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1. 发明授权

US06838251B1 Method for determining the coagulation potential of a plasma sample 有权
标题翻译：确定血浆样品凝固电位的方法
公开(公告)号：US06838251B1
公开(公告)日：2005-01-04
申请号：US09601073
申请日：1999-02-01
申请人： Thomas Exner
发明人： Thomas Exner
IPC分类号： G01N33/86 , C12Q1/56
CPC分类号： C12Q1/56 , G01N2333/462
摘要： A method of determining the coagulation potential of a plasma sample be pre-incubating the plasma sample with a reagent such that endogenous protein C in the plasma is at least partially converted into activated protein C by the reagent, adding factor Xa which is progressively inactivated by antithrombin III/heparin cofactor 2 during the preincubation, adding an exogenous reagent which activates factor X to Xa or prothrombin to thrombin in a factor V-dependent manner, monitoring a reaction indicative of the rate of coagulation of the plasma sample, comparing that rate of coagulation control, or the equivalent rate determined for an individual without impaired coagulation control, or the equivalent rate determined for the plasma sample in the absence of protein C activator, and determining the coagulation potential of the plasma sample from one or other of the compairsons.
摘要翻译：确定血浆样品的凝血电位的方法是用试剂预先培养血浆样品，使得血浆中的内源性蛋白C至少部分地被试剂转化成活化的蛋白质C，加入通过下述方法逐渐失活的添加因子Xa 抗凝血酶III /肝素辅因子2，加入外因试剂，以因子V依赖性方式将X因子激活至Xa或凝血酶凝血酶，监测血浆样品凝血速率的反应，凝血控制或对于没有受损凝血控制的个体而确定的等效速率，或者在不存在蛋白C激活剂的情况下为血浆样品确定的等效速率，以及确定来自一个或其它比较物的血浆样品的凝固电位。

2. 发明授权

US5846755A Method for determining the therapeutic activity of metalloproteinase inhibitor compounds 失效
标题翻译：确定金属蛋白酶抑制剂化合物治疗活性的方法
公开(公告)号：US5846755A
公开(公告)日：1998-12-08
申请号：US693021
申请日：1996-08-06
申请人： Vencenzo Politi , Silvana D'Alessio , Giovanni Di Stazio , Giovanna De Luca , Mario Materazzi
发明人： Vencenzo Politi , Silvana D'Alessio , Giovanni Di Stazio , Giovanna De Luca , Mario Materazzi
IPC分类号： C12N9/99 , A61K35/58 , A61K38/00 , A61K45/00 , A61P9/10 , A61P11/00 , A61P25/30 , A61P37/00 , A61P43/00 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/097 , C12Q1/37
CPC分类号： C12Q1/37 , C07K5/0202 , C07K5/0205 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06191 , C07K5/0821 , A61K38/00 , G01N2333/4613 , G01N2333/462 , G01N2333/78 , G01N2333/96486
摘要： A method for determining the therapeutic potential of peptidomimetic compounds as inhibitors of zinc-dependent metalloproteinase activity associated with pathological conditions of humans and animals.
摘要翻译：用于确定拟肽化合物作为与人和动物的病理状况相关的锌依赖性金属蛋白酶活性的抑制剂的治疗潜力的方法。

3. 发明授权

US5726028A Method for detecting disturbances of the protein c/protein s system 失效
标题翻译：检测蛋白质c /蛋白质系统紊乱的方法
公开(公告)号：US5726028A
公开(公告)日：1998-03-10
申请号：US511248
申请日：1995-08-04
申请人： Michael Kraus
发明人： Michael Kraus
IPC分类号： C12Q1/56 , G01N33/86
CPC分类号： G01N33/86 , G01N2333/462 , G01N2333/745 , G01N2333/91074 , G01N2333/9108 , G01N2333/91085 , G01N2333/96461 , G01N2405/04 , Y10S514/834
摘要： The present invention relates to a method for detecting disturbances of the protein C/protein S system.
摘要翻译：本发明涉及一种检测蛋白C /蛋白S系统的紊乱的方法。

