入穿透的眼组织，将远端和近端分别定位在生理流出道和前房中。在近端和远端之间进行水性幽默。

3. 发明授权

US08318198B1 Pharmaceutical composition of nanoparticles 失效
公开(公告)号：US08318198B1
公开(公告)日：2012-11-27
申请号：US13527886
申请日：2012-06-20
申请人： Hsing-Wen Sung , Zi-Xian Liao , Min-Fan Chung , Ko-Jie Chen , Hosheng Tu
发明人： Hsing-Wen Sung , Zi-Xian Liao , Min-Fan Chung , Ko-Jie Chen , Hosheng Tu
IPC分类号： A61L15/00
CPC分类号： A61K9/0004 , A61K9/1272 , A61K9/1278 , A61K9/5146 , A61K9/5153 , A61K9/5161 , A61K31/337 , A61K31/4745 , A61K31/704
摘要： The invention discloses a pharmaceutical composition of liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising at least one thermal triggered phase-transition compound as a targeting drug delivery system for physical cancer therapy.

4. 发明授权

US08287594B2 Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis 有权
标题翻译：膝关节假体和用于治疗骨关节炎的透明质酸盐组合物
公开(公告)号：US08287594B2
公开(公告)日：2012-10-16
申请号：US12949204
申请日：2010-11-18
申请人： Andrew H. Cragg , Richard J. Greff , George Wallace , Robert J. Socci, Jr. , Jonathan Kagan , Rodolfo C. Quijano , Hosheng Tu
发明人： Andrew H. Cragg , Richard J. Greff , George Wallace , Robert J. Socci, Jr. , Jonathan Kagan , Rodolfo C. Quijano , Hosheng Tu
IPC分类号： A61F2/08
CPC分类号： A61F2/30756 , A61F2/3872 , A61F2/461 , A61F2002/4635 , A61L27/20 , A61L27/50 , A61L27/52 , C08L5/08
摘要： A medical device and methods to relieve joint pain and adapted for knee joint repair, replacement and augmentation. The invention discloses joint lubricant, particularly hyaluronate compositions and methods for treatment of osteoarthritis.
摘要翻译：一种减轻关节疼痛并适应膝关节修复，置换和增大的医疗装置和方法。本发明公开了关节润滑剂，特别是透明质酸盐组合物和治疗骨关节炎的方法。

5. 发明授权

US08236281B1 Pharmaceutical composition of nanoparticles 有权
标题翻译：纳米粒子的药物组成
公开(公告)号：US08236281B1
公开(公告)日：2012-08-07
申请号：US13449157
申请日：2012-04-17
申请人： Hsing-Wen Sung , Kiran Sonaje , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55
摘要： The invention relates to a pharmaceutical composition of nanoparticles, wherein the nanoparticles comprise positively charged chitosan, a negatively charged substrate, optionally a zero-charge compound, and at least one bioactive agent for treating diabetes of an animal subject.
摘要翻译：本发明涉及纳米颗粒的药物组合物，其中纳米颗粒包含带正电荷的壳聚糖，带负电荷的底物，任选的零电荷化合物和用于治疗动物受试者的糖尿病的至少一种生物活性剂。

6. 发明授权

US08226602B2 Intragastric balloon system and therapeutic processes and products 有权
标题翻译：内窥镜气囊系统及治疗过程及产品
公开(公告)号：US08226602B2
公开(公告)日：2012-07-24
申请号：US11694536
申请日：2007-03-30
申请人： Rodolfo C. Quijana , Andrew H. Cragg , Hosheng Tu , Stephen A. Sosnowski , George Wallace
发明人： Rodolfo C. Quijana , Andrew H. Cragg , Hosheng Tu , Stephen A. Sosnowski , George Wallace
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61F5/0003 , A61F5/0036 , A61F5/0046
摘要： A gastric space filler device for treating obesity in a patient by reducing the stomach volume features at least one inflatable space filler with drag delivery and stimulation features and includes therapeutic devices and anchoring apparatus enabling tracking, visualization and optimized management of inter-balloon connecting sections, drug reservoirs and pumping systems along with related improvements.
摘要翻译：一种用于通过减少胃体积特征的用于治疗患者肥胖的胃空间填充装置，具有药物递送和刺激特征的至少一个可充气空间填充物，并且包括能够跟踪，可视化和优化管理球囊间连接部分的治疗装置和锚定装置，药物储库和抽水系统以及相关改进。

