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    • 4. 发明申请
    • METHOD AND APPARATUS FOR MAGNETIC RESONANCE IMAGING
    • 用于磁共振成像的方法和装置
    • WO1997035517A1
    • 1997-10-02
    • PCT/JP1997001055
    • 1997-03-27
    • HITACHI MEDICAL CORPORATIONTANIGUCHI, YoOCHI, HisaakiOKAJIMA, KenichiHIRATA, Satoshi
    • HITACHI MEDICAL CORPORATION
    • A61B05/055
    • G01R33/482G01R33/54
    • A magnetic resonance imaging apparatus including a pulse sequence control unit, which controls a predetermined pulse sequence of applying a high frequency magnetic field and a gradient magnetic field to an object in a static magnetic field to collect echoes; and an image reconstructing unit that reconstructs an image based on the collected echoes. The pulse sequence control unit includes a spatial resolution control section which sets a spatial resolution A in the readout gradient magnetic field direction of the reconstructed image; and a gradient magnetic field intensity control section which applies a readout magnetic field that causes the spatial resolution B determined by the readout gradient magnetic field intensity and the sampling period to become coarser than the spatial resolution A. The image reconstructing unit reconstructs an image with the minimum unit of the spatial resolution A taken as one pixel width in the readout direction of the reconstructed image.
    • 一种磁共振成像装置,包括:脉冲序列控制单元,其控制在静态磁场中对物体施加高频磁场和梯度磁场的预定脉冲序列以收集回波; 以及图像重建单元,其基于所收集的回波重建图像。 脉冲序列控制单元包括空间分辨率控制部分,其在重建图像的读出梯度磁场方向上设置空间分辨率A; 以及梯度磁场强度控制部分,其施加使由读出梯度磁场强度和采样周期确定的空间分辨率B变得比空间分辨率A更粗糙的读出磁场。图像重建单元用 空间分辨率A的最小单位作为重建图像的读出方向上的一个像素宽度。
    • 6. 发明申请
    • RADIOLABELED APATITE PARTICLES CONTAINING A PARAMAGNETIC ION
    • 含有PARAMAGNETIC ION的放射性APATITE颗粒
    • WO1997001304A1
    • 1997-01-16
    • PCT/US1996010808
    • 1996-06-25
    • MALLINCKRODT MEDICAL, INC.
    • MALLINCKRODT MEDICAL, INC.BRODACK, James, W.DEUTSCH, Edward, A.DEUTSCH, Karen, E.
    • A61B05/055
    • A61K51/1241A61K49/183A61K2121/00A61K2123/00
    • The present invention provides methods and compositions for improved medical diagnostic imaging and therapy for the treatment of rheumatoid arthritis. The compositions are derived from apatite particles including, but not limited to, hydroxyapatite, fluoroapatite, iodoapatite, carbonate-apatite, and mixtures and derivatives thereof. The compositions of the present invention contain a paramagnetic species incorporated into the apatite particles to improve magnetic resonance contrast and a radionuclide capable of providing a therapeutic dose of radioactivity. Also disclosed is a combination diagnostic/therapeutic composition and methods of performing medical diagnostic and therapeutic procedures which involve administering to a warm-blooded animal an amount of the above-described apatite particles containing a diagnostically effective amount of the paramagnetic ion and a therapeutically effective amount of the radionuclide and then performing the medical treatment and diagnostic procedures.
    • 本发明提供用于治疗类风湿性关节炎的用于改进的医学诊断成像和治疗的方法和组合物。 组合物衍生自磷灰石颗粒,包括但不限于羟基磷灰石,氟磷灰石,碘磷灰石,碳酸盐磷灰石及其混合物和衍生物。 本发明的组合物含有掺入磷灰石颗粒中以提高磁共振对比度的顺磁性物质,以及能够提供治疗剂量的放射性的放射性核素。 还公开了组合诊断/治疗组合物和执行医学诊断和治疗方法的方法,其涉及向温血动物施用一定量的含有诊断有效量的顺磁离子的磷酸钙颗粒和治疗有效量 的放射性核素,然后执行医疗和诊断程序。