4. 发明公开

EP0758021A3 Method for determining the therapeutic activity of metalloproteinase inhibitor compounds, new inhibitor compounds, and the therapeutic use thereof 失效
标题翻译：一种用于确定金属蛋白酶化合物，新的抑制剂化合物和它们的治疗用途的治疗效果的方法
公开(公告)号：EP0758021A3
公开(公告)日：1998-07-22
申请号：EP96830445
申请日：1996-08-02
申请人： POLIFARMA SPA
发明人： POLITI VINCENZO , D ALESSIO SILVANA , DI STAZIO GIOVANNI , DE LUCA GIOVANNA , MATERAZZI MARIO
IPC分类号： C12N9/99 , A61K35/58 , A61K38/00 , A61K45/00 , A61P9/10 , A61P11/00 , A61P25/30 , A61P37/00 , A61P43/00 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/097 , C12Q1/37
CPC分类号： C12Q1/37 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06191 , C07K5/0821 , G01N2333/4613 , G01N2333/462 , G01N2333/78 , G01N2333/96486
摘要： A method for determining the activity as pharmacological agents of zinc-dependent metalloproteinase inhibiting peptidomimetic chemical compounds extracted from snake venom for the therapeutic treatment of disturbances created in mammals by metalloproteinases of endogenous origin produced in the organism of the mammals themselves, along with new inhibitor compounds determined in this way and their pharmaceutical use in a variety of important human pathologies connected with endogenous metalloproteinase activation.

5. 发明申请

WO99039212A1 IMPROVED BLOOD COAGULATION TEST 审中-公开
标题翻译：改善血液凝血试验
公开(公告)号：WO99039212A1
公开(公告)日：1999-08-05
申请号：PCT/AU1999/000069
申请日：1999-02-01
IPC分类号： G01N33/86 , C12Q1/56
CPC分类号： C12Q1/56 , G01N2333/462
摘要： A method of determining the coagulation potential of a plasma sample comprising the steps of: (a) preincubating the plasma sample with whole dilute Agkistrodon Contortrix venom (ACCV) or like reagent such that (i) endogenous protein C in the plasma is converted into activated protein C by the reagent, and (ii) adding factor Xa which is progressively inactivated by antithrombin III/heparin cofactor (2) during the preincubation; (b) then adding reagents to initiate clotting comprising: (i) an exogenous reagent which activates factor X to Xa or prothrombin to thrombin in a factor V-dependent manner, and (ii) components, such as phospholipid and calcium ions, for efficient coagulation; (c) monitoring a reaction indicative of the rate of coagulation; (d) comparing the rate of coagulation detected in step (b) with the equivalent rate determined for a normal patient, or comparing the rate of coagulation detected in step (b) with the equivalent rate determined for the plasma sample in the absence of protein C activator; and (e) determining the coagulation potential of the plasma sample from one or other of the comparisons of step (d).
摘要翻译：一种确定血浆样品的凝固电位的方法，包括以下步骤：（a）将血浆样品与全部稀释的猕猴桃毒素（ACCV）或类似试剂预孵育，使得（i）血浆中的内源性蛋白C被转化为活化的蛋白C，以及（ii）在预培养期间加入由抗凝血酶III /肝素辅因子（2）逐渐灭活的因子Xa; （b）然后加入试剂以引发凝血，其包括：（i）以因子V依赖性方式将因子X转化为Xa或凝血酶的凝血酶的外源试剂，以及（ii）组分，例如磷脂和钙离子，用于有效凝固; （c）监测指示凝血速率的反应; （d）将步骤（b）中检测到的凝血速率与对于正常患者确定的等效比率进行比较，或将步骤（b）中检测到的凝血速率与在不存在蛋白质的情况下为血浆样品测定的等效比率进行比较 C活化剂; 和（e）从步骤（d）的一个或另一个比较确定血浆样品的凝血电位。

6. 发明授权

EP0758021B1 Method for determining the therapeutic activity of metalloproteinase inhibitor compounds, new inhibitor compounds, and the therapeutic use thereof 失效
标题翻译：一种用于确定金属蛋白酶化合物，新的抑制剂化合物和它们的治疗用途的治疗效果的方法
公开(公告)号：EP0758021B1
公开(公告)日：2006-03-29
申请号：EP96830445.1
申请日：1996-08-02
申请人： POLIFARMA S.p.A.
发明人： Politi, Vincenzo , D'Alessio, Silvana , Di Stazio, Giovanni , De Luca, Giovanna , Materazzi, Mario
IPC分类号： C12Q1/37 , C07K5/06 , A61K38/55
CPC分类号： C12Q1/37 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06191 , C07K5/0821 , G01N2333/4613 , G01N2333/462 , G01N2333/78 , G01N2333/96486