7. 发明授权

US08187570B1 Nanoparticles for protein drug delivery 有权
公开(公告)号：US08187570B1
公开(公告)日：2012-05-29
申请号：US13356583
申请日：2012-01-23
申请人： Hsing-Wen Sung , Zi-Xian Liao , Shu-Fen Peng , Hosheng Tu
发明人： Hsing-Wen Sung , Zi-Xian Liao , Shu-Fen Peng , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55
摘要： The invention discloses particulate complexes composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein equal moles of the positively charged chitosan and the negatively charged poly-glutamic acid substrate form an electrostatic network enabling improved loading the bioactive agent.

8. 发明授权

US08173106B1 Pharmaceutical composition of peptide drug and enzyme-inhibition compounds 有权
标题翻译：肽药物和酶抑制化合物的药物组合物
公开(公告)号：US08173106B1
公开(公告)日：2012-05-08
申请号：US13374135
申请日：2011-12-13
申请人： Hsing-Wen Sung , Kiran Sonaje , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Hosheng Tu
IPC分类号： A61B5/055
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55 , A61K47/645
摘要： The invention relates to a method of co-administering a peptide or protein drug with an enzyme-resistant PGA-complexone compound orally so to mitigate enzyme attack in the gastrointestinal tract of an animal subject.
摘要翻译：本发明涉及一种通过口服将肽或蛋白质药物与耐酶PGA-配合物化合物共同施用以减轻动物受试者的胃肠道中的酶侵袭的方法。

9. 发明申请

US20120109040A1 COMBINED TREATMENT FOR CATARACT AND GLAUCOMA TREATMENT 有权
标题翻译：联合治疗卡拉OK和玻璃体治疗
公开(公告)号：US20120109040A1
公开(公告)日：2012-05-03
申请号：US13118338
申请日：2011-05-27
申请人： Gregory T. Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas W. Burns
发明人： Gregory T. Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas W. Burns
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/00736 , A61F9/00754
摘要： A method is provided for treatment of cataract in combination with a glaucoma procedure while maintaining the intraocular pressure by permitting aqueous to flow out of an anterior chamber of the eye through a surgically stented pathway. A trabecular stent is adapted for implantation within the trabecular meshwork of an eye such that intraocular liquid flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular stent enabling post-cataract healing processes.
摘要翻译：提供一种用于治疗与青光眼手术相结合的白内障的方法，同时通过允许水通过手术支架的通路从眼前房流出而保持眼内压。小梁支架适于植入眼睛的小梁网内，使眼内液体从眼睛前房流向Schlemm运河，绕过小梁网。根据预期的具体治疗，可以将药物与小梁支架结合使用，以实现白内障后愈合过程。

10. 发明申请

US20120003306A1 Pharmaceutical composition of nanoparticles for protein drug delivery 有权
公开(公告)号：US20120003306A1
公开(公告)日：2012-01-05
申请号：US13199736
申请日：2011-09-08
申请人： Hsing-Wen Sung , Kiran Sonaje , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Hosheng Tu
IPC分类号： A61K9/48 , A61K9/28 , A61K9/14 , A61K9/50 , A61K31/351 , A61P37/06 , A61K31/4196 , A61K31/573 , A61K31/52 , A61K31/519 , A61K31/196 , A61K39/395 , A61K31/496
CPC分类号： A61K9/19 , A61K9/0043 , A61K9/2077 , A61K9/2081 , A61K9/2806 , A61K9/4891 , A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/26 , A61K47/34 , A61K47/36
摘要： The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.

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