7. 发明授权

EP0718628B2 Method for diagnosis of blood coagulation disorders 失效
标题翻译：一种用于诊断出血性疾病的方法
公开(公告)号：EP0718628B2
公开(公告)日：2005-02-23
申请号：EP95304016.9
申请日：1995-06-09
申请人： Diagnostic Reagents Limited
发明人： Denson, Kenneth William Ernest
IPC分类号： G01N33/86 , C12Q1/56
CPC分类号： C12Q1/56 , G01N2333/462 , G01N2333/745 , G01N2333/96461

8. 发明授权

EP0718628B1 Method for diagnosis of blood coagulation disorders 失效
标题翻译：一种用于诊断出血性疾病的方法
公开(公告)号：EP0718628B1
公开(公告)日：2001-04-18
申请号：EP95304016.9
申请日：1995-06-09
申请人： Diagnostic Reagents Limited
发明人： Denson, Kenneth William Ernest
IPC分类号： G01N33/86 , C12Q1/56
CPC分类号： C12Q1/56 , G01N2333/462 , G01N2333/745 , G01N2333/96461

9. 发明公开

EP0718628A1 Method for diagnosis of blood coagulation disorders 失效
标题翻译： Verfahren zur诊断vonBlutgerinnungsstörungen
公开(公告)号：EP0718628A1
公开(公告)日：1996-06-26
申请号：EP95304016.9
申请日：1995-06-09
申请人： Diagnostic Reagents Limited
发明人： Denson, Kenneth William Ernest
IPC分类号： G01N33/86 , C12Q1/56
CPC分类号： C12Q1/56 , G01N2333/462 , G01N2333/745 , G01N2333/96461
摘要： A method and kit for screening blood plasma for APC cofactor is provided. The method comprises:

(i) incubating a first portion of the sample with

(a) an exogenous reagent containing phospholipid which activates the contact mechanism in intrinsic clotting or an exogenous reagent which initiates extrinsic clotting; and incubating a second portion of the sample with
(b) the reagent of step (i) (a) and an exogenous Protein C (PC) activator which produces activated PC (APC) from endogenous Protein C and Protein S.

(ii) adding to each of the two portions a clotting agent and monitoring the conversion rate of fibrinogen to insoluble fibrin; and
(iii) calculating the ratio of the rate for the second portion of the sample to the rate for the first portion and comparing this ratio with the corresponding ratio for samples from normal subjects.
摘要翻译：提供了用于APC辅助因子筛选血浆的方法和试剂盒。该方法包括：（i）将样品的第一部分与（a）含有磷脂的外源试剂孵育，所述磷脂激活内在凝血中的接触机制或引发外在凝血的外源试剂; 和（b）步骤（i）（a）的试剂和从内源蛋白C和蛋白S产生活化的PC（APC）的外源蛋白C（PC）活化剂孵育第二部分样品。（ii）加入将两个部分中的每一个分成凝血剂并监测纤维蛋白原转化为不溶性纤维蛋白; 和（iii）计算样品的第二部分的速率与第一部分的比率的比率，并将该比率与来自正常受试者的样品的相应比率进行比较。

10. 发明公开

EP1068536A4 IMPROVED BLOOD COAGULATION TEST 有权
标题翻译：促进血液凝血试验
公开(公告)号：EP1068536A4
公开(公告)日：2002-09-04
申请号：EP99903537
申请日：1999-02-01
申请人： GRADIPORE LTD
发明人： EXNER THOMAS
IPC分类号： G01N33/86 , C12Q1/56
CPC分类号： C12Q1/56 , G01N2333/462
摘要： A method of determining the coagulation potential of a plasma sample comprising the steps of: (a) preincubating the plasma sample with whole dilute Agkistrodon Contortrix venom (ACCV) or like reagent such that (i) endogenous protein C in the plasma is converted into activated protein C by the reagent, and (ii) adding factor Xa which is progressively inactivated by antithrombin III/heparin cofactor (2) during the preincubation; (b) then adding reagents to initiate clotting comprising: (i) an exogenous reagent which activates factor X to Xa or prothrombin to thrombin in a factor V-dependent manner, and (ii) components, such as phospholipid and calcium ions, for efficient coagulation; (c) monitoring a reaction indicative of the rate of coagulation; (d) comparing the rate of coagulation detected in step (b) with the equivalent rate determined for a normal patient, or comparing the rate of coagulation detected in step (b) with the equivalent rate determined for the plasma sample in the absence of protein C activator; and (e) determining the coagulation potential of the plasma sample from one or other of the comparisons of step (d).

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